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UniProtKB - O00391 (QSOX1_HUMAN)

Entry version 185 (25 May 2022)
Sequence version 3 (01 Jun 2001)
Previous versions | rss
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Protein

Sulfhydryl oxidase 1

Gene

QSOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:17331072, PubMed:18393449, PubMed:23704371, PubMed:30367560, PubMed:23867277).

Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:17331072, PubMed:30367560, PubMed:22801504, PubMed:23867277).

In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:23704371, PubMed:30367560, PubMed:23867277).

6 Publications

Miscellaneous

'Quiescin Q6' means that it was the sixth clone to be found at a higher level of expression in quiescent fibroblasts.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD2 PublicationsNote: Binds 1 FAD per subunit.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei70Nucleophile2 Publications1
Active sitei73Nucleophile2 Publications1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei401FADCombined sources1 Publication1
Binding sitei408FADCombined sources1 Publication1
Binding sitei412FADCombined sources1 Publication1
Binding sitei451FADCombined sources1 Publication1
Binding sitei455FADCombined sources1 Publication1
Binding sitei500FADCombined sources1 Publication1
Binding sitei503FADCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi478 – 485FADCombined sources1 Publication8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		1.8.3.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00391

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-114608, Platelet degranulation
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6798695, Neutrophil degranulation
R-HSA-8957275, Post-translational protein phosphorylation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00391

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfhydryl oxidase 1 (EC:1.8.3.27 Publications)
Short name:
hQSOX
Alternative name(s):
Quiescin Q62 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:QSOX1
Synonyms:QSCN61 Publication
ORF Names:UNQ2520/PRO6013
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:9756, QSOX1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603120, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00391

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116260

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei710 – 730HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi70 – 73CGHC → AGHA: Loss of catalytic activity. Cannot prevent cell detachment after depletion of the endogenous protein. 2 Publications4
Mutagenesisi70C → S: Reduces activity by 93%. 1 Publication1
Mutagenesisi72H → A: Decreased protein stability and catalytic activity; when associated with S-119 or T-119. 1 Publication1
Mutagenesisi73C → S: Reduces activity by 93%. 1 Publication1
Mutagenesisi119P → S or T: Loss of catalytic activity. Decreased protein stability and catalytic activity; when associated with A-72. 1 Publication1
Mutagenesisi130N → Q: Loss of glycosylation site. 1 Publication1
Mutagenesisi243N → Q: Loss of glycosylation site. Abolishes secretion. No effect on catalytic activity. 1 Publication1
Mutagenesisi276 – 282TTVAPTT → ANVAPVA: Decreased O-glycosylation. 1 Publication7
Mutagenesisi449C → S: Reduces activity by 96%. 1 Publication1
Mutagenesisi452C → S: Loss of activity. 1 Publication1
Mutagenesisi509C → S: No effect. Reduces activity by 70%; when associated with S-512. 1 Publication1
Mutagenesisi512C → S: Reduces activity by 40%. Reduces activity by 70%; when associated with S-509. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5768

Open Targets

More...OpenTargetsi		ENSG00000116260

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA162400559

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00391, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523117

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		QSOX1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024953330 – 747Sulfhydryl oxidase 1Add BLAST718

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi70 ↔ 73Redox-activeCombined sources4 Publications
Disulfide bondi101 ↔ 110Combined sources2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi130N-linked (GlcNAc...) (complex) asparagine3 Publications1
Glycosylationi243N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi393 ↔ 405PROSITE-ProRule annotationCombined sources1 Publication
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei426Phosphoserine; by FAM20C1 Publication1
Disulfide bondi449 ↔ 452PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi509 ↔ 512PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi575N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated (PubMed:17331072, PubMed:29757379). O-glycosylated on Thr and Ser residues (PubMed:29757379).2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00391

