UniProtKB - O00391 (QSOX1_HUMAN)
Sulfhydryl oxidase 1
QSOX1
Functioni
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277).
Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277).
In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).
6 PublicationsMiscellaneous
Catalytic activityi
- EC:1.8.3.27 Publications
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 70 | Nucleophile2 Publications | 1 | |
Active sitei | 73 | Nucleophile2 Publications | 1 | |
Binding sitei | 401 | FADCombined sources1 Publication | 1 | |
Binding sitei | 408 | FADCombined sources1 Publication | 1 | |
Binding sitei | 412 | FADCombined sources1 Publication | 1 | |
Binding sitei | 451 | FADCombined sources1 Publication | 1 | |
Binding sitei | 455 | FADCombined sources1 Publication | 1 | |
Binding sitei | 500 | FADCombined sources1 Publication | 1 | |
Binding sitei | 503 | FADCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 478 – 485 | FADCombined sources1 Publication | 8 |
GO - Molecular functioni
- FAD binding Source: UniProtKB
- flavin-linked sulfhydryl oxidase activity Source: UniProtKB
- protein disulfide isomerase activity Source: UniProtKB
GO - Biological processi
- extracellular matrix assembly Source: UniProtKB
- negative regulation of macroautophagy Source: CACAO
- protein folding Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein |
Enzyme and pathway databases
BRENDAi | 1.8.3.2, 2681 |
PathwayCommonsi | O00391 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | O00391 |
Names & Taxonomyi
Protein namesi | Recommended name: Sulfhydryl oxidase 1 (EC:1.8.3.27 Publications)Short name: hQSOX Alternative name(s): Quiescin Q62 Publications |
Gene namesi | Name:QSOX1 Synonyms:QSCN61 Publication ORF Names:UNQ2520/PRO6013 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9756, QSOX1 |
MIMi | 603120, gene |
neXtProti | NX_O00391 |
VEuPathDBi | HostDB:ENSG00000116260 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane 2 Publications; Single-pass membrane protein 1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Note: A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor.1 Publication
Extracellular region or secreted
- Secreted 1 Publication
Note: Found in the extracellular medium of quiescent cells but is not found in proliferating cells.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum lumen Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
- intercellular bridge Source: HPA
Golgi apparatus
- Golgi apparatus Source: HPA
- Golgi membrane Source: UniProtKB
- integral component of Golgi membrane Source: UniProtKB
Other locations
- intracellular membrane-bounded organelle Source: HPA
- platelet alpha granule lumen Source: Reactome
- specific granule lumen Source: Reactome
- tertiary granule lumen Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 710 – 730 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Golgi apparatus, Membrane, SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 70 – 73 | CGHC → AGHA: Loss of catalytic activity. Cannot prevent cell detachment after depletion of the endogenous protein. 2 Publications | 4 | |
Mutagenesisi | 70 | C → S: Reduces activity by 93%. 1 Publication | 1 | |
Mutagenesisi | 72 | H → A: Decreased protein stability and catalytic activity; when associated with S-119 or T-119. 1 Publication | 1 | |
Mutagenesisi | 73 | C → S: Reduces activity by 93%. 1 Publication | 1 | |
Mutagenesisi | 119 | P → S or T: Loss of catalytic activity. Decreased protein stability and catalytic activity; when associated with A-72. 1 Publication | 1 | |
Mutagenesisi | 130 | N → Q: Loss of glycosylation site. 1 Publication | 1 | |
Mutagenesisi | 243 | N → Q: Loss of glycosylation site. Abolishes secretion. No effect on catalytic activity. 1 Publication | 1 | |
