TNFRSF11B

Functionⁱ

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	400	Involved in dimerization		1

GO - Molecular functionⁱ

cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 9168977
signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 9108485
tumor necrosis factor-activated receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic signaling pathway Source: GO_Central
extracellular matrix organization Source: Ensembl
immune response Source: GO_Central
inflammatory response Source: GO_Central
negative regulation of bone resorption Source: Ensembl
negative regulation of odontogenesis of dentin-containing tooth Source: Ensembl
regulation of apoptotic process Source: GO_Central
regulation of cell proliferation Source: GO_Central
response to arsenic-containing substance Source: Ensembl
response to drug Source: Ensembl
response to estrogen Source: Ensembl
response to lipopolysaccharide Source: GO_Central
response to magnesium ion Source: Ensembl
response to nutrient Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 9168977
skeletal system development
Source: ProtInc
Traceable author statementⁱ
- 9108485
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SIGNORⁱ	O00300

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor receptor superfamily member 11B Alternative name(s): Osteoclastogenesis inhibitory factor Osteoprotegerin
Gene namesⁱ	Name:TNFRSF11B Synonyms:OCIF, OPG
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164761.8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11909 TNFRSF11B
MIMⁱ	602643 gene
neXtProtⁱ	NX_O00300

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Paget disease of bone 5, juvenile-onset (PDB5)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_019413	182	Missing in PDB5. 1 Publication		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	78 – 79	DE → AA: Decreases inhibition of osteoclast differentiation. 1 Publication	2
Mutagenesisⁱ	116	E → A: Reduces affinity for TNFSF11. Decreases inhibition of osteoclast differentiation. 1 Publication	1
Mutagenesisⁱ	400 – 401	Missing : Abolishes dimerization.	2
Mutagenesisⁱ	400	C → S: Abolishes dimerization. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4982
MalaCards human disease database More...MalaCardsⁱ	TNFRSF11B
MIMⁱ	239000 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000164761
Orphanetⁱ	2801 Juvenile Paget disease
PharmGKBⁱ	PA36602

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF11B

BioMutaⁱ

TNFRSF11B

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	2 PublicationsAdd BLAST		21
ChainⁱPRO_0000034587	22 – 401	Tumor necrosis factor receptor superfamily member 11BAdd BLAST		380

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	41 ↔ 54	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	44 ↔ 62	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	65 ↔ 80	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	83 ↔ 97	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	87 ↔ 105	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	98	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	107 ↔ 118	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	124 ↔ 142	PROSITE-ProRule annotation1 Publication
Disulfide bondⁱ	145 ↔ 160	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	152	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	165	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	166 ↔ 185	PROSITE-ProRule annotation1 Publication
Glycosylationⁱ	178	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	289	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated. Contains sialic acid residues.1 Publication

The N-terminus is blocked.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	O00300
PeptideAtlas More...PeptideAtlasⁱ	O00300
PRIDEⁱ	O00300
ProteomicsDBⁱ	47829

PTM databases

iPTMnetⁱ	O00300
PhosphoSitePlusⁱ	O00300

Expressionⁱ

Tissue specificityⁱ

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

Inductionⁱ

Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.

Gene expression databases

Bgeeⁱ	ENSG00000164761 Expressed in 159 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_TNFRSF11B
ExpressionAtlasⁱ	O00300 baseline and differential
Genevisibleⁱ	O00300 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB034939

HPAⁱ

CAB034939

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with TNFSF10 and TNFSF11.2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
TNFSF11	O14788	3	EBI-15481185,EBI-7404021

With

Entry

#Exp.

IntAct

Notes

TNFSF11

O14788

3

EBI-15481185,EBI-7404021

GO - Molecular functionⁱ

cytokine activity
Source: ProtInc
Traceable author statementⁱ
- 9168977

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111028, 2 interactors
IntActⁱ	O00300, 2 interactors
STRINGⁱ	9606.ENSP00000297350

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 31	Combined sources	3
Beta strandⁱ	35 – 37	Combined sources	3
Beta strandⁱ	40 – 42	Combined sources	3
Beta strandⁱ	48 – 52	Combined sources	5
Beta strandⁱ	56 – 58	Combined sources	3
Beta strandⁱ	61 – 64	Combined sources	4
Beta strandⁱ	91 – 95	Combined sources	5
Beta strandⁱ	99 – 101	Combined sources	3
Beta strandⁱ	104 – 107	Combined sources	4
Beta strandⁱ	111 – 114	Combined sources	4
Beta strandⁱ	117 – 120	Combined sources	4
Beta strandⁱ	128 – 132	Combined sources	5
Beta strandⁱ	136 – 138	Combined sources	3
Beta strandⁱ	141 – 144	Combined sources	4
Beta strandⁱ	155 – 157	Combined sources	3
Beta strandⁱ	167 – 171	Combined sources	5

