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Protein

Bone morphogenetic protein receptor type-1B

Gene

BMPR1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1 and GDF5. Positively regulates chondrocyte differentiation through GDF5 interaction.By similarity

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei231ATPPROSITE-ProRule annotation1
Active sitei332Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 218ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: HGNC
  • growth factor binding Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine kinase activity Source: HGNC
  • SMAD binding Source: HGNC
  • transforming growth factor beta-activated receptor activity Source: GO_Central
  • transforming growth factor beta receptor activity, type I Source: GO_Central
  • transmembrane receptor protein serine/threonine kinase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionKinase, Receptor, Serine/threonine-protein kinase, Transferase
Biological processChondrogenesis
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-201451 Signaling by BMP
SignaLinkiO00238
SIGNORiO00238

Names & Taxonomyi

Protein namesi
Recommended name:
Bone morphogenetic protein receptor type-1B (EC:2.7.11.30)
Short name:
BMP type-1B receptor
Short name:
BMPR-1B
Alternative name(s):
CD_antigen: CDw293
Gene namesi
Name:BMPR1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000138696.10
HGNCiHGNC:1077 BMPR1B
MIMi603248 gene
neXtProtiNX_O00238

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini14 – 126ExtracellularSequence analysisAdd BLAST113
Transmembranei127 – 148HelicalSequence analysisAdd BLAST22
Topological domaini149 – 502CytoplasmicSequence analysisAdd BLAST354

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Acromesomelic dysplasia, Demirhan type (AMDD)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of chondrodysplasia. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers). AMDD inheritance is autosomal recessive.
See also OMIM:609441
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07552031R → C in AMDD; unknown pathological significance; mouse BMPR1B construct containing this mutation shows reduced GDF5-dependent receptor activation, mouse BMPR1B construct containing this mutation shows no loss of cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs745854387EnsemblClinVar.1
Natural variantiVAR_07552153C → R in AMDD; mouse BMPR1B construct containing this mutation shows loss of GDF5-dependent receptor activation, chicken BMPR1B construct containing this mutation does not show reduced chondrocyte differentiation, mouse BMPR1B construct containing this mutation shows no loss of cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs863225041EnsemblClinVar.1
Brachydactyly A2 (BDA2)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of brachydactyly. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. In brachydactyly type A2 shortening of the middle phalanges is confined to the index finger and the second toe, all other digits being more or less normal. Because of a rhomboid or triangular shape of the affected middle phalanx, the end of the second finger usually deviates radially.
See also OMIM:112600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023819200I → K in BDA2. 1 PublicationCorresponds to variant dbSNP:rs121434417EnsemblClinVar.1
Natural variantiVAR_023820486R → W in BDA2. 1 PublicationCorresponds to variant dbSNP:rs121434418EnsemblClinVar.1
Brachydactyly A1, D (BDA1D)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of brachydactyly type A1. Brachydactyly defines a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. Brachydactyly type A1 is characterized by middle phalanges of all the digits rudimentary or fused with the terminal phalanges. The proximal phalanges of the thumbs and big toes are short. BDA1D inheritance is autosomal dominant.
See also OMIM:616849
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_076406325K → N in BDA1D; acts in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs869025614EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi658
MalaCardsiBMPR1B
MIMi112600 phenotype
609441 phenotype
616849 phenotype
OpenTargetsiENSG00000138696
Orphaneti2098 Acromesomelic dysplasia, Grebe type
93388 Brachydactyly type A1
93396 Brachydactyly type A2
93384 Brachydactyly type C
2639 Fibular aplasia-complex brachydactyly syndrome
PharmGKBiPA25387

Chemistry databases

ChEMBLiCHEMBL5476
GuidetoPHARMACOLOGYi1789

Polymorphism and mutation databases

BioMutaiBMPR1B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 13Sequence analysisAdd BLAST13
ChainiPRO_000002441214 – 502Bone morphogenetic protein receptor type-1BAdd BLAST489

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 53By similarity
Disulfide bondi34 ↔ 38By similarity
Disulfide bondi47 ↔ 71By similarity
Disulfide bondi81 ↔ 95By similarity
Disulfide bondi96 ↔ 102By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiO00238
MaxQBiO00238
PaxDbiO00238
PeptideAtlasiO00238
PRIDEiO00238
ProteomicsDBi47802

PTM databases

iPTMnetiO00238
PhosphoSitePlusiO00238

Expressioni

Gene expression databases

BgeeiENSG00000138696 Expressed in 175 organ(s), highest expression level in metanephros
CleanExiHS_BMPR1B
ExpressionAtlasiO00238 baseline and differential
GenevisibleiO00238 HS

Interactioni

Subunit structurei

Interacts with high affinity with GDF5; positively regulates chondrocyte differentiation.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107126, 71 interactors
IntActiO00238, 3 interactors
MINTiO00238
STRINGi9606.ENSP00000264568

Chemistry databases

BindingDBiO00238

Structurei

Secondary structure

1502
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00238
SMRiO00238
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00238

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 203GSPROSITE-ProRule annotationAdd BLAST30
Domaini204 – 494Protein kinasePROSITE-ProRule annotationAdd BLAST291

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502
InParanoidiO00238
KOiK13578
OMAiLMMECWA
OrthoDBiEOG091G0BIU
PhylomeDBiO00238
TreeFamiTF314724

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
PRINTSiPR00653 ACTIVIN2R
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00238-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLRSAGKLN VGTKKEDGES TAPTPRPKVL RCKCHHHCPE DSVNNICSTD
60 70 80 90 100
GYCFTMIEED DSGLPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN
110 120 130 140 150
ECNKDLHPTL PPLKNRDFVD GPIHHRALLI SVTVCSLLLV LIILFCYFRY
160 170 180 190 200
KRQETRPRYS IGLEQDETYI PPGESLRDLI EQSQSSGSGS GLPLLVQRTI
210 220 230 240 250
AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS WFRETEIYQT
260 270 280 290 300
VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS
310 320 330 340 350
MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD
360 370 380 390 400
LGLAVKFISD TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM
410 420 430 440 450
YSFGLILWEV ARRCVSGGIV EEYQLPYHDL VPSDPSYEDM REIVCIKKLR
460 470 480 490 500
PSFPNRWSSD ECLRQMGKLM TECWAHNPAS RLTALRVKKT LAKMSESQDI

KL
Length:502
Mass (Da):56,930
Last modified:July 1, 1997 - v1
Checksum:iB283D9BF45535C79
GO
Isoform 2 (identifier: O00238-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MGWLEELNWQLHIFLLILLSMHTRANFLDNM

