UniProtKB - O00295 (TULP2_HUMAN)
Protein
Tubby-related protein 2
Gene
TULP2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- phosphatidylinositol binding Source: GO_Central
- protein-containing complex binding Source: MGI
GO - Biological processi
- protein localization to cilium Source: GO_Central
- protein localization to photoreceptor outer segment Source: GO_Central
- receptor localization to non-motile cilium Source: GO_Central
- visual perception Source: ProtInc
Names & Taxonomyi
Protein namesi | Recommended name: Tubby-related protein 2Alternative name(s): Cancer/testis antigen 65 Short name: CT65 Tubby-like protein 2 |
Gene namesi | Name:TULP2 Synonyms:TUBL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000104804.7 |
HGNCi | HGNC:12424 TULP2 |
MIMi | 602309 gene |
neXtProti | NX_O00295 |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
Keywords - Cellular componenti
Cytoplasm, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 7288 |
OpenTargetsi | ENSG00000104804 |
PharmGKBi | PA37086 |
Polymorphism and mutation databases
BioMutai | TULP2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186468 | 1 – 520 | Tubby-related protein 2Add BLAST | 520 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 135 | PhosphoserineBy similarity | 1 | |
Modified residuei | 190 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | O00295 |
PeptideAtlasi | O00295 |
PRIDEi | O00295 |
ProteomicsDBi | 47827 |
PTM databases
iPTMneti | O00295 |
PhosphoSitePlusi | O00295 |
Expressioni
Tissue specificityi
Strongly expressed in testis. Also expressed in retina. Expressed in cancer cell lines.2 Publications
Gene expression databases
Bgeei | ENSG00000104804 Expressed in 86 organ(s), highest expression level in sperm |
ExpressionAtlasi | O00295 baseline and differential |
Genevisiblei | O00295 HS |
Interactioni
Protein-protein interaction databases
BioGridi | 113139, 34 interactors |
IntActi | O00295, 3 interactors |
STRINGi | 9606.ENSP00000221399 |
Structurei
3D structure databases
ProteinModelPortali | O00295 |
SMRi | O00295 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the TUB family.Curated
Phylogenomic databases
eggNOGi | KOG2502 Eukaryota ENOG410XQFT LUCA |
GeneTreei | ENSGT00940000161908 |
HOGENOMi | HOG000016044 |
HOVERGENi | HBG018010 |
InParanoidi | O00295 |
OMAi | VQCRISR |
OrthoDBi | 1445357at2759 |
PhylomeDBi | O00295 |
TreeFami | TF314076 |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659 Tubby-like_C IPR000007 Tubby_C IPR018066 Tubby_C_CS IPR005398 Tubby_N |
Pfami | View protein in Pfam PF01167 Tub, 1 hit PF16322 Tub_N, 1 hit |
PRINTSi | PR01573 SUPERTUBBY PR01574 TUBBYPROTEIN |
SUPFAMi | SSF54518 SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200 TUB_1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
O00295-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSQDNDTLMR DILGHELAAM RLQKLEQQRR LFEKKQRQKR QELLMVQANP
60 70 80 90 100
DASPWLWRSC LREERLLGDR GLGNPFLRKK VSEAHLPSGI HSALGTVSCG
110 120 130 140 150
GDGRGERGLP TPRTEAVFRN LGLQSPFLSW LPDNSDAELE EVSVENGSVS
160 170 180 190 200
PPPFKQSPRI RRKGWQAHQR PGTRAEGESD SQDMGDAHKS PNMGPNPGMD
210 220 230 240 250
GDCVYENLAF QKEEDLEKKR EASESTGTNS SAAHNEELSK ALKGEGGTDS
260 270 280 290 300
DHMRHEASLA IRSPCPGLEE DMEAYVLRPA LPGTMMQCYL TRDKHGVDKG
310 320 330 340 350
LFPLYYLYLE TSDSLQRFLL AGRKRRRSKT SNYLISLDPT HLSRDGDNFV
360 370 380 390 400
GKVRSNVFST KFTIFDNGVN PDREHLTRNT ARIRQELGAV CYEPNVLGYL
410 420 430 440 450
GPRKMTVILP GTNSQNQRIN VQPLNEQESL LSRYQRGDKQ GLLLLHNKTP
460 470 480 490 500
SWDKENGVYT LNFHGRVTRA SVKNFQIVDP KHQEHLVLQF GRVGPDTFTM
510 520
DFCFPFSPLQ AFSICLSSFN
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBB5 | H0YBB5_HUMAN | Tubby-related protein 2 | TULP2 | 80 | Annotation score: | ||
E5RIF7 | E5RIF7_HUMAN | Tubby-related protein 2 | TULP2 | 230 | Annotation score: | ||
E5RHR0 | E5RHR0_HUMAN | Tubby-related protein 2 | TULP2 | 187 | Annotation score: | ||
E5RH05 | E5RH05_HUMAN | Tubby-related protein 2 | TULP2 | 210 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 341 | H → L in AAB53701 (PubMed:9096357).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029312 | 18 | A → T. Corresponds to variant dbSNP:rs7260579Ensembl. | 1 | |
Natural variantiVAR_057320 | 122 | G → S. Corresponds to variant dbSNP:rs34378208Ensembl. | 1 | |
Natural variantiVAR_064760 | 149 | V → I Found in a renal cell carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_022136 | 245 | E → K. Corresponds to variant dbSNP:rs2270945Ensembl. | 1 | |
Natural variantiVAR_024679 | 251 | D → N. Corresponds to variant dbSNP:rs8112811Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82469 mRNA Translation: AAB53701.1 CH471177 Genomic DNA Translation: EAW52410.1 BC026070 mRNA Translation: AAH26070.1 |
CCDSi | CCDS12739.1 |
RefSeqi | NP_003314.2, NM_003323.2 |
UniGenei | Hs.104636 |
Genome annotation databases
Ensembli | ENST00000221399; ENSP00000221399; ENSG00000104804 |
GeneIDi | 7288 |
KEGGi | hsa:7288 |
UCSCi | uc002pkz.3 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82469 mRNA Translation: AAB53701.1 CH471177 Genomic DNA Translation: EAW52410.1 BC026070 mRNA Translation: AAH26070.1 |
CCDSi | CCDS12739.1 |
RefSeqi | NP_003314.2, NM_003323.2 |
UniGenei | Hs.104636 |
3D structure databases
ProteinModelPortali | O00295 |
SMRi | O00295 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
BioGridi | 113139, 34 interactors |
IntActi | O00295, 3 interactors |
STRINGi | 9606.ENSP00000221399 |
PTM databases
iPTMneti | O00295 |
PhosphoSitePlusi | O00295 |
Polymorphism and mutation databases
BioMutai | TULP2 |
Proteomic databases
PaxDbi | O00295 |
PeptideAtlasi | O00295 |
PRIDEi | O00295 |
ProteomicsDBi | 47827 |
Protocols and materials databases
DNASUi | 7288 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000221399; ENSP00000221399; ENSG00000104804 |
GeneIDi | 7288 |
KEGGi | hsa:7288 |
UCSCi | uc002pkz.3 human |
Organism-specific databases
CTDi | 7288 |
DisGeNETi | 7288 |
EuPathDBi | HostDB:ENSG00000104804.7 |
GeneCardsi | TULP2 |
H-InvDBi | HIX0015306 |
HGNCi | HGNC:12424 TULP2 |
MIMi | 602309 gene |
neXtProti | NX_O00295 |
OpenTargetsi | ENSG00000104804 |
PharmGKBi | PA37086 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2502 Eukaryota ENOG410XQFT LUCA |
GeneTreei | ENSGT00940000161908 |
HOGENOMi | HOG000016044 |
HOVERGENi | HBG018010 |
InParanoidi | O00295 |
OMAi | VQCRISR |
OrthoDBi | 1445357at2759 |
PhylomeDBi | O00295 |
TreeFami | TF314076 |
Miscellaneous databases
GenomeRNAii | 7288 |
PROi | PR:O00295 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000104804 Expressed in 86 organ(s), highest expression level in sperm |
ExpressionAtlasi | O00295 baseline and differential |
Genevisiblei | O00295 HS |
Family and domain databases
Gene3Di | 3.20.90.10, 1 hit |
InterProi | View protein in InterPro IPR025659 Tubby-like_C IPR000007 Tubby_C IPR018066 Tubby_C_CS IPR005398 Tubby_N |
Pfami | View protein in Pfam PF01167 Tub, 1 hit PF16322 Tub_N, 1 hit |
PRINTSi | PR01573 SUPERTUBBY PR01574 TUBBYPROTEIN |
SUPFAMi | SSF54518 SSF54518, 1 hit |
PROSITEi | View protein in PROSITE PS01200 TUB_1, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | TULP2_HUMAN | |
Accessioni | O00295Primary (citable) accession number: O00295 Secondary accession number(s): Q8TC50 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | September 23, 2008 | |
Last modified: | February 13, 2019 | |
This is version 130 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations