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Entry version 158 (13 Feb 2019)
Sequence version 2 (05 May 2009)
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Protein

Sodium/nucleoside cotransporter 1

Gene

SLC28A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine). It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC). It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS). It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.41.2.3 the concentrative nucleoside transporter (cnt) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium/nucleoside cotransporter 1
Alternative name(s):
Concentrative nucleoside transporter 1
Short name:
CNT 1
Short name:
hCNT1
Na(+)/nucleoside cotransporter 1
Sodium-coupled nucleoside transporter 1
Solute carrier family 28 member 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC28A1
Synonyms:CNT1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000156222.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11001 SLC28A1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606207 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00337

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 80CytoplasmicSequence analysisAdd BLAST80
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 104HelicalSequence analysisAdd BLAST24
Topological domaini105 – 109ExtracellularSequence analysis5
Transmembranei110 – 128HelicalSequence analysisAdd BLAST19
Topological domaini129 – 147CytoplasmicSequence analysisAdd BLAST19
Transmembranei148 – 167HelicalSequence analysisAdd BLAST20
Topological domaini168 – 178ExtracellularSequence analysisAdd BLAST11
Transmembranei179 – 195HelicalSequence analysisAdd BLAST17
Topological domaini196 – 201CytoplasmicSequence analysis6
Transmembranei202 – 222HelicalSequence analysisAdd BLAST21
Topological domaini223 – 261ExtracellularSequence analysisAdd BLAST39
Transmembranei262 – 283HelicalSequence analysisAdd BLAST22
Topological domaini284 – 294CytoplasmicSequence analysisAdd BLAST11
Transmembranei295 – 318HelicalSequence analysisAdd BLAST24
Topological domaini319 – 337ExtracellularSequence analysisAdd BLAST19
Transmembranei338 – 360HelicalSequence analysisAdd BLAST23
Topological domaini361 – 366CytoplasmicSequence analysis6
Transmembranei367 – 386HelicalSequence analysisAdd BLAST20
Topological domaini387 – 423ExtracellularSequence analysisAdd BLAST37
Transmembranei424 – 446HelicalSequence analysisAdd BLAST23
Topological domaini447 – 457CytoplasmicSequence analysisAdd BLAST11
Transmembranei458 – 479HelicalSequence analysisAdd BLAST22
Topological domaini480 – 534ExtracellularSequence analysisAdd BLAST55
Transmembranei535 – 558HelicalSequence analysisAdd BLAST24
Topological domaini559 – 569CytoplasmicSequence analysisAdd BLAST11
Transmembranei570 – 592HelicalSequence analysisAdd BLAST23
Topological domaini593 – 649ExtracellularSequence analysisAdd BLAST57

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi318S → G: Enables transport of purine nucleosides. 1 Publication1
Mutagenesisi319Q → M: Increases transport of purine nucleosides; when associated with Gly-319. 1 Publication1
Mutagenesisi352S → T: Produces a full purine-type transporter; when associated with Gly-319 and Met-320. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
9154

Open Targets

More...
OpenTargetsi
ENSG00000156222

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA387

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5551

Drug and drug target database

More...
DrugBanki
DB00441 Gemcitabine
DB00649 Stavudine
DB00495 Zidovudine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC28A1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000704461 – 649Sodium/nucleoside cotransporter 1Add BLAST649

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi643N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00337

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00337

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00337

PeptideAtlas

More...
PeptideAtlasi
O00337

PRoteomics IDEntifications database

More...
PRIDEi
O00337

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47852
47853 [O00337-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00337

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00337

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000156222 Expressed in 79 organ(s), highest expression level in right lobe of liver

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00337 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00337 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019551

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000286749

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O00337

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00337

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00337

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi609 – 612Poly-Ser4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3747 Eukaryota
COG1972 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016025

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054073

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00337

KEGG Orthology (KO)

More...
KOi
K11536

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRWIVQT

Database of Orthologous Groups

More...
OrthoDBi
471043at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00337