Show »
Length:532
Mass (Da):60,582
Checksum:i5DF28FF01C96D541
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGW8D6RGW8_HUMAN
Bone morphogenetic protein receptor...
BMPR1B
125Annotation score:
D6RAW8D6RAW8_HUMAN
Bone morphogenetic protein receptor...
BMPR1B
114Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07552031R → C in AMDD; unknown pathological significance; mouse BMPR1B construct containing this mutation shows reduced GDF5-dependent receptor activation, mouse BMPR1B construct containing this mutation shows no loss of cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs745854387EnsemblClinVar.1
Natural variantiVAR_04140131R → H in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs200035802EnsemblClinVar.1
Natural variantiVAR_07552153C → R in AMDD; mouse BMPR1B construct containing this mutation shows loss of GDF5-dependent receptor activation, chicken BMPR1B construct containing this mutation does not show reduced chondrocyte differentiation, mouse BMPR1B construct containing this mutation shows no loss of cell membrane localization. 1 PublicationCorresponds to variant dbSNP:rs863225041EnsemblClinVar.1
Natural variantiVAR_041402149R → W1 PublicationCorresponds to variant dbSNP:rs34231464EnsemblClinVar.1
Natural variantiVAR_023819200I → K in BDA2. 1 PublicationCorresponds to variant dbSNP:rs121434417EnsemblClinVar.1
Natural variantiVAR_041403224R → H1 PublicationCorresponds to variant dbSNP:rs35973133EnsemblClinVar.1
Natural variantiVAR_041404297D → N in a metastatic melanoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_076406325K → N in BDA1D; acts in a dominant-negative manner. 1 PublicationCorresponds to variant dbSNP:rs869025614EnsemblClinVar.1
Natural variantiVAR_041405371R → Q1 PublicationCorresponds to variant dbSNP:rs34970181EnsemblClinVar.1
Natural variantiVAR_037967486R → Q in brachydactyly type C and BDA2; with also additional features of symphalangism-1. 1 PublicationCorresponds to variant dbSNP:rs121434419EnsemblClinVar.1
Natural variantiVAR_023820486R → W in BDA2. 1 PublicationCorresponds to variant dbSNP:rs121434418EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451001M → MGWLEELNWQLHIFLLILLS MHTRANFLDNM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89675 mRNA Translation: BAA19765.1
U89326 mRNA Translation: AAC28131.1
AK299930 mRNA Translation: BAG61763.1
AK313642 mRNA Translation: BAG36400.1
AC004061 Genomic DNA No translation available.
AC092609 Genomic DNA No translation available.
AC093634 Genomic DNA No translation available.
AC105395 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06060.1
BC047773 mRNA Translation: AAH47773.1
BC069796 mRNA Translation: AAH69796.1
BC069803 mRNA Translation: AAH69803.1
CCDSiCCDS3642.1 [O00238-1]
CCDS58919.1 [O00238-2]
RefSeqiNP_001194.1, NM_001203.2 [O00238-1]
NP_001243721.1, NM_001256792.1 [O00238-1]
NP_001243722.1, NM_001256793.1 [O00238-2]
NP_001243723.1, NM_001256794.1 [O00238-1]
XP_011530503.1, XM_011532201.2 [O00238-1]
XP_016864047.1, XM_017008558.1 [O00238-1]
XP_016864048.1, XM_017008559.1 [O00238-1]
XP_016864049.1, XM_017008560.1 [O00238-1]
XP_016864050.1, XM_017008561.1 [O00238-1]
UniGeneiHs.598475

Genome annotation databases

EnsembliENST00000264568; ENSP00000264568; ENSG00000138696 [O00238-1]
ENST00000394931; ENSP00000378389; ENSG00000138696 [O00238-1]
ENST00000440890; ENSP00000401907; ENSG00000138696 [O00238-2]
ENST00000509540; ENSP00000421671; ENSG00000138696 [O00238-1]
ENST00000512312; ENSP00000425444; ENSG00000138696 [O00238-1]
ENST00000515059; ENSP00000426617; ENSG00000138696 [O00238-1]
GeneIDi658
KEGGihsa:658
UCSCiuc003htm.5 human [O00238-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89675 mRNA Translation: BAA19765.1
U89326 mRNA Translation: AAC28131.1
AK299930 mRNA Translation: BAG61763.1
AK313642 mRNA Translation: BAG36400.1
AC004061 Genomic DNA No translation available.
AC092609 Genomic DNA No translation available.
AC093634 Genomic DNA No translation available.
AC105395 Genomic DNA No translation available.
CH471057 Genomic DNA Translation: EAX06060.1
BC047773 mRNA Translation: AAH47773.1
BC069796 mRNA Translation: AAH69796.1
BC069803 mRNA Translation: AAH69803.1
CCDSiCCDS3642.1 [O00238-1]
CCDS58919.1 [O00238-2]
RefSeqiNP_001194.1, NM_001203.2 [O00238-1]
NP_001243721.1, NM_001256792.1 [O00238-1]
NP_001243722.1, NM_001256793.1 [O00238-2]
NP_001243723.1, NM_001256794.1 [O00238-1]
XP_011530503.1, XM_011532201.2 [O00238-1]
XP_016864047.1, XM_017008558.1 [O00238-1]
XP_016864048.1, XM_017008559.1 [O00238-1]
XP_016864049.1, XM_017008560.1 [O00238-1]
XP_016864050.1, XM_017008561.1 [O00238-1]
UniGeneiHs.598475

