UniProtKB - O00321 (ETV2_HUMAN)
Protein
ETS translocation variant 2
Gene
ETV2
Organism
Homo sapiens (Human)
Status
Functioni
Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 240 – 320 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- blastocyst development Source: Ensembl
- blood vessel morphogenesis Source: Ensembl
- BMP signaling pathway involved in mesodermal cell fate specification Source: Ensembl
- cell differentiation Source: GO_Central
- erythrocyte differentiation Source: Ensembl
- Notch signaling pathway Source: Ensembl
- placenta development Source: Ensembl
- positive regulation of endothelial cell differentiation Source: Ensembl
- positive regulation of mesoderm development Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- Wnt signaling pathway Source: Ensembl
Keywordsi
Molecular function | DNA-binding |
Enzyme and pathway databases
PathwayCommonsi | O00321 |
SIGNORi | O00321 |
Names & Taxonomyi
Protein namesi | Recommended name: ETS translocation variant 2Alternative name(s): Ets-related protein 71 |
Gene namesi | Name:ETV2 Synonyms:ER71, ETSRP71 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000105672.14 |
HGNCi | HGNC:3491, ETV2 |
MIMi | 609358, gene |
neXtProti | NX_O00321 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 2116 |
PharmGKBi | PA27905 |
Miscellaneous databases
Pharosi | O00321, Tbio |
Polymorphism and mutation databases
BioMutai | ETV2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204112 | 1 – 342 | ETS translocation variant 2Add BLAST | 342 |
Proteomic databases
PaxDbi | O00321 |
PeptideAtlasi | O00321 |
PRIDEi | O00321 |
ProteomicsDBi | 1061 47837 [O00321-1] |
PTM databases
iPTMneti | O00321 |
PhosphoSitePlusi | O00321 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105672, Expressed in right testis and 129 other tissues |
ExpressionAtlasi | O00321, baseline and differential |
Genevisiblei | O00321, HS |
Organism-specific databases
HPAi | ENSG00000105672, Tissue enhanced (blood, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 108417, 1 interactor |
IntActi | O00321, 1 interactor |
STRINGi | 9606.ENSP00000384524 |
Miscellaneous databases
RNActi | O00321, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ETS family.Curated
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000162407 |
InParanoidi | O00321 |
OMAi | HTDCTTS |
OrthoDBi | 526256at2759 |
TreeFami | TF316214 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O00321-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW
60 70 80 90 100
KGTSSSLASF PQLDWGSALL HPEVPWGAEP DSQALPWSGD WTDMACTAWD
110 120 130 140 150
SWSGASQTLG PAPLGPGPIP AAGSEGAAGQ NCVPVAGEAT SWSRAQAAGS
160 170 180 190 200
NTSWDCSVGP DGDTYWGSGL GGEPRTDCTI SWGGPAGPDC TTSWNPGLHA
210 220 230 240 250
GGTTSLKRYQ SSALTVCSEP SPQSDRASLA RCPKTNHRGP IQLWQFLLEL
260 270 280 290 300
LHDGARSSCI RWTGNSREFQ LCDPKEVARL WGERKRKPGM NYEKLSRGLR
310 320 330 340
YYYRRDIVRK SGGRKYTYRF GGRVPSLAYP DCAGGGRGAE TQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketS4R454 | S4R454_HUMAN | ETS translocation variant 2 | ETV2 | 95 | Annotation score: | ||
K7ERX2 | K7ERX2_HUMAN | ETS translocation variant 2 | ETV2 | 249 | Annotation score: | ||
Q3KNT2 | Q3KNT2_HUMAN | ETS translocation variant 2 | ETV2 | 155 | Annotation score: | ||
A0A087WX03 | A0A087WX03_HUMAN | ETS translocation variant 2 | ETV2 | 184 | Annotation score: | ||
A0A087WTJ5 | A0A087WTJ5_HUMAN | ETS translocation variant 2 | ETV2 | 184 | Annotation score: |
