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UniProtKB - O00230 (CORT_HUMAN)
Protein
Cortistatin
Gene
CORT
Organism
Homo sapiens (Human)
Status
Functioni
Binds to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
GO - Molecular functioni
- chromatin binding Source: GO_Central
- G protein-coupled receptor binding Source: UniProtKB
- neuropeptide hormone activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
- chemical synaptic transmission Source: UniProtKB
- replication fork processing Source: GO_Central
- resolution of meiotic recombination intermediates Source: GO_Central
Keywordsi
Molecular function | Hormone |
Enzyme and pathway databases
PathwayCommonsi | O00230 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | O00230 |
SIGNORi | O00230 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CORT ORF Names:UNQ307/PRO350 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2257, CORT |
MIMi | 602784, gene |
neXtProti | NX_O00230 |
VEuPathDBi | HostDB:ENSG00000241563 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: UniProtKB
Nucleus
- FANCM-MHF complex Source: GO_Central
- Fanconi anaemia nuclear complex Source: GO_Central
Other locations
- synapse Source: GOC
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 1325 |
OpenTargetsi | ENSG00000241563 |
PharmGKBi | PA26773 |
Miscellaneous databases
Pharosi | O00230, Tbio |
Genetic variation databases
BioMutai | CORT |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
PropeptideiPRO_0000033154 | 19 – 74 | Sequence analysisAdd BLAST | 56 | |
PeptideiPRO_0000033155 | 77 – 105 | Cortistatin-29Sequence analysisAdd BLAST | 29 | |
PeptideiPRO_0000033156 | 89 – 105 | Cortistatin-17Add BLAST | 17 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 93 ↔ 104 | By similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bondProteomic databases
MassIVEi | O00230 |
PaxDbi | O00230 |
PeptideAtlasi | O00230 |
PRIDEi | O00230 |
ProteomicsDBi | 47795 |
PTM databases
iPTMneti | O00230 |
PhosphoSitePlusi | O00230 |
Expressioni
Tissue specificityi
Expressed in a subset of GABAergic cells in the cortex and hippocampus.
Gene expression databases
Bgeei | ENSG00000241563, Expressed in putamen and 105 other tissues |
Genevisiblei | O00230, HS |
Organism-specific databases
HPAi | ENSG00000241563, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Cortistatin-17 (PRO_0000033156)
With | #Exp. | IntAct |
---|---|---|
Amyloid-beta protein 42 (PRO_0000000092) | 4 | EBI-20824092,EBI-821758 |
GO - Molecular functioni
- G protein-coupled receptor binding Source: UniProtKB
- neuropeptide hormone activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107718, 20 interactors |
IntActi | O00230, 3 interactors |
STRINGi | 9606.ENSP00000366248 |
Miscellaneous databases
RNActi | O00230, protein |
Structurei
3D structure databases
AlphaFoldDBi | O00230 |
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PDBe-KBi | Search... |
Family & Domainsi
Sequence similaritiesi
Belongs to the somatostatin family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S1NT, Eukaryota |
GeneTreei | ENSGT00730000111752 |
HOGENOMi | CLU_124515_0_0_1 |
InParanoidi | O00230 |
OMAi | SGHMQEV |
OrthoDBi | 1614009at2759 |
PhylomeDBi | O00230 |
Family and domain databases
InterProi | View protein in InterPro IPR004250, Somatostatin IPR018142, Somatostatin/Cortistatin_C |
Pfami | View protein in Pfam PF03002, Somatostatin, 1 hit |
PIRSFi | PIRSF001814, Somatostatin, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O00230-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLSPGLLLL LLSGATATAA LPLEGGPTGR DSEHMQEAAG IRKSSLLTFL
60 70 80 90 100
AWWFEWTSQA SAGPLIGEEA REVARRQEGA PPQQSARRDR MPCRNFFWKT
FSSCK
Sequence cautioni
The sequence AAI19725 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAI19726 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAQ89950 differs from that shown. Reason: Erroneous initiation.Curated
