LEFTY2

Functionⁱ

Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding.

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth factor activity Source: UniProtKB-KW
transforming growth factor beta receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
multicellular organism development
Source: ProtInc
Traceable author statementⁱ
- 10053005
platelet degranulation Source: Reactome
positive regulation of pathway-restricted SMAD protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of apoptotic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of MAPK cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
SMAD protein signal transduction
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transforming growth factor beta receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 9153275

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Developmental protein, Growth factor

Molecular function

Cytokine, Developmental protein, Growth factor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL
SIGNORⁱ	O00292

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Left-right determination factor 2 Alternative name(s): Endometrial bleeding-associated factor Left-right determination factor A Protein lefty-2 Protein lefty-A Transforming growth factor beta-4 Short name: TGF-beta-4
Gene namesⁱ	Name:LEFTY2 Synonyms:EBAF, LEFTA, LEFTYA, TGFB4 ORF Names:PSEC0024
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000143768.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3122 LEFTY2
MIMⁱ	601877 gene+phenotype
neXtProtⁱ	NX_O00292

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Left-right axis malformations (LRAM)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionThe defect includes left pulmonary isomerism, with cardiac anomalies characterized by complete atrioventricular canal defect and hypoplastic left ventricle, and interrupted inferior vena cava.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_010385	342	S → N in LRAM. 1 PublicationCorresponds to variant dbSNP:rs121909126EnsemblClinVar.		1

Keywords - Diseaseⁱ

Disease mutation, Heterotaxy

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7044
MalaCards human disease database More...MalaCardsⁱ	LEFTY2
MIMⁱ	601877 gene+phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000143768
Orphanetⁱ	157769 Situs ambiguus
PharmGKBⁱ	PA27580

Polymorphism and mutation databases

BioMutaⁱ	LEFTY2

BioMutaⁱ

LEFTY2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 21	Sequence analysisAdd BLAST	21
PropeptideⁱPRO_0000033806	22 – 76	Or 135Sequence analysisAdd BLAST	55
ChainⁱPRO_0000033807	77 – 366	Left-right determination factor 2Add BLAST	290

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	158	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	251 ↔ 264	By similarity
Disulfide bondⁱ	263 ↔ 316	By similarity
Disulfide bondⁱ	293 ↔ 351	By similarity
Disulfide bondⁱ	297 ↔ 353	By similarity

Post-translational modificationⁱ

The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

EPDⁱ	O00292
PaxDbⁱ	O00292
PeptideAtlas More...PeptideAtlasⁱ	O00292
PRIDEⁱ	O00292
ProteomicsDBⁱ	47824

PTM databases

iPTMnetⁱ	O00292
PhosphoSitePlusⁱ	O00292

Expressionⁱ

Tissue specificityⁱ

Mesenchymal cells of the endometrial stroma.

Developmental stageⁱ

Transiently expressed before and during menstrual bleeding.

Gene expression databases

Bgeeⁱ	ENSG00000143768 Expressed in 113 organ(s), highest expression level in decidua
CleanExⁱ	HS_LEFTY2
ExpressionAtlasⁱ	O00292 baseline and differential
Genevisibleⁱ	O00292 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025801 HPA047883 HPA056210

HPAⁱ

CAB025801
HPA047883
HPA056210

Interactionⁱ

GO - Molecular functionⁱ

cytokine activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
growth factor activity Source: UniProtKB-KW
transforming growth factor beta receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112902, 3 interactors
IntActⁱ	O00292, 2 interactors
STRINGⁱ	9606.ENSP00000355785

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	O00292
SMRⁱ	O00292
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the TGF-beta family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000010056
HOGENOMⁱ	HOG000113317
HOVERGENⁱ	HBG074429
InParanoidⁱ	O00292
KEGG Orthology (KO) More...KOⁱ	K04668
OMAⁱ	ETGWKSF
PhylomeDBⁱ	O00292
TreeFamⁱ	TF106462

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR003942 LRDF IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR015615 TGF-beta-rel IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PIRSFⁱ	PIRSF037402 TGFb4, 1 hit
PRINTSⁱ	PR01427 TGFBETA4
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: O00292-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK 
        60         70         80         90        100
LVIPAHVRAQ YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEASTHLLV 
       110        120        130        140        150
FGMEQRLPPN SELVQAVLRL FQEPVPKAAL HRHGRLSPRS AQARVTVEWL 
       160        170        180        190        200
RVRDDGSNRT SLIDSRLVSV HESGWKAFDV TEAVNFWQQL SRPRQPLLLQ 
       210        220        230        240        250
VSVQREHLGP LASGAHKLVR FASQGAPAGL GEPQLELHTL DLRDYGAQGD 
       260        270        280        290        300
CDPEAPMTEG TRCCRQEMYI DLQGMKWAKN WVLEPPGFLA YECVGTCQQP 
       310        320        330        340        350
PEALAFNWPF LGPRQCIASE TASLPMIVSI KEGGRTRPQV VSLPNMRVQK 
       360 
CSCASDGALV PRRLQP

Length:366

Mass (Da):40,920

Last modified:February 21, 2001 - v2

Checksum:ⁱ63A416CAE30F7A39

GO

Isoform 2 (identifier: O00292-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
94-127: Missing.

