UniProtKB - O00321 (ETV2_HUMAN)

BLAST

>sp|O00321|ETV2_HUMAN ETS translocation variant 2 OS=Homo sapiens OX=9606 GN=ETV2 PE=2 SV=2
MDLWNWDEASPQEVPPGNKLAGLEGAKLGFCFPDLALQGDTPTATAETCWKGTSSSLASF
PQLDWGSALLHPEVPWGAEPDSQALPWSGDWTDMACTAWDSWSGASQTLGPAPLGPGPIP
AAGSEGAAGQNCVPVAGEATSWSRAQAAGSNTSWDCSVGPDGDTYWGSGLGGEPRTDCTI
SWGGPAGPDCTTSWNPGLHAGGTTSLKRYQSSALTVCSEPSPQSDRASLARCPKTNHRGP
IQLWQFLLELLHDGARSSCIRWTGNSREFQLCDPKEVARLWGERKRKPGMNYEKLSRGLR
YYYRRDIVRKSGGRKYTYRFGGRVPSLAYPDCAGGGRGAETQ

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History
Entry version 135 (07 Nov 2018)
Sequence version 2 (31 Oct 2012)
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Protein

ETS translocation variant 2

Gene

ETV2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.By similarity

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	240 – 320	ETSPROSITE-ProRule annotationAdd BLAST		81

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

blastocyst development Source: Ensembl
blood vessel morphogenesis Source: Ensembl
BMP signaling pathway involved in mesodermal cell fate specification Source: Ensembl
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
erythrocyte differentiation Source: Ensembl
Notch signaling pathway Source: Ensembl
placenta development Source: Ensembl
positive regulation of endothelial cell differentiation Source: Ensembl
positive regulation of mesoderm development Source: Ensembl
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
Wnt signaling pathway Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding

Molecular function

DNA-binding

Enzyme and pathway databases

SIGNORⁱ	O00321

SIGNORⁱ

O00321

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: ETS translocation variant 2 Alternative name(s): Ets-related protein 71
Gene namesⁱ	Name:ETV2 Synonyms:ER71, ETSRP71
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105672.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3491 ETV2
MIMⁱ	609358 gene
neXtProtⁱ	NX_O00321

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA27905

PharmGKBⁱ

PA27905

Polymorphism and mutation databases

BioMutaⁱ	ETV2

BioMutaⁱ

ETV2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000204112	1 – 342	ETS translocation variant 2Add BLAST		342

Proteomic databases

PaxDbⁱ	O00321
PeptideAtlas More...PeptideAtlasⁱ	O00321
PRIDEⁱ	O00321
ProteomicsDBⁱ	47837

PTM databases

iPTMnetⁱ	O00321
PhosphoSitePlusⁱ	O00321

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000105672 Expressed in 109 organ(s), highest expression level in right testis
CleanExⁱ	HS_ETV2
ExpressionAtlasⁱ	O00321 baseline and differential
Genevisibleⁱ	O00321 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	108417, 1 interactor
STRINGⁱ	9606.ENSP00000384524

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00321
SMRⁱ	O00321
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ETS family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3806 Eukaryota ENOG410Z0ZF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118907
HOGENOMⁱ	HOG000293214
HOVERGENⁱ	HBG005616
InParanoidⁱ	O00321
KEGG Orthology (KO) More...KOⁱ	K09432
OMAⁱ	DCTTSSK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F77
TreeFamⁱ	TF316214

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O00321-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLWNWDEAS PQEVPPGNKL AGLEGAKLGF CFPDLALQGD TPTATAETCW 
        60         70         80         90        100
KGTSSSLASF PQLDWGSALL HPEVPWGAEP DSQALPWSGD WTDMACTAWD 
       110        120        130        140        150
SWSGASQTLG PAPLGPGPIP AAGSEGAAGQ NCVPVAGEAT SWSRAQAAGS 
       160        170        180        190        200
NTSWDCSVGP DGDTYWGSGL GGEPRTDCTI SWGGPAGPDC TTSWNPGLHA 
       210        220        230        240        250
GGTTSLKRYQ SSALTVCSEP SPQSDRASLA RCPKTNHRGP IQLWQFLLEL 
       260        270        280        290        300
LHDGARSSCI RWTGNSREFQ LCDPKEVARL WGERKRKPGM NYEKLSRGLR 
       310        320        330        340 
YYYRRDIVRK SGGRKYTYRF GGRVPSLAYP DCAGGGRGAE TQ

