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UniProtKB - O00273 (DFFA_HUMAN)

Entry version 209 (10 Feb 2021)
Sequence version 1 (01 Jul 1997)
Previous versions | rss
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Protein

DNA fragmentation factor subunit alpha

Gene

DFFA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inhibitor of the caspase-activated DNase (DFF40).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00273

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140342, Apoptosis induced DNA fragmentation

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00273

SIGNOR Signaling Network Open Resource

More...SIGNORi		O00273

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA fragmentation factor subunit alpha
Alternative name(s):
DNA fragmentation factor 45 kDa subunit
Short name:
DFF-45
Inhibitor of CAD
Short name:
ICAD
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DFFA
Synonyms:DFF1, DFF45
ORF Names:H13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2772, DFFA

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601882, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00273

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000160049.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1676

Open Targets

More...OpenTargetsi		ENSG00000160049

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27254

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00273, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DFFA

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447161 – 331DNA fragmentation factor subunit alphaAdd BLAST331

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei243PhosphothreonineCombined sources1
Modified residuei315PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei117 – 118Cleavage; by caspase-32
Sitei224 – 225Cleavage; by caspase-32

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00273

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00273

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00273

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00273

PeptideAtlas

More...PeptideAtlasi		O00273

PRoteomics IDEntifications database

More...PRIDEi		O00273

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47820 [O00273-1]
47821 [O00273-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00273

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00273

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000160049, Expressed in medial globus pallidus and 243 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00273, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00273, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000160049, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of DFFA and DFFB.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108040, 46 interactors

Protein interaction database and analysis system

More...IntActi		O00273, 14 interactors

Molecular INTeraction database

More...MINTi		O00273

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366237

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00273, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1331
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		O00273

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00273

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O00273

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 96CIDE-NPROSITE-ProRule annotationAdd BLAST80

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RQ19, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000018596

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_086234_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00273

Identification of Orthologs from Complete Genome Data

More...OMAi		NWDIRKT

Database of Orthologous Groups

More...OrthoDBi		1564672at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00273

TreeFam database of animal gene trees

More...TreeFami		TF102021

Family and domain databases

Database of protein disorder

More...DisProti		DP00173

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003508, CIDE-N_dom
IPR027296, DFF-C
IPR017299, DFF45
IPR015121, DNA_fragmentation_mid_dom

The PANTHER Classification System

More...PANTHERi		PTHR12306:SF16, PTHR12306:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02017, CIDE-N, 1 hit
PF09033, DFF-C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF037865, DFF_alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00266, CAD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF81783, SSF81783, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51135, CIDE_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform DFF45 (identifier: O00273-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVTGDAGVP ESGEIRTLKP CLLRRNYSRE QHGVAASCLE DLRSKACDIL 
        60         70         80         90        100
AIDKSLTPVT LVLAEDGTIV DDDDYFLCLP SNTKFVALAS NEKWAYNNSD 
       110        120        130        140        150
GGTAWISQES FDVDETDSGA GLKWKNVARQ LKEDLSSIIL LSEEDLQMLV 
       160        170        180        190        200
DAPCSDLAQE LRQSCATVQR LQHTLQQVLD QREEVRQSKQ LLQLYLQALE 
       210        220        230        240        250
KEGSLLSKQE ESKAAFGEEV DAVDTGISRE TSSDVALASH ILTALREKQA 
       260        270        280        290        300
PELSLSSQDL ELVTKEDPKA LAVALNWDIK KTETVQEACE RELALRLQQT 
       310        320        330 
QSLHSLRSIS ASKASPPGDL QNPKRARQDP T
Length:331
Mass (Da):36,522
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8656FE45DB003DF3
GO
Isoform DFF35 (identifier: O00273-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     262-268: LVTKEDP → VGGNQGH
     269-331: Missing.

Show »
Length:268
Mass (Da):29,411
Checksum:iEA130F9D27145474
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ERT1K7ERT1_HUMAN
DNA fragmentation factor subunit al...
DFFA
159Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti291R → W in AAH07721 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_001085262 – 268LVTKEDP → VGGNQGH in isoform DFF35. 2 Publications7
Alternative sequenceiVSP_001086269 – 331Missing in isoform DFF35. 2 PublicationsAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U91985 mRNA Translation: AAC51249.1
AF087573 mRNA Translation: AAD32953.1
AF103799 mRNA Translation: AAF02419.1
BT006980 mRNA Translation: AAP35626.1
AK313317 mRNA Translation: BAG36122.1
AL354956 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71656.1
CH471130 Genomic DNA Translation: EAW71657.1
BC000037 mRNA Translation: AAH00037.1
BC007112 mRNA Translation: AAH07112.1
BC007721 mRNA Translation: AAH07721.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS118.1 [O00273-1]
CCDS119.1 [O00273-2]

