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Protein

12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor

Gene

GPR31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE). 12-(S)-HETE is an arachidonic acid metabolite secreted by platelets and tumor cells, and known to induce endothelial cells retraction allowing invasive cell access to the subendothelial matrix, which is a critical step for extravasation or metastasis. Ligand-binding lead to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B.1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444209 Free fatty acid receptors

Names & Taxonomyi

Protein namesi
Recommended name:
12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptor
Short name:
12-(S)-HETE receptor
Short name:
12-HETER
Alternative name(s):
G-protein coupled receptor 31
Gene namesi
Name:GPR31
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000120436.3
HGNCiHGNC:4486 GPR31
MIMi602043 gene
neXtProtiNX_O00270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 37Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini38 – 52CytoplasmicSequence analysisAdd BLAST15
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 91ExtracellularSequence analysisAdd BLAST18
Transmembranei92 – 110Helical; Name=3Sequence analysisAdd BLAST19
Topological domaini111 – 131CytoplasmicSequence analysisAdd BLAST21
Transmembranei132 – 152Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini153 – 180ExtracellularSequence analysisAdd BLAST28
Transmembranei181 – 201Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini202 – 219CytoplasmicSequence analysisAdd BLAST18
Transmembranei220 – 240Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini241 – 265ExtracellularSequence analysisAdd BLAST25
Transmembranei266 – 284Helical; Name=7Sequence analysisAdd BLAST19
Topological domaini285 – 319CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000120436
PharmGKBiPA28874

Polymorphism and mutation databases

BioMutaiGPR31

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695511 – 31912-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid receptorAdd BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiO00270
PRIDEiO00270
ProteomicsDBi47819

Expressioni

Gene expression databases

BgeeiENSG00000120436 Expressed in 1 organ(s), highest expression level in spleen
CleanExiHS_GPR31
GenevisibleiO00270 HS

Organism-specific databases

HPAiHPA014014
HPA027108

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000355799

Structurei

3D structure databases

ProteinModelPortaliO00270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE56 Eukaryota
ENOG410ZU85 LUCA
GeneTreeiENSGT00510000046798
HOGENOMiHOG000285939
HOVERGENiHBG100615
InParanoidiO00270
KOiK08406
OMAiLKVWKPY
OrthoDBiEOG091G0G4Y
PhylomeDBiO00270
TreeFamiTF337237

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

O00270-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPFPNCSAPS TVVATAVGVL LGLECGLGLL GNAVALWTFL FRVRVWKPYA
60 70 80 90 100
VYLLNLALAD LLLAACLPFL AAFYLSLQAW HLGRVGCWAL HFLLDLSRSV
110 120 130 140 150
GMAFLAAVAL DRYLRVVHPR LKVNLLSPQA ALGVSGLVWL LMVALTCPGL
160 170 180 190 200
LISEAAQNST RCHSFYSRAD GSFSIIWQEA LSCLQFVLPF GLIVFCNAGI
210 220 230 240 250
IRALQKRLRE PEKQPKLQRA QALVTLVVVL FALCFLPCFL ARVLMHIFQN
260 270 280 290 300
LGSCRALCAV AHTSDVTGSL TYLHSVLNPV VYCFSSPTFR SSYRRVFHTL
310
RGKGQAAEPP DFNPRDSYS
Length:319
Mass (Da):35,075
Last modified:March 1, 2005 - v2
Checksum:i2ACD0350AD7FB53A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti73F → L in AAH95537 (PubMed:15489334).Curated1
Sequence conflicti277L → V in AAC51375 (PubMed:9205127).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04939291H → R4 PublicationsCorresponds to variant dbSNP:rs6902566Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65402 Genomic DNA Translation: AAC51375.1
EU432117 Genomic DNA Translation: ABY87916.1
AL121935 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47505.1
BC095537 mRNA Translation: AAH95537.1
CCDSiCCDS5299.1
RefSeqiNP_005290.2, NM_005299.2
UniGeneiHs.248124

Genome annotation databases

EnsembliENST00000366834; ENSP00000355799; ENSG00000120436
GeneIDi2853
KEGGihsa:2853
UCSCiuc011egq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65402 Genomic DNA Translation: AAC51375.1
EU432117 Genomic DNA Translation: ABY87916.1
AL121935 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47505.1
BC095537 mRNA Translation: AAH95537.1
CCDSiCCDS5299.1
RefSeqiNP_005290.2, NM_005299.2
UniGeneiHs.248124

3D structure databases

ProteinModelPortaliO00270
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000355799

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR31

Proteomic databases

PaxDbiO00270
PRIDEiO00270
ProteomicsDBi47819

Protocols and materials databases

DNASUi2853
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366834; ENSP00000355799; ENSG00000120436
GeneIDi2853
KEGGihsa:2853
UCSCiuc011egq.3 human

Organism-specific databases

CTDi2853
EuPathDBiHostDB:ENSG00000120436.3
GeneCardsiGPR31
HGNCiHGNC:4486 GPR31
HPAiHPA014014
HPA027108
MIMi602043 gene
neXtProtiNX_O00270
OpenTargetsiENSG00000120436
PharmGKBiPA28874
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE56 Eukaryota
ENOG410ZU85 LUCA
GeneTreeiENSGT00510000046798
HOGENOMiHOG000285939
HOVERGENiHBG100615
InParanoidiO00270
KOiK08406
OMAiLKVWKPY
OrthoDBiEOG091G0G4Y
PhylomeDBiO00270
TreeFamiTF337237

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-444209 Free fatty acid receptors

Miscellaneous databases

GeneWikiiGPR31
GenomeRNAii2853
PROiPR:O00270
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000120436 Expressed in 1 organ(s), highest expression level in spleen
CleanExiHS_GPR31
GenevisibleiO00270 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPR31_HUMAN
AccessioniPrimary (citable) accession number: O00270
Secondary accession number(s): B0M0K2, Q4VBL3, Q9NQ20
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 1, 2005
Last modified: November 7, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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