ARNTL

Functionⁱ

Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core clock genes and clock-controlled genes (involved in key metabolic processes), harboring E-box elements (5'-CACGTG-3') within their promoters. The core clock genes: PER1/2/3 and CRY1/2 which are transcriptional repressors form the negative limb of the feedback loop and interact with the CLOCK|NPAS2-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer inhibiting its activity and thereby negatively regulating their own expression. This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate and repress ARNTL/BMAL1 transcription, respectively. ARNTL/BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway. Plays a role in normal pancreatic beta-cell function; regulates glucose-stimulated insulin secretion via the regulation of antioxidant genes NFE2L2/NRF2 and its targets SESN2, PRDX3, CCLC and CCLM. Negatively regulates the mTORC1 signaling pathway; regulates the expression of MTOR and DEPTOR. Controls diurnal oscillations of Ly6C inflammatory monocytes; rhythmic recruitment of the PRC2 complex imparts diurnal variation to chemokine expression that is necessary to sustain Ly6C monocyte rhythms. Regulates the expression of HSD3B2, STAR, PTGS2, CYP11A1, CYP19A1 and LHCGR in the ovary and also the genes involved in hair growth. Plays an important role in adult hippocampal neurogenesis by regulating the timely entry of neural stem/progenitor cells (NSPCs) into the cell cycle and the number of cell divisions that take place prior to cell-cycle exit. Regulates the circadian expression of CIART and KLF11. The CLOCK-ARNTL/BMAL1 heterodimer regulates the circadian expression of SERPINE1/PAI1, VWF, B3, CCRN4L/NOC, NAMPT, DBP, MYOD1, PPARGC1A, PPARGC1B, SIRT1, GYS2, F7, NGFR, GNRHR, BHLHE40/DEC1, ATF4, MTA1, KLF10 and also genes implicated in glucose and lipid metabolism. Promotes rhythmic chromatin opening, regulating the DNA accessibility of other transcription factors. The NPAS2-ARNTL/BMAL1 heterodimer positively regulates the expression of MAOA, F7 and LDHA and modulates the circadian rhythm of daytime contrast sensitivity by regulating the rhythmic expression of adenylate cyclase type 1 (ADCY1) in the retina. The preferred binding motif for the CLOCK-ARNTL/BMAL1 heterodimer is 5'-CACGTGA-3', which contains a flanking Ala residue in addition to the canonical 6-nucleotide E-box sequence (PubMed:23229515). CLOCK specifically binds to the half-site 5'-CAC-3', while ARNTL binds to the half-site 5'-GTGA-3' (PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer also recognizes the non-canonical E-box motifs 5'-AACGTGA-3' and 5'-CATGTGA-3' (PubMed:23229515). Essential for the rhythmic interaction of CLOCK with ASS1 and plays a critical role in positively regulating CLOCK-mediated acetylation of ASS1 (PubMed:28985504).7 Publications

Miscellaneous

CLOCK-ARNTL/BMAL1 double mutations within the PAS domains result in synergistic desensitization to high levels of CRY on repression of CLOCK-ARNTL/BMAL1 transcriptional activity of PER1 and, disrupt circadian rhythmicity.

Activity regulationⁱ

There is conflicting data about the effect of NAD cofactors on activity. PubMed:11441146 suggests that the redox state of the cell can modulate the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer; NADH and NADPH enhance the DNA-binding activity of the heterodimer. PubMed:23229515 reports that NADH and NADPH have no significant effect on DNA-binding activity of the CLOCK-ARNTL/BMAL1 heterodimer.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	125	Important for interaction with CLOCK1 Publication		1

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 9079689
bHLH transcription factor binding Source: Ensembl
DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11441146
DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
DNA-binding transcription factor activity, RNA polymerase II-specific Source: BHF-UCL
E-box binding
Source: UniProtKB
Inferred from direct assayⁱ
- 12738229
- 23785138
Hsp90 protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 9079689
protein heterodimerization activity Source: Ensembl
repressing transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25936801
RNA polymerase II distal enhancer sequence-specific DNA binding Source: UniProtKB
sequence-specific DNA binding Source: UniProtKB
transcription regulatory region sequence-specific DNA binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

circadian regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 24005054
circadian rhythm Source: Reactome
maternal process involved in parturition Source: Ensembl
negative regulation of cold-induced thermogenesis
Source: YuBioLab
Inferred from sequence or structural similarityⁱ
- 25749863
negative regulation of fat cell differentiation Source: UniProtKB
negative regulation of glucocorticoid receptor signaling pathway Source: UniProtKB
negative regulation of TOR signaling Source: UniProtKB
negative regulation of transcription, DNA-templated Source: UniProtKB
oxidative stress-induced premature senescence Source: UniProtKB
positive regulation of canonical Wnt signaling pathway Source: UniProtKB
positive regulation of circadian rhythm Source: UniProtKB
positive regulation of protein acetylation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 28985504
positive regulation of skeletal muscle cell differentiation Source: UniProtKB
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 20093779
proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
protein import into nucleus, translocation Source: Ensembl
regulation of cell cycle Source: UniProtKB
regulation of cellular senescence Source: UniProtKB
regulation of hair cycle
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24005054
regulation of insulin secretion Source: UniProtKB
regulation of neurogenesis Source: UniProtKB
regulation of protein catabolic process Source: Ensembl
regulation of transcription, DNA-templated Source: UniProtKB
regulation of type B pancreatic cell development Source: UniProtKB
response to redox state
Source: UniProtKB
Inferred from direct assayⁱ
- 11441146
spermatogenesis Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Biological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781 PPARA activates gene expression R-HSA-400253 Circadian Clock
SIGNORⁱ	O00327

