UniProtKB - O00241 (SIRB1_HUMAN)
Protein
Signal-regulatory protein beta-1
Gene
SIRPB1
Organism
Homo sapiens (Human)
Status
Functioni
Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. Triggers activation of myeloid cells when associated with TYROBP (PubMed:10604985).1 Publication
GO - Biological processi
- cell surface receptor signaling pathway Source: ProtInc
- innate immune response Source: Reactome
- neutrophil degranulation Source: Reactome
- positive regulation of phagocytosis Source: GO_Central
- positive regulation of T cell activation Source: GO_Central
- signal transduction Source: ProtInc
Enzyme and pathway databases
PathwayCommonsi | O00241 |
Reactomei | R-HSA-2172127, DAP12 interactions R-HSA-391160, Signal regulatory protein family interactions R-HSA-6798695, Neutrophil degranulation |
Protein family/group databases
TCDBi | 8.A.23.1.34, the basigin (basigin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Signal-regulatory protein beta-1Short name: SIRP-beta-1 Alternative name(s): CD172 antigen-like family member B CD_antigen: CD172b |
Gene namesi | Name:SIRPB1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15928, SIRPB1 |
MIMi | 603889, gene |
neXtProti | NX_O00241 |
VEuPathDBi | HostDB:ENSG00000101307.15 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Sequence analysis
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: GO_Central
Other locations
- cell surface Source: ARUK-UCL
- secretory granule membrane Source: Reactome
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 30 – 371 | ExtracellularSequence analysisAdd BLAST | 342 | |
Transmembranei | 372 – 392 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 393 – 398 | CytoplasmicSequence analysis | 6 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 10326 |
OpenTargetsi | ENSG00000101307 |
PharmGKBi | PA38051 |
Miscellaneous databases
Pharosi | O00241, Tbio |
Genetic variation databases
BioMutai | SIRPB1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000014956 | 30 – 398 | Signal-regulatory protein beta-1Add BLAST | 369 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 54 ↔ 120 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 169 ↔ 227 | PROSITE-ProRule annotation | ||
Glycosylationi | 244 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 269 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 291 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 320 | InterchainPROSITE-ProRule annotation1 Publication |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | O00241 |
jPOSTi | O00241 |
MassIVEi | O00241 |
PeptideAtlasi | O00241 |
PRIDEi | O00241 |
ProteomicsDBi | 47803 [O00241-1] 47804 [O00241-2] |
PTM databases
GlyGeni | O00241, 6 sites |
iPTMneti | O00241 |
PhosphoSitePlusi | O00241 |
Expressioni
Tissue specificityi
Detected in monocytes and dendritic cells.1 Publication
Gene expression databases
Bgeei | ENSG00000101307, Expressed in blood and 136 other tissues |
ExpressionAtlasi | O00241, baseline and differential |
Genevisiblei | O00241, HS |
Organism-specific databases
HPAi | ENSG00000101307, Tissue enriched (blood) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Interacts with TYROBP. This interaction results in the recruitment of SYK.
