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Protein

Cell division cycle 7-related protein kinase

Gene

CDC7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to phosphorylate critical substrates that regulate the G1/S phase transition and/or DNA replication. Can phosphorylates MCM2 and MCM3.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei90ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei177Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi64 – 72ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • kinase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • protein kinase activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processCell cycle, Cell division
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-176187 Activation of ATR in response to replication stress
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-8953750 Transcriptional Regulation by E2F6

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O00311

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O00311

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cell division cycle 7-related protein kinase (EC:2.7.11.1)
Short name:
CDC7-related kinase
Short name:
HsCdc7
Short name:
huCdc7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDC7
Synonyms:CDC7L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000097046.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1745 CDC7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603311 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00311

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8317

Open Targets

More...
OpenTargetsi
ENSG00000097046

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26272

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5443

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1960

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDC7

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000857631 – 574Cell division cycle 7-related protein kinaseAdd BLAST574

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei27PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei503PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O00311

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O00311

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00311

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00311

PeptideAtlas

More...
PeptideAtlasi
O00311

PRoteomics IDEntifications database

More...
PRIDEi
O00311

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47836

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00311

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00311

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000097046 Expressed in 165 organ(s), highest expression level in secondary oocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_CDC7

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00311 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00311 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB002669
HPA035831

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Forms a complex with either DBF4/DBF4A or DBF4B, leading to the activation of the kinase activity.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113914, 42 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
O00311

Database of interacting proteins

More...
DIPi
DIP-31728N

Protein interaction database and analysis system

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IntActi
O00311, 42 interactors

Molecular INTeraction database

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MINTi
O00311

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000234626

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O00311

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1574
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F99X-ray2.33A37-574[»]
4F9AX-ray2.17A/C37-574[»]
4F9BX-ray2.50A/C37-574[»]
4F9CX-ray2.08A37-574[»]
5UWQX-ray2.28D456-473[»]
5UWRX-ray2.24D456-478[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00311

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00311

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini58 – 574Protein kinasePROSITE-ProRule annotationAdd BLAST517

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1167 Eukaryota
ENOG410YKCM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075011

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000193450

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003991

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00311

KEGG Orthology (KO)

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KOi
K02214

Identification of Orthologs from Complete Genome Data

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OMAi
QMDEPMA

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00311

TreeFam database of animal gene trees

More...
TreeFami
TF101052

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00069 Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00220 S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 1 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms may be produced.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O00311-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEASLGIQMD EPMAFSPQRD RFQAEGSLKK NEQNFKLAGV KKDIEKLYEA
60 70 80 90 100
VPQLSNVFKI EDKIGEGTFS SVYLATAQLQ VGPEEKIALK HLIPTSHPIR
110 120 130 140 150
IAAELQCLTV AGGQDNVMGV KYCFRKNDHV VIAMPYLEHE SFLDILNSLS
160 170 180 190 200
FQEVREYMLN LFKALKRIHQ FGIVHRDVKP SNFLYNRRLK KYALVDFGLA
210 220 230 240 250
QGTHDTKIEL LKFVQSEAQQ ERCSQNKSHI ITGNKIPLSG PVPKELDQQS
260 270 280 290 300
TTKASVKRPY TNAQIQIKQG KDGKEGSVGL SVQRSVFGER NFNIHSSISH
310 320 330 340 350
ESPAVKLMKQ SKTVDVLSRK LATKKKAIST KVMNSAVMRK TASSCPASLT
360 370 380 390 400
CDCYATDKVC SICLSRRQQV APRAGTPGFR APEVLTKCPN QTTAIDMWSA
410 420 430 440 450
GVIFLSLLSG RYPFYKASDD LTALAQIMTI RGSRETIQAA KTFGKSILCS
460 470 480 490 500
KEVPAQDLRK LCERLRGMDS STPKLTSDIQ GHASHQPAIS EKTDHKASCL
510 520 530 540 550
VQTPPGQYSG NSFKKGDSNS CEHCFDEYNT NLEGWNEVPD EAYDLLDKLL
560 570
DLNPASRITA EEALLHPFFK DMSL
Length:574
Mass (Da):63,888
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90D549BEE20AE583
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AMW7B1AMW7_HUMAN
Cell division cycle 7-related prote...
CDC7
157Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti89L → V in AAB97512 (PubMed:9405610).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01925523Q → P1 PublicationCorresponds to variant dbSNP:rs13447459Ensembl.1
Natural variantiVAR_01925699I → V1 PublicationCorresponds to variant dbSNP:rs13447492Ensembl.1
Natural variantiVAR_019257112G → W1 PublicationCorresponds to variant dbSNP:rs13447493Ensembl.1
Natural variantiVAR_019258162F → L2 PublicationsCorresponds to variant dbSNP:rs13447503Ensembl.1
Natural variantiVAR_040403208I → M1 PublicationCorresponds to variant dbSNP:rs34979509Ensembl.1
Natural variantiVAR_040404209E → D1 PublicationCorresponds to variant dbSNP:rs56327502Ensembl.1
Natural variantiVAR_019259441K → R2 PublicationsCorresponds to variant dbSNP:rs13447539Ensembl.1
Natural variantiVAR_040405472T → I1 PublicationCorresponds to variant dbSNP:rs56381770Ensembl.1
Natural variantiVAR_040406498S → A1 PublicationCorresponds to variant dbSNP:rs35055915Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB003698 mRNA Translation: BAA19962.1
AF015592 mRNA Translation: AAC52080.1
AF005209 mRNA Translation: AAB97512.1
AY585721 Genomic DNA Translation: AAS79323.1
AL355871 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73114.1
CH471097 Genomic DNA Translation: EAW73115.1
BC110526 mRNA Translation: AAI10527.1
BC110527 mRNA Translation: AAI10528.1
BC111044 mRNA Translation: AAI11045.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS734.1 [O00311-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001127891.1, NM_001134419.1 [O00311-1]
NP_001127892.1, NM_001134420.1 [O00311-1]
NP_003494.1, NM_003503.3 [O00311-1]
XP_005271298.1, XM_005271241.2 [O00311-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.533573

