UniProtKB - O00341 (EAA5_HUMAN)

BLAST

>sp|O00341|EAA5_HUMAN Excitatory amino acid transporter 5 OS=Homo sapiens OX=9606 GN=SLC1A7 PE=2 SV=2
MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRM
LKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAA
QKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPR
RILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMG
DSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTV
VCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNH
IDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAA
GIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKD
FARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQDEE
LPAASLNHCTIQISELETNV

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History
Entry version 153 (07 Nov 2018)
Sequence version 2 (23 Sep 2008)
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Protein

Excitatory amino acid transporter 5

Gene

SLC1A7

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Transports L-glutamate; the L-glutamate uptake is sodium- and voltage-dependent and chloride-independent. Its associated chloride conductance may participate in visual processing.

GO - Molecular functionⁱ

amino acid transmembrane transporter activity Source: Reactome
high-affinity glutamate transmembrane transporter activity Source: Reactome
L-glutamate transmembrane transporter activity
Source: UniProtKB
Traceable author statementⁱ
- 9108121

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

dicarboxylic acid transport
Source: UniProtKB
Traceable author statementⁱ
- 9108121
glutamate secretion Source: Reactome
ion transport Source: Reactome
neurotransmitter reuptake
Source: SynGO
Inferred from experimentⁱ
- 9108121
neurotransmitter uptake
Source: SynGO
Inferred from experimentⁱ
- 9108121

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Symport, Transport

Biological process

Symport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Reactomeⁱ

R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Protein family/group databases

TCDBⁱ	2.A.23.2.5 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

TCDBⁱ

2.A.23.2.5 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Excitatory amino acid transporter 5 Alternative name(s): Retinal glutamate transporter Solute carrier family 1 member 7
Gene namesⁱ	Name:SLC1A7 Synonyms:EAAT5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162383.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10945 SLC1A7
MIMⁱ	604471 gene
neXtProtⁱ	NX_O00341

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 16	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	17 – 37	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	60 – 80	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	94 – 114	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	115 – 216	ExtracellularSequence analysisAdd BLAST	102
Transmembraneⁱ	217 – 237	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	260 – 280	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	300 – 320	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	330 – 350	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	372 – 392	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	414 – 434	HelicalSequence analysisAdd BLAST	21
Transmembraneⁱ	457 – 477	HelicalSequence analysisAdd BLAST	21

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6512
Open Targets More...OpenTargetsⁱ	ENSG00000162383
PharmGKBⁱ	PA35832

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00142 L-Glutamic Acid
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	872

Polymorphism and mutation databases

BioMutaⁱ	SLC1A7

BioMutaⁱ

SLC1A7

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000202073	1 – 560	Excitatory amino acid transporter 5Add BLAST		560

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Glycosylationⁱ	191	N-linked (GlcNAc...) asparagineSequence analysis		1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	O00341
PaxDbⁱ	O00341
PeptideAtlas More...PeptideAtlasⁱ	O00341
PRIDEⁱ	O00341
ProteomicsDBⁱ	47860

PTM databases

iPTMnetⁱ	O00341
PhosphoSitePlusⁱ	O00341

Expressionⁱ

Tissue specificityⁱ

Expressed primarily in retina. Detectable in liver, heart, muscle and brain.

Gene expression databases

Bgeeⁱ	ENSG00000162383 Expressed in 107 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_SLC1A7
ExpressionAtlasⁱ	O00341 baseline and differential
Genevisibleⁱ	O00341 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA049124

HPAⁱ

HPA049124

Interactionⁱ

Subunit structureⁱ

Interacts with the PDZ domains of DLG4.

Protein-protein interaction databases

BioGridⁱ	112403, 2 interactors
IntActⁱ	O00341, 1 interactor
STRINGⁱ	9606.ENSP00000360549

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00341
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A7 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3787 Eukaryota COG1301 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119117
HOGENOMⁱ	HOG000208776
HOVERGENⁱ	HBG000080
InParanoidⁱ	O00341
KEGG Orthology (KO) More...KOⁱ	K05618
PhylomeDBⁱ	O00341
TreeFamⁱ	TF315206