Length:342

Mass (Da):36,633

Last modified:October 31, 2012 - v2

Checksum:ⁱ9B0103D5D4B1AB8C

Isoform 2 (identifier: O00321-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
23-23: L → LGRLPRLPQRVWGGCPGGASADPNPLSPA

« Hide

        10         20         30         40         50
MDLWNWDEAS PQEVPPGNKL AGLGRLPRLP QRVWGGCPGG ASADPNPLSP 
        60         70         80         90        100
AEGAKLGFCF PDLALQGDTP TATAETCWKG TSSSLASFPQ LDWGSALLHP 
       110        120        130        140        150
EVPWGAEPDS QALPWSGDWT DMACTAWDSW SGASQTLGPA PLGPGPIPAA 
       160        170        180        190        200
GSEGAAGQNC VPVAGEATSW SRAQAAGSNT SWDCSVGPDG DTYWGSGLGG 
       210        220        230        240        250
EPRTDCTISW GGPAGPDCTT SWNPGLHAGG TTSLKRYQSS ALTVCSEPSP 
       260        270        280        290        300
QSDRASLARC PKTNHRGPIQ LWQFLLELLH DGARSSCIRW TGNSREFQLC 
       310        320        330        340        350
DPKEVARLWG ERKRKPGMNY EKLSRGLRYY YRRDIVRKSG GRKYTYRFGG 
       360        370
RVPSLAYPDC AGGGRGAETQ

Note: No experimental confirmation available.

Show »

Length:370

Mass (Da):39,442

Checksum:ⁱ01A55C7D10160AF5

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

K7ERX2	K7ERX2_HUMAN	ETS translocation variant 2 ETS translocation variant 2	ETV2	249	Annotation score:
Q3KNT2	Q3KNT2_HUMAN	ETS translocation variant 2 ETS translocation variant 2 (ETV2 protein)	ETV2	155	Annotation score:
S4R454	S4R454_HUMAN	ETS translocation variant 2 ETS translocation variant 2	ETV2	95	Annotation score:
A0A087WX03	A0A087WX03_HUMAN	ETS translocation variant 2 ETS translocation variant 2	ETV2	184	Annotation score:
A0A087WTJ5	A0A087WTJ5_HUMAN	ETS translocation variant 2 ETS translocation variant 2	ETV2	184	Annotation score:

Sequence cautionⁱ

The sequence AAB57630 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	214	L → F in AAD00861 (Ref. 4) Curated		1
Sequence conflictⁱ	303	Y → L in AAD00861 (Ref. 4) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071062	90	D → N1 PublicationCorresponds to variant dbSNP:rs2285419Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055488	23	L → LGRLPRLPQRVWGGCPGGAS ADPNPLSPA in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK097439 mRNA Translation: BAG53472.1 AC002115 Genomic DNA Translation: AAB57630.1 Sequence problems. BC140746 mRNA Translation: AAI40747.1 AF000671 mRNA Translation: AAD00861.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32995.2 [O00321-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_055024.2, NM_014209.3 [O00321-1] XP_005258709.1, XM_005258652.2 [O00321-2]
UniGeneⁱ	Hs.194061

Genome annotation databases

Ensemblⁱ	ENST00000379026; ENSP00000368312; ENSG00000105672 [O00321-2] ENST00000402764; ENSP00000384524; ENSG00000105672 [O00321-1] ENST00000403402; ENSP00000385369; ENSG00000105672 [O00321-1]
GeneIDⁱ	2116
KEGGⁱ	hsa:2116
UCSC genome browser More...UCSCⁱ	uc002oar.2 human [O00321-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00321	ETS variant 2		GORGO		342	UniRef90_O00321
ETV2 isoform 3		PONAB		342
Uncharacterized protein		PANPA		342
ETS variant 2		PANTR		342
ETV2 protein		HUMAN		341
+2
O00321-2	Uncharacterized protein		MACMU		348	UniRef90_F6YE27
Uncharacterized protein		MACFA		376
Uncharacterized protein		MACNE		376
Uncharacterized protein		CHLSB		375
ETS variant 2		PANTR		370
+29

