Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cortistatin

Gene

CORT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.

GO - Molecular functioni

  • G protein-coupled receptor binding Source: UniProtKB
  • neuropeptide hormone activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiO00230

Names & Taxonomyi

Protein namesi
Recommended name:
Cortistatin
Cleaved into the following 2 chains:
Gene namesi
Name:CORT
ORF Names:UNQ307/PRO350
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000241563.3
HGNCiHGNC:2257 CORT
MIMi602784 gene
neXtProtiNX_O00230

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi1325
OpenTargetsiENSG00000241563
PharmGKBiPA26773

Polymorphism and mutation databases

BioMutaiCORT

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000003315419 – 74Sequence analysisAdd BLAST56
PeptideiPRO_000003315577 – 105Cortistatin-29Sequence analysisAdd BLAST29
PeptideiPRO_000003315689 – 105Cortistatin-17Add BLAST17

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi93 ↔ 104By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiO00230
PeptideAtlasiO00230
PRIDEiO00230
ProteomicsDBi47795

PTM databases

iPTMnetiO00230
PhosphoSitePlusiO00230

Expressioni

Tissue specificityi

Expressed in a subset of GABAergic cells in the cortex and hippocampus.

Gene expression databases

BgeeiENSG00000241563 Expressed in 83 organ(s), highest expression level in putamen
CleanExiHS_CORT
GenevisibleiO00230 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107718, 7 interactors
STRINGi9606.ENSP00000366248

Structurei

3D structure databases

ProteinModelPortaliO00230
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatostatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J3SG Eukaryota
ENOG411196C LUCA
GeneTreeiENSGT00730000111752
HOVERGENiHBG017816
InParanoidiO00230
KOiK05238
OMAiRMPLPLC
OrthoDBiEOG091G157X
PhylomeDBiO00230

Family and domain databases

InterProiView protein in InterPro
IPR004250 Somatostatin
IPR018142 Somatostatin/Cortistatin_C
PfamiView protein in Pfam
PF03002 Somatostatin, 1 hit
PIRSFiPIRSF001814 Somatostatin, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00230-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL
60 70 80 90 100
AWWFEWTSQA SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT

FSSCK
Length:105
Mass (Da):11,532
Last modified:July 1, 1997 - v1
Checksum:i09578F4520201551
GO

Sequence cautioni

The sequence AAI19725 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI19726 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ89950 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW71650 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000263 mRNA Translation: BAA19770.1
AF013252 mRNA Translation: AAB66895.1
AL354956 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71650.1 Different initiation.
BC119724 mRNA Translation: AAI19725.1 Different initiation.
BC119725 mRNA Translation: AAI19726.1 Different initiation.
AY358561 mRNA Translation: AAQ89950.1 Different initiation.
CCDSiCCDS117.2
PIRiJC5414
RefSeqiNP_001293.3, NM_001302.4
UniGeneiHs.412311

Genome annotation databases

EnsembliENST00000377049; ENSP00000366248; ENSG00000241563
GeneIDi1325
KEGGihsa:1325
UCSCiuc001ari.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000263 mRNA Translation: BAA19770.1
AF013252 mRNA Translation: AAB66895.1
AL354956 Genomic DNA No translation available.
CH471130 Genomic DNA Translation: EAW71650.1 Different initiation.
BC119724 mRNA Translation: AAI19725.1 Different initiation.
BC119725 mRNA Translation: AAI19726.1 Different initiation.
AY358561 mRNA Translation: AAQ89950.1 Different initiation.
CCDSiCCDS117.2
PIRiJC5414
RefSeqiNP_001293.3, NM_001302.4
UniGeneiHs.412311

3D structure databases

ProteinModelPortaliO00230
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107718, 7 interactors
STRINGi9606.ENSP00000366248

PTM databases

iPTMnetiO00230
PhosphoSitePlusiO00230

Polymorphism and mutation databases

BioMutaiCORT

Proteomic databases

PaxDbiO00230
PeptideAtlasiO00230
PRIDEiO00230
ProteomicsDBi47795

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377049; ENSP00000366248; ENSG00000241563
GeneIDi1325
KEGGihsa:1325
UCSCiuc001ari.5 human

Organism-specific databases

CTDi1325
DisGeNETi1325
EuPathDBiHostDB:ENSG00000241563.3
GeneCardsiCORT
HGNCiHGNC:2257 CORT
MIMi602784 gene
neXtProtiNX_O00230
OpenTargetsiENSG00000241563
PharmGKBiPA26773
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3SG Eukaryota
ENOG411196C LUCA
GeneTreeiENSGT00730000111752
HOVERGENiHBG017816
InParanoidiO00230
KOiK05238
OMAiRMPLPLC
OrthoDBiEOG091G157X
PhylomeDBiO00230

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
SIGNORiO00230

Miscellaneous databases

GeneWikiiCortistatin_(neuropeptide)
GenomeRNAii1325
PROiPR:O00230
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241563 Expressed in 83 organ(s), highest expression level in putamen
CleanExiHS_CORT
GenevisibleiO00230 HS

Family and domain databases

InterProiView protein in InterPro
IPR004250 Somatostatin
IPR018142 Somatostatin/Cortistatin_C
PfamiView protein in Pfam
PF03002 Somatostatin, 1 hit
PIRSFiPIRSF001814 Somatostatin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCORT_HUMAN
AccessioniPrimary (citable) accession number: O00230
Secondary accession number(s): Q5T6G0, Q6UX11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again