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Entry version 157 (07 Apr 2021)
Sequence version 1 (01 Jul 1997)
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Protein

Uroplakin-1a

Gene

UPK1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O00322

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.40.7.1, the tetraspanin (tetraspanin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Uroplakin-1a
Short name:
UP1a
Alternative name(s):
Tetraspanin-21
Short name:
Tspan-21
Uroplakin Ia
Short name:
UPIa
Short name:
UPKa
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UPK1A
Synonyms:TSPAN21
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12577, UPK1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611557, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00322

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000105668.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 14CytoplasmicSequence analysisAdd BLAST14
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei15 – 35HelicalSequence analysisAdd BLAST21
Topological domaini36 – 59ExtracellularSequence analysisAdd BLAST24
Transmembranei60 – 86HelicalSequence analysisAdd BLAST27
Topological domaini87 – 91CytoplasmicSequence analysis5
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 230ExtracellularSequence analysisAdd BLAST118
Transmembranei231 – 252HelicalSequence analysisAdd BLAST22
Topological domaini253 – 258CytoplasmicSequence analysis6

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
11045

Open Targets

More...
OpenTargetsi
ENSG00000105668

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37209

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
O00322, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UPK1A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002192861 – 258Uroplakin-1aAdd BLAST258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi170N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00322

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O00322

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00322

PeptideAtlas

More...
PeptideAtlasi
O00322

PRoteomics IDEntifications database

More...
PRIDEi
O00322

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
47838 [O00322-1]
47839 [O00322-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
O00322, 1 site

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate. Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000105668, Expressed in urinary bladder and 99 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00322, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000105668, Tissue enhanced (prostate, urinary bladder)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked.

Interacts with uroplakin-2 (UPK2) (By similarity).

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
116233, 90 interactors

Protein interaction database and analysis system

More...
IntActi
O00322, 82 interactors

Molecular INTeraction database

More...
MINTi
O00322

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478942

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
O00322, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tetraspanin (TM4SF) family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3882, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160881

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_088971_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00322

Identification of Orthologs from Complete Genome Data

More...
OMAi
HVDYLFT

Database of Orthologous Groups

More...
OrthoDBi
944403at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00322

TreeFam database of animal gene trees

More...
TreeFami
TF335659

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR008952, Tetraspanin_EC2_sf
IPR034765, Uroplakin-1a

The PANTHER Classification System

More...
PANTHERi
PTHR19282:SF25, PTHR19282:SF25, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00335, Tetraspanin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002419, Tetraspanin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00259, TMFOUR

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48652, SSF48652, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O00322-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASAAAAEAE KGSPVVVGLL VVGNIIILLS GLSLFAETIW VTADQYRVYP
60 70 80 90 100
LMGVSGKDDV FAGAWIAIFC GFSFFMVASF GVGAALCRRR SMVLTYLVLM
110 120 130 140 150
LIVYIFECAS CITSYTHRDY MVSNPSLITK QMLTFYSADT DQGQELTRLW
160 170 180 190 200
DRVMIEQECC GTSGPMDWVN FTSAFRAATP EVVFPWPPLC CRRTGNFIPL
210 220 230 240 250
NEEGCRLGHM DYLFTKGCFE HIGHAIDSYT WGISWFGFAI LMWTLPVMLI

AMYFYTML
Length:258
Mass (Da):28,879
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79AF29E0DAEC4E44
GO
Isoform 2 (identifier: O00322-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-258: GCFEHIGHAI...LIAMYFYTML → AGVQWHNLSS...GVSRGLGLPS

