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Protein

Copper transport protein ATOX1

Gene

ATOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi12Copper1
Metal bindingi15Copper1

GO - Molecular functioni

  • ATPase binding Source: Ensembl
  • copper chaperone activity Source: UniProtKB
  • copper-dependent protein binding Source: UniProtKB
  • copper ion binding Source: UniProtKB
  • copper ion transmembrane transporter activity Source: Ensembl
  • metallochaperone activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6803544 Ion influx/efflux at host-pathogen interface

Names & Taxonomyi

Protein namesi
Recommended name:
Copper transport protein ATOX1
Alternative name(s):
Metal transport protein ATX1
Gene namesi
Name:ATOX1
Synonyms:HAH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000177556.11
HGNCiHGNC:798 ATOX1
MIMi602270 gene
neXtProtiNX_O00244

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi475
OpenTargetsiENSG00000177556
PharmGKBiPA25096

Chemistry databases

DrugBankiDB03127 Benzamidine
DB02772 Sucrose

Polymorphism and mutation databases

BioMutaiATOX1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002125371 – 68Copper transport protein ATOX1Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei47PhosphoserineCombined sources1
Modified residuei60N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiO00244
MaxQBiO00244
PaxDbiO00244
PeptideAtlasiO00244
PRIDEiO00244
ProteomicsDBi47805
TopDownProteomicsiO00244

PTM databases

iPTMnetiO00244
PhosphoSitePlusiO00244

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000177556
CleanExiHS_ATOX1
ExpressionAtlasiO00244 baseline and differential
GenevisibleiO00244 HS

Organism-specific databases

HPAiHPA055036

Interactioni

Subunit structurei

Interacts with ATP7B (PubMed:10966647). Interacts with ATP7A (PubMed:21667063).2 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ATPase binding Source: Ensembl
  • copper-dependent protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106965, 14 interactors
IntActiO00244, 6 interactors
STRINGi9606.ENSP00000316854

Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 8Combined sources6
Helixi13 – 26Combined sources14
Beta strandi28 – 34Combined sources7
Turni35 – 38Combined sources4
Beta strandi39 – 46Combined sources8
Helixi48 – 56Combined sources9
Turni57 – 59Combined sources3
Beta strandi62 – 66Combined sources5

3D structure databases

ProteinModelPortaliO00244
SMRiO00244
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00244

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

Sequence similaritiesi

Belongs to the ATX1 family.Curated

Phylogenomic databases

eggNOGiKOG1603 Eukaryota
COG2608 LUCA
GeneTreeiENSGT00390000005805
HOGENOMiHOG000038877
HOVERGENiHBG050610
InParanoidiO00244
KOiK07213
PhylomeDBiO00244
TreeFamiTF352589

Family and domain databases

CDDicd00371 HMA, 1 hit
InterProiView protein in InterPro
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
PROSITEiView protein in PROSITE
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

Sequencei

Sequence statusi: Complete.

O00244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT
60
LLATLKKTGK TVSYLGLE
Length:68
Mass (Da):7,402
Last modified:July 1, 1997 - v1
Checksum:i0B364B1BD1279314
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70660 mRNA Translation: AAC51227.1
AY165037 Genomic DNA Translation: AAN84554.1
BT009786 mRNA Translation: AAP88788.1
AK293063 mRNA Translation: BAF85752.1
AY986502 Genomic DNA Translation: AAX81411.1
CH471062 Genomic DNA Translation: EAW61663.1
CH471062 Genomic DNA Translation: EAW61664.1
BC112248 mRNA Translation: AAI12249.1
BC112250 mRNA Translation: AAI12251.1
CCDSiCCDS47317.1
RefSeqiNP_004036.1, NM_004045.3
UniGeneiHs.125213

Genome annotation databases

EnsembliENST00000313115; ENSP00000316854; ENSG00000177556
ENST00000522710; ENSP00000429814; ENSG00000177556
ENST00000524142; ENSP00000430598; ENSG00000177556
GeneIDi475
KEGGihsa:475
UCSCiuc003luk.4 human

Similar proteinsi

Entry informationi

Entry nameiATOX1_HUMAN
AccessioniPrimary (citable) accession number: O00244
Secondary accession number(s): A8KAJ8
, D3DQI2, Q2M1R6, Q56AP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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