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UniProtKB - O00300 (TR11B_HUMAN)

Entry version 173 (02 Dec 2020)
Sequence version 3 (08 Feb 2011)
Previous versions | rss
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Protein

Tumor necrosis factor receptor superfamily member 11B

Gene

TNFRSF11B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei400Involved in dimerization1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00300

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-5669034, TNFs bind their physiological receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		O00300

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 11B
Alternative name(s):
Osteoclastogenesis inhibitory factor
Osteoprotegerin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF11B
Synonyms:OCIF, OPG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000164761.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:11909, TNFRSF11B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602643, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Paget disease of bone 5, juvenile-onset (PDB5)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, juvenile-onset form of Paget disease, a disorder of bone remodeling characterized by increased bone turnover affecting one or more sites throughout the skeleton, primarily the axial skeleton. Osteoclastic overactivity followed by compensatory osteoblastic activity leads to a structurally disorganized mosaic of bone (woven bone), which is mechanically weaker, larger, less compact, more vascular, and more susceptible to fracture than normal adult lamellar bone. PDB5 clinical manifestations include short stature, progressive long bone deformities, fractures, vertebral collapse, skull enlargement, and hyperostosis with progressive deafness.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019413182Missing in PDB5. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi78 – 79DE → AA: Decreases inhibition of osteoclast differentiation. 1 Publication2
Mutagenesisi116E → A: Reduces affinity for TNFSF11. Decreases inhibition of osteoclast differentiation. 1 Publication1
Mutagenesisi400 – 401Missing : Abolishes dimerization. 2
Mutagenesisi400C → S: Abolishes dimerization. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		4982

MalaCards human disease database

More...MalaCardsi		TNFRSF11B
MIMi239000, phenotype

Open Targets

More...OpenTargetsi		ENSG00000164761

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		1416, Familial calcium pyrophosphate deposition
2801, Juvenile Paget disease

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36602

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00300, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TNFRSF11B

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 212 PublicationsAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003458722 – 401Tumor necrosis factor receptor superfamily member 11BAdd BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 54PROSITE-ProRule annotation1 Publication
Disulfide bondi44 ↔ 62PROSITE-ProRule annotation1 Publication
Disulfide bondi65 ↔ 80PROSITE-ProRule annotation1 Publication
Disulfide bondi83 ↔ 97PROSITE-ProRule annotation1 Publication
Disulfide bondi87 ↔ 105PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi107 ↔ 118PROSITE-ProRule annotation1 Publication
Disulfide bondi124 ↔ 142PROSITE-ProRule annotation1 Publication
Disulfide bondi145 ↔ 160PROSITE-ProRule annotation1 Publication
Glycosylationi152N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi166 ↔ 185PROSITE-ProRule annotation1 Publication
Glycosylationi178N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated. Contains sialic acid residues.1 Publication
The N-terminus is blocked.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00300

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00300

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00300

PeptideAtlas

More...PeptideAtlasi		O00300

PRoteomics IDEntifications database

More...PRIDEi		O00300

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47829

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		O00300, 6 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00300

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00300

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by increasing calcium-concentration in the medium and estrogens. Down-regulated by glucocorticoids.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000164761, Expressed in tendon of biceps brachii and 169 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00300, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00300, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000164761, Tissue enhanced (kidney, thyroid gland)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with TNFSF10 and TNFSF11.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		111028, 2 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-4663, Osteoprotegerin complex

Protein interaction database and analysis system

More...IntActi		O00300, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000297350

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00300, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00300

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati24 – 62TNFR-Cys 1Add BLAST39
Repeati65 – 105TNFR-Cys 2Add BLAST41
Repeati107 – 142TNFR-Cys 3Add BLAST36
Repeati145 – 185TNFR-Cys 4Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 269Death 1Add BLAST72
Domaini270 – 365Death 2Add BLAST96

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QVRT, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155167

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_057708_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00300

Identification of Orthologs from Complete Genome Data

More...OMAi		KFLCCTL

Database of Orthologous Groups

More...OrthoDBi		358120at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00300

TreeFam database of animal gene trees

More...TreeFami		TF331157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR022323, TNFR_11
IPR017371, TNFR_11B
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00531, Death, 1 hit
PF00020, TNFR_c6, 3 hits

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF038065, TNFR_11B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01961, TNFACTORR11
PR01975, TNFACTORR11B

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00005, DEATH, 1 hit
SM01411, Ephrin_rec_like, 2 hits
SM00208, TNFR, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00652, TNFR_NGFR_1, 1 hit
PS50050, TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O00300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNLLCCALV FLDISIKWTT QETFPPKYLH YDEETSHQLL CDKCPPGTYL 
        60         70         80         90        100
KQHCTAKWKT VCAPCPDHYY TDSWHTSDEC LYCSPVCKEL QYVKQECNRT 
       110        120        130        140        150
HNRVCECKEG RYLEIEFCLK HRSCPPGFGV VQAGTPERNT VCKRCPDGFF 
       160        170        180        190        200
SNETSSKAPC RKHTNCSVFG LLLTQKGNAT HDNICSGNSE STQKCGIDVT 
       210        220        230        240        250
LCEEAFFRFA VPTKFTPNWL SVLVDNLPGT KVNAESVERI KRQHSSQEQT 
       260        270        280        290        300
FQLLKLWKHQ NKDQDIVKKI IQDIDLCENS VQRHIGHANL TFEQLRSLME 
       310        320        330        340        350
SLPGKKVGAE DIEKTIKACK PSDQILKLLS LWRIKNGDQD TLKGLMHALK 
       360        370        380        390        400
HSKTYHFPKT VTQSLKKTIR FLHSFTMYKL YQKLFLEMIG NQVQSVKISC 