Show »
Length:273
Mass (Da):30,020
Checksum:i509462D619800662
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05233233S → A. Corresponds to variant dbSNP:rs2267586Ensembl.1
Natural variantiVAR_020094257M → T1 PublicationCorresponds to variant dbSNP:rs2285421Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_030005217 – 258GCFEH…FYTML → AGVQWHNLSSLQRLPPGFKG FSHLSFQSSWDYRAASNTSA TPSTATRGVSRGLGLPS in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC002115 Genomic DNA Translation: AAB57631.1
AC002314 Genomic DNA Translation: AAB62736.1
BC107097 mRNA Translation: AAI07098.1
BC107098 mRNA Translation: AAI07099.1
AF085807 mRNA Translation: AAC34887.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12470.1 [O00322-1]
CCDS62640.1 [O00322-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001268372.1, NM_001281443.1 [O00322-2]
NP_008931.1, NM_007000.3 [O00322-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000222275; ENSP00000222275; ENSG00000105668 [O00322-1]
ENST00000379013; ENSP00000368298; ENSG00000105668 [O00322-2]
ENST00000616789; ENSP00000478942; ENSG00000105668 [O00322-2]
ENST00000617999; ENSP00000483176; ENSG00000105668 [O00322-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
11045

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:11045

UCSC genome browser

More...
UCSCi
uc002oaw.5, human [O00322-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002115 Genomic DNA Translation: AAB57631.1
AC002314 Genomic DNA Translation: AAB62736.1
BC107097 mRNA Translation: AAI07098.1
BC107098 mRNA Translation: AAI07099.1
AF085807 mRNA Translation: AAC34887.1
CCDSiCCDS12470.1 [O00322-1]
CCDS62640.1 [O00322-2]
RefSeqiNP_001268372.1, NM_001281443.1 [O00322-2]
NP_008931.1, NM_007000.3 [O00322-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi116233, 90 interactors
IntActiO00322, 82 interactors
MINTiO00322
STRINGi9606.ENSP00000478942

Protein family/group databases

TCDBi8.A.40.7.1, the tetraspanin (tetraspanin) family

PTM databases

GlyGeniO00322, 1 site

Genetic variation databases

BioMutaiUPK1A

Proteomic databases

jPOSTiO00322
MassIVEiO00322
PaxDbiO00322
PeptideAtlasiO00322
PRIDEiO00322
ProteomicsDBi47838 [O00322-1]
47839 [O00322-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
54114, 122 antibodies

Genome annotation databases

EnsembliENST00000222275; ENSP00000222275; ENSG00000105668 [O00322-1]
ENST00000379013; ENSP00000368298; ENSG00000105668 [O00322-2]
ENST00000616789; ENSP00000478942; ENSG00000105668 [O00322-2]
ENST00000617999; ENSP00000483176; ENSG00000105668 [O00322-1]
GeneIDi11045
KEGGihsa:11045
UCSCiuc002oaw.5, human [O00322-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
11045
DisGeNETi11045

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UPK1A
HGNCiHGNC:12577, UPK1A
HPAiENSG00000105668, Tissue enhanced (prostate, urinary bladder)
MIMi611557, gene
neXtProtiNX_O00322
OpenTargetsiENSG00000105668
PharmGKBiPA37209
VEuPathDBiHostDB:ENSG00000105668.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3882, Eukaryota
GeneTreeiENSGT00940000160881
HOGENOMiCLU_088971_1_0_1
InParanoidiO00322
OMAiHVDYLFT
OrthoDBi944403at2759
PhylomeDBiO00322
TreeFamiTF335659

Enzyme and pathway databases

PathwayCommonsiO00322

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
11045, 31 hits in 986 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
UPK1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
11045
PharosiO00322, Tbio

Protein Ontology

More...
PROi
PR:O00322
RNActiO00322, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000105668, Expressed in urinary bladder and 99 other tissues
GenevisibleiO00322, HS

Family and domain databases

InterProiView protein in InterPro
IPR000301, Tetraspanin
IPR018499, Tetraspanin/Peripherin
IPR008952, Tetraspanin_EC2_sf
IPR034765, Uroplakin-1a
PANTHERiPTHR19282:SF25, PTHR19282:SF25, 1 hit
PfamiView protein in Pfam
PF00335, Tetraspanin, 1 hit
PIRSFiPIRSF002419, Tetraspanin, 1 hit
PRINTSiPR00259, TMFOUR
SUPFAMiSSF48652, SSF48652, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUPK1A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00322
Secondary accession number(s): Q3KNU5, Q3KNU6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: April 7, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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