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Aryl hydrocarbon receptor nuclear translocator-like protein 1 Alternative name(s): Basic-helix-loop-helix-PAS protein MOP3 Brain and muscle ARNT-like 1 Class E basic helix-loop-helix protein 5 Short name: bHLHe5 Member of PAS protein 3 PAS domain-containing protein 3 bHLH-PAS protein JAP3
Gene namesⁱ	Name:ARNTL Synonyms:BHLHE5, BMAL1, MOP3, PASD3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000133794.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:701 ARNTL
MIMⁱ	602550 gene
neXtProtⁱ	NX_O00327

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	9	S → A or E: Enhanced PER1 reporter activity by CLOCK-ARNTL/BMAL1. 1 Publication	1
Mutagenesisⁱ	9	S → F: 2-2.5-fold increase in CLOCK-BMAL1 transcriptional activity in the absence of CRY1. No change in repression activity in the presence of CRY1. 1 Publication	1
Mutagenesisⁱ	10	S → A or E: Enhanced PER1 reporter activity by CLOCK-ARNTL/BMAL1. 1 Publication	1
Mutagenesisⁱ	10	S → L: 2-2.5-fold increase in CLOCK-ARNTL/BMAL1 transcriptional activity in the absence of CRY1. No change in repression activity in the presence of CRY1. 1 Publication	1
Mutagenesisⁱ	78	S → E: Phosphomimetic mutant which severely impairs DNA binding and CLOCK-ARNTL/BMAL1 transcriptional activity. 1 Publication	1
Mutagenesisⁱ	88	M → F: No effect on CLOCK binding. 1 Publication	1
Mutagenesisⁱ	90	S → E: Phosphomimetic mutant with no effect on DNA binding or CLOCK-ARNTL/BMAL1 transcriptional activity. 1 Publication	1
Mutagenesisⁱ	125	L → H: Impaired CLOCK binding. 1 Publication	1
Mutagenesisⁱ	611	A → S or T: Increased desensitization to CRY1, in the presence of CLOCK. Approximately 2-fold increase in CLOCK-ARNTL/BMAL1 transcriptional activity in the absence of CRY1; when associated with E-407. 1 Publication	1
Mutagenesisⁱ	612	G → E: Increased desensitization to CRY1, in the presence of CLOCK. Approximately 2-fold increase in CLOCK-ARNTL/BMAL1 transcriptional activity in the absence of CRY1. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	406
Open Targets More...OpenTargetsⁱ	ENSG00000133794
PharmGKBⁱ	PA24996

Polymorphism and mutation databases

BioMutaⁱ	ARNTL

BioMutaⁱ

ARNTL

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127156	1 – 626	Aryl hydrocarbon receptor nuclear translocator-like protein 1Add BLAST		626

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	17	Phosphoserine; by GSK3-betaBy similarity	1
Modified residueⁱ	21	Phosphothreonine; by GSK3-betaBy similarity	1
Modified residueⁱ	78	Phosphoserine1 Publication	1
Modified residueⁱ	90	Phosphoserine; by CK2By similarity	1
Cross-linkⁱ	252	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2 and SUMO3)By similarity
Cross-linkⁱ	259	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	538	N6-acetyllysineBy similarity	1

Post-translational modificationⁱ

Ubiquitinated, leading to its proteasomal degradation.By similarity

O-glycosylated; contains O-GlcNAc. O-glycosylation by OGT prevents protein degradation by inhibiting ubiquitination. It also stabilizes the CLOCK-ARNTL/BMAL1 heterodimer thereby increasing CLOCK-ARNTL/BMAL1-mediated transcription of genes in the negative loop of the circadian clock such as PER1/2/3 and CRY1/2.By similarity

Acetylated on Lys-538 upon dimerization with CLOCK. Acetylation facilitates CRY1-mediated repression. Deacetylated by SIRT1, which may result in decreased protein stability.By similarity

Phosphorylated upon dimerization with CLOCK. Phosphorylation enhances the transcriptional activity, alters the subcellular localization and decreases the stability of the CLOCK-ARNTL/BMAL1 heterodimer by promoting its degradation. Phosphorylation shows circadian variations in the liver with a peak between CT10 to CT14. Phosphorylation at Ser-90 by CK2 is essential for its nuclear localization, its interaction with CLOCK and controls CLOCK nuclear entry (By similarity). Dephosphorylation at Ser-78 is important for dimerization with CLOCK and transcriptional activity (PubMed:23229515).By similarity1 Publication

Sumoylated on Lys-259 upon dimerization with CLOCK. Predominantly conjugated to poly-SUMO2/3 rather than SUMO1 and the level of these conjugates undergo rhythmic variation, peaking at CT9-CT12. Sumoylation localizes it exclusively to the PML body and promotes its ubiquitination in the PML body, ubiquitin-dependent proteasomal degradation and the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer.By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	O00327
PeptideAtlas More...PeptideAtlasⁱ	O00327
PRIDEⁱ	O00327
ProteomicsDBⁱ	47841 47842 [O00327-1] 47843 [O00327-3] 47844 [O00327-4] 47845 [O00327-5] 47846 [O00327-6] 47847 [O00327-7] 47848 [O00327-8] 47849 [O00327-9]

PTM databases

iPTMnetⁱ	O00327
PhosphoSitePlusⁱ	O00327

Expressionⁱ

Tissue specificityⁱ

Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000133794 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasⁱ	O00327 baseline and differential
Genevisibleⁱ	O00327 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB045962 HPA050938