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234626; ENSP00000234626; ENSG00000097046 [O00311-1]
ENST00000428239; ENSP00000393139; ENSG00000097046 [O00311-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
8317

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8317

UCSC genome browser

More...
UCSCi
uc001doe.4 human [O00311-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB003698 mRNA Translation: BAA19962.1
AF015592 mRNA Translation: AAC52080.1
AF005209 mRNA Translation: AAB97512.1
AY585721 Genomic DNA Translation: AAS79323.1
AL355871 Genomic DNA No translation available.
CH471097 Genomic DNA Translation: EAW73114.1
CH471097 Genomic DNA Translation: EAW73115.1
BC110526 mRNA Translation: AAI10527.1
BC110527 mRNA Translation: AAI10528.1
BC111044 mRNA Translation: AAI11045.1
CCDSiCCDS734.1 [O00311-1]
RefSeqiNP_001127891.1, NM_001134419.1 [O00311-1]
NP_001127892.1, NM_001134420.1 [O00311-1]
NP_003494.1, NM_003503.3 [O00311-1]
XP_005271298.1, XM_005271241.2 [O00311-1]
UniGeneiHs.533573

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F99X-ray2.33A37-574[»]
4F9AX-ray2.17A/C37-574[»]
4F9BX-ray2.50A/C37-574[»]
4F9CX-ray2.08A37-574[»]
5UWQX-ray2.28D456-473[»]
5UWRX-ray2.24D456-478[»]
ProteinModelPortaliO00311
SMRiO00311
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113914, 42 interactors
CORUMiO00311
DIPiDIP-31728N
IntActiO00311, 42 interactors
MINTiO00311
STRINGi9606.ENSP00000234626

Chemistry databases

BindingDBiO00311
ChEMBLiCHEMBL5443
GuidetoPHARMACOLOGYi1960

PTM databases

iPTMnetiO00311
PhosphoSitePlusiO00311

Polymorphism and mutation databases

BioMutaiCDC7

Proteomic databases

EPDiO00311
jPOSTiO00311
MaxQBiO00311
PaxDbiO00311
PeptideAtlasiO00311
PRIDEiO00311
ProteomicsDBi47836

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
8317
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234626; ENSP00000234626; ENSG00000097046 [O00311-1]
ENST00000428239; ENSP00000393139; ENSG00000097046 [O00311-1]
GeneIDi8317
KEGGihsa:8317
UCSCiuc001doe.4 human [O00311-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8317
DisGeNETi8317
EuPathDBiHostDB:ENSG00000097046.12

GeneCards: human genes, protein and diseases

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GeneCardsi
CDC7
HGNCiHGNC:1745 CDC7
HPAiCAB002669
HPA035831
MIMi603311 gene
neXtProtiNX_O00311
OpenTargetsiENSG00000097046
PharmGKBiPA26272

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1167 Eukaryota
ENOG410YKCM LUCA
GeneTreeiENSGT00550000075011
HOGENOMiHOG000193450
HOVERGENiHBG003991
InParanoidiO00311
KOiK02214
OMAiQMDEPMA
OrthoDBi1318335at2759
PhylomeDBiO00311
TreeFamiTF101052

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-176187 Activation of ATR in response to replication stress
R-HSA-68962 Activation of the pre-replicative complex
R-HSA-8953750 Transcriptional Regulation by E2F6
SignaLinkiO00311
SIGNORiO00311

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cell_division_cycle_7-related_protein_kinase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8317

Protein Ontology

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PROi
PR:O00311

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000097046 Expressed in 165 organ(s), highest expression level in secondary oocyte
CleanExiHS_CDC7
ExpressionAtlasiO00311 baseline and differential
GenevisibleiO00311 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 2 hits
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDC7_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00311
Secondary accession number(s): D3DT31, O00558, Q5T5U5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 1, 1997
Last modified: January 16, 2019
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
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