Family and domain databases

Gene3Dⁱ	1.10.3860.10, 2 hits
InterProⁱ	View protein in InterPro IPR001991 Na-dicarboxylate_symporter IPR018107 Na-dicarboxylate_symporter_CS IPR036458 Na:dicarbo_symporter_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00375 SDF, 1 hit
SUPFAMⁱ	SSF118215 SSF118215, 1 hit
PROSITEⁱ	View protein in PROSITE PS00713 NA_DICARBOXYL_SYMP_1, 1 hit PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O00341-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVPHAILARG RDVCRRNGLL ILSVLSVIVG CLLGFFLRTR RLSPQEISYF 
        60         70         80         90        100
QFPGELLMRM LKMMILPLVV SSLMSGLASL DAKTSSRLGV LTVAYYLWTT 
       110        120        130        140        150
FMAVIVGIFM VSIIHPGSAA QKETTEQSGK PIMSSADALL DLIRNMFPAN 
       160        170        180        190        200
LVEATFKQYR TKTTPVVKSP KVAPEEAPPR RILIYGVQEE NGSHVQNFAL 
       210        220        230        240        250
DLTPPPEVVY KSEPGTSDGM NVLGIVFFSA TMGIMLGRMG DSGAPLVSFC 
       260        270        280        290        300
QCLNESVMKI VAVAVWYFPF GIVFLIAGKI LEMDDPRAVG KKLGFYSVTV 
       310        320        330        340        350
VCGLVLHGLF ILPLLYFFIT KKNPIVFIRG ILQALLIALA TSSSSATLPI 
       360        370        380        390        400
TFKCLLENNH IDRRIARFVL PVGATINMDG TALYEAVAAI FIAQVNNYEL 
       410        420        430        440        450
DFGQIITISI TATAASIGAA GIPQAGLVTM VIVLTSVGLP TDDITLIIAV 
       460        470        480        490        500
DWALDRFRTM INVLGDALAA GIMAHICRKD FARDTGTEKL LPCETKPVSL 
       510        520        530        540        550
QEIVAAQQNG CVKSVAEASE LTLGPTCPHH VPVQVEQDEE LPAASLNHCT 
       560
IQISELETNV

Length:560

Mass (Da):60,658

Last modified:September 23, 2008 - v2

Checksum:ⁱ17C527B745BB01E6

Isoform 2 (identifier: O00341-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
145-158: NMFPANLVEATFKQ → QKEESWRNGPKGPG
159-560: Missing.

« Hide

        10         20         30         40         50
MVPHAILARG RDVCRRNGLL ILSVLSVIVG CLLGFFLRTR RLSPQEISYF 
        60         70         80         90        100
QFPGELLMRM LKMMILPLVV SSLMSGLASL DAKTSSRLGV LTVAYYLWTT 
       110        120        130        140        150
FMAVIVGIFM VSIIHPGSAA QKETTEQSGK PIMSSADALL DLIRQKEESW 

RNGPKGPG

Note: No experimental confirmation available.

Show »

Length:158

Mass (Da):17,383

Checksum:ⁱ8C1A9A4905368917

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F1T0D2	F1T0D2_HUMAN	Amino acid transporter Amino acid transporter	SLC1A7	158	Annotation score:
A0A087WUF9	A0A087WUF9_HUMAN	Amino acid transporter Amino acid transporter	SLC1A7	619	Annotation score:
F1T0D4	F1T0D4_HUMAN	Amino acid transporter Amino acid transporter	SLC1A7	472	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	5	A → T in AAB53971 (PubMed:9108121).Curated	1
Sequence conflictⁱ	70	V → F in AAB53971 (PubMed:9108121).Curated	1
Sequence conflictⁱ	244	A → G in AAB53971 (PubMed:9108121).Curated	1
Sequence conflictⁱ	412	A → G in AAB53971 (PubMed:9108121).Curated	1
Sequence conflictⁱ	449	A → G in AAB53971 (PubMed:9108121).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035707	41	R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs375136400Ensembl.		1
Natural variantⁱVAR_052488	537	Q → R3 PublicationsCorresponds to variant dbSNP:rs1288401Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_056560	145 – 158	NMFPA…ATFKQ → QKEESWRNGPKGPG in isoform 2. 1 PublicationAdd BLAST		14
Alternative sequenceⁱVSP_056561	159 – 560	Missing in isoform 2. 1 PublicationAdd BLAST		402

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76362 mRNA Translation: AAB53971.1 AL445183 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06754.1 CH471059 Genomic DNA Translation: EAX06755.1 BC000651 mRNA Translation: AAH00651.1 BC012119 mRNA Translation: AAH12119.1 BC017242 mRNA Translation: AAH17242.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS574.1 [O00341-1] CCDS72798.1 [O00341-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001274525.1, NM_001287596.1 [O00341-2] NP_001274526.1, NM_001287597.1 NP_006662.3, NM_006671.5 [O00341-1]
UniGeneⁱ	Hs.104637

Genome annotation databases

Ensemblⁱ	ENST00000371491; ENSP00000360546; ENSG00000162383 [O00341-2] ENST00000371494; ENSP00000360549; ENSG00000162383 [O00341-1]
GeneIDⁱ	6512
KEGGⁱ	hsa:6512
UCSC genome browser More...UCSCⁱ	uc001cuy.5 human [O00341-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00341	Excitatory amino acid transporter 5		MOUSE		559	UniRef90_O00341
Amino acid transporter		Florida manatee		576
Amino acid transporter		ICTTR		575
excitatory amino acid transporter 5		BALAS		574
Amino acid transporter		DELLE		574
+120
O00341-2	Amino acid transporter		DELLE		177	UniRef90_O00341-2
Amino acid transporter		ODORO		158
Amino acid transporter		PANPA		158
Amino acid transporter		RHIRO		158
Amino acid transporter		PAPAN		158
+18