HPAⁱ

CAB045962
HPA050938

Interactionⁱ

Subunit structureⁱ

Component of the circadian clock oscillator which includes the CRY1/2 proteins, CLOCK or NPAS2, ARNTL/BMAL1 or ARNTL2/BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER1/2/3 proteins (By similarity). Forms a heterodimer with CLOCK (PubMed:9616112, PubMed:23229515). The CLOCK-ARNTL/BMAL1 heterodimer is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL/BMAL1 (By similarity). Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian manner (By similarity). Interacts with NPAS2 (By similarity). Interacts with EZH2 (By similarity). Interacts with SUMO3 (By similarity). Interacts with SIRT1 (By similarity). Interacts with AHR (PubMed:9079689). Interacts with ID1, ID2 and ID3 (By similarity). Interacts with DDX4 (By similarity). Interacts with OGT (By similarity). Interacts with EED and SUZ12 (By similarity). Interacts with MTA1 (By similarity). Interacts with CIART (PubMed:24385426). Interacts with HSP90 (PubMed:9079689). Interacts with KAT2B and EP300 (PubMed:14645221). Interacts with BHLHE40/DEC1 and BHLHE41/DEC2 (By similarity). Interacts with RELB and the interaction is enhanced in the presence of CLOCK (By similarity). Interacts with PER1, PER2, CRY1 and CRY2 and this interaction requires a translocation to the nucleus (By similarity). Interaction of the CLOCK-ARNTL/BMAL1 heterodimer with PER or CRY inhibits transcription activation (By similarity). Interaction of the CLOCK-ARNTL/BMAL1 with CRY1 is independent of DNA but with PER2 is off DNA (By similarity). The CLOCK-ARNTL/BMAL1 heterodimer interacts with GSK3B (By similarity). Interacts with KDM5A (PubMed:21960634). Interacts with KMT2A; in a circadian manner (By similarity). Interacts with UBE3A (PubMed:24728990). Interacts with PRKCG (By similarity). Interacts with MAGEL2 (By similarity). Interacts with NCOA2 (By similarity). Interacts with THRAP3 (By similarity). The CLOCK-ARNTL/BMAL1 heterodimer interacts with PASD1 (PubMed:25936801). Interacts with PASD1 (PubMed:25936801).By similarity9 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Siteⁱ	77	Interaction with E-box DNA1 Publication	1
Siteⁱ	80	Interaction with E-box DNA1 Publication	1
Siteⁱ	81	Interaction with E-box DNA1 Publication	1
Siteⁱ	85	Interaction with E-box DNA1 Publication	1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CLOCK	O15516	4	EBI-11991546,EBI-1794265
HIF1A	D0VY79	3	EBI-1794206,EBI-10179332
NPAS2	Q99743	4	EBI-11991546,EBI-3932727

GO - Molecular functionⁱ

aryl hydrocarbon receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 9079689
bHLH transcription factor binding Source: Ensembl
Hsp90 protein binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 9079689
protein heterodimerization activity Source: Ensembl
repressing transcription factor binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 25936801

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106899, 61 interactors
ComplexPortalⁱ	CPX-3229 CLOCK-BMAL1 transcription complex
Database of interacting proteins More...DIPⁱ	DIP-46008N
IntActⁱ	O00327, 13 interactors
Molecular INTeraction database More...MINTⁱ	O00327
STRINGⁱ	9606.ENSP00000374357

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	71 – 98	Combined sources	28
Helixⁱ	100 – 103	Combined sources	4
Helixⁱ	111 – 125	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	O00327
SMRⁱ	O00327
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	72 – 125	bHLHPROSITE-ProRule annotationAdd BLAST	54
Domainⁱ	143 – 215	PAS 1PROSITE-ProRule annotationAdd BLAST	73
Domainⁱ	326 – 396	PAS 2PROSITE-ProRule annotationAdd BLAST	71
Domainⁱ	401 – 444	PACAdd BLAST	44

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	508 – 588	Interaction with CIARTBy similarityAdd BLAST		81

Motif

Feature key	Position(s)	DescriptionActions	Length
Motifⁱ	36 – 41	Nuclear localization signalBy similarity	6
Motifⁱ	142 – 152	Nuclear export signal 1By similarityAdd BLAST	11
Motifⁱ	361 – 369	Nuclear export signal 2By similarity	9

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG3561 Eukaryota ENOG410XRJI LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000234379
HOVERGENⁱ	HBG107503
InParanoidⁱ	O00327
KEGG Orthology (KO) More...KOⁱ	K02296
OMAⁱ	EKINTNC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G126J
PhylomeDBⁱ	O00327
TreeFamⁱ	TF319983

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits

Sequences (9+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 9 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Additional isoforms seem to exist.

This entry has 9 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform BMAL1B (identifier: O00327-2) [UniParc]FASTA Add to basket

Also known as: JAP3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM 
        60         70         80         90        100
DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP 
       110        120        130        140        150
TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL 
       160        170        180        190        200
ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD 
       210        220        230        240        250
IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR 
       260        270        280        290        300
MKCNRPSVKV EDKDFPSTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE 
       310        320        330        340        350
DNEPDNEGCN LSCLVAIGRL HSHVVPQPVN GEIRVKSMEY VSRHAIDGKF 
       360        370        380        390        400
VFVDQRATAI LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT 
       410        420        430        440        450
TNCYKFKIKD GSFITLRSRW FSFMNPWTKE VEYIVSTNTV VLANVLEGGD 
       460        470        480        490        500
PTFPQLTASP HSMDSMLPSG EGGPKRTHPT VPGIPGGTRA GAGKIGRMIA 
       510        520        530        540        550
EEIMEIHRIR GSSPSSCGSS PLNITSTPPP DASSPGGKKI LNGGTPDIPS 
       560        570        580        590        600
SGLLSGQAQE NPGYPYSDSS SILGENPHIG IDMIDNDQGS SSPSNDEAAM 
       610        620 
AVIMSLLEAD AGLGGPVDFS DLPWPL