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00391

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00391

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00391

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00391

PeptideAtlas

More...PeptideAtlasi		O00391

PRoteomics IDEntifications database

More...PRIDEi		O00391

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47862 [O00391-1]
47863 [O00391-2]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1774, 24 N-Linked glycans (4 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O00391, 6 sites, 27 N-linked glycans (4 sites), 2 O-linked glycans (2 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00391

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00391

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in quiescent cells just as fibroblasts begin to leave the proliferative cycle and enter quiescence.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116260, Expressed in right testis and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00391, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00391, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116260, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111734, 88 interactors

Protein interaction database and analysis system

More...IntActi		O00391, 24 interactors

Molecular INTeraction database

More...MINTi		O00391

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356574

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O00391

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00391, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1747
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		O00391

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00391

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O00391

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini36 – 156ThioredoxinPROSITE-ProRule annotationAdd BLAST121
Domaini396 – 503ERV/ALR sulfhydryl oxidasePROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni573 – 633DisorderedSequence analysisAdd BLAST61

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1731, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159504

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020182_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00391

Identification of Orthologs from Complete Genome Data

More...OMAi		YLWKAHN

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00391

TreeFam database of animal gene trees

More...TreeFami		TF316749

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.1960, 1 hit
1.20.120.310, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR036774, ERV/ALR_sulphydryl_oxid_sf
IPR017905, ERV/ALR_sulphydryl_oxidase
IPR040986, QSOX_FAD-bd_dom
IPR042568, QSOX_FAD-bd_sf
IPR041269, QSOX_Trx1
IPR039798, Sulfhydryl_oxidase
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain

The PANTHER Classification System

More...PANTHERi		PTHR22897, PTHR22897, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF04777, Evr1_Alr, 1 hit
PF18371, FAD_SOX, 1 hit
PF18108, QSOX_Trx1, 1 hit
PF00085, Thioredoxin, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52833, SSF52833, 1 hit
SSF69000, SSF69000, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51324, ERV_ALR, 1 hit
PS51352, THIOREDOXIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00391-1) [UniParc]FASTAAdd to basket
Also known as: a1 Publication, QSOX-L1 Publication

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRCNSGSGP PPSLLLLLLW LLAVPGANAA PRSALYSPSD PLTLLQADTV 
        60         70         80         90        100
RGAVLGSRSA WAVEFFASWC GHCIAFAPTW KALAEDVKAW RPALYLAALD 
       110        120        130        140        150
CAEETNSAVC RDFNIPGFPT VRFFKAFTKN GSGAVFPVAG ADVQTLRERL 
       160        170        180        190        200
IDALESHHDT WPPACPPLEP AKLEEIDGFF ARNNEEYLAL IFEKGGSYLG 
       210        220        230        240        250
REVALDLSQH KGVAVRRVLN TEANVVRKFG VTDFPSCYLL FRNGSVSRVP 
       260        270        280        290        300
VLMESRSFYT AYLQRLSGLT REAAQTTVAP TTANKIAPTV WKLADRSKIY 
       310        320        330        340        350
MADLESALHY ILRIEVGRFP VLEGQRLVAL KKFVAVLAKY FPGRPLVQNF 
       360        370        380        390        400
LHSVNEWLKR QKRNKIPYSF FKTALDDRKE GAVLAKKVNW IGCQGSEPHF 
       410        420        430        440        450
RGFPCSLWVL FHFLTVQAAR QNVDHSQEAA KAKEVLPAIR GYVHYFFGCR 
       460        470        480        490        500
DCASHFEQMA AASMHRVGSP NAAVLWLWSS HNRVNARLAG APSEDPQFPK 
       510        520        530        540        550
VQWPPRELCS ACHNERLDVP VWDVEATLNF LKAHFSPSNI ILDFPAAGSA 
       560        570        580        590        600
ARRDVQNVAA APELAMGALE LESRNSTLDP GKPEMMKSPT NTTPHVPAEG 
       610        620        630        640        650
PEASRPPKLH PGLRAAPGQE PPEHMAELQR NEQEQPLGQW HLSKRDTGAA 
       660        670        680        690        700
LLAESRAEKN RLWGPLEVRR VGRSSKQLVD IPEGQLEARA GRGRGQWLQV 
       710        720        730        740 
LGGGFSYLDI SLCVGLYSLS FMGLLAMYTY FQAKIRALKG HAGHPAA
Length:747
Mass (Da):82,578
Last modified:June 1, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i52639D09A50E00C5
GO
Isoform 2 (identifier: O00391-2) [UniParc]FASTAAdd to basket
Also known as: b, QSOX-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     603-604: AS → LI
     605-747: Missing.

