Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Putative P2Y purinoceptor 10

Gene

P2RY10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Putative receptor for purines coupled to G-proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Putative P2Y purinoceptor 10
Short name:
P2Y10
Alternative name(s):
P2Y-like receptor
Gene namesi
Name:P2RY10
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000078589.12
HGNCiHGNC:19906 P2RY10
MIMi300529 gene
neXtProtiNX_O00398

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 68CytoplasmicSequence analysis8
Transmembranei69 – 89Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini90 – 103ExtracellularSequence analysisAdd BLAST14
Transmembranei104 – 124Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini125 – 149CytoplasmicSequence analysisAdd BLAST25
Transmembranei150 – 170Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini171 – 193ExtracellularSequence analysisAdd BLAST23
Transmembranei194 – 214Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini215 – 244CytoplasmicSequence analysisAdd BLAST30
Transmembranei245 – 265Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini266 – 288ExtracellularSequence analysisAdd BLAST23
Transmembranei289 – 309Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini310 – 339CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi27334
OpenTargetsiENSG00000078589
PharmGKBiPA134873055

Chemistry databases

ChEMBLiCHEMBL3562166
GuidetoPHARMACOLOGYi165

Polymorphism and mutation databases

BioMutaiP2RY10

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700341 – 339Putative P2Y purinoceptor 10Add BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi16N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 181PROSITE-ProRule annotation
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00398
PeptideAtlasiO00398
PRIDEiO00398
ProteomicsDBi47864

PTM databases

PhosphoSitePlusiO00398

Expressioni

Tissue specificityi

Weakly expressed in blood leukocytes.1 Publication

Developmental stagei

Up-regulated during promyelocytic cell differentiation along the monocytic pathway, but not during granulocytic differentiation.

Gene expression databases

BgeeiENSG00000078589
CleanExiHS_P2RY10
GenevisibleiO00398 HS

Organism-specific databases

HPAiHPA036757
HPA065766

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000171757

Chemistry databases

BindingDBiO00398

Structurei

3D structure databases

ProteinModelPortaliO00398
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHMZ Eukaryota
ENOG410ZZCA LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231258
HOVERGENiHBG099867
InParanoidiO00398
KOiK04274
OMAiQSTLYFH
OrthoDBiEOG091G0DAI
PhylomeDBiO00398
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR027676 P2Y10_rcpt
PANTHERiPTHR24232:SF47 PTHR24232:SF47, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O00398-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANLDKYTET FKMGSNSTST AEIYCNVTNV KFQYSLYATT YILIFIPGLL
60 70 80 90 100
ANSAALWVLC RFISKKNKAI IFMINLSVAD LAHVLSLPLR IYYYISHHWP
110 120 130 140 150
FQRALCLLCF YLKYLNMYAS ICFLTCISLQ RCFFLLKPFR ARDWKRRYDV
160 170 180 190 200
GISAAIWIVV GTACLPFPIL RSTDLNNNKS CFADLGYKQM NAVALVGMIT
210 220 230 240 250
VAELAGFVIP VIIIAWCTWK TTISLRQPPM AFQGISERQK ALRMVFMCAA
260 270 280 290 300
VFFICFTPYH INFIFYTMVK ETIISSCPVV RIALYFHPFC LCLASLCCLL
310 320 330
DPILYYFMAS EFRDQLSRHG SSVTRSRLMS KESGSSMIG
Length:339
Mass (Da):38,774
Last modified:July 1, 1997 - v1
Checksum:i2C043E4DC342FA0D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0334813N → H. Corresponds to variant dbSNP:rs6618868Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF000545 Genomic DNA Translation: AAB57836.1
AY275461 Genomic DNA Translation: AAP32293.1
Z82200 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98594.1
CH471104 Genomic DNA Translation: EAW98595.1
BC051875 mRNA Translation: AAH51875.2
BC095498 mRNA Translation: AAH95498.1
CCDSiCCDS14442.1
RefSeqiNP_001311147.1, NM_001324218.1
NP_055314.1, NM_014499.3
NP_938147.1, NM_198333.2
UniGeneiHs.296433
Hs.445500

Genome annotation databases

EnsembliENST00000171757; ENSP00000171757; ENSG00000078589
ENST00000544091; ENSP00000443138; ENSG00000078589
GeneIDi27334
KEGGihsa:27334
UCSCiuc004ede.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiP2Y10_HUMAN
AccessioniPrimary (citable) accession number: O00398
Secondary accession number(s): D3DTE5, Q4VBN7, Q86V16
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health