4 PublicationsBinary interactionsi
Hide detailsO00241
With | #Exp. | IntAct |
---|---|---|
TYROBP [O43914] | 4 | EBI-2615458,EBI-2214794 |
Isoform 2 [O00241-2]
Protein-protein interaction databases
BioGRIDi | 115609, 9 interactors |
IntActi | O00241, 10 interactors |
STRINGi | 9606.ENSP00000371018 |
Miscellaneous databases
RNActi | O00241, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O00241 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O00241 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 136 | Ig-like V-typeAdd BLAST | 107 | |
Domaini | 147 – 246 | Ig-like C1-type 1Add BLAST | 100 | |
Domaini | 253 – 347 | Ig-like C1-type 2Add BLAST | 95 |
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502S1XD, Eukaryota |
GeneTreei | ENSGT00960000186656 |
InParanoidi | O00241 |
OrthoDBi | 904196at2759 |
PhylomeDBi | O00241 |
TreeFami | TF341862 |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07654, C1-set, 2 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00407, IGc1, 2 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O00241-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MPVPASWPHL PSPFLLMTLL LGRLTGVAGE DELQVIQPEK SVSVAAGESA
60 70 80 90 100
TLRCAMTSLI PVGPIMWFRG AGAGRELIYN QKEGHFPRVT TVSELTKRNN
110 120 130 140 150
LDFSISISNI TPADAGTYYC VKFRKGSPDD VEFKSGAGTE LSVRAKPSAP
160 170 180 190 200
VVSGPAVRAT PEHTVSFTCE SHGFSPRDIT LKWFKNGNEL SDFQTNVDPA
210 220 230 240 250
GDSVSYSIHS TARVVLTRGD VHSQVICEIA HITLQGDPLR GTANLSEAIR
260 270 280 290 300
VPPTLEVTQQ PMRAENQANV TCQVSNFYPR GLQLTWLENG NVSRTETAST
310 320 330 340 350
LIENKDGTYN WMSWLLVNTC AHRDDVVLTC QVEHDGQQAV SKSYALEISA
360 370 380 390
HQKEHGSDIT HEAALAPTAP LLVALLLGPK LLLVVGVSAI YICWKQKA
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH9KV29 | H9KV29_HUMAN | Signal-regulatory protein beta-1 | SIRPB1 | 180 | Annotation score: | ||
H3BQ21 | H3BQ21_HUMAN | Signal-regulatory protein beta-1 | SIRPB1 | 236 | Annotation score: | ||
H3BU43 | H3BU43_HUMAN | Signal-regulatory protein beta-1 | SIRPB1 | 77 | Annotation score: | ||
H3BTT9 | H3BTT9_HUMAN | Signal-regulatory protein beta-1 | SIRPB1 | 58 | Annotation score: | ||
H3BRP9 | H3BRP9_HUMAN | Signal-regulatory protein beta-1 | SIRPB1 | 156 | Annotation score: | ||
H3BSK5 | H3BSK5_HUMAN | Signal-regulatory protein beta-1 | SIRPB1 | 131 | Annotation score: | ||
H3BUW0 | H3BUW0_HUMAN | Signal-regulatory protein beta-1 | SIRPB1 | 182 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 102 | D → N in CAA71404 (PubMed:9062191).Curated | 1 | |
Sequence conflicti | 106 | S → R in BAG36297 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_028789 | 23 | R → G. Corresponds to variant dbSNP:rs1535882Ensembl. | 1 | |
Natural variantiVAR_028790 | 53 | R → H. Corresponds to variant dbSNP:rs2746603Ensembl. | 1 | |
Natural variantiVAR_028791 | 229 | I → M2 PublicationsCorresponds to variant dbSNP:rs2253427Ensembl. | 1 | |
Natural variantiVAR_028792 | 363 | A → P3 PublicationsCorresponds to variant dbSNP:rs2243603Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007026 | 145 – 361 | Missing in isoform 2. 1 PublicationAdd BLAST | 217 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10376 mRNA Translation: CAA71404.1 AK313517 mRNA Translation: BAG36297.1 AL049634 Genomic DNA No translation available. AL138804 Genomic DNA No translation available. BC025286 mRNA Translation: AAH25286.1 BC075835 mRNA Translation: AAH75835.1 |
CCDSi | CCDS13019.1 [O00241-1] CCDS42850.1 [O00241-2] |
RefSeqi | NP_001077379.1, NM_001083910.3 [O00241-2] NP_001317568.1, NM_001330639.1 NP_006056.2, NM_006065.4 [O00241-1] XP_016883066.1, XM_017027577.1 [O00241-1] |