Show »
Length:604
Mass (Da):66,861
Checksum:iB557EE4D1525E7FB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8MXT8A8MXT8_HUMAN
Sulfhydryl oxidase 1
QSOX1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5Z8H0Y5Z8_HUMAN
Sulfhydryl oxidase 1
QSOX1
72Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD92517 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027429114N → S. Corresponds to variant dbSNP:rs3894211EnsemblClinVar.1
Natural variantiVAR_027430200G → A3 PublicationsCorresponds to variant dbSNP:rs17855475Ensembl.1
Natural variantiVAR_027431256R → M. Corresponds to variant dbSNP:rs4360492Ensembl.1
Natural variantiVAR_027432294A → S. Corresponds to variant dbSNP:rs2278943Ensembl.1
Natural variantiVAR_027433444H → R1 PublicationCorresponds to variant dbSNP:rs12371Ensembl.1
Natural variantiVAR_027434591N → H. Corresponds to variant dbSNP:rs3738115Ensembl.1
Natural variantiVAR_053652605R → P. Corresponds to variant dbSNP:rs16855466EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020489603 – 604AS → LI in isoform 2. 2 Publications2
Alternative sequenceiVSP_020490605 – 747Missing in isoform 2. 2 PublicationsAdd BLAST143

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U97276 mRNA Translation: AAC09010.2
AF361868 mRNA Translation: AAM00263.1
AY358941 mRNA Translation: AAQ89300.1
AB209280 mRNA Translation: BAD92517.1 Different initiation.
AL390718 Genomic DNA No translation available.
BC017692 mRNA Translation: AAH17692.1
BC100023 mRNA Translation: AAI00024.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1337.1 [O00391-1]
CCDS30950.1 [O00391-2]

NCBI Reference Sequences

More...RefSeqi		NP_001004128.1, NM_001004128.2 [O00391-2]
NP_002817.2, NM_002826.4 [O00391-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000367600.5; ENSP00000356572.5; ENSG00000116260.17 [O00391-2]
ENST00000367602.8; ENSP00000356574.3; ENSG00000116260.17

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5768

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5768

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000367602.8; ENSP00000356574.3; NM_002826.5; NP_002817.2

UCSC genome browser

More...UCSCi		uc001gny.4, human [O00391-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U97276 mRNA Translation: AAC09010.2
AF361868 mRNA Translation: AAM00263.1
AY358941 mRNA Translation: AAQ89300.1
AB209280 mRNA Translation: BAD92517.1 Different initiation.
AL390718 Genomic DNA No translation available.
BC017692 mRNA Translation: AAH17692.1
BC100023 mRNA Translation: AAI00024.1
CCDSiCCDS1337.1 [O00391-1]
CCDS30950.1 [O00391-2]
RefSeqiNP_001004128.1, NM_001004128.2 [O00391-2]
NP_002817.2, NM_002826.4 [O00391-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LLIX-ray2.05A286-546[»]
3LLKX-ray2.00A/B/C286-546[»]
3Q6OX-ray2.05A33-272[»]
4IJ3X-ray2.70A33-272[»]
AlphaFoldDBiO00391
SMRiO00391
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111734, 88 interactors
IntActiO00391, 24 interactors
MINTiO00391
STRINGi9606.ENSP00000356574

