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Protein

Copper transport protein ATOX1

Gene

ATOX1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi12Copper1
Metal bindingi15Copper1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase binding Source: Ensembl
  • copper chaperone activity Source: UniProtKB
  • copper-dependent protein binding Source: UniProtKB
  • copper ion binding Source: UniProtKB
  • metallochaperone activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processCopper transport, Ion transport, Transport
LigandCopper, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6803544 Ion influx/efflux at host-pathogen interface

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Copper transport protein ATOX1
Alternative name(s):
Metal transport protein ATX1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATOX1
Synonyms:HAH1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000177556.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:798 ATOX1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602270 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00244

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
475

Open Targets

More...
OpenTargetsi
ENSG00000177556

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25096

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB03127 Benzamidine
DB02772 Sucrose

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ATOX1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002125371 – 68Copper transport protein ATOX1Add BLAST68

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47PhosphoserineCombined sources1
Modified residuei60N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00244

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00244

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00244

PeptideAtlas

More...
PeptideAtlasi
O00244

PRoteomics IDEntifications database

More...
PRIDEi
O00244

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47805

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O00244

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00244

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00244

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177556 Expressed in 225 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_ATOX1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00244 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00244 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055036

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ATP7B (PubMed:10966647). Interacts with ATP7A (PubMed:21667063).2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
106965, 14 interactors

Protein interaction database and analysis system

More...
IntActi
O00244, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316854

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

168
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00244

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00244

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O00244

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2 – 68HMAPROSITE-ProRule annotationAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATX1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1603 Eukaryota
COG2608 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162517

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000038877

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG050610

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00244

KEGG Orthology (KO)

More...
KOi
K07213

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00244

TreeFam database of animal gene trees

More...
TreeFami
TF352589

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00371 HMA, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00403 HMA, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55008 SSF55008, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O00244-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPKHEFSVDM TCGGCAEAVS RVLNKLGGVK YDIDLPNKKV CIESEHSMDT
60
LLATLKKTGK TVSYLGLE
Length:68
Mass (Da):7,402
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0B364B1BD1279314
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIM7E5RIM7_HUMAN
Copper transport protein ATOX1
ATOX1
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RGN3E5RGN3_HUMAN
Copper transport protein ATOX1
ATOX1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U70660 mRNA Translation: AAC51227.1
AY165037 Genomic DNA Translation: AAN84554.1
BT009786 mRNA Translation: AAP88788.1
AK293063 mRNA Translation: BAF85752.1
AY986502 Genomic DNA Translation: AAX81411.1
CH471062 Genomic DNA Translation: EAW61663.1
CH471062 Genomic DNA Translation: EAW61664.1
BC112248 mRNA Translation: AAI12249.1
BC112250 mRNA Translation: AAI12251.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS47317.1

NCBI Reference Sequences

More...
RefSeqi
NP_004036.1, NM_004045.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.125213

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000313115; ENSP00000316854; ENSG00000177556
ENST00000522710; ENSP00000429814; ENSG00000177556
ENST00000524142; ENSP00000430598; ENSG00000177556

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
475

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:475

UCSC genome browser

More...
UCSCi
uc003luk.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U70660 mRNA Translation: AAC51227.1
AY165037 Genomic DNA Translation: AAN84554.1
BT009786 mRNA Translation: AAP88788.1
AK293063 mRNA Translation: BAF85752.1
AY986502 Genomic DNA Translation: AAX81411.1
CH471062 Genomic DNA Translation: EAW61663.1
CH471062 Genomic DNA Translation: EAW61664.1
BC112248 mRNA Translation: AAI12249.1
BC112250 mRNA Translation: AAI12251.1
CCDSiCCDS47317.1
RefSeqiNP_004036.1, NM_004045.3
UniGeneiHs.125213

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FE0X-ray1.75A/B1-68[»]
1FE4X-ray1.75A/B1-68[»]
1FEEX-ray1.80A/B1-68[»]
1TL4NMR-A1-68[»]
1TL5NMR-A1-68[»]
2K1RNMR-B1-68[»]
2LQ9NMR-A1-68[»]
3CJKX-ray1.80A2-68[»]
3IWLX-ray1.60A1-68[»]
3IWXX-ray2.14A/B1-68[»]
4QOTX-ray2.20A/B1-68[»]
4YDXX-ray1.60A2-68[»]
4YEAX-ray2.14A/B2-68[»]
5F0WX-ray2.70A/B/C/D1-68[»]
5T7LX-ray2.83A2-68[»]
ProteinModelPortaliO00244
SMRiO00244
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106965, 14 interactors
IntActiO00244, 6 interactors
STRINGi9606.ENSP00000316854

Chemistry databases

DrugBankiDB03127 Benzamidine
DB02772 Sucrose

PTM databases

iPTMnetiO00244
PhosphoSitePlusiO00244

Polymorphism and mutation databases

BioMutaiATOX1

Proteomic databases

EPDiO00244
MaxQBiO00244
PaxDbiO00244
PeptideAtlasiO00244
PRIDEiO00244
ProteomicsDBi47805
TopDownProteomicsiO00244

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
475
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000313115; ENSP00000316854; ENSG00000177556
ENST00000522710; ENSP00000429814; ENSG00000177556
ENST00000524142; ENSP00000430598; ENSG00000177556
GeneIDi475
KEGGihsa:475
UCSCiuc003luk.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
475
DisGeNETi475
EuPathDBiHostDB:ENSG00000177556.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ATOX1
HGNCiHGNC:798 ATOX1
HPAiHPA055036
MIMi602270 gene
neXtProtiNX_O00244
OpenTargetsiENSG00000177556
PharmGKBiPA25096

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1603 Eukaryota
COG2608 LUCA
GeneTreeiENSGT00940000162517
HOGENOMiHOG000038877
HOVERGENiHBG050610
InParanoidiO00244
KOiK07213
PhylomeDBiO00244
TreeFamiTF352589

Enzyme and pathway databases

ReactomeiR-HSA-3299685 Detoxification of Reactive Oxygen Species
R-HSA-6803544 Ion influx/efflux at host-pathogen interface

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ATOX1 human
EvolutionaryTraceiO00244

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ATOX1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
475

Protein Ontology

More...
PROi
PR:O00244

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000177556 Expressed in 225 organ(s), highest expression level in adult mammalian kidney
CleanExiHS_ATOX1
ExpressionAtlasiO00244 baseline and differential
GenevisibleiO00244 HS

Family and domain databases

CDDicd00371 HMA, 1 hit
InterProiView protein in InterPro
IPR017969 Heavy-metal-associated_CS
IPR006121 HMA_dom
IPR036163 HMA_dom_sf
PfamiView protein in Pfam
PF00403 HMA, 1 hit
SUPFAMiSSF55008 SSF55008, 1 hit
PROSITEiView protein in PROSITE
PS01047 HMA_1, 1 hit
PS50846 HMA_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATOX1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00244
Secondary accession number(s): A8KAJ8
, D3DQI2, Q2M1R6, Q56AP3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: December 5, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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