Sequence cautioni
The sequence AAB57630 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 214 | L → F in AAD00861 (Ref. 4) Curated | 1 | |
Sequence conflicti | 303 | Y → L in AAD00861 (Ref. 4) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071062 | 90 | D → N1 PublicationCorresponds to variant dbSNP:rs2285419Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055488 | 23 | L → LGRLPRLPQRVWGGCPGGAS ADPNPLSPA in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097439 mRNA Translation: BAG53472.1 AC002115 Genomic DNA Translation: AAB57630.1 Sequence problems. BC140746 mRNA Translation: AAI40747.1 AF000671 mRNA Translation: AAD00861.1 |
CCDSi | CCDS32995.2 [O00321-1] |
RefSeqi | NP_055024.2, NM_014209.3 [O00321-1] XP_005258709.1, XM_005258652.2 [O00321-2] |
Genome annotation databases
Ensembli | ENST00000379026; ENSP00000368312; ENSG00000105672 [O00321-2] ENST00000402764; ENSP00000384524; ENSG00000105672 [O00321-1] ENST00000403402; ENSP00000385369; ENSG00000105672 [O00321-1] |
GeneIDi | 2116 |
KEGGi | hsa:2116 |
UCSCi | uc002oar.2, human [O00321-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK097439 mRNA Translation: BAG53472.1 AC002115 Genomic DNA Translation: AAB57630.1 Sequence problems. BC140746 mRNA Translation: AAI40747.1 AF000671 mRNA Translation: AAD00861.1 |
CCDSi | CCDS32995.2 [O00321-1] |
RefSeqi | NP_055024.2, NM_014209.3 [O00321-1] XP_005258709.1, XM_005258652.2 [O00321-2] |
3D structure databases
SMRi | O00321 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 108417, 1 interactor |
IntActi | O00321, 1 interactor |
STRINGi | 9606.ENSP00000384524 |
PTM databases
iPTMneti | O00321 |
PhosphoSitePlusi | O00321 |
Polymorphism and mutation databases
BioMutai | ETV2 |
Proteomic databases
PaxDbi | O00321 |
PeptideAtlasi | O00321 |
PRIDEi | O00321 |
ProteomicsDBi | 1061 47837 [O00321-1] |
Protocols and materials databases
Antibodypediai | 29485, 155 antibodies |
DNASUi | 2116 |
Genome annotation databases
Ensembli | ENST00000379026; ENSP00000368312; ENSG00000105672 [O00321-2] ENST00000402764; ENSP00000384524; ENSG00000105672 [O00321-1] ENST00000403402; ENSP00000385369; ENSG00000105672 [O00321-1] |
GeneIDi | 2116 |
KEGGi | hsa:2116 |
UCSCi | uc002oar.2, human [O00321-1] |
Organism-specific databases
CTDi | 2116 |
DisGeNETi | 2116 |
EuPathDBi | HostDB:ENSG00000105672.14 |
GeneCardsi | ETV2 |
HGNCi | HGNC:3491, ETV2 |
HPAi | ENSG00000105672, Tissue enhanced (blood, testis) |
MIMi | 609358, gene |
neXtProti | NX_O00321 |
PharmGKBi | PA27905 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000162407 |
InParanoidi | O00321 |
OMAi | HTDCTTS |
OrthoDBi | 526256at2759 |
TreeFami | TF316214 |
Enzyme and pathway databases
PathwayCommonsi | O00321 |
SIGNORi | O00321 |
Miscellaneous databases
BioGRID-ORCSi | 2116, 3 hits in 864 CRISPR screens |
GenomeRNAii | 2116 |
Pharosi | O00321, Tbio |
PROi | PR:O00321 |
RNActi | O00321, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105672, Expressed in right testis and 129 other tissues |
ExpressionAtlasi | O00321, baseline and differential |
Genevisiblei | O00321, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ETV2_HUMAN | |
Accessioni | O00321Primary (citable) accession number: O00321 Secondary accession number(s): A6NFN5 Q9UEA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | October 31, 2012 | |
Last modified: | December 2, 2020 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations