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Protein

Excitatory amino acid transporter 5

Gene

SLC1A7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Protein family/group databases

TCDBi2.A.23.2.5 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 5
Alternative name(s):
Retinal glutamate transporter
Solute carrier family 1 member 7
Gene namesi
Name:SLC1A7
Synonyms:EAAT5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000162383.11
HGNCiHGNC:10945 SLC1A7
MIMi604471 gene
neXtProtiNX_O00341

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei60 – 80HelicalSequence analysisAdd BLAST21
Transmembranei94 – 114HelicalSequence analysisAdd BLAST21
Topological domaini115 – 216ExtracellularSequence analysisAdd BLAST102
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei260 – 280HelicalSequence analysisAdd BLAST21
Transmembranei300 – 320HelicalSequence analysisAdd BLAST21
Transmembranei330 – 350HelicalSequence analysisAdd BLAST21
Transmembranei372 – 392HelicalSequence analysisAdd BLAST21
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Transmembranei457 – 477HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6512
OpenTargetsiENSG00000162383
PharmGKBiPA35832

Chemistry databases

DrugBankiDB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYi872

Polymorphism and mutation databases

BioMutaiSLC1A7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002020731 – 560Excitatory amino acid transporter 5Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi191N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiO00341
PaxDbiO00341
PeptideAtlasiO00341
PRIDEiO00341
ProteomicsDBi47860

PTM databases

iPTMnetiO00341
PhosphoSitePlusiO00341

Expressioni

Tissue specificityi

Expressed primarily in retina. Detectable in liver, heart, muscle and brain.

Gene expression databases

BgeeiENSG00000162383 Expressed in 107 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC1A7
ExpressionAtlasiO00341 baseline and differential
GenevisibleiO00341 HS

Organism-specific databases

HPAiHPA049124

Interactioni

Subunit structurei

Interacts with the PDZ domains of DLG4.

Protein-protein interaction databases

BioGridi112403, 2 interactors
IntActiO00341, 1 interactor
STRINGi9606.ENSP00000360549

Structurei

3D structure databases

ProteinModelPortaliO00341
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiO00341
KOiK05618
PhylomeDBiO00341
TreeFamiTF315206

Family and domain databases

Gene3Di1.10.3860.10, 2 hits
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00341-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVPHAILARG RDVCRRNGLL ILSVLSVIVG CLLGFFLRTR RLSPQEISYF
60 70 80 90 100
QFPGELLMRM LKMMILPLVV SSLMSGLASL DAKTSSRLGV LTVAYYLWTT
110 120 130 140 150
FMAVIVGIFM VSIIHPGSAA QKETTEQSGK PIMSSADALL DLIRNMFPAN
160 170 180 190 200
LVEATFKQYR TKTTPVVKSP KVAPEEAPPR RILIYGVQEE NGSHVQNFAL
210 220 230 240 250
DLTPPPEVVY KSEPGTSDGM NVLGIVFFSA TMGIMLGRMG DSGAPLVSFC
260 270 280 290 300
QCLNESVMKI VAVAVWYFPF GIVFLIAGKI LEMDDPRAVG KKLGFYSVTV
310 320 330 340 350
VCGLVLHGLF ILPLLYFFIT KKNPIVFIRG ILQALLIALA TSSSSATLPI
360 370 380 390 400
TFKCLLENNH IDRRIARFVL PVGATINMDG TALYEAVAAI FIAQVNNYEL
410 420 430 440 450
DFGQIITISI TATAASIGAA GIPQAGLVTM VIVLTSVGLP TDDITLIIAV
460 470 480 490 500
DWALDRFRTM INVLGDALAA GIMAHICRKD FARDTGTEKL LPCETKPVSL
510 520 530 540 550
QEIVAAQQNG CVKSVAEASE LTLGPTCPHH VPVQVEQDEE LPAASLNHCT
560
IQISELETNV
Length:560
Mass (Da):60,658
Last modified:September 23, 2008 - v2
Checksum:i17C527B745BB01E6
GO
Isoform 2 (identifier: O00341-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     145-158: NMFPANLVEATFKQ → QKEESWRNGPKGPG
     159-560: Missing.

Note: No experimental confirmation available.
Show »
Length:158
Mass (Da):17,383
Checksum:i8C1A9A4905368917
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1T0D2F1T0D2_HUMAN
Amino acid transporter
SLC1A7
158Annotation score:
A0A087WUF9A0A087WUF9_HUMAN
Amino acid transporter
SLC1A7
619Annotation score:
F1T0D4F1T0D4_HUMAN
Amino acid transporter
SLC1A7
472Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → T in AAB53971 (PubMed:9108121).Curated1
Sequence conflicti70V → F in AAB53971 (PubMed:9108121).Curated1
Sequence conflicti244A → G in AAB53971 (PubMed:9108121).Curated1
Sequence conflicti412A → G in AAB53971 (PubMed:9108121).Curated1
Sequence conflicti449A → G in AAB53971 (PubMed:9108121).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03570741R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs375136400Ensembl.1
Natural variantiVAR_052488537Q → R3 PublicationsCorresponds to variant dbSNP:rs1288401Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056560145 – 158NMFPA…ATFKQ → QKEESWRNGPKGPG in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_056561159 – 560Missing in isoform 2. 1 PublicationAdd BLAST402

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76362 mRNA Translation: AAB53971.1
AL445183 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06754.1
CH471059 Genomic DNA Translation: EAX06755.1
BC000651 mRNA Translation: AAH00651.1
BC012119 mRNA Translation: AAH12119.1
BC017242 mRNA Translation: AAH17242.1
CCDSiCCDS574.1 [O00341-1]
CCDS72798.1 [O00341-2]
RefSeqiNP_001274525.1, NM_001287596.1 [O00341-2]
NP_001274526.1, NM_001287597.1
NP_006662.3, NM_006671.5 [O00341-1]
UniGeneiHs.104637

Genome annotation databases

EnsembliENST00000371491; ENSP00000360546; ENSG00000162383 [O00341-2]
ENST00000371494; ENSP00000360549; ENSG00000162383 [O00341-1]
GeneIDi6512
KEGGihsa:6512
UCSCiuc001cuy.5 human [O00341-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76362 mRNA Translation: AAB53971.1
AL445183 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06754.1
CH471059 Genomic DNA Translation: EAX06755.1
BC000651 mRNA Translation: AAH00651.1
BC012119 mRNA Translation: AAH12119.1
BC017242 mRNA Translation: AAH17242.1
CCDSiCCDS574.1 [O00341-1]
CCDS72798.1 [O00341-2]
RefSeqiNP_001274525.1, NM_001287596.1 [O00341-2]
NP_001274526.1, NM_001287597.1
NP_006662.3, NM_006671.5 [O00341-1]
UniGeneiHs.104637

3D structure databases

ProteinModelPortaliO00341
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112403, 2 interactors
IntActiO00341, 1 interactor
STRINGi9606.ENSP00000360549

Chemistry databases

DrugBankiDB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYi872

Protein family/group databases

TCDBi2.A.23.2.5 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

iPTMnetiO00341
PhosphoSitePlusiO00341

Polymorphism and mutation databases

BioMutaiSLC1A7

Proteomic databases

EPDiO00341
PaxDbiO00341
PeptideAtlasiO00341
PRIDEiO00341
ProteomicsDBi47860

Protocols and materials databases

DNASUi6512
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371491; ENSP00000360546; ENSG00000162383 [O00341-2]
ENST00000371494; ENSP00000360549; ENSG00000162383 [O00341-1]
GeneIDi6512
KEGGihsa:6512
UCSCiuc001cuy.5 human [O00341-1]

Organism-specific databases

CTDi6512
DisGeNETi6512
EuPathDBiHostDB:ENSG00000162383.11
GeneCardsiSLC1A7
H-InvDBiHIX0000592
HIX0159667
HGNCiHGNC:10945 SLC1A7
HPAiHPA049124
MIMi604471 gene
neXtProtiNX_O00341
OpenTargetsiENSG00000162383
PharmGKBiPA35832
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00760000119117
HOGENOMiHOG000208776
HOVERGENiHBG000080
InParanoidiO00341
KOiK05618
PhylomeDBiO00341
TreeFamiTF315206

Enzyme and pathway databases

ReactomeiR-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Miscellaneous databases

GeneWikiiExcitatory_amino-acid_transporter_5
GenomeRNAii6512
PROiPR:O00341
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162383 Expressed in 107 organ(s), highest expression level in pigmented layer of retina
CleanExiHS_SLC1A7
ExpressionAtlasiO00341 baseline and differential
GenevisibleiO00341 HS

Family and domain databases

Gene3Di1.10.3860.10, 2 hits
InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEAA5_HUMAN
AccessioniPrimary (citable) accession number: O00341
Secondary accession number(s): Q5VVZ0, Q969Z8, Q9BW45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 23, 2008
Last modified: November 7, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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