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Protein

E3 ubiquitin-protein ligase RNF103

Gene

RNF103

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri621 – 663RING-typePROSITE-ProRule annotationAdd BLAST43

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-901032 ER Quality Control Compartment (ERQC)

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF103 (EC:2.3.2.27)
Alternative name(s):
KF-1
Short name:
hKF-1
RING finger protein 103
RING-type E3 ubiquitin transferase RNF103Curated
Zinc finger protein 103 homolog
Short name:
Zfp-103
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF103
Synonyms:ZFP103
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000239305.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12859 RNF103

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602507 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00237

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi621C → S: Loss of E2-dependent ubiquitination. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
7844

Open Targets

More...
OpenTargetsi
ENSG00000239305

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37448

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNF103

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000560841 – 685E3 ubiquitin-protein ligase RNF103Add BLAST685

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00237

PeptideAtlas

More...
PeptideAtlasi
O00237

PRoteomics IDEntifications database

More...
PRIDEi
O00237

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47801

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00237

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00237

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the normal cerebellum but not in the cerebral cortex.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000239305 Expressed in 234 organ(s), highest expression level in middle temporal gyrus

CleanEx database of gene expression profiles

More...
CleanExi
HS_RNF103

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00237 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA057922

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DERL1 and VCP.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113601, 13 interactors

Protein interaction database and analysis system

More...
IntActi
O00237, 9 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000237455

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00237

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00237

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri621 – 663RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0800 Eukaryota
ENOG41121N2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006413

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006578

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG054144

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00237

KEGG Orthology (KO)

More...
KOi
K15695

Identification of Orthologs from Complete Genome Data

More...
OMAi
GKVHWEK

Database of Orthologous Groups

More...
OrthoDBi
1487241at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00237

TreeFam database of animal gene trees

More...
TreeFami
TF329229

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13639 zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00184 RING, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50089 ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

O00237-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT
60 70 80 90 100
ILECRGLGYS GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN
110 120 130 140 150
FSGEMHFYEL VEDTKDGIWL VQVIANDRSP LVGKIHWEKM VKKVSRFGIR
160 170 180 190 200
TGTFNCSSDP RYCRRRGWVR STLIMSVPQT STSKGKVMLK EYSGRKIEVE
210 220 230 240 250
HIFKWITAHA ASRIKTIYNA EHLKEEWNKS DQYWLKIYLF ANLDQPPAFF
260 270 280 290 300
SALSIKFTGR VEFIFVNVEN WDNKSYMTDI GIYNMPSYIL RTPEGIYRYG
310 320 330 340 350
NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI
360 370 380 390 400
KRFVVLISTL GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LKLLRYSNTT
410 420 430 440 450
TLASWVRADW MFYSSHPALF LSTYLGHGLL IDYFEKKRRR NNNNDEVNAN
460 470 480 490 500
NLEWLSSLWD WYTSYLFHPI ASFQNFPVES DWDEDPDLFL ERLAFPDLWL
510 520 530 540 550
HPLIPTDYIK NLPMWRFKCL GVQSEEEMSE GSQDTENDSE SENTDTLSSE
560 570 580 590 600
KEVFEDKQSV LHNSPGTASH CDAEACSCAN KYCQTSPCER KGRSYGSYNT
610 620 630 640 650
NEDMEPDWLT WPADMLHCTE CVVCLENFEN GCLLMGLPCG HVFHQNCIVM
660 670 680
WLAGGRHCCP VCRWPSYKKK QPYAQHQPLS NDVPS
Length:685
Mass (Da):79,405
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AE7283EB38F533F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti22F → L in BAG36861 (PubMed:14702039).Curated1
Sequence conflicti251S → P in AAH35053 (PubMed:15489334).Curated1
Sequence conflicti287S → P in BAG36861 (PubMed:14702039).Curated1
Sequence conflicti502P → H in AAH35053 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D76444 mRNA Translation: BAA19739.1
AB052743 Genomic DNA Translation: BAB20900.1
AK314180 mRNA Translation: BAG36861.1
AC015971 Genomic DNA Translation: AAX93079.1
BC035053 mRNA Translation: AAH35053.1
BC110333 mRNA Translation: AAI10334.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33237.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5392

NCBI Reference Sequences

More...
RefSeqi
NP_001185880.1, NM_001198951.1
NP_001185881.1, NM_001198952.1
NP_005658.1, NM_005667.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.469199
Hs.731426

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000237455; ENSP00000237455; ENSG00000239305

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7844

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7844

UCSC genome browser

More...
UCSCi
uc002srn.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D76444 mRNA Translation: BAA19739.1
AB052743 Genomic DNA Translation: BAB20900.1
AK314180 mRNA Translation: BAG36861.1
AC015971 Genomic DNA Translation: AAX93079.1
BC035053 mRNA Translation: AAH35053.1
BC110333 mRNA Translation: AAI10334.1
CCDSiCCDS33237.1
PIRiJC5392
RefSeqiNP_001185880.1, NM_001198951.1
NP_001185881.1, NM_001198952.1
NP_005658.1, NM_005667.3
UniGeneiHs.469199
Hs.731426

3D structure databases

ProteinModelPortaliO00237
SMRiO00237
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113601, 13 interactors
IntActiO00237, 9 interactors
STRINGi9606.ENSP00000237455

PTM databases

iPTMnetiO00237
PhosphoSitePlusiO00237

Polymorphism and mutation databases

BioMutaiRNF103

Proteomic databases

PaxDbiO00237
PeptideAtlasiO00237
PRIDEiO00237
ProteomicsDBi47801

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7844
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237455; ENSP00000237455; ENSG00000239305
GeneIDi7844
KEGGihsa:7844
UCSCiuc002srn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7844
DisGeNETi7844
EuPathDBiHostDB:ENSG00000239305.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RNF103
HGNCiHGNC:12859 RNF103
HPAiHPA057922
MIMi602507 gene
neXtProtiNX_O00237
OpenTargetsiENSG00000239305
PharmGKBiPA37448

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00390000006413
HOGENOMiHOG000006578
HOVERGENiHBG054144
InParanoidiO00237
KOiK15695
OMAiGKVHWEK
OrthoDBi1487241at2759
PhylomeDBiO00237
TreeFamiTF329229

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7844

Protein Ontology

More...
PROi
PR:O00237

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000239305 Expressed in 234 organ(s), highest expression level in middle temporal gyrus
CleanExiHS_RNF103
GenevisibleiO00237 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRN103_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00237
Secondary accession number(s): A6NFV6
, B2RAG4, Q53SU6, Q8IVB9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 1, 1997
Last modified: January 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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