Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O00300 (TR11B_HUMAN)

(max 400 entries)x

Your basket is currently empty. i

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tumor necrosis factor receptor superfamily member 11B

Gene

TNFRSF11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei400Involved in dimerization1

GO - Molecular functioni

  • cytokine activity Source: ProtInc
  • signaling receptor activity Source: ProtInc
  • tumor necrosis factor-activated receptor activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-HSA-5669034 TNFs bind their physiological receptors
SIGNORiO00300

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11B
Alternative name(s):
Osteoclastogenesis inhibitory factor
Osteoprotegerin
Gene namesi
Name:TNFRSF11B
Synonyms:OCIF, OPG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000164761.8
HGNCiHGNC:11909 TNFRSF11B
MIMi602643 gene
neXtProtiNX_O00300

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

Paget disease of bone 5, juvenile-onset (PDB5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.
See also OMIM:239000
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019413182Missing in PDB5. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi78 – 79DE → AA: Decreases inhibition of osteoclast differentiation. 1 Publication2
Mutagenesisi116E → A: Reduces affinity for TNFSF11. Decreases inhibition of osteoclast differentiation. 1 Publication1
Mutagenesisi400 – 401Missing : Abolishes dimerization. 2
Mutagenesisi400C → S: Abolishes dimerization. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi4982
MalaCardsiTNFRSF11B
MIMi239000 phenotype
OpenTargetsiENSG00000164761
Orphaneti2801 Juvenile Paget disease
PharmGKBiPA36602

Polymorphism and mutation databases

BioMutaiTNFRSF11B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 212 PublicationsAdd BLAST21
ChainiPRO_000003458722 – 401Tumor necrosis factor receptor superfamily member 11BAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 54PROSITE-ProRule annotation1 Publication
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation1 Publication
Disulfide bondi65 ↔ 80PROSITE-ProRule annotation1 Publication
Disulfide bondi83 ↔ 97PROSITE-ProRule annotation1 Publication
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation1 Publication
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation1 Publication
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation1 Publication
Disulfide bondi145 ↔ 160PROSITE-ProRule annotation1 Publication
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi178N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated. Contains sialic acid residues.1 Publication
The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00300
PeptideAtlasiO00300
PRIDEiO00300
ProteomicsDBi47829

PTM databases

iPTMnetiO00300
PhosphoSitePlusiO00300

Expressioni

Tissue specificityi

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

Inductioni

Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.

Gene expression databases

BgeeiENSG00000164761
CleanExiHS_TNFRSF11B
ExpressionAtlasiO00300 baseline and differential
GenevisibleiO00300 HS

Organism-specific databases

HPAiCAB034939

Interactioni

Subunit structurei

Homodimer. Interacts with TNFSF10 and TNFSF11.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TNFSF11O147883EBI-15481185,EBI-7404021

GO - Molecular functioni

  • cytokine activity Source: ProtInc
View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111028, 2 interactors
IntActiO00300, 2 interactors
STRINGi9606.ENSP00000297350

Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 31Combined sources3
Beta strandi35 – 37Combined sources3
Beta strandi40 – 42Combined sources3
Beta strandi48 – 52Combined sources5
Beta strandi56 – 58Combined sources3
Beta strandi61 – 64Combined sources4
Beta strandi91 – 95Combined sources5
Beta strandi99 – 101Combined sources3
Beta strandi104 – 107Combined sources4
Beta strandi111 – 114Combined sources4
Beta strandi117 – 120Combined sources4
Beta strandi128 – 132Combined sources5
Beta strandi136 – 138Combined sources3
Beta strandi141 – 144Combined sources4
Beta strandi155 – 157Combined sources3
Beta strandi167 – 171Combined sources5

3D structure databases

ProteinModelPortaliO00300
SMRiO00300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati24 – 62TNFR-Cys 1Add BLAST39
Repeati65 – 105TNFR-Cys 2Add BLAST41
Repeati107 – 142TNFR-Cys 3Add BLAST36
Repeati145 – 185TNFR-Cys 4Add BLAST41
Domaini198 – 269Death 1Add BLAST72
Domaini270 – 365Death 2Add BLAST96

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFEM Eukaryota
ENOG4111PUQ LUCA
GeneTreeiENSGT00760000119204
HOGENOMiHOG000273896
HOVERGENiHBG061495
InParanoidiO00300
KOiK05148
OMAiSRQLMCD
OrthoDBiEOG091G03XW
PhylomeDBiO00300
TreeFamiTF331157

Family and domain databases

InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR022323 TNFR_11
IPR017371 TNFR_11B
IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 3 hits
PIRSFiPIRSF038065 TNFR_11B, 1 hit
PRINTSiPR01961 TNFACTORR11
PR01975 TNFACTORR11B
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM01411 Ephrin_rec_like, 2 hits
SM00208 TNFR, 4 hits
SUPFAMiSSF47986 SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS00652 TNFR_NGFR_1, 1 hit
PS50050 TNFR_NGFR_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00300-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL 
        60         70         80         90        100
KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT 
       110        120        130        140        150
HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF 
       160        170        180        190        200
SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQKCGIDVT 
       210        220        230        240        250
LCEEAFFRFA VPTKFTPNWL SVLVDNLPGT KVNAESVERI KRQHSSQEQT 
       260        270        280        290        300
FQLLKLWKHQ NKDQDIVKKI IQDIDLCENS VQRHIGHANL TFEQLRSLME 
       310        320        330        340        350
SLPGKKVGAE DIEKTIKACK PSDQILKLLS LWRIKNGDQD TLKGLMHALK 
       360        370        380        390        400
HSKTYHFPKT VTQSLKKTIR FLHSFTMYKL YQKLFLEMIG NQVQSVKISC 

L
Length:401
Mass (Da):46,026
Last modified:February 8, 2011 - v3
Checksum:i2A23AC07BFA1E2DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263D → A in AAB53709 (PubMed:9108485).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0134393N → K5 PublicationsCorresponds to variant dbSNP:rs2073618EnsemblClinVar.1
Natural variantiVAR_018957104V → M1 PublicationCorresponds to variant dbSNP:rs11573906Ensembl.1
Natural variantiVAR_019413182Missing in PDB5. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94332 mRNA Translation: AAB53709.1
AB002146 mRNA Translation: BAA25910.1
AB008822 Genomic DNA Translation: BAA32076.1
AK313710 mRNA Translation: BAG36455.1
AK223155 mRNA Translation: BAD96875.1
AY466112 Genomic DNA Translation: AAR23265.1
AC107953 Genomic DNA No translation available.
AP004283 Genomic DNA No translation available.
BC030155 mRNA Translation: AAH30155.1
AF134187 mRNA Translation: AAF20168.1
CCDSiCCDS6326.1
RefSeqiNP_002537.3, NM_002546.3
UniGeneiHs.81791

Genome annotation databases

EnsembliENST00000297350; ENSP00000297350; ENSG00000164761
GeneIDi4982
KEGGihsa:4982
UCSCiuc003yon.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTR11B_HUMAN
AccessioniPrimary (citable) accession number: O00300
Secondary accession number(s): B2R9A8
, O60236, Q53FX6, Q9UHP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: February 8, 2011
Last modified: July 18, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health