Length:626

Mass (Da):68,762

Last modified:August 15, 2003 - v2

Checksum:ⁱ820F0E07DC6265A6

GO

Isoform BMAL1A (identifier: O00327-1) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQ → MINI

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        10         20         30         40         50
MINIESMDTD KDDPHGRLEY TEHQGRIKNA REAHSQIEKR RRDKMNSFID 
        60         70         80         90        100
ELASLVPTCN AMSRKLDKLT VLRMAVQHMK TLRGATNPYT EANYKPTFLS 
       110        120        130        140        150
DDELKHLILR AADGFLFVVG CDRGKILFVS ESVFKILNYS QNDLIGQSLF 
       160        170        180        190        200
DYLHPKDIAK VKEQLSSSDT APRERLIDAK TGLPVKTDIT PGPSRLCSGA 
       210        220        230        240        250
RRSFFCRMKC NRPSVKVEDK DFPSTCSKKK ADRKSFCTIH STGYLKSWPP 
       260        270        280        290        300
TKMGLDEDNE PDNEGCNLSC LVAIGRLHSH VVPQPVNGEI RVKSMEYVSR 
       310        320        330        340        350
HAIDGKFVFV DQRATAILAY LPQELLGTSC YEYFHQDDIG HLAECHRQVL 
       360        370        380        390        400
QTREKITTNC YKFKIKDGSF ITLRSRWFSF MNPWTKEVEY IVSTNTVVLA 
       410        420        430        440        450
NVLEGGDPTF PQLTASPHSM DSMLPSGEGG PKRTHPTVPG IPGGTRAGAG 
       460        470        480        490        500
KIGRMIAEEI MEIHRIRGSS PSSCGSSPLN ITSTPPPDAS SPGGKKILNG 
       510        520        530        540        550
GTPDIPSSGL LSGQAQENPG YPYSDSSSIL GENPHIGIDM IDNDQGSSSP 
       560        570        580 
SNDEAAMAVI MSLLEADAGL GGPVDFSDLP WPL

Show »

Length:583

Mass (Da):64,207

Checksum:ⁱ2AA8E7EEB4A71119

GO

Isoform BMAL1C (identifier: O00327-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
224-224: T → R
225-626: Missing.

« Hide

        10         20         30         40         50
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM 
        60         70         80         90        100
DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP 
       110        120        130        140        150
TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL 
       160        170        180        190        200
ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD 
       210        220 
IAKVKEQLSS SDTAPRERLI DAKR

Show »

Length:224

Mass (Da):25,353

Checksum:ⁱ0A0580AEDC5A45A0

GO

Isoform BMAL1D (identifier: O00327-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
274-391: Missing.

« Hide

        10         20         30         40         50
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM 
        60         70         80         90        100
DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP 
       110        120        130        140        150
TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL 
       160        170        180        190        200
ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD 
       210        220        230        240        250
IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR 
       260        270        280        290        300
MKCNRPSVKV EDKDFPSTCS KKKVLQTREK ITTNCYKFKI KDGSFITLRS 
       310        320        330        340        350
RWFSFMNPWT KEVEYIVSTN TVVLANVLEG GDPTFPQLTA SPHSMDSMLP 
       360        370        380        390        400
SGEGGPKRTH PTVPGIPGGT RAGAGKIGRM IAEEIMEIHR IRGSSPSSCG 
       410        420        430        440        450
SSPLNITSTP PPDASSPGGK KILNGGTPDI PSSGLLSGQA QENPGYPYSD 
       460        470        480        490        500
SSSILGENPH IGIDMIDNDQ GSSSPSNDEA AMAVIMSLLE ADAGLGGPVD 

FSDLPWPL

Show »

Length:508

Mass (Da):55,462

Checksum:ⁱ5FAB2403FD8AAB32

GO

Isoform BMAL1E (identifier: O00327-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
278-301: SFCTIHSTGYLKSWPPTKMGLDED → AFCTIHSTGYFGIFTTRTSRHIVL
302-626: Missing.

« Hide

        10         20         30         40         50
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM 
        60         70         80         90        100
DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP 
       110        120        130        140        150
TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL 
       160        170        180        190        200
ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD 
       210        220        230        240        250
IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR 
       260        270        280        290        300
MKCNRPSVKV EDKDFPSTCS KKKADRKAFC TIHSTGYFGI FTTRTSRHIV 

L

Show »

Length:301

Mass (Da):33,922

Checksum:ⁱEC942D8A9C9219B3

GO

Isoform BMAL1F (identifier: O00327-6) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
443-526: ANVLEGGDPT...CGSSPLNITS → SRVDTGHLGQ...QGEPGLGQEK
527-626: Missing.

« Hide

        10         20         30         40         50
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM 
        60         70         80         90        100
DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP 
       110        120        130        140        150
TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL 
       160        170        180        190        200
ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD 
       210        220        230        240        250
IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR 
       260        270        280        290        300
MKCNRPSVKV EDKDFPSTCS KKKADRKSFC TIHSTGYLKS WPPTKMGLDE 
       310        320        330        340        350
DNEPDNEGCN LSCLVAIGRL HSHVVPQPVN GEIRVKSMEY VSRHAIDGKF 
       360        370        380        390        400
VFVDQRATAI LAYLPQELLG TSCYEYFHQD DIGHLAECHR QVLQTREKIT 
       410        420        430        440        450
TNCYKFKIKD GSFITLRSRW FSFMNPWTKE VEYIVSTNTV VLSRVDTGHL 
       460        470        480        490        500
GQVERCTVLS RPNSRFLIAG MFTEPTSWKA GTQPSHSSQH PPTAWTACCP 
       510        520 
LEKVAQRGPT PLFQGFQGEP GLGQEK

Show »

Length:526

Mass (Da):59,242

Checksum:ⁱED01AF63A26CE4E0

GO

Isoform MOP3 (identifier: O00327-7) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-59: MADQRMDISS...MDTDKDDPHG → MSKEAVSLWA...CFYLLLFPPP

