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Protein

Chloride intracellular channel protein 1

Gene

CLIC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.7 Publications

Miscellaneous

The protein seems to have very low affinity for glutathione, even though glutathione binding was observed in protein crystals.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei64Glutathione; via carbonyl oxygen1 Publication1
Binding sitei77Glutathione1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • chloride channel activity Source: MGI
  • voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChloride channel, Ion channel, Voltage-gated channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O00299

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.12.1.2 the intracellular chloride channel (clic) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chloride intracellular channel protein 1
Alternative name(s):
Chloride channel ABP
Nuclear chloride ion channel 27
Short name:
NCC27
Regulatory nuclear chloride ion channel protein
Short name:
hRNCC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CLIC1
Synonyms:G6, NCC27
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000213719.8

Human Gene Nomenclature Database

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HGNCi
HGNC:2062 CLIC1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
602872 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00299

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei26 – 46Helical; Note=After insertion into the membraneSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24C → S: Loss of dimerization and of ion transport activity. 1 Publication1
Mutagenesisi59C → S: Loss of dimerization and of ion transport activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
1192

Open Targets

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OpenTargetsi
ENSG00000213719

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26588

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CLIC1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001442012 – 241Chloride intracellular channel protein 1Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei13N6-acetyllysineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 59Alternate1 Publication
Modified residuei24S-glutathionyl cysteine; alternate1 Publication1
Modified residuei119N6-acetyllysineCombined sources1
Modified residuei121PhosphoserineCombined sources1
Modified residuei131N6-acetyllysineCombined sources1
Modified residuei156PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei233PhosphotyrosineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.

Keywords - PTMi

Acetylation, Disulfide bond, Glutathionylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O00299

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O00299

PeptideAtlas

More...
PeptideAtlasi
O00299

PRoteomics IDEntifications database

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PRIDEi
O00299

ProteomicsDB human proteome resource

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ProteomicsDBi
47828

Consortium for Top Down Proteomics

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TopDownProteomicsi
O00299

2D gel databases

USC-OGP 2-DE database

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OGPi
O00299

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

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SWISS-2DPAGEi
O00299

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00299

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O00299

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O00299

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expression is prominent in heart, placenta, liver, kidney and pancreas.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000213719 Expressed in 88 organ(s), highest expression level in blood

CleanEx database of gene expression profiles

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CleanExi
HS_CLIC1

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O00299 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00299 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB020825
CAB040557

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer. Homodimer (in vitro). Interacts with TRAPPC2. Dimerization requires a conformation change that leads to the exposure of a large hydrophobic surface. In vivo, this may lead to membrane insertion. Interacts with AKAP9.4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
PSMD10O758329EBI-347404,EBI-752185

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107604, 62 interactors

Protein interaction database and analysis system

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IntActi
O00299, 46 interactors

Molecular INTeraction database

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MINTi
O00299

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000364934

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1241
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O00299

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O00299

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O00299

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini93 – 233GST C-terminalAdd BLAST141

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 90Required for insertion into the membraneAdd BLAST89

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.2 Publications

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the chloride channel CLIC family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410INGZ Eukaryota
ENOG410ZZZX LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000154708

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000231548

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG050994

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O00299

KEGG Orthology (KO)

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KOi
K05021

Identification of Orthologs from Complete Genome Data

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OMAi
KVVCLKY

Database of Orthologous Groups

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OrthoDBi
EOG091G0IHT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00299

TreeFam database of animal gene trees

More...
TreeFami
TF315438

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR002946 CLIC
IPR030259 CLIC-1
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf

The PANTHER Classification System

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PANTHERi
PTHR43920:SF2 PTHR43920:SF2, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13409 GST_N_2, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01263 INTCLCHANNEL

Structure-Function Linkage Database

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SFLDi
SFLDS00019 Glutathione_Transferase_(cytos, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00862 O-ClC, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50405 GST_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

O00299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEEQPQVEL FVKAGSDGAK IGNCPFSQRL FMVLWLKGVT FNVTTVDTKR
60 70 80 90 100
RTETVQKLCP GGQLPFLLYG TEVHTDTNKI EEFLEAVLCP PRYPKLAALN
110 120 130 140 150
PESNTAGLDI FAKFSAYIKN SNPALNDNLE KGLLKALKVL DNYLTSPLPE
160 170 180 190 200
EVDETSAEDE GVSQRKFLDG NELTLADCNL LPKLHIVQVV CKKYRGFTIP
210 220 230 240
EAFRGVHRYL SNAYAREEFA STCPDDEEIE LAYEQVAKAL K
Length:241
Mass (Da):26,923
Last modified:January 23, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i163EEB7481826A0A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti63Q → E in AAC25675 (PubMed:9139710).Curated1
Sequence conflicti63Q → E in AAD26137 (PubMed:10191309).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U93205 mRNA Translation: AAC25675.1
AF034607 mRNA Translation: AAD20437.1
AF109197 mRNA Translation: AAD26137.1
AJ012008 Genomic DNA Translation: CAB46078.1
CR542071 mRNA Translation: CAG46868.1
AF129756 Genomic DNA Translation: AAD18073.1
BA000025 Genomic DNA Translation: BAB63376.1
AL662899 Genomic DNA No translation available.
BC064527 mRNA Translation: AAH64527.1
BC095469 mRNA Translation: AAH95469.1
X87689 mRNA Translation: CAA61020.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4719.1

