Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

E3 ubiquitin-protein ligase RNF103

Gene

RNF103

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.2 Publications

Catalytic activityi

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri621 – 663RING-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • ubiquitin-protein transferase activity Source: UniProtKB

GO - Biological processi

  • central nervous system development Source: ProtInc
  • endoplasmic reticulum mannose trimming Source: Reactome
  • protein ubiquitination Source: UniProtKB
  • ubiquitin-dependent ERAD pathway Source: UniProtKB

Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-901032 ER Quality Control Compartment (ERQC)
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF103 (EC:2.3.2.27)
Alternative name(s):
KF-1
Short name:
hKF-1
RING finger protein 103
RING-type E3 ubiquitin transferase RNF103Curated
Zinc finger protein 103 homolog
Short name:
Zfp-103
Gene namesi
Name:RNF103
Synonyms:ZFP103
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000239305.6
HGNCiHGNC:12859 RNF103
MIMi602507 gene
neXtProtiNX_O00237

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalSequence analysisAdd BLAST21
Transmembranei326 – 346HelicalSequence analysisAdd BLAST21
Transmembranei366 – 386HelicalSequence analysisAdd BLAST21
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi621C → S: Loss of E2-dependent ubiquitination. 1 Publication1

Organism-specific databases

DisGeNETi7844
OpenTargetsiENSG00000239305
PharmGKBiPA37448

Polymorphism and mutation databases

BioMutaiRNF103

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000560841 – 685E3 ubiquitin-protein ligase RNF103Add BLAST685

Proteomic databases

PaxDbiO00237
PeptideAtlasiO00237
PRIDEiO00237
ProteomicsDBi47801

PTM databases

iPTMnetiO00237
PhosphoSitePlusiO00237

Expressioni

Tissue specificityi

Highly expressed in the normal cerebellum but not in the cerebral cortex.1 Publication

Gene expression databases

BgeeiENSG00000239305
CleanExiHS_RNF103
GenevisibleiO00237 HS

Organism-specific databases

HPAiHPA057922

Interactioni

Subunit structurei

Interacts with DERL1 and VCP.1 Publication

Protein-protein interaction databases

BioGridi113601, 13 interactors
IntActiO00237, 9 interactors
STRINGi9606.ENSP00000237455

Structurei

3D structure databases

ProteinModelPortaliO00237
SMRiO00237
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri621 – 663RING-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00390000006413
HOGENOMiHOG000006578
HOVERGENiHBG054144
InParanoidiO00237
KOiK15695
OMAiGKVHWEK
OrthoDBiEOG091G0EZD
PhylomeDBiO00237
TreeFamiTF329229

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639 zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS50089 ZF_RING_2, 1 hit

Sequencei

Sequence statusi: Complete.

O00237-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWLKLFFLLL YFLVLFVLAR FFEAIVWYET GIFATQLVDP VALSFKKLKT
60 70 80 90 100
ILECRGLGYS GLPEKKDVRE LVEKSGDLME GELYSALKEE EASESVSSTN
110 120 130 140 150
FSGEMHFYEL VEDTKDGIWL VQVIANDRSP LVGKIHWEKM VKKVSRFGIR
160 170 180 190 200
TGTFNCSSDP RYCRRRGWVR STLIMSVPQT STSKGKVMLK EYSGRKIEVE
210 220 230 240 250
HIFKWITAHA ASRIKTIYNA EHLKEEWNKS DQYWLKIYLF ANLDQPPAFF
260 270 280 290 300
SALSIKFTGR VEFIFVNVEN WDNKSYMTDI GIYNMPSYIL RTPEGIYRYG
310 320 330 340 350
NHTGEFISLQ AMDSFLRSLQ PEVNDLFVLS LVLVNLMAWM DLFITQGATI
360 370 380 390 400
KRFVVLISTL GTYNSLLIIS WLPVLGFLQL PYLDSFYEYS LKLLRYSNTT
410 420 430 440 450
TLASWVRADW MFYSSHPALF LSTYLGHGLL IDYFEKKRRR NNNNDEVNAN
460 470 480 490 500
NLEWLSSLWD WYTSYLFHPI ASFQNFPVES DWDEDPDLFL ERLAFPDLWL
510 520 530 540 550
HPLIPTDYIK NLPMWRFKCL GVQSEEEMSE GSQDTENDSE SENTDTLSSE
560 570 580 590 600
KEVFEDKQSV LHNSPGTASH CDAEACSCAN KYCQTSPCER KGRSYGSYNT
610 620 630 640 650
NEDMEPDWLT WPADMLHCTE CVVCLENFEN GCLLMGLPCG HVFHQNCIVM
660 670 680
WLAGGRHCCP VCRWPSYKKK QPYAQHQPLS NDVPS
Length:685
Mass (Da):79,405
Last modified:July 1, 1997 - v1
Checksum:i5AE7283EB38F533F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22F → L in BAG36861 (PubMed:14702039).Curated1
Sequence conflicti251S → P in AAH35053 (PubMed:15489334).Curated1
Sequence conflicti287S → P in BAG36861 (PubMed:14702039).Curated1
Sequence conflicti502P → H in AAH35053 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D76444 mRNA Translation: BAA19739.1
AB052743 Genomic DNA Translation: BAB20900.1
AK314180 mRNA Translation: BAG36861.1
AC015971 Genomic DNA Translation: AAX93079.1
BC035053 mRNA Translation: AAH35053.1
BC110333 mRNA Translation: AAI10334.1
CCDSiCCDS33237.1
PIRiJC5392
RefSeqiNP_001185880.1, NM_001198951.1
NP_001185881.1, NM_001198952.1
NP_005658.1, NM_005667.3
UniGeneiHs.469199
Hs.731426

Genome annotation databases

EnsembliENST00000237455; ENSP00000237455; ENSG00000239305
GeneIDi7844
KEGGihsa:7844
UCSCiuc002srn.4 human

Similar proteinsi

Entry informationi

Entry nameiRN103_HUMAN
AccessioniPrimary (citable) accession number: O00237
Secondary accession number(s): A6NFV6
, B2RAG4, Q53SU6, Q8IVB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 1, 1997
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health