UniProtKB - O00232 (PSD12_HUMAN)
26S proteasome non-ATPase regulatory subunit 12
PSMD12
Functioni
GO - Biological processi
- anaphase-promoting complex-dependent catabolic process Source: Reactome
- antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
- Fc-epsilon receptor signaling pathway Source: Reactome
- interleukin-1-mediated signaling pathway Source: Reactome
- MAPK cascade Source: Reactome
- negative regulation of canonical Wnt signaling pathway Source: Reactome
- negative regulation of G2/M transition of mitotic cell cycle Source: Reactome
- neutrophil degranulation Source: Reactome
- NIK/NF-kappaB signaling Source: Reactome
- positive regulation of canonical Wnt signaling pathway Source: Reactome
- post-translational protein modification Source: Reactome
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein deubiquitination Source: Reactome
- protein polyubiquitination Source: Reactome
- regulation of cellular amino acid metabolic process Source: Reactome
- regulation of hematopoietic stem cell differentiation Source: Reactome
- regulation of mitotic cell cycle phase transition Source: Reactome
- regulation of mRNA stability Source: Reactome
- regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: Reactome
- stimulatory C-type lectin receptor signaling pathway Source: Reactome
- T cell receptor signaling pathway Source: Reactome
- transmembrane transport Source: Reactome
- tumor necrosis factor-mediated signaling pathway Source: Reactome
- Wnt signaling pathway, planar cell polarity pathway Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | O00232 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | Recommended name: 26S proteasome non-ATPase regulatory subunit 12Alternative name(s): 26S proteasome regulatory subunit RPN5 26S proteasome regulatory subunit p55 |
Gene namesi | Name:PSMD12 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197170.9 |
HGNCi | HGNC:9557, PSMD12 |
MIMi | 604450, gene |
neXtProti | NX_O00232 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nuclear proteasome complex Source: GO_Central
- nucleoplasm Source: Reactome
Other locations
- cytoplasm Source: GO_Central
- ficolin-1-rich granule lumen Source: Reactome
- membrane Source: UniProtKB
- proteasome accessory complex Source: UniProtKB
- proteasome complex Source: UniProtKB
- proteasome regulatory particle Source: ProtInc
- proteasome regulatory particle, lid subcomplex Source: GO_Central
- secretory granule lumen Source: Reactome
Keywords - Cellular componenti
ProteasomePathology & Biotechi
Involvement in diseasei
Stankiewicz-Isidor syndrome (STISS)1 Publication
Keywords - Diseasei
Mental retardationOrganism-specific databases
DisGeNETi | 5718 |
MalaCardsi | PSMD12 |
MIMi | 617516, phenotype |
OpenTargetsi | ENSG00000197170 |
Orphaneti | 529962, 17q24.2 microdeletion syndrome 528084, Non-specific syndromic intellectual disability |
PharmGKBi | PA33903 |
Miscellaneous databases
Pharosi | O00232, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
Polymorphism and mutation databases
BioMutai | PSMD12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000173861 | 2 – 456 | 26S proteasome non-ATPase regulatory subunit 12Add BLAST | 455 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Cross-linki | 92 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources | ||
Cross-linki | 92 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Modified residuei | 221 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 368 | N6-acetyllysineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Ubl conjugationProteomic databases
EPDi | O00232 |
jPOSTi | O00232 |
MassIVEi | O00232 |
MaxQBi | O00232 |
PaxDbi | O00232 |
PeptideAtlasi | O00232 |
PRIDEi | O00232 |
ProteomicsDBi | 47797 [O00232-1] 47798 [O00232-2] |
PTM databases
iPTMneti | O00232 |
MetOSitei | O00232 |
PhosphoSitePlusi | O00232 |
SwissPalmi | O00232 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197170, Expressed in heart right ventricle and 242 other tissues |
ExpressionAtlasi | O00232, baseline and differential |
Genevisiblei | O00232, HS |
Organism-specific databases
HPAi | ENSG00000197170, Low tissue specificity |
Interactioni
Subunit structurei
Component of the 19S proteasome regulatory particle complex (PubMed:27428775,PubMed:27342858). The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP) (PubMed:27428775,PubMed:27342858). The regulatory particle is made of a lid composed of 9 subunits including PSMD12, a base containing 6 ATPases and few additional components (PubMed:27428775,PubMed:27342858).
Interacts with ERCC6 (PubMed:26030138).