Chemistry databases

BindingDBiO00391
ChEMBLiCHEMBL4523117

PTM databases

GlyConnecti1774, 24 N-Linked glycans (4 sites)
GlyGeniO00391, 6 sites, 27 N-linked glycans (4 sites), 2 O-linked glycans (2 sites)
iPTMnetiO00391
PhosphoSitePlusiO00391

Genetic variation databases

BioMutaiQSOX1

Proteomic databases

EPDiO00391
jPOSTiO00391
MassIVEiO00391
MaxQBiO00391
PaxDbiO00391
PeptideAtlasiO00391
PRIDEiO00391
ProteomicsDBi47862 [O00391-1]
47863 [O00391-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		O00391, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		47086, 200 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		5768

Genome annotation databases

EnsembliENST00000367600.5; ENSP00000356572.5; ENSG00000116260.17 [O00391-2]
ENST00000367602.8; ENSP00000356574.3; ENSG00000116260.17
GeneIDi5768
KEGGihsa:5768
MANE-SelectiENST00000367602.8; ENSP00000356574.3; NM_002826.5; NP_002817.2
UCSCiuc001gny.4, human [O00391-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5768
DisGeNETi5768

GeneCards: human genes, protein and diseases

More...GeneCardsi		QSOX1
HGNCiHGNC:9756, QSOX1
HPAiENSG00000116260, Low tissue specificity
MIMi603120, gene
neXtProtiNX_O00391
OpenTargetsiENSG00000116260
PharmGKBiPA162400559
VEuPathDBiHostDB:ENSG00000116260

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1731, Eukaryota
GeneTreeiENSGT00940000159504
HOGENOMiCLU_020182_1_0_1
InParanoidiO00391
OMAiYLWKAHN
PhylomeDBiO00391
TreeFamiTF316749

Enzyme and pathway databases

BRENDAi1.8.3.2, 2681
PathwayCommonsiO00391
ReactomeiR-HSA-114608, Platelet degranulation
R-HSA-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-6798695, Neutrophil degranulation
R-HSA-8957275, Post-translational protein phosphorylation
SignaLinkiO00391

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		5768, 17 hits in 1076 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		QSOX1, human
EvolutionaryTraceiO00391

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		QSOX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5768
PharosiO00391, Tbio

Protein Ontology

More...PROi		PR:O00391
RNActiO00391, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116260, Expressed in right testis and 240 other tissues
ExpressionAtlasiO00391, baseline and differential
GenevisibleiO00391, HS

Family and domain databases

Gene3Di1.20.120.1960, 1 hit
1.20.120.310, 1 hit
InterProiView protein in InterPro
IPR036774, ERV/ALR_sulphydryl_oxid_sf
IPR017905, ERV/ALR_sulphydryl_oxidase
IPR040986, QSOX_FAD-bd_dom
IPR042568, QSOX_FAD-bd_sf
IPR041269, QSOX_Trx1
IPR039798, Sulfhydryl_oxidase
IPR036249, Thioredoxin-like_sf
IPR013766, Thioredoxin_domain
PANTHERiPTHR22897, PTHR22897, 1 hit
PfamiView protein in Pfam
PF04777, Evr1_Alr, 1 hit
PF18371, FAD_SOX, 1 hit
PF18108, QSOX_Trx1, 1 hit
PF00085, Thioredoxin, 1 hit
SUPFAMiSSF52833, SSF52833, 1 hit
SSF69000, SSF69000, 1 hit
PROSITEiView protein in PROSITE
PS51324, ERV_ALR, 1 hit
PS51352, THIOREDOXIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQSOX1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00391
Secondary accession number(s): Q59G29
, Q5T2X0, Q8TDL6, Q8WVP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: June 1, 2001
Last modified: May 25, 2022
This is version 185 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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