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MDYX-ray2.05A/C168-502[»]
ProteinModelPortaliO00238
SMRiO00238
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107126, 71 interactors
IntActiO00238, 3 interactors
MINTiO00238
STRINGi9606.ENSP00000264568

Chemistry databases

BindingDBiO00238
ChEMBLiCHEMBL5476
GuidetoPHARMACOLOGYi1789

PTM databases

iPTMnetiO00238
PhosphoSitePlusiO00238

Polymorphism and mutation databases

BioMutaiBMPR1B

Proteomic databases

EPDiO00238
MaxQBiO00238
PaxDbiO00238
PeptideAtlasiO00238
PRIDEiO00238
ProteomicsDBi47802

Protocols and materials databases

DNASUi658
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264568; ENSP00000264568; ENSG00000138696 [O00238-1]
ENST00000394931; ENSP00000378389; ENSG00000138696 [O00238-1]
ENST00000440890; ENSP00000401907; ENSG00000138696 [O00238-2]
ENST00000509540; ENSP00000421671; ENSG00000138696 [O00238-1]
ENST00000512312; ENSP00000425444; ENSG00000138696 [O00238-1]
ENST00000515059; ENSP00000426617; ENSG00000138696 [O00238-1]
GeneIDi658
KEGGihsa:658
UCSCiuc003htm.5 human [O00238-1]

Organism-specific databases

CTDi658
DisGeNETi658
EuPathDBiHostDB:ENSG00000138696.10
GeneCardsiBMPR1B
HGNCiHGNC:1077 BMPR1B
MalaCardsiBMPR1B
MIMi112600 phenotype
603248 gene
609441 phenotype
616849 phenotype
neXtProtiNX_O00238
OpenTargetsiENSG00000138696
Orphaneti2098 Acromesomelic dysplasia, Grebe type
93388 Brachydactyly type A1
93396 Brachydactyly type A2
93384 Brachydactyly type C
2639 Fibular aplasia-complex brachydactyly syndrome
PharmGKBiPA25387
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2052 Eukaryota
ENOG410XQT0 LUCA
GeneTreeiENSGT00760000118876
HOGENOMiHOG000230587
HOVERGENiHBG054502
InParanoidiO00238
KOiK13578
OMAiLMMECWA
OrthoDBiEOG091G0BIU
PhylomeDBiO00238
TreeFamiTF314724

Enzyme and pathway databases

BRENDAi2.7.10.2 2681
ReactomeiR-HSA-201451 Signaling by BMP
SignaLinkiO00238
SIGNORiO00238

Miscellaneous databases

ChiTaRSiBMPR1B human
EvolutionaryTraceiO00238
GeneWikiiBMPR1B
GenomeRNAii658
PROiPR:O00238
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138696 Expressed in 175 organ(s), highest expression level in metanephros
CleanExiHS_BMPR1B
ExpressionAtlasiO00238 baseline and differential
GenevisibleiO00238 HS

Family and domain databases

InterProiView protein in InterPro
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor
PANTHERiPTHR23255 PTHR23255, 1 hit
PfamiView protein in Pfam
PF01064 Activin_recp, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PF08515 TGF_beta_GS, 1 hit
PRINTSiPR00653 ACTIVIN2R
SMARTiView protein in SMART
SM00467 GS, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51256 GS, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBMR1B_HUMAN
AccessioniPrimary (citable) accession number: O00238
Secondary accession number(s): B2R953, B4DSV1, P78366
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 195 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  8. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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