Show more details

3D structure databases

ProteinModelPortalⁱ	O00300
SMRⁱ	O00300
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	24 – 62	TNFR-Cys 1Add BLAST	39
Repeatⁱ	65 – 105	TNFR-Cys 2Add BLAST	41
Repeatⁱ	107 – 142	TNFR-Cys 3Add BLAST	36
Repeatⁱ	145 – 185	TNFR-Cys 4Add BLAST	41
Domainⁱ	198 – 269	Death 1Add BLAST	72
Domainⁱ	270 – 365	Death 2Add BLAST	96

Keywords - Domainⁱ

Repeat, Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IFEM Eukaryota ENOG4111PUQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119204
HOGENOMⁱ	HOG000273896
HOVERGENⁱ	HBG061495
InParanoidⁱ	O00300
KEGG Orthology (KO) More...KOⁱ	K05148
OMAⁱ	SRQLMCD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	O00300
TreeFamⁱ	TF331157

Family and domain databases

InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001368 TNFR/NGFR_Cys_rich_reg IPR022323 TNFR_11 IPR017371 TNFR_11B IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 3 hits
PIRSFⁱ	PIRSF038065 TNFR_11B, 1 hit
PRINTSⁱ	PR01961 TNFACTORR11 PR01975 TNFACTORR11B
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM01411 Ephrin_rec_like, 2 hits SM00208 TNFR, 4 hits
SUPFAMⁱ	SSF47986 SSF47986, 2 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 2 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.ⁱShow all

O00300-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL 
        60         70         80         90        100
KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT 
       110        120        130        140        150
HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF 
       160        170        180        190        200
SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQKCGIDVT 
       210        220        230        240        250
LCEEAFFRFA VPTKFTPNWL SVLVDNLPGT KVNAESVERI KRQHSSQEQT 
       260        270        280        290        300
FQLLKLWKHQ NKDQDIVKKI IQDIDLCENS VQRHIGHANL TFEQLRSLME 
       310        320        330        340        350
SLPGKKVGAE DIEKTIKACK PSDQILKLLS LWRIKNGDQD TLKGLMHALK 
       360        370        380        390        400
HSKTYHFPKT VTQSLKKTIR FLHSFTMYKL YQKLFLEMIG NQVQSVKISC 

L

Length:401

Mass (Da):46,026

Last modified:February 8, 2011 - v3

Checksum:ⁱ2A23AC07BFA1E2DE

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	E5RFV7	E5RFV7_HUMAN		Tumor necrosis factor receptor supe... Tumor necrosis factor receptor superfamily member 11B	TNFRSF11B	145	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	263	D → A in AAB53709 (PubMed:9108485).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_013439	3	N → K5 PublicationsCorresponds to variant dbSNP:rs2073618EnsemblClinVar.	1
Natural variantⁱVAR_018957	104	V → M1 PublicationCorresponds to variant dbSNP:rs11573906Ensembl.	1
Natural variantⁱVAR_019413	182	Missing in PDB5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U94332 mRNA Translation: AAB53709.1 AB002146 mRNA Translation: BAA25910.1 AB008822 Genomic DNA Translation: BAA32076.1 AK313710 mRNA Translation: BAG36455.1 AK223155 mRNA Translation: BAD96875.1 AY466112 Genomic DNA Translation: AAR23265.1 AC107953 Genomic DNA No translation available. AP004283 Genomic DNA No translation available. BC030155 mRNA Translation: AAH30155.1 AF134187 mRNA Translation: AAF20168.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6326.1
NCBI Reference Sequences More...RefSeqⁱ	NP_002537.3, NM_002546.3
UniGeneⁱ	Hs.81791

Genome annotation databases

Ensemblⁱ	ENST00000297350; ENSP00000297350; ENSG00000164761
GeneIDⁱ	4982
KEGGⁱ	hsa:4982
UCSC genome browser More...UCSCⁱ	uc003yon.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00300	Tumor necrosis factor receptor superfamily member 11B		LOXAF		402	UniRef90_O00300
Tumor necrosis factor receptor superfamily member 11B		PAPAN		401
Tumor necrosis factor receptor superfamily member 11B		MACFA		401
Tumor necrosis factor receptor superfamily member 11B		MACNE		396
Tumor necrosis factor receptor superfamily member 11B		CALJA		401
+10

Protein	Similar proteins		Species	Score	Length	Source
O00300	Tumor necrosis factor receptor superfamily member 11B	)	MOUSE		401	UniRef50_O00300
Tumor necrosis factor receptor superfamily member 11B		RAT		401
Tumor necrosis factor receptor superfamily member 11B		BOVIN		402
Tumor necrosis factor receptor superfamily member 11B		LOXAF		402
Tumor necrosis factor receptor superfamily member 11B		CALJA		401
+165