« Hide

        10         20         30         40         50
MSKEAVSLWA LTVSLQPPVP LCVCREMTGS GRRKQQCVTL PFISRELCFY 
        60         70         80         90        100
LLLFPPPRLE YTEHQGRIKN AREAHSQIEK RRRDKMNSFI DELASLVPTC 
       110        120        130        140        150
NAMSRKLDKL TVLRMAVQHM KTLRGATNPY TEANYKPTFL SDDELKHLIL 
       160        170        180        190        200
RAADGFLFVV GCDRGKILFV SESVFKILNY SQNDLIGQSL FDYLHPKDIA 
       210        220        230        240        250
KVKEQLSSSD TAPRERLIDA KTGLPVKTDI TPGPSRLCSG ARRSFFCRMK 
       260        270        280        290        300
CNRPSVKVED KDFPSTCSKK KADRKSFCTI HSTGYLKSWP PTKMGLDEDN 
       310        320        330        340        350
EPDNEGCNLS CLVAIGRLHS HVVPQPVNGE IRVKSMEYVS RHAIDGKFVF 
       360        370        380        390        400
VDQRATAILA YLPQELLGTS CYEYFHQDDI GHLAECHRQV LQTREKITTN 
       410        420        430        440        450
CYKFKIKDGS FITLRSRWFS FMNPWTKEVE YIVSTNTVVL ANVLEGGDPT 
       460        470        480        490        500
FPQLTASPHS MDSMLPSGEG GPKRTHPTVP GIPGGTRAGA GKIGRMIAEE 
       510        520        530        540        550
IMEIHRIRGS SPSSCGSSPL NITSTPPPDA SSPGGKKILN GGTPDIPSSG 
       560        570        580        590        600
LLSGQAQENP GYPYSDSSSI LGENPHIGID MIDNDQGSSS PSNDEAAMAV 
       610        620 
IMSLLEADAG LGGPVDFSDL PWPL

Show »

Length:624

Mass (Da):68,828

Checksum:ⁱ7A3FD8FAE5E496D7

GO

Isoform 8 (identifier: O00327-8) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
274-274: Missing.

« Hide

        10         20         30         40         50
MADQRMDISS TISDFMSPGP TDLLSSSLGT SGVDCNRKRK GSSTDYQESM 
        60         70         80         90        100
DTDKDDPHGR LEYTEHQGRI KNAREAHSQI EKRRRDKMNS FIDELASLVP 
       110        120        130        140        150
TCNAMSRKLD KLTVLRMAVQ HMKTLRGATN PYTEANYKPT FLSDDELKHL 
       160        170        180        190        200
ILRAADGFLF VVGCDRGKIL FVSESVFKIL NYSQNDLIGQ SLFDYLHPKD 
       210        220        230        240        250
IAKVKEQLSS SDTAPRERLI DAKTGLPVKT DITPGPSRLC SGARRSFFCR 
       260        270        280        290        300
MKCNRPSVKV EDKDFPSTCS KKKDRKSFCT IHSTGYLKSW PPTKMGLDED 
       310        320        330        340        350
NEPDNEGCNL SCLVAIGRLH SHVVPQPVNG EIRVKSMEYV SRHAIDGKFV 
       360        370        380        390        400
FVDQRATAIL AYLPQELLGT SCYEYFHQDD IGHLAECHRQ VLQTREKITT 
       410        420        430        440        450
NCYKFKIKDG SFITLRSRWF SFMNPWTKEV EYIVSTNTVV LANVLEGGDP 
       460        470        480        490        500
TFPQLTASPH SMDSMLPSGE GGPKRTHPTV PGIPGGTRAG AGKIGRMIAE 
       510        520        530        540        550
EIMEIHRIRG SSPSSCGSSP LNITSTPPPD ASSPGGKKIL NGGTPDIPSS 
       560        570        580        590        600
GLLSGQAQEN PGYPYSDSSS ILGENPHIGI DMIDNDQGSS SPSNDEAAMA 
       610        620 
VIMSLLEADA GLGGPVDFSD LPWPL

Show »

Length:625

Mass (Da):68,691

Checksum:ⁱ3F3F7D5688A6FFE2

GO

Isoform 9 (identifier: O00327-9) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-47: MADQRMDISSTISDFMSPGPTDLLSSSLGTSGVDCNRKRKGSSTDYQ → MINI
274-274: Missing.

« Hide

        10         20         30         40         50
MINIESMDTD KDDPHGRLEY TEHQGRIKNA REAHSQIEKR RRDKMNSFID 
        60         70         80         90        100
ELASLVPTCN AMSRKLDKLT VLRMAVQHMK TLRGATNPYT EANYKPTFLS 
       110        120        130        140        150
DDELKHLILR AADGFLFVVG CDRGKILFVS ESVFKILNYS QNDLIGQSLF 
       160        170        180        190        200
DYLHPKDIAK VKEQLSSSDT APRERLIDAK TGLPVKTDIT PGPSRLCSGA 
       210        220        230        240        250
RRSFFCRMKC NRPSVKVEDK DFPSTCSKKK DRKSFCTIHS TGYLKSWPPT 
       260        270        280        290        300
KMGLDEDNEP DNEGCNLSCL VAIGRLHSHV VPQPVNGEIR VKSMEYVSRH 
       310        320        330        340        350
AIDGKFVFVD QRATAILAYL PQELLGTSCY EYFHQDDIGH LAECHRQVLQ 
       360        370        380        390        400
TREKITTNCY KFKIKDGSFI TLRSRWFSFM NPWTKEVEYI VSTNTVVLAN 
       410        420        430        440        450
VLEGGDPTFP QLTASPHSMD SMLPSGEGGP KRTHPTVPGI PGGTRAGAGK 
       460        470        480        490        500
IGRMIAEEIM EIHRIRGSSP SSCGSSPLNI TSTPPPDASS PGGKKILNGG 
       510        520        530        540        550
TPDIPSSGLL SGQAQENPGY PYSDSSSILG ENPHIGIDMI DNDQGSSSPS 
       560        570        580 
NDEAAMAVIM SLLEADAGLG GPVDFSDLPW PL