Protein	Similar proteins		Species	Score	Length	Source
O00341	Excitatory amino acid transporter 5		MOUSE		559	UniRef50_O00341
Amino acid transporter		Florida manatee		576
Amino acid transporter		ICTTR		575
Amino acid transporter		CANLF		574
Amino acid transporter		LIPVE		574
+561
O00341-2	Amino acid transporter		DELLE		177	UniRef50_O00341-2
Amino acid transporter		RHIBE		158
Amino acid transporter		RHIRO		158
Amino acid transporter		PAPAN		158
Amino acid transporter		CERAT		158
+35

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U76362 mRNA Translation: AAB53971.1 AL445183 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06754.1 CH471059 Genomic DNA Translation: EAX06755.1 BC000651 mRNA Translation: AAH00651.1 BC012119 mRNA Translation: AAH12119.1 BC017242 mRNA Translation: AAH17242.1
CCDSⁱ	CCDS574.1 [O00341-1] CCDS72798.1 [O00341-2]
RefSeqⁱ	NP_001274525.1, NM_001287596.1 [O00341-2] NP_001274526.1, NM_001287597.1 NP_006662.3, NM_006671.5 [O00341-1]
UniGeneⁱ	Hs.104637

3D structure databases

ProteinModelPortalⁱ	O00341
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112403, 2 interactors
IntActⁱ	O00341, 1 interactor
STRINGⁱ	9606.ENSP00000360549

Chemistry databases

DrugBankⁱ	DB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYⁱ	872

Protein family/group databases

TCDBⁱ	2.A.23.2.5 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

TCDBⁱ

2.A.23.2.5 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

iPTMnetⁱ	O00341
PhosphoSitePlusⁱ	O00341

Polymorphism and mutation databases

BioMutaⁱ	SLC1A7

BioMutaⁱ

SLC1A7

Proteomic databases

EPDⁱ	O00341
PaxDbⁱ	O00341
PeptideAtlasⁱ	O00341
PRIDEⁱ	O00341
ProteomicsDBⁱ	47860

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6512
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371491; ENSP00000360546; ENSG00000162383 [O00341-2] ENST00000371494; ENSP00000360549; ENSG00000162383 [O00341-1]
GeneIDⁱ	6512
KEGGⁱ	hsa:6512
UCSCⁱ	uc001cuy.5 human [O00341-1]

Organism-specific databases

CTDⁱ	6512
DisGeNETⁱ	6512
EuPathDBⁱ	HostDB:ENSG00000162383.11
GeneCardsⁱ	SLC1A7
H-InvDBⁱ	HIX0000592 HIX0159667
HGNCⁱ	HGNC:10945 SLC1A7
HPAⁱ	HPA049124
MIMⁱ	604471 gene
neXtProtⁱ	NX_O00341
OpenTargetsⁱ	ENSG00000162383
PharmGKBⁱ	PA35832
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3787 Eukaryota COG1301 LUCA
GeneTreeⁱ	ENSGT00760000119117
HOGENOMⁱ	HOG000208776
HOVERGENⁱ	HBG000080
InParanoidⁱ	O00341
KOⁱ	K05618
PhylomeDBⁱ	O00341
TreeFamⁱ	TF315206

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Reactomeⁱ

R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

Miscellaneous databases

GeneWikiⁱ	Excitatory_amino-acid_transporter_5
GenomeRNAiⁱ	6512
Protein Ontology More...PROⁱ	PR:O00341
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162383 Expressed in 107 organ(s), highest expression level in pigmented layer of retina
CleanExⁱ	HS_SLC1A7
ExpressionAtlasⁱ	O00341 baseline and differential
Genevisibleⁱ	O00341 HS

Family and domain databases

Gene3Dⁱ	1.10.3860.10, 2 hits
InterProⁱ	View protein in InterPro IPR001991 Na-dicarboxylate_symporter IPR018107 Na-dicarboxylate_symporter_CS IPR036458 Na:dicarbo_symporter_sf
Pfamⁱ	View protein in Pfam PF00375 SDF, 1 hit
SUPFAMⁱ	SSF118215 SSF118215, 1 hit
PROSITEⁱ	View protein in PROSITE PS00713 NA_DICARBOXYL_SYMP_1, 1 hit PS00714 NA_DICARBOXYL_SYMP_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EAA5_HUMAN
Accessionⁱ	O00341Primary (citable) accession number: O00341 Secondary accession number(s): Q5VVZ0, Q969Z8, Q9BW45
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	September 23, 2008
	Last modified:	November 7, 2018
	This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O00341 (EAA5_HUMAN)

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Excitatory amino acid transporter 5

SLC1A7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