Genome annotation databases
Ensembli | ENST00000381603; ENSP00000371016; ENSG00000101307 [O00241-2] ENST00000381605; ENSP00000371018; ENSG00000101307 [O00241-1] |
GeneIDi | 10326 |
UCSCi | uc002wfk.5, human [O00241-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10376 mRNA Translation: CAA71404.1 AK313517 mRNA Translation: BAG36297.1 AL049634 Genomic DNA No translation available. AL138804 Genomic DNA No translation available. BC025286 mRNA Translation: AAH25286.1 BC075835 mRNA Translation: AAH75835.1 |
CCDSi | CCDS13019.1 [O00241-1] CCDS42850.1 [O00241-2] |
RefSeqi | NP_001077379.1, NM_001083910.3 [O00241-2] NP_001317568.1, NM_001330639.1 NP_006056.2, NM_006065.4 [O00241-1] XP_016883066.1, XM_017027577.1 [O00241-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2D9C | NMR | - | A | 32-154 | [»] | |
2JJU | X-ray | 1.19 | A/B | 30-148 | [»] | |
SMRi | O00241 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115609, 9 interactors |
IntActi | O00241, 10 interactors |
STRINGi | 9606.ENSP00000371018 |
Protein family/group databases
TCDBi | 8.A.23.1.34, the basigin (basigin) family |
PTM databases
GlyGeni | O00241, 6 sites |
iPTMneti | O00241 |
PhosphoSitePlusi | O00241 |
Genetic variation databases
BioMutai | SIRPB1 |
Proteomic databases
EPDi | O00241 |
jPOSTi | O00241 |
MassIVEi | O00241 |
PeptideAtlasi | O00241 |
PRIDEi | O00241 |
ProteomicsDBi | 47803 [O00241-1] 47804 [O00241-2] |
Protocols and materials databases
Antibodypediai | 23124, 324 antibodies |
DNASUi | 10326 |
Genome annotation databases
Ensembli | ENST00000381603; ENSP00000371016; ENSG00000101307 [O00241-2] ENST00000381605; ENSP00000371018; ENSG00000101307 [O00241-1] |
GeneIDi | 10326 |
UCSCi | uc002wfk.5, human [O00241-1] |
Organism-specific databases
CTDi | 10326 |
DisGeNETi | 10326 |
GeneCardsi | SIRPB1 |
HGNCi | HGNC:15928, SIRPB1 |
HPAi | ENSG00000101307, Tissue enriched (blood) |
MIMi | 603889, gene |
neXtProti | NX_O00241 |
OpenTargetsi | ENSG00000101307 |
PharmGKBi | PA38051 |
VEuPathDBi | HostDB:ENSG00000101307.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1XD, Eukaryota |
GeneTreei | ENSGT00960000186656 |
InParanoidi | O00241 |
OrthoDBi | 904196at2759 |
PhylomeDBi | O00241 |
TreeFami | TF341862 |
Enzyme and pathway databases
PathwayCommonsi | O00241 |
Reactomei | R-HSA-2172127, DAP12 interactions R-HSA-391160, Signal regulatory protein family interactions R-HSA-6798695, Neutrophil degranulation |
Miscellaneous databases
BioGRID-ORCSi | 10326, 6 hits in 981 CRISPR screens |
ChiTaRSi | SIRPB1, human |
EvolutionaryTracei | O00241 |
GeneWikii | SIRPB1 |
GenomeRNAii | 10326 |
Pharosi | O00241, Tbio |
RNActi | O00241, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000101307, Expressed in blood and 136 other tissues |
ExpressionAtlasi | O00241, baseline and differential |
Genevisiblei | O00241, HS |
Family and domain databases
Gene3Di | 2.60.40.10, 3 hits |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003597, Ig_C1-set IPR003599, Ig_sub IPR013106, Ig_V-set |
Pfami | View protein in Pfam PF07654, C1-set, 2 hits PF07686, V-set, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 2 hits SM00407, IGc1, 2 hits |
SUPFAMi | SSF48726, SSF48726, 3 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SIRB1_HUMAN | |
Accessioni | O00241Primary (citable) accession number: O00241 Secondary accession number(s): A6NLM2 Q9Y4V0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2002 |
Last sequence update: | November 2, 2010 | |
Last modified: | April 7, 2021 | |
This is version 188 of the entry and version 5 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references