Mutagenesisi | 276 – 282 | TTVAPTT → ANVAPVA: Decreased O-glycosylation. 1 Publication | 7 | |
Mutagenesisi | 449 | C → S: Reduces activity by 96%. 1 Publication | 1 | |
Mutagenesisi | 452 | C → S: Loss of activity. 1 Publication | 1 | |
Mutagenesisi | 509 | C → S: No effect. Reduces activity by 70%; when associated with S-512. 1 Publication | 1 | |
Mutagenesisi | 512 | C → S: Reduces activity by 40%. Reduces activity by 70%; when associated with S-509. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 5768 |
OpenTargetsi | ENSG00000116260 |
PharmGKBi | PA162400559 |
Miscellaneous databases
Pharosi | O00391, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4523117 |
Genetic variation databases
BioMutai | QSOX1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000249533 | 30 – 747 | Sulfhydryl oxidase 1Add BLAST | 718 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 70 ↔ 73 | Redox-activeCombined sources4 Publications | ||
Disulfide bondi | 101 ↔ 110 | Combined sources2 Publications | ||
Glycosylationi | 130 | N-linked (GlcNAc...) (complex) asparagine3 Publications | 1 | |
Glycosylationi | 243 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 393 ↔ 405 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Modified residuei | 426 | Phosphoserine; by FAM20C1 Publication | 1 | |
Disulfide bondi | 449 ↔ 452 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Disulfide bondi | 509 ↔ 512 | PROSITE-ProRule annotationCombined sources1 Publication | ||
Glycosylationi | 575 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | O00391 |
jPOSTi | O00391 |
MassIVEi | O00391 |
MaxQBi | O00391 |
PaxDbi | O00391 |
PeptideAtlasi | O00391 |
PRIDEi | O00391 |
ProteomicsDBi | 47862 [O00391-1] 47863 [O00391-2] |
PTM databases
GlyConnecti | 1774, 24 N-Linked glycans (4 sites) |
GlyGeni | O00391, 6 sites, 27 N-linked glycans (4 sites), 2 O-linked glycans (2 sites) |
iPTMneti | O00391 |
PhosphoSitePlusi | O00391 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000116260, Expressed in right testis and 240 other tissues |
ExpressionAtlasi | O00391, baseline and differential |
Genevisiblei | O00391, HS |
Organism-specific databases
HPAi | ENSG00000116260, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 111734, 88 interactors |
IntActi | O00391, 24 interactors |
MINTi | O00391 |
STRINGi | 9606.ENSP00000356574 |
Chemistry databases
BindingDBi | O00391 |
Miscellaneous databases
RNActi | O00391, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | O00391 |
SMRi | O00391 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O00391 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 156 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 121 | |
Domaini | 396 – 503 | ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST | 108 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 573 – 633 | DisorderedSequence analysisAdd BLAST | 61 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1731, Eukaryota |
GeneTreei | ENSGT00940000159504 |
HOGENOMi | CLU_020182_1_0_1 |
InParanoidi | O00391 |
OMAi | YLWKAHN |
PhylomeDBi | O00391 |
TreeFami | TF316749 |
Family and domain databases
Gene3Di | 1.20.120.1960, 1 hit 1.20.120.310, 1 hit |
InterProi | View protein in InterPro IPR036774, ERV/ALR_sulphydryl_oxid_sf IPR017905, ERV/ALR_sulphydryl_oxidase IPR040986, QSOX_FAD-bd_dom IPR042568, QSOX_FAD-bd_sf IPR041269, QSOX_Trx1 IPR039798, Sulfhydryl_oxidase IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR22897, PTHR22897, 1 hit |
Pfami | View protein in Pfam PF04777, Evr1_Alr, 1 hit PF18371, FAD_SOX, 1 hit PF18108, QSOX_Trx1, 1 hit PF00085, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit SSF69000, SSF69000, 1 hit |