3 PublicationsBinary interactionsi
O00232
With | #Exp. | IntAct |
---|---|---|
PSMD4 [P55036] | 2 | EBI-359733,EBI-359318 |
Protein-protein interaction databases
BioGRIDi | 111690, 181 interactors |
CORUMi | O00232 |
DIPi | DIP-27549N |
IntActi | O00232, 62 interactors |
MINTi | O00232 |
STRINGi | 9606.ENSP00000348442 |
Miscellaneous databases
RNActi | O00232, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 242 – 420 | PCIPROSITE-ProRule annotationAdd BLAST | 179 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1498, Eukaryota |
GeneTreei | ENSGT00940000153510 |
HOGENOMi | CLU_033860_2_0_1 |
InParanoidi | O00232 |
OMAi | MVQECCT |
OrthoDBi | 937686at2759 |
PhylomeDBi | O00232 |
TreeFami | TF105721 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035297, PSMD12 IPR040134, PSMD12/CSN4 IPR040896, RPN5_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10855, PTHR10855, 1 hit PTHR10855:SF1, PTHR10855:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF18098, RPN5_C, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADGGSERAD GRIVKMEVDY SATVDQRLPE CAKLAKEGRL QEVIETLLSL
60 70 80 90 100
EKQTRTASDM VSTSRILVAV VKMCYEAKEW DLLNENIMLL SKRRSQLKQA
110 120 130 140 150
VAKMVQQCCT YVEEITDLPI KLRLIDTLRM VTEGKIYVEI ERARLTKTLA
160 170 180 190 200
TIKEQNGDVK EAASILQELQ VETYGSMEKK ERVEFILEQM RLCLAVKDYI
210 220 230 240 250
RTQIISKKIN TKFFQEENTE KLKLKYYNLM IQLDQHEGSY LSICKHYRAI
260 270 280 290 300
YDTPCIQAES EKWQQALKSV VLYVILAPFD NEQSDLVHRI SGDKKLEEIP
310 320 330 340 350
KYKDLLKLFT TMELMRWSTL VEDYGMELRK GSLESPATDV FGSTEEGEKR
360 370 380 390 400
WKDLKNRVVE HNIRIMAKYY TRITMKRMAQ LLDLSVDESE AFLSNLVVNK
410 420 430 440 450
TIFAKVDRLA GIINFQRPKD PNNLLNDWSQ KLNSLMSLVN KTTHLIAKEE
MIHNLQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KSK1 | J3KSK1_HUMAN | 26S proteasome non-ATPase regulator... | PSMD12 | 42 | Annotation score: | ||
J3KTJ5 | J3KTJ5_HUMAN | 26S proteasome non-ATPase regulator... | PSMD12 | 38 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 300 | P → S in BAD96399 (Ref. 3) Curated | 1 | |
Sequence conflicti | 398 | V → D in BAD96399 (Ref. 3) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051558 | 358 | V → A. Corresponds to variant dbSNP:rs2230680Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042718 | 37 – 56 | Missing in isoform 2. 1 PublicationAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB003103 mRNA Translation: BAA19749.1 AK091198 mRNA Translation: BAG52303.1 AK222679 mRNA Translation: BAD96399.1 AC110921 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89028.1 BC019062 mRNA Translation: AAH19062.1 BC065826 mRNA Translation: AAH65826.1 Different initiation. |
CCDSi | CCDS11669.1 [O00232-1] CCDS11670.1 [O00232-2] |
PIRi | PC6501, JC6523 |
RefSeqi | NP_001303270.1, NM_001316341.1 NP_002807.1, NM_002816.4 [O00232-1] NP_777360.1, NM_174871.3 [O00232-2] |
Genome annotation databases
Ensembli | ENST00000356126; ENSP00000348442; ENSG00000197170 [O00232-1] ENST00000357146; ENSP00000349667; ENSG00000197170 [O00232-2] |
GeneIDi | 5718 |
KEGGi | hsa:5718 |
UCSCi | uc002jfy.4, human [O00232-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB003103 mRNA Translation: BAA19749.1 AK091198 mRNA Translation: BAG52303.1 AK222679 mRNA Translation: BAD96399.1 AC110921 Genomic DNA No translation available. CH471099 Genomic DNA Translation: EAW89028.1 BC019062 mRNA Translation: AAH19062.1 BC065826 mRNA Translation: AAH65826.1 Different initiation. |
CCDSi | CCDS11669.1 [O00232-1] CCDS11670.1 [O00232-2] |
PIRi | PC6501, JC6523 |
RefSeqi | NP_001303270.1, NM_001316341.1 NP_002807.1, NM_002816.4 [O00232-1] NP_777360.1, NM_174871.3 [O00232-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5GJQ | electron microscopy | 4.50 | P | 1-456 | [»] | |
5GJR | electron microscopy | 3.50 | 3/P | 1-456 | [»] | |
5L4K | electron microscopy | 4.50 | P | 1-456 | [»] | |
5LN3 | electron microscopy | 6.80 | P | 1-456 | [»] | |
5M32 | electron microscopy | 3.80 | k | 1-456 | [»] | |
5T0C | electron microscopy | 3.80 | AW/BW | 1-456 | [»] | |
5T0G | electron microscopy | 4.40 | W | 1-456 | [»] | |
5T0H | electron microscopy | 6.80 | W | 1-456 | [»] | |
5T0I | electron microscopy | 8.00 | W | 1-456 | [»] | |
5T0J | electron microscopy | 8.00 | W | 1-456 | [»] | |
5VFP | electron microscopy | 4.20 | W | 1-456 | [»] | |
5VFQ | electron microscopy | 4.20 | W | 1-456 | [»] | |
5VFR | electron microscopy | 4.90 | W | 1-456 | [»] | |
5VFS | electron microscopy | 3.60 | W | 1-456 | [»] | |
5VFT | electron microscopy | 7.00 | W | 1-456 | [»] | |
5VFU | electron microscopy | 5.80 | W | 1-456 | [»] | |
5VGZ | electron microscopy | 3.70 | W | 1-456 | [»] | |
5VHF | electron microscopy | 5.70 | W | 1-456 | [»] | |
5VHH | electron microscopy | 6.10 | W | 1-456 | [»] | |
5VHI | electron microscopy | 6.80 | W | 1-456 | [»] | |
5VHS | electron microscopy | 8.80 | W | 1-456 | [»] | |
6MSB | electron microscopy | 3.00 | W | 1-456 | [»] | |
6MSD | electron microscopy | 3.20 | W | 1-456 | [»] | |
6MSE | electron microscopy | 3.30 | W | 1-456 | [»] | |
6MSG | electron microscopy | 3.50 | W | 1-456 | [»] | |
6MSH | electron microscopy | 3.60 | W | 1-456 | [»] | |
6MSJ | electron microscopy | 3.30 | W | 1-456 | [»] | |
6MSK | electron microscopy | 3.20 | W | 1-456 | [»] | |
6WJD | electron microscopy | 4.80 | W | 1-456 | [»] | |
6WJN | electron microscopy | 5.70 | W | 1-456 | [»] | |
SMRi | O00232 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111690, 181 interactors |
CORUMi | O00232 |
DIPi | DIP-27549N |
IntActi | O00232, 62 interactors |
MINTi | O00232 |
STRINGi | 9606.ENSP00000348442 |
Chemistry databases
ChEMBLi | CHEMBL2364701 |
PTM databases
iPTMneti | O00232 |
MetOSitei | O00232 |
PhosphoSitePlusi | O00232 |
SwissPalmi | O00232 |
Polymorphism and mutation databases
BioMutai | PSMD12 |
Proteomic databases
EPDi | O00232 |
jPOSTi | O00232 |
MassIVEi | O00232 |
MaxQBi | O00232 |
PaxDbi | O00232 |
PeptideAtlasi | O00232 |
PRIDEi | O00232 |
ProteomicsDBi | 47797 [O00232-1] 47798 [O00232-2] |
Protocols and materials databases
Antibodypediai | 19204, 205 antibodies |
DNASUi | 5718 |
Genome annotation databases
Ensembli | ENST00000356126; ENSP00000348442; ENSG00000197170 [O00232-1] ENST00000357146; ENSP00000349667; ENSG00000197170 [O00232-2] |
GeneIDi | 5718 |
KEGGi | hsa:5718 |
UCSCi | uc002jfy.4, human [O00232-1] |
Organism-specific databases
CTDi | 5718 |
DisGeNETi | 5718 |
EuPathDBi | HostDB:ENSG00000197170.9 |
GeneCardsi | PSMD12 |
HGNCi | HGNC:9557, PSMD12 |
HPAi | ENSG00000197170, Low tissue specificity |
MalaCardsi | PSMD12 |
MIMi | 604450, gene 617516, phenotype |
neXtProti | NX_O00232 |
OpenTargetsi | ENSG00000197170 |
Orphaneti | 529962, 17q24.2 microdeletion syndrome 528084, Non-specific syndromic intellectual disability |
PharmGKBi | PA33903 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1498, Eukaryota |
GeneTreei | ENSGT00940000153510 |
HOGENOMi | CLU_033860_2_0_1 |
InParanoidi | O00232 |
OMAi | MVQECCT |
OrthoDBi | 937686at2759 |
PhylomeDBi | O00232 |
TreeFami | TF105721 |
Enzyme and pathway databases
PathwayCommonsi | O00232 |
Reactomei | R-HSA-1169091, Activation of NF-kappaB in B cells R-HSA-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-1236974, ER-Phagosome pathway R-HSA-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-HSA-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-HSA-174113, SCF-beta-TrCP mediated degradation of Emi1 R-HSA-174154, APC/C:Cdc20 mediated degradation of Securin R-HSA-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-HSA-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-HSA-180534, Vpu mediated degradation of CD4 R-HSA-180585, Vif-mediated degradation of APOBEC3G R-HSA-187577, SCF(Skp2)-mediated degradation of p27/p21 R-HSA-195253, Degradation of beta-catenin by the destruction complex R-HSA-202424, Downstream TCR signaling R-HSA-211733, Regulation of activated PAK-2p34 by proteasome mediated degradation R-HSA-2467813, Separation of Sister Chromatids R-HSA-2871837, FCERI mediated NF-kB activation R-HSA-349425, Autodegradation of the E3 ubiquitin ligase COP1 R-HSA-350562, Regulation of ornithine decarboxylase (ODC) R-HSA-382556, ABC-family proteins mediated transport R-HSA-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-HSA-4608870, Asymmetric localization of PCP proteins R-HSA-4641257, Degradation of AXIN R-HSA-4641258, Degradation of DVL R-HSA-5358346, Hedgehog ligand biogenesis R-HSA-5362768, Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5607764, CLEC7A (Dectin-1) signaling R-HSA-5610780, Degradation of GLI1 by the proteasome R-HSA-5610783, Degradation of GLI2 by the proteasome R-HSA-5610785, GLI3 is processed to GLI3R by the proteasome R-HSA-5632684, Hedgehog 'on' state R-HSA-5658442, Regulation of RAS by GAPs R-HSA-5668541, TNFR2 non-canonical NF-kB pathway R-HSA-5676590, NIK-->noncanonical NF-kB signaling R-HSA-5678895, Defective CFTR causes cystic fibrosis R-HSA-5687128, MAPK6/MAPK4 signaling R-HSA-5689603, UCH proteinases R-HSA-5689880, Ub-specific processing proteases R-HSA-6798695, Neutrophil degranulation R-HSA-68827, CDT1 association with the CDC6:ORC:origin complex R-HSA-68949, Orc1 removal from chromatin R-HSA-69017, CDK-mediated phosphorylation and removal of Cdc6 R-HSA-69481, G2/M Checkpoints R-HSA-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-HSA-75815, Ubiquitin-dependent degradation of Cyclin D R-HSA-8852276, The role of GTSE1 in G2/M progression after G2 checkpoint R-HSA-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-8941858, Regulation of RUNX3 expression and activity R-HSA-8948751, Regulation of PTEN stability and activity R-HSA-8951664, Neddylation R-HSA-9010553, Regulation of expression of SLITs and ROBOs R-HSA-9020702, Interleukin-1 signaling R-HSA-9604323, Negative regulation of NOTCH4 signaling R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 5718, 750 hits in 847 CRISPR screens |
ChiTaRSi | PSMD12, human |
GeneWikii | PSMD12 |
GenomeRNAii | 5718 |
Pharosi | O00232, Tbio |
PROi | PR:O00232 |
RNActi | O00232, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000197170, Expressed in heart right ventricle and 242 other tissues |
ExpressionAtlasi | O00232, baseline and differential |
Genevisiblei | O00232, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000717, PCI_dom IPR035297, PSMD12 IPR040134, PSMD12/CSN4 IPR040896, RPN5_C IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
PANTHERi | PTHR10855, PTHR10855, 1 hit PTHR10855:SF1, PTHR10855:SF1, 1 hit |
Pfami | View protein in Pfam PF01399, PCI, 1 hit PF18098, RPN5_C, 1 hit |
SMARTi | View protein in SMART SM00088, PINT, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS50250, PCI, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PSD12_HUMAN | |
Accessioni | O00232Primary (citable) accession number: O00232 Secondary accession number(s): A6NP15, Q53HA2, Q6P053 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2002 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations