Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cell division cycle 7-related protein kinase

Gene

CDC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei90ATPPROSITE-ProRule annotation1
Active sitei177Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi64 – 72ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  • cell cycle phase transition Source: BHF-UCL
  • cell division Source: UniProtKB-KW
  • DNA replication Source: Reactome
  • DNA replication initiation Source: GO_Central
  • double-strand break repair via break-induced replication Source: GO_Central
  • G1/S transition of mitotic cell cycle Source: Reactome
  • negative regulation of G0 to G1 transition Source: Reactome
  • peptidyl-serine phosphorylation Source: GO_Central
  • phagocytosis Source: GO_Central
  • positive regulation of cell proliferation Source: HGNC
  • positive regulation of G2/M transition of mitotic cell cycle Source: UniProtKB
  • positive regulation of nuclear cell cycle DNA replication Source: UniProtKB
  • regulation of cell shape Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-176187 Activation of ATR in response to replication stress
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-8953750 Transcriptional Regulation by E2F6
SignaLinkiO00311
SIGNORiO00311

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division cycle 7-related protein kinase (EC:2.7.11.1)
Short name:
CDC7-related kinase
Short name:
HsCdc7
Short name:
huCdc7
Gene namesi
Name:CDC7
Synonyms:CDC7L1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000097046.12
HGNCiHGNC:1745 CDC7
MIMi603311 gene
neXtProtiNX_O00311

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8317
OpenTargetsiENSG00000097046
PharmGKBiPA26272

Chemistry databases

ChEMBLiCHEMBL5443
GuidetoPHARMACOLOGYi1960

Polymorphism and mutation databases

BioMutaiCDC7

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000857631 – 574Cell division cycle 7-related protein kinaseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei503PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO00311
MaxQBiO00311
PaxDbiO00311
PeptideAtlasiO00311
PRIDEiO00311
ProteomicsDBi47836

PTM databases

iPTMnetiO00311
PhosphoSitePlusiO00311

Expressioni

Gene expression databases

BgeeiENSG00000097046
CleanExiHS_CDC7
ExpressionAtlasiO00311 baseline and differential
GenevisibleiO00311 HS

Organism-specific databases

HPAiCAB002669
HPA035831

Interactioni

Subunit structurei

Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113914, 39 interactors
CORUMiO00311
DIPiDIP-31728N
IntActiO00311, 42 interactors
MINTiO00311
STRINGi9606.ENSP00000234626

Chemistry databases

BindingDBiO00311

Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi42 – 50Combined sources9
Helixi52 – 56Combined sources5
Beta strandi59 – 66Combined sources8
Beta strandi68 – 79Combined sources12
Beta strandi84 – 92Combined sources9
Helixi98 – 110Combined sources13
Beta strandi121 – 126Combined sources6
Beta strandi129 – 135Combined sources7
Helixi142 – 146Combined sources5
Helixi151 – 170Combined sources20
Helixi180 – 182Combined sources3
Beta strandi183 – 186Combined sources4
Turni187 – 190Combined sources4
Beta strandi191 – 194Combined sources4
Helixi209 – 213Combined sources5
Turni217 – 219Combined sources3
Helixi377 – 379Combined sources3
Helixi382 – 385Combined sources4
Helixi394 – 409Combined sources16
Beta strandi412 – 415Combined sources4
Helixi420 – 431Combined sources12
Helixi433 – 442Combined sources10
Beta strandi445 – 451Combined sources7
Helixi458 – 465Combined sources8
Helixi540 – 549Combined sources10
Turni554 – 556Combined sources3
Helixi560 – 564Combined sources5
Helixi567 – 569Combined sources3

3D structure databases

ProteinModelPortaliO00311
SMRiO00311
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 574Protein kinasePROSITE-ProRule annotationAdd BLAST517

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1167 Eukaryota
ENOG410YKCM LUCA
GeneTreeiENSGT00550000075011
HOGENOMiHOG000193450
HOVERGENiHBG003991
InParanoidiO00311
KOiK02214
OMAiRYPFYKA
OrthoDBiEOG091G0O6H
PhylomeDBiO00311
TreeFamiTF101052