PROSITEi | View protein in PROSITE PS51324, ERV_ALR, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRRCNSGSGP PPSLLLLLLW LLAVPGANAA PRSALYSPSD PLTLLQADTV
60 70 80 90 100
RGAVLGSRSA WAVEFFASWC GHCIAFAPTW KALAEDVKAW RPALYLAALD
110 120 130 140 150
CAEETNSAVC RDFNIPGFPT VRFFKAFTKN GSGAVFPVAG ADVQTLRERL
160 170 180 190 200
IDALESHHDT WPPACPPLEP AKLEEIDGFF ARNNEEYLAL IFEKGGSYLG
210 220 230 240 250
REVALDLSQH KGVAVRRVLN TEANVVRKFG VTDFPSCYLL FRNGSVSRVP
260 270 280 290 300
VLMESRSFYT AYLQRLSGLT REAAQTTVAP TTANKIAPTV WKLADRSKIY
310 320 330 340 350
MADLESALHY ILRIEVGRFP VLEGQRLVAL KKFVAVLAKY FPGRPLVQNF
360 370 380 390 400
LHSVNEWLKR QKRNKIPYSF FKTALDDRKE GAVLAKKVNW IGCQGSEPHF
410 420 430 440 450
RGFPCSLWVL FHFLTVQAAR QNVDHSQEAA KAKEVLPAIR GYVHYFFGCR
460 470 480 490 500
DCASHFEQMA AASMHRVGSP NAAVLWLWSS HNRVNARLAG APSEDPQFPK
510 520 530 540 550
VQWPPRELCS ACHNERLDVP VWDVEATLNF LKAHFSPSNI ILDFPAAGSA
560 570 580 590 600
ARRDVQNVAA APELAMGALE LESRNSTLDP GKPEMMKSPT NTTPHVPAEG
610 620 630 640 650
PEASRPPKLH PGLRAAPGQE PPEHMAELQR NEQEQPLGQW HLSKRDTGAA
660 670 680 690 700
LLAESRAEKN RLWGPLEVRR VGRSSKQLVD IPEGQLEARA GRGRGQWLQV
710 720 730 740
LGGGFSYLDI SLCVGLYSLS FMGLLAMYTY FQAKIRALKG HAGHPAA
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA8MXT8 | A8MXT8_HUMAN | Sulfhydryl oxidase 1 | QSOX1 | 155 | Annotation score: | ||
H0Y5Z8 | H0Y5Z8_HUMAN | Sulfhydryl oxidase 1 | QSOX1 | 72 | Annotation score: |
Sequence cautioni
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027429 | 114 | N → S. Corresponds to variant dbSNP:rs3894211EnsemblClinVar. | 1 | |
Natural variantiVAR_027430 | 200 | G → A3 PublicationsCorresponds to variant dbSNP:rs17855475Ensembl. | 1 | |
Natural variantiVAR_027431 | 256 | R → M. Corresponds to variant dbSNP:rs4360492Ensembl. | 1 | |
Natural variantiVAR_027432 | 294 | A → S. Corresponds to variant dbSNP:rs2278943Ensembl. | 1 | |
Natural variantiVAR_027433 | 444 | H → R1 PublicationCorresponds to variant dbSNP:rs12371Ensembl. | 1 | |
Natural variantiVAR_027434 | 591 | N → H. Corresponds to variant dbSNP:rs3738115Ensembl. | 1 | |
Natural variantiVAR_053652 | 605 | R → P. Corresponds to variant dbSNP:rs16855466EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020489 | 603 – 604 | AS → LI in isoform 2. 2 Publications | 2 | |
Alternative sequenceiVSP_020490 | 605 – 747 | Missing in isoform 2. 2 PublicationsAdd BLAST | 143 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U97276 mRNA Translation: AAC09010.2 AF361868 mRNA Translation: AAM00263.1 AY358941 mRNA Translation: AAQ89300.1 AB209280 mRNA Translation: BAD92517.1 Different initiation. AL390718 Genomic DNA No translation available. BC017692 mRNA Translation: AAH17692.1 BC100023 mRNA Translation: AAI00024.1 |
CCDSi | CCDS1337.1 [O00391-1] CCDS30950.1 [O00391-2] |
RefSeqi | NP_001004128.1, NM_001004128.2 [O00391-2] NP_002817.2, NM_002826.4 [O00391-1] |
Genome annotation databases
Ensembli | ENST00000367600.5; ENSP00000356572.5; ENSG00000116260.17 [O00391-2] ENST00000367602.8; ENSP00000356574.3; ENSG00000116260.17 |
GeneIDi | 5768 |
KEGGi | hsa:5768 |
MANE-Selecti | ENST00000367602.8; ENSP00000356574.3; NM_002826.5; NP_002817.2 |
UCSCi | uc001gny.4, human [O00391-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U97276 mRNA Translation: AAC09010.2 AF361868 mRNA Translation: AAM00263.1 AY358941 mRNA Translation: AAQ89300.1 AB209280 mRNA Translation: BAD92517.1 Different initiation. AL390718 Genomic DNA No translation available. BC017692 mRNA Translation: AAH17692.1 BC100023 mRNA Translation: AAI00024.1 |
CCDSi | CCDS1337.1 [O00391-1] CCDS30950.1 [O00391-2] |
RefSeqi | NP_001004128.1, NM_001004128.2 [O00391-2] NP_002817.2, NM_002826.4 [O00391-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3LLI | X-ray | 2.05 | A | 286-546 | [»] | |