TreeFam database of animal gene trees

More...
TreeFami
TF314131

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom

The PANTHER Classification System

More...
PANTHERi
PTHR10590 PTHR10590, 1 hit
PTHR10590:SF16 PTHR10590:SF16, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00804 nupC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O00337-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MENDPSRRRE SISLTPVAKG LENMGADFLE SLEEGQLPRS DLSPAEIRSS
60 70 80 90 100
WSEAAPKPFS RWRNLQPALR ARSFCREHMQ LFRWIGTGLL CTGLSAFLLV
110 120 130 140 150
ACLLDFQRAL ALFVLTCVVL TFLGHRLLKR LLGPKLRRFL KPQGHPRLLL
160 170 180 190 200
WFKRGLALAA FLGLVLWLSL DTSQRPEQLV SFAGICVFVA LLFACSKHHC
210 220 230 240 250
AVSWRAVSWG LGLQFVLGLL VIRTEPGFIA FEWLGEQIRI FLSYTKAGSS
260 270 280 290 300
FVFGEALVKD VFAFQVLPII VFFSCVISVL YHVGLMQWVI LKIAWLMQVT
310 320 330 340 350
MGTTATETLS VAGNIFVSQT EAPLLIRPYL ADMTLSEVHV VMTGGYATIA
360 370 380 390 400
GSLLGAYISF GIDATSLIAA SVMAAPCALA LSKLVYPEVE ESKFRREEGV
410 420 430 440 450
KLTYGDAQNL IEAASTGAAI SVKVVANIAA NLIAFLAVLD FINAALSWLG
460 470 480 490 500
DMVDIQGLSF QLICSYILRP VAFLMGVAWE DCPVVAELLG IKLFLNEFVA
510 520 530 540 550
YQDLSKYKQR RLAGAEEWVG DRKQWISVRA EVLTTFALCG FANFSSIGIM
560 570 580 590 600
LGGLTSMVPQ RKSDFSQIVL RALFTGACVS LVNACMAGIL YMPRGAEVDC
610 620 630 640
MSLLNTTLSS SSFEIYQCCR EAFQSVNPEF SPEALDNCCR FYNHTICAQ
Length:649
Mass (Da):71,584
Last modified:May 5, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42E952443B46B102
GO
Isoform 2 (identifier: O00337-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     155-175: GLALAAFLGLVLWLSLDTSQR → DPRPWSKEGPNQYLPQITWTV
     176-649: Missing.

Show »
Length:175
Mass (Da):20,180
Checksum:i34C7DD93D84F60EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z3L6B7Z3L6_HUMAN
cDNA FLJ58165, highly similar to So...
SLC28A1
483Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00949934E → G in allele A. 2 Publications1
Natural variantiVAR_009500140L → LV in allele A. 2 Publications1
Natural variantiVAR_009501189V → I in allele A. 2 PublicationsCorresponds to variant dbSNP:rs2290272Ensembl.1
Natural variantiVAR_057194190A → S. Corresponds to variant dbSNP:rs45523532Ensembl.1
Natural variantiVAR_057195237Q → K. Corresponds to variant dbSNP:rs8187758Ensembl.1
Natural variantiVAR_009502409N → S in allele B. 1 PublicationCorresponds to variant dbSNP:rs1174011667Ensembl.1
Natural variantiVAR_057196510R → C1 PublicationCorresponds to variant dbSNP:rs2242047Ensembl.1
Natural variantiVAR_009503521D → N in alleles B and C. 2 PublicationsCorresponds to variant dbSNP:rs2242046Ensembl.1
Natural variantiVAR_061802546S → P. Corresponds to variant dbSNP:rs45584739Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_037221155 – 175GLALA…DTSQR → DPRPWSKEGPNQYLPQITWT V in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_037222176 – 649Missing in isoform 2. 1 PublicationAdd BLAST474

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U62966 mRNA Translation: AAB53837.1
U62967 mRNA Translation: AAB53838.1
U62968 mRNA Translation: AAB53839.1
AF187978
, AF187969, AF187970, AF187971, AF187972, AF187973, AF187974, AF187975, AF187976, AF187977 Genomic DNA Translation: AAF15353.1
AK291997 mRNA Translation: BAF84686.1
AC087468 Genomic DNA No translation available.
AC103741 Genomic DNA No translation available.
BC029788 mRNA Translation: AAH29788.1
BC039898 mRNA Translation: AAH39898.1
BC126204 mRNA Translation: AAI26205.1
BC126206 mRNA Translation: AAI26207.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10334.1 [O00337-1]
CCDS10335.1 [O00337-2]

NCBI Reference Sequences

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RefSeqi
NP_001274691.1, NM_001287762.1 [O00337-1]
NP_004204.3, NM_004213.4 [O00337-1]
NP_964014.1, NM_201651.2 [O00337-2]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.459187