NCBI Reference Sequences

More...
RefSeqi
NP_001274522.1, NM_001287593.1
NP_001274523.1, NM_001287594.1
NP_001279.2, NM_001288.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.414565

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000375779; ENSP00000364934; ENSG00000213719
ENST00000375780; ENSP00000364935; ENSG00000213719
ENST00000375784; ENSP00000364940; ENSG00000213719
ENST00000383404; ENSP00000372896; ENSG00000206394
ENST00000383405; ENSP00000372897; ENSG00000206394
ENST00000395892; ENSP00000379229; ENSG00000213719
ENST00000400052; ENSP00000382926; ENSG00000206394
ENST00000400058; ENSP00000382931; ENSG00000206394
ENST00000415179; ENSP00000409247; ENSG00000226248
ENST00000418285; ENSP00000407791; ENSG00000226417
ENST00000420458; ENSP00000410965; ENSG00000226651
ENST00000422167; ENSP00000407429; ENSG00000226248
ENST00000423055; ENSP00000406968; ENSG00000226417
ENST00000423143; ENSP00000404589; ENSG00000223639
ENST00000423804; ENSP00000409979; ENSG00000230685
ENST00000425464; ENSP00000401292; ENSG00000223639
ENST00000431921; ENSP00000408357; ENSG00000226248
ENST00000433916; ENSP00000391395; ENSG00000226651
ENST00000434202; ENSP00000400532; ENSG00000226651
ENST00000435242; ENSP00000412217; ENSG00000226417
ENST00000438708; ENSP00000406088; ENSG00000226248
ENST00000438750; ENSP00000404037; ENSG00000223639
ENST00000442045; ENSP00000400280; ENSG00000226417
ENST00000447338; ENSP00000413330; ENSG00000230685
ENST00000447369; ENSP00000408094; ENSG00000230685
ENST00000451546; ENSP00000416211; ENSG00000223639
ENST00000456863; ENSP00000406335; ENSG00000226651
ENST00000457485; ENSP00000398056; ENSG00000230685
ENST00000614673; ENSP00000480256; ENSG00000230685
ENST00000614982; ENSP00000477623; ENSG00000206394
ENST00000616760; ENSP00000479808; ENSG00000213719
ENST00000618288; ENSP00000479501; ENSG00000226417
ENST00000619727; ENSP00000482255; ENSG00000226651
ENST00000621055; ENSP00000478930; ENSG00000226248
ENST00000622613; ENSP00000484581; ENSG00000223639

Database of genes from NCBI RefSeq genomes

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GeneIDi
1192

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1192

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93205 mRNA Translation: AAC25675.1
AF034607 mRNA Translation: AAD20437.1
AF109197 mRNA Translation: AAD26137.1
AJ012008 Genomic DNA Translation: CAB46078.1
CR542071 mRNA Translation: CAG46868.1
AF129756 Genomic DNA Translation: AAD18073.1
BA000025 Genomic DNA Translation: BAB63376.1
AL662899 Genomic DNA No translation available.
BC064527 mRNA Translation: AAH64527.1
BC095469 mRNA Translation: AAH95469.1
X87689 mRNA Translation: CAA61020.1
CCDSiCCDS4719.1
RefSeqiNP_001274522.1, NM_001287593.1
NP_001274523.1, NM_001287594.1
NP_001279.2, NM_001288.4
UniGeneiHs.414565

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K0MX-ray1.40A/B1-241[»]
1K0NX-ray1.80A/B1-241[»]
1K0OX-ray1.75A/B1-241[»]
1RK4X-ray1.79A/B1-241[»]
3O3TX-ray1.70A1-241[»]
3P8WX-ray2.00A1-241[»]
3P90X-ray2.30A1-241[»]
3QR6X-ray1.78A1-241[»]
3SWLX-ray2.35A6-241[»]
3TGZX-ray2.30A/B1-241[»]
3UVHX-ray1.84A/B1-241[»]
4IQAX-ray2.49A/B6-241[»]
4JZQX-ray1.35A/B1-241[»]
4K0GX-ray1.40A2-241[»]
4K0NX-ray1.25A1-241[»]
ProteinModelPortaliO00299
SMRiO00299
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107604, 62 interactors
IntActiO00299, 46 interactors
MINTiO00299
STRINGi9606.ENSP00000364934

Protein family/group databases

TCDBi1.A.12.1.2 the intracellular chloride channel (clic) family

PTM databases

iPTMnetiO00299
PhosphoSitePlusiO00299
SwissPalmiO00299

Polymorphism and mutation databases

BioMutaiCLIC1

2D gel databases

OGPiO00299
SWISS-2DPAGEiO00299

Proteomic databases

EPDiO00299
PaxDbiO00299
PeptideAtlasiO00299
PRIDEiO00299
ProteomicsDBi47828
TopDownProteomicsiO00299

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1192
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375779; ENSP00000364934; ENSG00000213719
ENST00000375780; ENSP00000364935; ENSG00000213719
ENST00000375784; ENSP00000364940; ENSG00000213719
ENST00000383404; ENSP00000372896; ENSG00000206394
ENST00000383405; ENSP00000372897; ENSG00000206394
ENST00000395892; ENSP00000379229; ENSG00000213719
ENST00000400052; ENSP00000382926; ENSG00000206394
ENST00000400058; ENSP00000382931; ENSG00000206394
ENST00000415179; ENSP00000409247; ENSG00000226248
ENST00000418285; ENSP00000407791; ENSG00000226417
ENST00000420458; ENSP00000410965; ENSG00000226651
ENST00000422167; ENSP00000407429; ENSG00000226248
ENST00000423055; ENSP00000406968; ENSG00000226417
ENST00000423143; ENSP00000404589; ENSG00000223639
ENST00000423804; ENSP00000409979; ENSG00000230685
ENST00000425464; ENSP00000401292; ENSG00000223639
ENST00000431921; ENSP00000408357; ENSG00000226248
ENST00000433916; ENSP00000391395; ENSG00000226651
ENST00000434202; ENSP00000400532; ENSG00000226651
ENST00000435242; ENSP00000412217; ENSG00000226417
ENST00000438708; ENSP00000406088; ENSG00000226248
ENST00000438750; ENSP00000404037; ENSG00000223639
ENST00000442045; ENSP00000400280; ENSG00000226417
ENST00000447338; ENSP00000413330; ENSG00000230685
ENST00000447369; ENSP00000408094; ENSG00000230685
ENST00000451546; ENSP00000416211; ENSG00000223639
ENST00000456863; ENSP00000406335; ENSG00000226651
ENST00000457485; ENSP00000398056; ENSG00000230685
ENST00000614673; ENSP00000480256; ENSG00000230685
ENST00000614982; ENSP00000477623; ENSG00000206394
ENST00000616760; ENSP00000479808; ENSG00000213719
ENST00000618288; ENSP00000479501; ENSG00000226417
ENST00000619727; ENSP00000482255; ENSG00000226651
ENST00000621055; ENSP00000478930; ENSG00000226248
ENST00000622613; ENSP00000484581; ENSG00000223639
GeneIDi1192
KEGGihsa:1192

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
1192
DisGeNETi1192
EuPathDBiHostDB:ENSG00000213719.8

GeneCards: human genes, protein and diseases

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GeneCardsi
CLIC1
HGNCiHGNC:2062 CLIC1
HPAiCAB020825
CAB040557
MIMi602872 gene
neXtProtiNX_O00299
OpenTargetsiENSG00000213719
PharmGKBiPA26588

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410INGZ Eukaryota
ENOG410ZZZX LUCA
GeneTreeiENSGT00940000154708
HOGENOMiHOG000231548
HOVERGENiHBG050994
InParanoidiO00299
KOiK05021
OMAiKVVCLKY
OrthoDBiEOG091G0IHT
PhylomeDBiO00299
TreeFamiTF315438

Enzyme and pathway databases

SignaLinkiO00299

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CLIC1 human
EvolutionaryTraceiO00299

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CLIC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1192

Protein Ontology

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PROi
PR:O00299

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000213719 Expressed in 88 organ(s), highest expression level in blood
CleanExiHS_CLIC1
ExpressionAtlasiO00299 baseline and differential
GenevisibleiO00299 HS

Family and domain databases

InterProiView protein in InterPro
IPR002946 CLIC
IPR030259 CLIC-1
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR040079 Glutathione_S-Trfase
IPR004045 Glutathione_S-Trfase_N
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR43920:SF2 PTHR43920:SF2, 1 hit
PfamiView protein in Pfam
PF13409 GST_N_2, 1 hit
PRINTSiPR01263 INTCLCHANNEL
SFLDiSFLDS00019 Glutathione_Transferase_(cytos, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00862 O-ClC, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCLIC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00299
Secondary accession number(s): Q15089, Q502X1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 23, 2007
Last modified: December 5, 2018
This is version 202 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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