NCBI Reference Sequences

More...RefSeqi		NP_004392.1, NM_004401.2 [O00273-1]
NP_998731.1, NM_213566.1 [O00273-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377036; ENSP00000366235; ENSG00000160049 [O00273-2]
ENST00000377038; ENSP00000366237; ENSG00000160049 [O00273-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1676

UCSC genome browser

More...UCSCi		uc001arj.4, human [O00273-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U91985 mRNA Translation: AAC51249.1
AF087573 mRNA Translation: AAD32953.1
AF103799 mRNA Translation: AAF02419.1
BT006980 mRNA Translation: AAP35626.1
AK313317 mRNA Translation: BAG36122.1
AL354956 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71656.1
CH471130 Genomic DNA Translation: EAW71657.1
BC000037 mRNA Translation: AAH00037.1
BC007112 mRNA Translation: AAH07112.1
BC007721 mRNA Translation: AAH07721.1
CCDSiCCDS118.1 [O00273-1]
CCDS119.1 [O00273-2]
RefSeqiNP_004392.1, NM_004401.2 [O00273-1]
NP_998731.1, NM_213566.1 [O00273-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IBXNMR-B11-100[»]
1IYRNMR-A225-331[»]
1KOYNMR-A239-300[»]
BMRBiO00273
SMRiO00273
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108040, 46 interactors
IntActiO00273, 14 interactors
MINTiO00273
STRINGi9606.ENSP00000366237

PTM databases

iPTMnetiO00273
PhosphoSitePlusiO00273

Genetic variation databases

BioMutaiDFFA

Proteomic databases

EPDiO00273
jPOSTiO00273
MassIVEiO00273
PaxDbiO00273
PeptideAtlasiO00273
PRIDEiO00273
ProteomicsDBi47820 [O00273-1]
47821 [O00273-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3633, 817 antibodies

The DNASU plasmid repository

More...DNASUi		1676

Genome annotation databases

EnsembliENST00000377036; ENSP00000366235; ENSG00000160049 [O00273-2]
ENST00000377038; ENSP00000366237; ENSG00000160049 [O00273-1]
GeneIDi1676
KEGGihsa:1676
UCSCiuc001arj.4, human [O00273-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1676
DisGeNETi1676

GeneCards: human genes, protein and diseases

More...GeneCardsi		DFFA
HGNCiHGNC:2772, DFFA
HPAiENSG00000160049, Low tissue specificity
MIMi601882, gene
neXtProtiNX_O00273
OpenTargetsiENSG00000160049
PharmGKBiPA27254
VEuPathDBiHostDB:ENSG00000160049.11

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RQ19, Eukaryota
GeneTreeiENSGT00390000018596
HOGENOMiCLU_086234_0_0_1
InParanoidiO00273
OMAiNWDIRKT
OrthoDBi1564672at2759
PhylomeDBiO00273
TreeFamiTF102021

Enzyme and pathway databases

PathwayCommonsiO00273
ReactomeiR-HSA-140342, Apoptosis induced DNA fragmentation
SignaLinkiO00273
SIGNORiO00273

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1676, 3 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DFFA, human
EvolutionaryTraceiO00273

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		DFFA

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1676
PharosiO00273, Tbio

Protein Ontology

More...PROi		PR:O00273
RNActiO00273, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000160049, Expressed in medial globus pallidus and 243 other tissues
ExpressionAtlasiO00273, baseline and differential
GenevisibleiO00273, HS

Family and domain databases

DisProtiDP00173
InterProiView protein in InterPro
IPR003508, CIDE-N_dom
IPR027296, DFF-C
IPR017299, DFF45
IPR015121, DNA_fragmentation_mid_dom
PANTHERiPTHR12306:SF16, PTHR12306:SF16, 1 hit
PfamiView protein in Pfam
PF02017, CIDE-N, 1 hit
PF09033, DFF-C, 1 hit
PIRSFiPIRSF037865, DFF_alpha, 1 hit
SMARTiView protein in SMART
SM00266, CAD, 1 hit
SUPFAMiSSF81783, SSF81783, 1 hit
PROSITEiView protein in PROSITE
PS51135, CIDE_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDFFA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00273
Secondary accession number(s): Q5T6G5
, Q5T6G6, Q96I97, Q9Y6C6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: February 10, 2021
This is version 209 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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