Show »

Length:582

Mass (Da):64,136

Checksum:ⁱE8D6943E4DD24037

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PKF0	E9PKF0_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	135	Annotation score:
E9PPV4	E9PPV4_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	141	Annotation score:
E9PI92	E9PI92_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	72	Annotation score:
E9PL54	E9PL54_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	100	Annotation score:
E9PRB1	E9PRB1_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	46	Annotation score:
H0YER9	H0YER9_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	171	Annotation score:
E9PKN1	E9PKN1_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	59	Annotation score:
E9PKG7	E9PKG7_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	76	Annotation score:
E9PSD2	E9PSD2_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	23	Annotation score:
E9PNI4	E9PNI4_HUMAN	Aryl hydrocarbon receptor nuclear t... Aryl hydrocarbon receptor nuclear translocator-like protein 1	ARNTL	60	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	69	R → G in AAC51213 (PubMed:9079689).Curated	1
Sequence conflictⁱ	123	K → R in BAA19935 (PubMed:9144434).Curated	1
Sequence conflictⁱ	173	S → P in BAA19939 (PubMed:9144434).Curated	1
Sequence conflictⁱ	259	K → N in BAA19938 (PubMed:9144434).Curated	1
Sequence conflictⁱ	264	D → N in BAA19938 (PubMed:9144434).Curated	1
Sequence conflictⁱ	418	S → N in BAA19937 (PubMed:9144434).Curated	1
Sequence conflictⁱ	513 – 514	SP → LR in AAC51213 (PubMed:9079689).Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002095	1 – 59	MADQR…DDPHG → MSKEAVSLWALTVSLQPPVP LCVCREMTGSGRRKQQCVTL PFISRELCFYLLLFPPP in isoform MOP3. 1 PublicationAdd BLAST	59
Alternative sequenceⁱVSP_002094	1 – 47	MADQR…STDYQ → MINI in isoform BMAL1A and isoform 9. 2 PublicationsAdd BLAST	47
Alternative sequenceⁱVSP_002096	224	T → R in isoform BMAL1C. Curated	1
Alternative sequenceⁱVSP_002097	225 – 626	Missing in isoform BMAL1C. CuratedAdd BLAST	402
Alternative sequenceⁱVSP_002098	274 – 391	Missing in isoform BMAL1D. CuratedAdd BLAST	118
Alternative sequenceⁱVSP_035457	274	Missing in isoform 8 and isoform 9. 2 Publications	1
Alternative sequenceⁱVSP_002099	278 – 301	SFCTI…GLDED → AFCTIHSTGYFGIFTTRTSR HIVL in isoform BMAL1E. CuratedAdd BLAST	24
Alternative sequenceⁱVSP_002100	302 – 626	Missing in isoform BMAL1E. CuratedAdd BLAST	325
Alternative sequenceⁱVSP_002101	443 – 526	ANVLE…LNITS → SRVDTGHLGQVERCTVLSRP NSRFLIAGMFTEPTSWKAGT QPSHSSQHPPTAWTACCPLE KVAQRGPTPLFQGFQGEPGL GQEK in isoform BMAL1F. CuratedAdd BLAST	84
Alternative sequenceⁱVSP_002102	527 – 626	Missing in isoform BMAL1F. CuratedAdd BLAST	100

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D89722 mRNA Translation: BAA19968.1 AB000812 mRNA Translation: BAA19935.1 AB000813 Genomic DNA Translation: BAA19936.1 AB000814 mRNA Translation: BAA19937.1 AB000815 mRNA Translation: BAA19938.1 AB000816 mRNA Translation: BAA19939.1 U51627 mRNA Translation: AAC51213.1 U60415 mRNA Translation: AAB37248.1 AF044288 mRNA Translation: AAC24353.1 AK095749 mRNA Translation: BAG53120.1 AK291510 mRNA Translation: BAF84199.1 EF015894 Genomic DNA Translation: ABM64205.1 AC016884 Genomic DNA No translation available. AC022878 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68504.1 CH471064 Genomic DNA Translation: EAW68505.1 CH471064 Genomic DNA Translation: EAW68510.1 CH471064 Genomic DNA Translation: EAW68511.1 CH471064 Genomic DNA Translation: EAW68513.1 BC016674 mRNA Translation: AAH16674.1 BC031214 mRNA Translation: AAH31214.1 BC041129 mRNA Translation: AAH41129.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31430.1 [O00327-8] CCDS44543.1 [O00327-9] CCDS73259.1 [O00327-2] CCDS76387.1 [O00327-1]
PIRⁱ	JC5405 JC5407 PC4288 PC4289
NCBI Reference Sequences More...RefSeqⁱ	NP_001025443.1, NM_001030272.2 [O00327-8] NP_001025444.1, NM_001030273.2 [O00327-9] NP_001169.3, NM_001178.5 [O00327-8] NP_001284648.1, NM_001297719.1 [O00327-2] NP_001284651.1, NM_001297722.1 [O00327-2] NP_001284653.1, NM_001297724.1 [O00327-1] XP_011518414.1, XM_011520112.2 XP_011518415.1, XM_011520113.1 XP_016873231.1, XM_017017742.1 XP_016873232.1, XM_017017743.1 XP_016873235.1, XM_017017746.1 XP_016873236.1, XM_017017747.1 XP_016873237.1, XM_017017748.1 [O00327-9]
UniGeneⁱ	Hs.65734