The sequence EAW71650 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB000263 mRNA Translation: BAA19770.1 AF013252 mRNA Translation: AAB66895.1 AL354956 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71650.1 Different initiation. BC119724 mRNA Translation: AAI19725.1 Different initiation. BC119725 mRNA Translation: AAI19726.1 Different initiation. AY358561 mRNA Translation: AAQ89950.1 Different initiation. |
CCDSi | CCDS117.2 |
PIRi | JC5414 |
RefSeqi | NP_001293.3, NM_001302.4 |
Genome annotation databases
Ensembli | ENST00000377049.4; ENSP00000366248.4; ENSG00000241563.4 |
GeneIDi | 1325 |
KEGGi | hsa:1325 |
MANE-Selecti | ENST00000377049.4; ENSP00000366248.4; NM_001302.5; NP_001293.3 |
UCSCi | uc001ari.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB000263 mRNA Translation: BAA19770.1 AF013252 mRNA Translation: AAB66895.1 AL354956 Genomic DNA No translation available. CH471130 Genomic DNA Translation: EAW71650.1 Different initiation. BC119724 mRNA Translation: AAI19725.1 Different initiation. BC119725 mRNA Translation: AAI19726.1 Different initiation. AY358561 mRNA Translation: AAQ89950.1 Different initiation. |
CCDSi | CCDS117.2 |
PIRi | JC5414 |
RefSeqi | NP_001293.3, NM_001302.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
7VDL | electron microscopy | 3.22 | L | 92-105 | [»] | |
7VV4 | electron microscopy | 2.97 | L | 92-105 | [»] | |
AlphaFoldDBi | O00230 | |||||
ModBasei | Search... | |||||
SWISS-MODEL-Workspacei | Submit a new modelling project... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 107718, 20 interactors |
IntActi | O00230, 3 interactors |
STRINGi | 9606.ENSP00000366248 |
PTM databases
iPTMneti | O00230 |
PhosphoSitePlusi | O00230 |
Genetic variation databases
BioMutai | CORT |
Proteomic databases
MassIVEi | O00230 |
PaxDbi | O00230 |
PeptideAtlasi | O00230 |
PRIDEi | O00230 |
ProteomicsDBi | 47795 |
Protocols and materials databases
Antibodypediai | 57276, 51 antibodies from 11 providers |
DNASUi | 1325 |
Genome annotation databases
Ensembli | ENST00000377049.4; ENSP00000366248.4; ENSG00000241563.4 |
GeneIDi | 1325 |
KEGGi | hsa:1325 |
MANE-Selecti | ENST00000377049.4; ENSP00000366248.4; NM_001302.5; NP_001293.3 |
UCSCi | uc001ari.5, human |
Organism-specific databases
CTDi | 1325 |
DisGeNETi | 1325 |
GeneCardsi | CORT |
HGNCi | HGNC:2257, CORT |
HPAi | ENSG00000241563, Tissue enriched (brain) |
MIMi | 602784, gene |
neXtProti | NX_O00230 |
OpenTargetsi | ENSG00000241563 |
PharmGKBi | PA26773 |
VEuPathDBi | HostDB:ENSG00000241563 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1NT, Eukaryota |
GeneTreei | ENSGT00730000111752 |
HOGENOMi | CLU_124515_0_0_1 |
InParanoidi | O00230 |
OMAi | SGHMQEV |
OrthoDBi | 1614009at2759 |
PhylomeDBi | O00230 |
Enzyme and pathway databases
PathwayCommonsi | O00230 |
Reactomei | R-HSA-375276, Peptide ligand-binding receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | O00230 |
SIGNORi | O00230 |
Miscellaneous databases
BioGRID-ORCSi | 1325, 29 hits in 1032 CRISPR screens |
ChiTaRSi | CORT, human |
GeneWikii | Cortistatin_(neuropeptide) |
GenomeRNAii | 1325 |
Pharosi | O00230, Tbio |
PROi | PR:O00230 |
RNActi | O00230, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000241563, Expressed in putamen and 105 other tissues |
Genevisiblei | O00230, HS |
Family and domain databases
InterProi | View protein in InterPro IPR004250, Somatostatin IPR018142, Somatostatin/Cortistatin_C |
Pfami | View protein in Pfam PF03002, Somatostatin, 1 hit |
PIRSFi | PIRSF001814, Somatostatin, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CORT_HUMAN | |
Accessioni | O00230Primary (citable) accession number: O00230 Secondary accession number(s): Q5T6G0, Q6UX11 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1998 |
Last sequence update: | July 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families