3LLK | X-ray | 2.00 | A/B/C | 286-546 | [»] | |
3Q6O | X-ray | 2.05 | A | 33-272 | [»] | |
4IJ3 | X-ray | 2.70 | A | 33-272 | [»] | |
AlphaFoldDBi | O00391 | |||||
SMRi | O00391 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111734, 88 interactors |
IntActi | O00391, 24 interactors |
MINTi | O00391 |
STRINGi | 9606.ENSP00000356574 |
Chemistry databases
BindingDBi | O00391 |
ChEMBLi | CHEMBL4523117 |
PTM databases
GlyConnecti | 1774, 24 N-Linked glycans (4 sites) |
GlyGeni | O00391, 6 sites, 27 N-linked glycans (4 sites), 2 O-linked glycans (2 sites) |
iPTMneti | O00391 |
PhosphoSitePlusi | O00391 |
Genetic variation databases
BioMutai | QSOX1 |
Proteomic databases
EPDi | O00391 |
jPOSTi | O00391 |
MassIVEi | O00391 |
MaxQBi | O00391 |
PaxDbi | O00391 |
PeptideAtlasi | O00391 |
PRIDEi | O00391 |
ProteomicsDBi | 47862 [O00391-1] 47863 [O00391-2] |
Protocols and materials databases
ABCDi | O00391, 2 sequenced antibodies |
Antibodypediai | 47086, 200 antibodies from 33 providers |
DNASUi | 5768 |
Genome annotation databases
Ensembli | ENST00000367600.5; ENSP00000356572.5; ENSG00000116260.17 [O00391-2] ENST00000367602.8; ENSP00000356574.3; ENSG00000116260.17 |
GeneIDi | 5768 |
KEGGi | hsa:5768 |
MANE-Selecti | ENST00000367602.8; ENSP00000356574.3; NM_002826.5; NP_002817.2 |
UCSCi | uc001gny.4, human [O00391-1] |
Organism-specific databases
CTDi | 5768 |
DisGeNETi | 5768 |
GeneCardsi | QSOX1 |
HGNCi | HGNC:9756, QSOX1 |
HPAi | ENSG00000116260, Low tissue specificity |
MIMi | 603120, gene |
neXtProti | NX_O00391 |
OpenTargetsi | ENSG00000116260 |
PharmGKBi | PA162400559 |
VEuPathDBi | HostDB:ENSG00000116260 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1731, Eukaryota |
GeneTreei | ENSGT00940000159504 |
HOGENOMi | CLU_020182_1_0_1 |
InParanoidi | O00391 |
OMAi | YLWKAHN |
PhylomeDBi | O00391 |
TreeFami | TF316749 |
Enzyme and pathway databases
BRENDAi | 1.8.3.2, 2681 |
PathwayCommonsi | O00391 |
Reactomei | R-HSA-114608, Platelet degranulation R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-6798695, Neutrophil degranulation R-HSA-8957275, Post-translational protein phosphorylation |
SignaLinki | O00391 |
Miscellaneous databases
BioGRID-ORCSi | 5768, 17 hits in 1076 CRISPR screens |
ChiTaRSi | QSOX1, human |
EvolutionaryTracei | O00391 |
GeneWikii | QSOX1 |
GenomeRNAii | 5768 |
Pharosi | O00391, Tbio |
PROi | PR:O00391 |
RNActi | O00391, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116260, Expressed in right testis and 240 other tissues |
ExpressionAtlasi | O00391, baseline and differential |
Genevisiblei | O00391, HS |
Family and domain databases
Gene3Di | 1.20.120.1960, 1 hit 1.20.120.310, 1 hit |
InterProi | View protein in InterPro IPR036774, ERV/ALR_sulphydryl_oxid_sf IPR017905, ERV/ALR_sulphydryl_oxidase IPR040986, QSOX_FAD-bd_dom IPR042568, QSOX_FAD-bd_sf IPR041269, QSOX_Trx1 IPR039798, Sulfhydryl_oxidase IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
PANTHERi | PTHR22897, PTHR22897, 1 hit |
Pfami | View protein in Pfam PF04777, Evr1_Alr, 1 hit PF18371, FAD_SOX, 1 hit PF18108, QSOX_Trx1, 1 hit PF00085, Thioredoxin, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit SSF69000, SSF69000, 1 hit |
PROSITEi | View protein in PROSITE PS51324, ERV_ALR, 1 hit PS51352, THIOREDOXIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QSOX1_HUMAN | |
Accessioni | O00391Primary (citable) accession number: O00391 Secondary accession number(s): Q59G29 Q8WVP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | June 1, 2001 | |
Last modified: | May 25, 2022 | |
This is version 185 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families