Genome annotation databases

Ensemblⁱ	ENST00000389707; ENSP00000374357; ENSG00000133794 [O00327-8] ENST00000401424; ENSP00000385915; ENSG00000133794 [O00327-1] ENST00000403290; ENSP00000384517; ENSG00000133794 [O00327-2] ENST00000403482; ENSP00000385897; ENSG00000133794 [O00327-7] ENST00000403510; ENSP00000385581; ENSG00000133794 [O00327-9]
GeneIDⁱ	406
KEGGⁱ	hsa:406
UCSC genome browser More...UCSCⁱ	uc001mko.4 human [O00327-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00327	ARNTL isoform 3		PANTR		626	UniRef100_O00327
ARNTL isoform 11		PONAB		626
Uncharacterized protein		PANPA		626
Aryl hydrocarbon receptor nuclear translocator like		GORGO		626
UPI0003E71041		HUMAN		376
+3
O00327-1	ARNTL isoform 5		PANTR		583	UniRef100_O00327-1
ARNTL isoform 7		PONAB		583
Uncharacterized protein		CERAT		583
Uncharacterized protein		RHIRO		583
Uncharacterized protein		PAPAN		583
+6
O00327-7	ARNTL isoform 2		PANTR		624	UniRef100_O00327-7
O00327-8	Testis tissue sperm-binding protein Li 50e		HUMAN		625	UniRef100_A0A140VKD3
ARNTL isoform 6		PONAB		625
ARNTL isoform 4		PANTR		625
Testis cDNA clone: QtsA-14192, similar to human aryl hydrocarbon receptor nuclear translocator-like(ARNTL)		MACFA		375
Uncharacterized protein		MACNE		375
+1
O00327-9	ARNTL isoform 12		PONAB		582	UniRef100_A0A2J8UQ25
ARNTL isoform 7		PANTR		582
Uncharacterized protein		MANLE		582
UPI000B7B1E38		PAPAN		677
UPI00075FCB72		MACFA		608

Protein	Similar proteins		Species	Score	Length	Source
O00327	ARNTL isoform 3		PANTR		626	UniRef90_O00327
ARNTL isoform 11		PONAB		626
Uncharacterized protein		PANPA		626
Aryl hydrocarbon receptor nuclear translocator like		GORGO		626
aryl hydrocarbon receptor nuclear translocator-like protein 1 isoform X3		TARSY		626
+64
O00327-1	ARNTL isoform 5		PANTR		583	UniRef90_O00327-1
ARNTL isoform 7		PONAB		583
Uncharacterized protein		CERAT		583
Uncharacterized protein		RHIRO		583
Uncharacterized protein		PAPAN		583
+38
O00327-3	Uncharacterized protein		ORNAN		237	UniRef90_O00327-3
Aryl hydrocarbon receptor nuclear translocator-like 1 (Fragment)		golden-collared manakin		71
Aryl hydrocarbon receptor nuclear translocator-like 1 (Fragment)		Buceros rhinoceros silvestris		71
O00327-7	Isoform BMAL1A of Aryl hydrocarbon receptor nuclear translocator-like protein 1		HUMAN		583	UniRef90_O00327-1
ARNTL isoform 5		PANTR		583
ARNTL isoform 7		PONAB		583
Uncharacterized protein		CERAT		583
Uncharacterized protein		RHIRO		583
+38
O00327-9	Isoform BMAL1A of Aryl hydrocarbon receptor nuclear translocator-like protein 1		HUMAN		583	UniRef90_O00327-1
ARNTL isoform 5		PANTR		583
ARNTL isoform 7		PONAB		583
Uncharacterized protein		CERAT		583
Uncharacterized protein		RHIRO		583
+38

Protein	Similar proteins		Species	Score	Length	Source
O00327	Aryl hydrocarbon receptor nuclear translocator-like protein 1	)	MOUSE		632	UniRef50_Q9WTL8
Aryl hydrocarbon receptor nuclear translocator-like protein 1		TYTAL		633
Aryl hydrocarbon receptor nuclear translocator-like protein 1		CHICK		633
Aryl hydrocarbon receptor nuclear translocator-like protein 1		RAT		626
Aryl hydrocarbon receptor nuclear translocator-like protein 1		NANGA		626
+990
O00327-3	Uncharacterized protein		ORNAN		237	UniRef50_O00327-3
Aryl hydrocarbon receptor nuclear translocator-like 1 (Fragment)		golden-collared manakin		71
Aryl hydrocarbon receptor nuclear translocator-like 1 (Fragment)		Buceros rhinoceros silvestris		71
Aryl hydrocarbon receptor nuclear translocator-like protein 1		CRAGI		228
Aryl hydrocarbon receptor nuclear translocator-like 2 (Fragment)		Nothobranchius korthausae		195
+12
O00327-5	BMAL1 (Fragment)		MELGA		296	UniRef50_O00327-5
UPI00084DCD7A		XENLA		348
O00327-6	Aryl hydrocarbon receptor nuclear translocator-like 1a		GASAC		600	UniRef50_O00327-6
Uncharacterized protein		ONCMY		623
UPI000C29C1F9		Ugandan red Colobus		526
UPI0005F407BE		CERAT		507