« Hide

        10         20         30         40         50
MWPLWLCWAL WVLPLAGPGA ALTEEQLLGS LLRQLQLSEV PVLDRADMEK 
        60         70         80         90        100
LVIPAHVRAQ YVVLLRRSHG DRSRGKRFSQ SFREVAGRFL ASEAALHRHG 
       110        120        130        140        150
RLSPRSAQAR VTVEWLRVRD DGSNRTSLID SRLVSVHESG WKAFDVTEAV 
       160        170        180        190        200
NFWQQLSRPR QPLLLQVSVQ REHLGPLASG AHKLVRFASQ GAPAGLGEPQ 
       210        220        230        240        250
LELHTLDLRD YGAQGDCDPE APMTEGTRCC RQEMYIDLQG MKWAKNWVLE 
       260        270        280        290        300
PPGFLAYECV GTCQQPPEAL AFNWPFLGPR QCIASETASL PMIVSIKEGG 
       310        320        330 
RTRPQVVSLP NMRVQKCSCA SDGALVPRRL QP

Note: No experimental confirmation available.

Show »

Length:332

Mass (Da):37,093

Checksum:ⁱ1E838AE7C0D31017

GO

Sequence cautionⁱ

The sequence AAB53269 differs from that shown. Authors have revised their sequence, but have not submitted the revised DNA sequence.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	132	R → G in BAG65344 (PubMed:14702039).Curated		1
Sequence conflictⁱ	183	A → P in BAC11556 (PubMed:16303743).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021980	92	S → L. Corresponds to variant dbSNP:rs366439EnsemblClinVar.	1
Natural variantⁱVAR_021981	286	P → L. Corresponds to variant dbSNP:rs2295418EnsemblClinVar.	1
Natural variantⁱVAR_010385	342	S → N in LRAM. 1 PublicationCorresponds to variant dbSNP:rs121909126EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045264	94 – 127	Missing in isoform 2. 1 PublicationAdd BLAST		34

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U81523 mRNA Translation: AAB53269.1 Sequence problems. AF081511 , AF081508, AF081509, AF081510 Genomic DNA Translation: AAC32600.1 AF081513 mRNA Translation: AAD48145.1 AK027520 mRNA Translation: BAG51336.1 AK075344 mRNA Translation: BAC11556.1 AK304549 mRNA Translation: BAG65344.1 AL117348 Genomic DNA No translation available. BC035718 mRNA Translation: AAH35718.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1549.1 [O00292-1] CCDS53479.1 [O00292-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001165896.1, NM_001172425.2 [O00292-2] NP_003231.2, NM_003240.4 [O00292-1]
UniGeneⁱ	Hs.520187

Genome annotation databases

Ensemblⁱ	ENST00000366820; ENSP00000355785; ENSG00000143768 [O00292-1] ENST00000420304; ENSP00000388009; ENSG00000143768 [O00292-2]
GeneIDⁱ	7044
KEGGⁱ	hsa:7044
UCSC genome browser More...UCSCⁱ	uc001hpt.3 human [O00292-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00292	Left-right determination factor		HUMAN		366	UniRef100_O00292
Left-right determination factor		PANTR		366
Left-right determination factor		PANPA		366
O00292-2	LEFTY2 isoform 1		PANTR		332	UniRef100_H2Q182
Uncharacterized protein		PANPA		332

Protein	Similar proteins		Species	Score	Length	Source
O00292	Left-right determination factor 1		HUMAN		366	UniRef90_O00292
Left-right determination factor		PANTR		366
Left-right determination factor		PANPA		366
Left-right determination factor		PONAB		366
Left-right determination factor		SAIBB		366
+37
O00292-2	LEFTY2 isoform 1		PANTR		332	UniRef90_H2Q182
Uncharacterized protein		PANPA		332
LEFTY2 isoform 2		PONAB		332
Uncharacterized protein		CERAT		332
Uncharacterized protein		PAPAN		332
+13

Protein	Similar proteins		Species	Score	Length	Source
O00292	Left-right determination factor 1		HUMAN		366	UniRef50_O00292
Left-right determination factor 2		MOUSE		368
Left-right determination factor		PANTR		366
Left-right determination factor		PANPA		366
Left-right determination factor		CERAT		366
+158
O00292-2	Left-right determination factor		MONDO		368	UniRef50_F6W095
left-right determination factor 2-like isoform X2		ERIEU		330
Uncharacterized protein		PANPA		325
Left-right determination factor		SARHA		368
Uncharacterized protein		PROCO		330
+98

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U81523 mRNA Translation: AAB53269.1 Sequence problems. AF081511 , AF081508, AF081509, AF081510 Genomic DNA Translation: AAC32600.1 AF081513 mRNA Translation: AAD48145.1 AK027520 mRNA Translation: BAG51336.1 AK075344 mRNA Translation: BAC11556.1 AK304549 mRNA Translation: BAG65344.1 AL117348 Genomic DNA No translation available. BC035718 mRNA Translation: AAH35718.1
CCDSⁱ	CCDS1549.1 [O00292-1] CCDS53479.1 [O00292-2]
RefSeqⁱ	NP_001165896.1, NM_001172425.2 [O00292-2] NP_003231.2, NM_003240.4 [O00292-1]
UniGeneⁱ	Hs.520187

3D structure databases

ProteinModelPortalⁱ	O00292
SMRⁱ	O00292
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112902, 3 interactors
IntActⁱ	O00292, 2 interactors
STRINGⁱ	9606.ENSP00000355785

PTM databases

iPTMnetⁱ	O00292
PhosphoSitePlusⁱ	O00292

Polymorphism and mutation databases

BioMutaⁱ	LEFTY2

BioMutaⁱ

LEFTY2

Proteomic databases

EPDⁱ	O00292
PaxDbⁱ	O00292
PeptideAtlasⁱ	O00292
PRIDEⁱ	O00292
ProteomicsDBⁱ	47824

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000366820; ENSP00000355785; ENSG00000143768 [O00292-1] ENST00000420304; ENSP00000388009; ENSG00000143768 [O00292-2]
GeneIDⁱ	7044
KEGGⁱ	hsa:7044
UCSCⁱ	uc001hpt.3 human [O00292-1]

Organism-specific databases

CTDⁱ	7044
DisGeNETⁱ	7044
EuPathDBⁱ	HostDB:ENSG00000143768.11
GeneCardsⁱ	LEFTY2
HGNCⁱ	HGNC:3122 LEFTY2
HPAⁱ	CAB025801 HPA047883 HPA056210
MalaCardsⁱ	LEFTY2
MIMⁱ	601877 gene+phenotype
neXtProtⁱ	NX_O00292
OpenTargetsⁱ	ENSG00000143768
Orphanetⁱ	157769 Situs ambiguus
PharmGKBⁱ	PA27580
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3900 Eukaryota ENOG410XT8Z LUCA
GeneTreeⁱ	ENSGT00390000010056
HOGENOMⁱ	HOG000113317
HOVERGENⁱ	HBG074429
InParanoidⁱ	O00292
KOⁱ	K04668
OMAⁱ	ETGWKSF
PhylomeDBⁱ	O00292
TreeFamⁱ	TF106462

Enzyme and pathway databases

Reactomeⁱ	R-HSA-114608 Platelet degranulation R-HSA-1181150 Signaling by NODAL R-HSA-1433617 Regulation of signaling by NODAL
SIGNORⁱ	O00292

Miscellaneous databases

ChiTaRSⁱ	LEFTY2 human
GenomeRNAiⁱ	7044
Protein Ontology More...PROⁱ	PR:O00292
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000143768 Expressed in 113 organ(s), highest expression level in decidua
CleanExⁱ	HS_LEFTY2
ExpressionAtlasⁱ	O00292 baseline and differential
Genevisibleⁱ	O00292 HS

Family and domain databases

Gene3Dⁱ	2.10.90.10, 1 hit
InterProⁱ	View protein in InterPro IPR029034 Cystine-knot_cytokine IPR003942 LRDF IPR001839 TGF-b_C IPR001111 TGF-b_propeptide IPR015615 TGF-beta-rel IPR017948 TGFb_CS
PANTHERⁱ	PTHR11848 PTHR11848, 1 hit
Pfamⁱ	View protein in Pfam PF00019 TGF_beta, 1 hit PF00688 TGFb_propeptide, 1 hit
PIRSFⁱ	PIRSF037402 TGFb4, 1 hit
PRINTSⁱ	PR01427 TGFBETA4
SMARTⁱ	View protein in SMART SM00204 TGFB, 1 hit
SUPFAMⁱ	SSF57501 SSF57501, 1 hit
PROSITEⁱ	View protein in PROSITE PS00250 TGF_BETA_1, 1 hit PS51362 TGF_BETA_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LFTY2_HUMAN
Accessionⁱ	O00292Primary (citable) accession number: O00292 Secondary accession number(s): B3KNH4 , B4E332, E9PDM4, O75611, Q5TE89, Q8NBQ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	February 21, 2001
	Last modified:	November 7, 2018
	This is version 181 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O00292 (LFTY2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Left-right determination factor 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