L
Length:401
Mass (Da):46,026
Last modified:February 8, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A23AC07BFA1E2DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFV7E5RFV7_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF11B
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti263D → A in AAB53709 (PubMed:9108485).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0134393N → K5 PublicationsCorresponds to variant dbSNP:rs2073618EnsemblClinVar.1
Natural variantiVAR_018957104V → M1 PublicationCorresponds to variant dbSNP:rs11573906EnsemblClinVar.1
Natural variantiVAR_019413182Missing in PDB5. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U94332 mRNA Translation: AAB53709.1
AB002146 mRNA Translation: BAA25910.1
AB008822 Genomic DNA Translation: BAA32076.1
AK313710 mRNA Translation: BAG36455.1
AK223155 mRNA Translation: BAD96875.1
AY466112 Genomic DNA Translation: AAR23265.1
AC107953 Genomic DNA No translation available.
AP004283 Genomic DNA No translation available.
BC030155 mRNA Translation: AAH30155.1
AF134187 mRNA Translation: AAF20168.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6326.1

NCBI Reference Sequences

More...RefSeqi		NP_002537.3, NM_002546.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000297350; ENSP00000297350; ENSG00000164761

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4982

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4982

UCSC genome browser

More...UCSCi		uc003yon.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U94332 mRNA Translation: AAB53709.1
AB002146 mRNA Translation: BAA25910.1
AB008822 Genomic DNA Translation: BAA32076.1
AK313710 mRNA Translation: BAG36455.1
AK223155 mRNA Translation: BAD96875.1
AY466112 Genomic DNA Translation: AAR23265.1
AC107953 Genomic DNA No translation available.
AP004283 Genomic DNA No translation available.
BC030155 mRNA Translation: AAH30155.1
AF134187 mRNA Translation: AAF20168.1
CCDSiCCDS6326.1
RefSeqiNP_002537.3, NM_002546.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3URFX-ray2.70Z22-186[»]
SMRiO00300
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111028, 2 interactors
ComplexPortaliCPX-4663, Osteoprotegerin complex
IntActiO00300, 2 interactors
STRINGi9606.ENSP00000297350

PTM databases

GlyGeniO00300, 6 sites
iPTMnetiO00300
PhosphoSitePlusiO00300

Polymorphism and mutation databases

BioMutaiTNFRSF11B

Proteomic databases

jPOSTiO00300
MassIVEiO00300
PaxDbiO00300
PeptideAtlasiO00300
PRIDEiO00300
ProteomicsDBi47829

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		13632, 755 antibodies

Genome annotation databases

EnsembliENST00000297350; ENSP00000297350; ENSG00000164761
GeneIDi4982
KEGGihsa:4982
UCSCiuc003yon.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4982
DisGeNETi4982
EuPathDBiHostDB:ENSG00000164761.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		TNFRSF11B
HGNCiHGNC:11909, TNFRSF11B
HPAiENSG00000164761, Tissue enhanced (kidney, thyroid gland)
MalaCardsiTNFRSF11B
MIMi239000, phenotype
602643, gene
neXtProtiNX_O00300
OpenTargetsiENSG00000164761
Orphaneti1416, Familial calcium pyrophosphate deposition
2801, Juvenile Paget disease
PharmGKBiPA36602

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QVRT, Eukaryota
GeneTreeiENSGT00940000155167
HOGENOMiCLU_057708_0_0_1
InParanoidiO00300
OMAiKFLCCTL
OrthoDBi358120at2759
PhylomeDBiO00300
TreeFamiTF331157

Enzyme and pathway databases

PathwayCommonsiO00300
ReactomeiR-HSA-5669034, TNFs bind their physiological receptors
SIGNORiO00300

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4982, 3 hits in 846 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TNFRSF11B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Osteoprotegerin

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4982
PharosiO00300, Tbio

Protein Ontology

More...PROi		PR:O00300
RNActiO00300, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000164761, Expressed in tendon of biceps brachii and 169 other tissues
ExpressionAtlasiO00300, baseline and differential
GenevisibleiO00300, HS

Family and domain databases

InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR001368, TNFR/NGFR_Cys_rich_reg
IPR022323, TNFR_11
IPR017371, TNFR_11B
IPR011641, Tyr-kin_ephrin_A/B_rcpt-like
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF00020, TNFR_c6, 3 hits
PIRSFiPIRSF038065, TNFR_11B, 1 hit
PRINTSiPR01961, TNFACTORR11
PR01975, TNFACTORR11B
SMARTiView protein in SMART
SM00005, DEATH, 1 hit
SM01411, Ephrin_rec_like, 2 hits
SM00208, TNFR, 4 hits
SUPFAMiSSF47986, SSF47986, 2 hits
PROSITEiView protein in PROSITE
PS00652, TNFR_NGFR_1, 1 hit
PS50050, TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTR11B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00300
Secondary accession number(s): B2R9A8
, O60236, Q53FX6, Q9UHP4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: February 8, 2011
Last modified: December 2, 2020
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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