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D89722 mRNA Translation: BAA19968.1 AB000812 mRNA Translation: BAA19935.1 AB000813 Genomic DNA Translation: BAA19936.1 AB000814 mRNA Translation: BAA19937.1 AB000815 mRNA Translation: BAA19938.1 AB000816 mRNA Translation: BAA19939.1 U51627 mRNA Translation: AAC51213.1 U60415 mRNA Translation: AAB37248.1 AF044288 mRNA Translation: AAC24353.1 AK095749 mRNA Translation: BAG53120.1 AK291510 mRNA Translation: BAF84199.1 EF015894 Genomic DNA Translation: ABM64205.1 AC016884 Genomic DNA No translation available. AC022878 Genomic DNA No translation available. CH471064 Genomic DNA Translation: EAW68504.1 CH471064 Genomic DNA Translation: EAW68505.1 CH471064 Genomic DNA Translation: EAW68510.1 CH471064 Genomic DNA Translation: EAW68511.1 CH471064 Genomic DNA Translation: EAW68513.1 BC016674 mRNA Translation: AAH16674.1 BC031214 mRNA Translation: AAH31214.1 BC041129 mRNA Translation: AAH41129.2
CCDSⁱ	CCDS31430.1 [O00327-8] CCDS44543.1 [O00327-9] CCDS73259.1 [O00327-2] CCDS76387.1 [O00327-1]
PIRⁱ	JC5405 JC5407 PC4288 PC4289
RefSeqⁱ	NP_001025443.1, NM_001030272.2 [O00327-8] NP_001025444.1, NM_001030273.2 [O00327-9] NP_001169.3, NM_001178.5 [O00327-8] NP_001284648.1, NM_001297719.1 [O00327-2] NP_001284651.1, NM_001297722.1 [O00327-2] NP_001284653.1, NM_001297724.1 [O00327-1] XP_011518414.1, XM_011520112.2 XP_011518415.1, XM_011520113.1 XP_016873231.1, XM_017017742.1 XP_016873232.1, XM_017017743.1 XP_016873235.1, XM_017017746.1 XP_016873236.1, XM_017017747.1 XP_016873237.1, XM_017017748.1 [O00327-9]
UniGeneⁱ	Hs.65734

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4H10	X-ray	2.40	A	66-128	[»]
ProteinModelPortalⁱ	O00327
SMRⁱ	O00327
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106899, 61 interactors
ComplexPortalⁱ	CPX-3229 CLOCK-BMAL1 transcription complex
DIPⁱ	DIP-46008N
IntActⁱ	O00327, 13 interactors
MINTⁱ	O00327
STRINGⁱ	9606.ENSP00000374357

PTM databases

iPTMnetⁱ	O00327
PhosphoSitePlusⁱ	O00327

Polymorphism and mutation databases

BioMutaⁱ	ARNTL

BioMutaⁱ

ARNTL

Proteomic databases

PaxDbⁱ	O00327
PeptideAtlasⁱ	O00327
PRIDEⁱ	O00327
ProteomicsDBⁱ	47841 47842 [O00327-1] 47843 [O00327-3] 47844 [O00327-4] 47845 [O00327-5] 47846 [O00327-6] 47847 [O00327-7] 47848 [O00327-8] 47849 [O00327-9]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	406
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000389707; ENSP00000374357; ENSG00000133794 [O00327-8] ENST00000401424; ENSP00000385915; ENSG00000133794 [O00327-1] ENST00000403290; ENSP00000384517; ENSG00000133794 [O00327-2] ENST00000403482; ENSP00000385897; ENSG00000133794 [O00327-7] ENST00000403510; ENSP00000385581; ENSG00000133794 [O00327-9]
GeneIDⁱ	406
KEGGⁱ	hsa:406
UCSCⁱ	uc001mko.4 human [O00327-2]

Organism-specific databases

CTDⁱ	406
DisGeNETⁱ	406
EuPathDBⁱ	HostDB:ENSG00000133794.17
GeneCardsⁱ	ARNTL
HGNCⁱ	HGNC:701 ARNTL
HPAⁱ	CAB045962 HPA050938
MIMⁱ	602550 gene
neXtProtⁱ	NX_O00327
OpenTargetsⁱ	ENSG00000133794
PharmGKBⁱ	PA24996
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3561 Eukaryota ENOG410XRJI LUCA
GeneTreeⁱ	ENSGT00760000118788
HOGENOMⁱ	HOG000234379
HOVERGENⁱ	HBG107503
InParanoidⁱ	O00327
KOⁱ	K02296
OMAⁱ	EKINTNC
OrthoDBⁱ	EOG091G126J
PhylomeDBⁱ	O00327
TreeFamⁱ	TF319983

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression R-HSA-1989781 PPARA activates gene expression R-HSA-400253 Circadian Clock
SIGNORⁱ	O00327

Miscellaneous databases

ChiTaRSⁱ	ARNTL human
GeneWikiⁱ	ARNTL
GenomeRNAiⁱ	406
Protein Ontology More...PROⁱ	PR:O00327
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000133794 Expressed in 217 organ(s), highest expression level in left lobe of thyroid gland
ExpressionAtlasⁱ	O00327 baseline and differential
Genevisibleⁱ	O00327 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit cd00130 PAS, 2 hits
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR001067 Nuc_translocat IPR001610 PAC IPR000014 PAS IPR035965 PAS-like_dom_sf IPR013767 PAS_fold
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit PF00989 PAS, 1 hit
PRINTSⁱ	PR00785 NCTRNSLOCATR
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit SM00086 PAC, 1 hit SM00091 PAS, 2 hits
SUPFAMⁱ	SSF47459 SSF47459, 1 hit SSF55785 SSF55785, 2 hits
TIGRFAMsⁱ	TIGR00229 sensory_box, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit PS50112 PAS, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BMAL1_HUMAN
Accessionⁱ	O00327Primary (citable) accession number: O00327 Secondary accession number(s): A2I2N6 Q99649
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	August 15, 2003
	Last modified:	November 7, 2018
	This is version 192 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM

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UniProtKB - O00327 (BMAL1_HUMAN)

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Aryl hydrocarbon receptor nuclear translocator-like protein 1

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