Protein	Similar proteins		Species	Score	Length	Source
O00321	ETS translocation variant 2		MOUSE		335	UniRef50_P41163
Ets variant 2		RAT		336
ETS variant 2		TOKOS		335
ETS translocation variant 2 isoform X2		PHYCD		333
LOW QUALITY PROTEIN: ETS translocation variant 2		Yangtze finless porpoise		374
+135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK097439 mRNA Translation: BAG53472.1 AC002115 Genomic DNA Translation: AAB57630.1 Sequence problems. BC140746 mRNA Translation: AAI40747.1 AF000671 mRNA Translation: AAD00861.1
CCDSⁱ	CCDS32995.2 [O00321-1]
RefSeqⁱ	NP_055024.2, NM_014209.3 [O00321-1] XP_005258709.1, XM_005258652.2 [O00321-2]
UniGeneⁱ	Hs.194061

3D structure databases

ProteinModelPortalⁱ	O00321
SMRⁱ	O00321
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108417, 1 interactor
STRINGⁱ	9606.ENSP00000384524

PTM databases

iPTMnetⁱ	O00321
PhosphoSitePlusⁱ	O00321

Polymorphism and mutation databases

BioMutaⁱ	ETV2

BioMutaⁱ

ETV2

Proteomic databases

PaxDbⁱ	O00321
PeptideAtlasⁱ	O00321
PRIDEⁱ	O00321
ProteomicsDBⁱ	47837

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2116
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379026; ENSP00000368312; ENSG00000105672 [O00321-2] ENST00000402764; ENSP00000384524; ENSG00000105672 [O00321-1] ENST00000403402; ENSP00000385369; ENSG00000105672 [O00321-1]
GeneIDⁱ	2116
KEGGⁱ	hsa:2116
UCSCⁱ	uc002oar.2 human [O00321-1]

Organism-specific databases

CTDⁱ	2116
EuPathDBⁱ	HostDB:ENSG00000105672.14
GeneCardsⁱ	ETV2
HGNCⁱ	HGNC:3491 ETV2
MIMⁱ	609358 gene
neXtProtⁱ	NX_O00321
PharmGKBⁱ	PA27905
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3806 Eukaryota ENOG410Z0ZF LUCA
GeneTreeⁱ	ENSGT00760000118907
HOGENOMⁱ	HOG000293214
HOVERGENⁱ	HBG005616
InParanoidⁱ	O00321
KOⁱ	K09432
OMAⁱ	DCTTSSK
OrthoDBⁱ	EOG091G0F77
TreeFamⁱ	TF316214

Enzyme and pathway databases

SIGNORⁱ	O00321

SIGNORⁱ

O00321

Miscellaneous databases

GenomeRNAiⁱ	2116
Protein Ontology More...PROⁱ	PR:O00321
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105672 Expressed in 109 organ(s), highest expression level in right testis
CleanExⁱ	HS_ETV2
ExpressionAtlasⁱ	O00321 baseline and differential
Genevisibleⁱ	O00321 HS

Family and domain databases

Gene3Dⁱ	1.10.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000418 Ets_dom IPR036388 WH-like_DNA-bd_sf IPR036390 WH_DNA-bd_sf
Pfamⁱ	View protein in Pfam PF00178 Ets, 1 hit
PRINTSⁱ	PR00454 ETSDOMAIN
SMARTⁱ	View protein in SMART SM00413 ETS, 1 hit
SUPFAMⁱ	SSF46785 SSF46785, 1 hit
PROSITEⁱ	View protein in PROSITE PS00345 ETS_DOMAIN_1, 1 hit PS00346 ETS_DOMAIN_2, 1 hit PS50061 ETS_DOMAIN_3, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ETV2_HUMAN
Accessionⁱ	O00321Primary (citable) accession number: O00321 Secondary accession number(s): A6NFN5 , B3KUL0, B9EIN1, Q9UEA0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	October 31, 2012
	Last modified:	November 7, 2018
	This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

Proteomes

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Supporting data

UniProtKB - O00321 (ETV2_HUMAN)

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ETS translocation variant 2

ETV2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