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U94332 mRNA Translation: AAB53709.1 AB002146 mRNA Translation: BAA25910.1 AB008822 Genomic DNA Translation: BAA32076.1 AK313710 mRNA Translation: BAG36455.1 AK223155 mRNA Translation: BAD96875.1 AY466112 Genomic DNA Translation: AAR23265.1 AC107953 Genomic DNA No translation available. AP004283 Genomic DNA No translation available. BC030155 mRNA Translation: AAH30155.1 AF134187 mRNA Translation: AAF20168.1
CCDSⁱ	CCDS6326.1
RefSeqⁱ	NP_002537.3, NM_002546.3
UniGeneⁱ	Hs.81791

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3URF	X-ray	2.70	Z	22-186	[»]
ProteinModelPortalⁱ	O00300
SMRⁱ	O00300
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111028, 2 interactors
IntActⁱ	O00300, 2 interactors
STRINGⁱ	9606.ENSP00000297350

PTM databases

iPTMnetⁱ	O00300
PhosphoSitePlusⁱ	O00300

Polymorphism and mutation databases

BioMutaⁱ	TNFRSF11B

BioMutaⁱ

TNFRSF11B

Proteomic databases

PaxDbⁱ	O00300
PeptideAtlasⁱ	O00300
PRIDEⁱ	O00300
ProteomicsDBⁱ	47829

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000297350; ENSP00000297350; ENSG00000164761
GeneIDⁱ	4982
KEGGⁱ	hsa:4982
UCSCⁱ	uc003yon.5 human

Organism-specific databases

CTDⁱ	4982
DisGeNETⁱ	4982
EuPathDBⁱ	HostDB:ENSG00000164761.8
GeneCardsⁱ	TNFRSF11B
H-InvDBⁱ	HIX0007748
HGNCⁱ	HGNC:11909 TNFRSF11B
HPAⁱ	CAB034939
MalaCardsⁱ	TNFRSF11B
MIMⁱ	239000 phenotype 602643 gene
neXtProtⁱ	NX_O00300
OpenTargetsⁱ	ENSG00000164761
Orphanetⁱ	2801 Juvenile Paget disease
PharmGKBⁱ	PA36602
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFEM Eukaryota ENOG4111PUQ LUCA
GeneTreeⁱ	ENSGT00760000119204
HOGENOMⁱ	HOG000273896
HOVERGENⁱ	HBG061495
InParanoidⁱ	O00300
KOⁱ	K05148
OMAⁱ	SRQLMCD
OrthoDBⁱ	EOG091G03XW
PhylomeDBⁱ	O00300
TreeFamⁱ	TF331157

Enzyme and pathway databases

Reactomeⁱ	R-HSA-5669034 TNFs bind their physiological receptors
SIGNORⁱ	O00300

Miscellaneous databases

ChiTaRSⁱ	TNFRSF11B human
GeneWikiⁱ	Osteoprotegerin
GenomeRNAiⁱ	4982
Protein Ontology More...PROⁱ	PR:O00300
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164761 Expressed in 159 organ(s), highest expression level in tendon of biceps brachii
CleanExⁱ	HS_TNFRSF11B
ExpressionAtlasⁱ	O00300 baseline and differential
Genevisibleⁱ	O00300 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011029 DEATH-like_dom_sf IPR000488 Death_domain IPR001368 TNFR/NGFR_Cys_rich_reg IPR022323 TNFR_11 IPR017371 TNFR_11B IPR011641 Tyr-kin_ephrin_A/B_rcpt-like
Pfamⁱ	View protein in Pfam PF00531 Death, 1 hit PF00020 TNFR_c6, 3 hits
PIRSFⁱ	PIRSF038065 TNFR_11B, 1 hit
PRINTSⁱ	PR01961 TNFACTORR11 PR01975 TNFACTORR11B
SMARTⁱ	View protein in SMART SM00005 DEATH, 1 hit SM01411 Ephrin_rec_like, 2 hits SM00208 TNFR, 4 hits
SUPFAMⁱ	SSF47986 SSF47986, 2 hits
PROSITEⁱ	View protein in PROSITE PS00652 TNFR_NGFR_1, 1 hit PS50050 TNFR_NGFR_2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TR11B_HUMAN
Accessionⁱ	O00300Primary (citable) accession number: O00300 Secondary accession number(s): B2R9A8 , O60236, Q53FX6, Q9UHP4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
	Last sequence update:	February 8, 2011
	Last modified:	September 12, 2018
	This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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Supporting data

UniProtKB - O00300 (TR11B_HUMAN)

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Tumor necrosis factor receptor superfamily member 11B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