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000286749; ENSP00000286749; ENSG00000156222 [O00337-1]
ENST00000338602; ENSP00000341629; ENSG00000156222 [O00337-2]
ENST00000394573; ENSP00000378074; ENSG00000156222 [O00337-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9154

UCSC genome browser

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UCSCi
uc002blf.5 human [O00337-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62966 mRNA Translation: AAB53837.1
U62967 mRNA Translation: AAB53838.1
U62968 mRNA Translation: AAB53839.1
AF187978
, AF187969, AF187970, AF187971, AF187972, AF187973, AF187974, AF187975, AF187976, AF187977 Genomic DNA Translation: AAF15353.1
AK291997 mRNA Translation: BAF84686.1
AC087468 Genomic DNA No translation available.
AC103741 Genomic DNA No translation available.
BC029788 mRNA Translation: AAH29788.1
BC039898 mRNA Translation: AAH39898.1
BC126204 mRNA Translation: AAI26205.1
BC126206 mRNA Translation: AAI26207.1
CCDSiCCDS10334.1 [O00337-1]
CCDS10335.1 [O00337-2]
RefSeqiNP_001274691.1, NM_001287762.1 [O00337-1]
NP_004204.3, NM_004213.4 [O00337-1]
NP_964014.1, NM_201651.2 [O00337-2]
UniGeneiHs.459187

3D structure databases

ProteinModelPortaliO00337
SMRiO00337
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000286749

Chemistry databases

BindingDBiO00337
ChEMBLiCHEMBL5551
DrugBankiDB00441 Gemcitabine
DB00649 Stavudine
DB00495 Zidovudine

Protein family/group databases

TCDBi2.A.41.2.3 the concentrative nucleoside transporter (cnt) family

PTM databases

iPTMnetiO00337
PhosphoSitePlusiO00337

Polymorphism and mutation databases

BioMutaiSLC28A1

Proteomic databases

EPDiO00337
jPOSTiO00337
PaxDbiO00337
PeptideAtlasiO00337
PRIDEiO00337
ProteomicsDBi47852
47853 [O00337-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9154
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000286749; ENSP00000286749; ENSG00000156222 [O00337-1]
ENST00000338602; ENSP00000341629; ENSG00000156222 [O00337-2]
ENST00000394573; ENSP00000378074; ENSG00000156222 [O00337-1]
GeneIDi9154
KEGGihsa:9154
UCSCiuc002blf.5 human [O00337-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9154
DisGeNETi9154
EuPathDBiHostDB:ENSG00000156222.11

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC28A1
HGNCiHGNC:11001 SLC28A1
HPAiHPA019551
MIMi606207 gene
neXtProtiNX_O00337
OpenTargetsiENSG00000156222
PharmGKBiPA387

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3747 Eukaryota
COG1972 LUCA
GeneTreeiENSGT00390000016025
HOVERGENiHBG054073
InParanoidiO00337
KOiK11536
OMAiHRWIVQT
OrthoDBi471043at2759
PhylomeDBiO00337
TreeFamiTF314131

Enzyme and pathway databases

ReactomeiR-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC28A1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Concentrative_nucleoside_transporter_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9154

Protein Ontology

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PROi
PR:O00337

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000156222 Expressed in 79 organ(s), highest expression level in right lobe of liver
ExpressionAtlasiO00337 baseline and differential
GenevisibleiO00337 HS

Family and domain databases

InterProiView protein in InterPro
IPR008276 C_nuclsd_transpt
IPR018270 C_nuclsd_transpt_met_bac
IPR030212 CNT1/CNT2
IPR011657 CNT_C_dom
IPR002668 CNT_N_dom
IPR011642 Gate_dom
PANTHERiPTHR10590 PTHR10590, 1 hit
PTHR10590:SF16 PTHR10590:SF16, 1 hit
PfamiView protein in Pfam
PF07670 Gate, 1 hit
PF07662 Nucleos_tra2_C, 1 hit
PF01773 Nucleos_tra2_N, 1 hit
TIGRFAMsiTIGR00804 nupC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS28A1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00337
Secondary accession number(s): A0AV42
, A8K7I2, O00335, O00336, Q5U5S6, Q5U648, Q9UEZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 5, 2009
Last modified: February 13, 2019
This is version 158 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
UniProt is an ELIXIR core data resource
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