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 3 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms may be produced.
Isoform 1 (identifier: O00311-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEASLGIQMD EPMAFSPQRD RFQAEGSLKK NEQNFKLAGV KKDIEKLYEA
60 70 80 90 100
VPQLSNVFKI EDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR
110 120 130 140 150
IAAELQCLTV AGGQDNVMGV KYCFRKNDHV VIAMPYLEHE SFLDILNSLS
160 170 180 190 200
FQEVREYMLN LFKALKRIHQ FGIVHRDVKP SNFLYNRRLK KYALVDFGLA
210 220 230 240 250
QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG PVPKELDQQS
260 270 280 290 300
TTKASVKRPY TNAQIQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH
310 320 330 340 350
ESPAVKLMKQ SKTVDVLSRK LATKKKAIST KVMNSAVMRK TASSCPASLT
360 370 380 390 400
CDCYATDKVC SICLSRRQQV APRAGTPGFR APEVLTKCPN QTTAIDMWSA
410 420 430 440 450
GVIFLSLLSG RYPFYKASDD LTALAQIMTI RGSRETIQAA KTFGKSILCS
460 470 480 490 500
KEVPAQDLRK LCERLRGMDS STPKLTSDIQ GHASHQPAIS EKTDHKASCL
510 520 530 540 550
VQTPPGQYSG NSFKKGDSNS CEHCFDEYNT NLEGWNEVPD EAYDLLDKLL
560 570
DLNPASRITA EEALLHPFFK DMSL
Length:574
Mass (Da):63,888
Last modified:July 1, 1997 - v1
Checksum:i90D549BEE20AE583
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti89L → V in AAB97512 (PubMed:9405610).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01925523Q → P1 PublicationCorresponds to variant dbSNP:rs13447459Ensembl.1
Natural variantiVAR_01925699I → V1 PublicationCorresponds to variant dbSNP:rs13447492Ensembl.1
Natural variantiVAR_019257112G → W1 PublicationCorresponds to variant dbSNP:rs13447493Ensembl.1
Natural variantiVAR_019258162F → L2 PublicationsCorresponds to variant dbSNP:rs13447503Ensembl.1
Natural variantiVAR_040403208I → M1 PublicationCorresponds to variant dbSNP:rs34979509Ensembl.1
Natural variantiVAR_040404209E → D1 PublicationCorresponds to variant dbSNP:rs56327502Ensembl.1
Natural variantiVAR_019259441K → R2 PublicationsCorresponds to variant dbSNP:rs13447539Ensembl.1
Natural variantiVAR_040405472T → I1 PublicationCorresponds to variant dbSNP:rs56381770Ensembl.1
Natural variantiVAR_040406498S → A1 PublicationCorresponds to variant dbSNP:rs35055915Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003698 mRNA Translation: BAA19962.1
AF015592 mRNA Translation: AAC52080.1
AF005209 mRNA Translation: AAB97512.1
AY585721 Genomic DNA Translation: AAS79323.1
AL355871 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73114.1
CH471097 Genomic DNA Translation: EAW73115.1
BC110526 mRNA Translation: AAI10527.1
BC110527 mRNA Translation: AAI10528.1
BC111044 mRNA Translation: AAI11045.1
CCDSiCCDS734.1 [O00311-1]
RefSeqiNP_001127891.1, NM_001134419.1 [O00311-1]
NP_001127892.1, NM_001134420.1 [O00311-1]
NP_003494.1, NM_003503.3 [O00311-1]
XP_005271298.1, XM_005271241.2 [O00311-1]
UniGeneiHs.533573

Genome annotation databases

EnsembliENST00000234626; ENSP00000234626; ENSG00000097046 [O00311-1]
ENST00000428239; ENSP00000393139; ENSG00000097046 [O00311-1]
GeneIDi8317
KEGGihsa:8317
UCSCiuc001doe.4 human [O00311-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCDC7_HUMAN
AccessioniPrimary (citable) accession number: O00311
Secondary accession number(s): D3DT31, O00558, Q5T5U5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 1, 1997
Last modified: July 18, 2018
This is version 183 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health