UniProtKB - O00222 (GRM8_HUMAN)

BLAST

>sp|O00222|GRM8_HUMAN Metabotropic glutamate receptor 8 OS=Homo sapiens OX=9606 GN=GRM8 PE=1 SV=2
MVCEGKRSASCPCFFLLTAKFYWILTMMQRTHSQEYAHSIRVDGDIILGGLFPVHAKGER
GVPCGELKKEKGIHRLEAMLYAIDQINKDPDLLSNITLGVRILDTCSRDTYALEQSLTFV
QALIEKDASDVKCANGDPPIFTKPDKISGVIGAAASSVSIMVANILRLFKIPQISYASTA
PELSDNTRYDFFSRVVPPDSYQAQAMVDIVTALGWNYVSTLASEGNYGESGVEAFTQISR
EIGGVCIAQSQKIPREPRPGEFEKIIKRLLETPNARAVIMFANEDDIRRILEAAKKLNQS
GHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRASIDGFDRYFRSRTLANNRRNVWFA
EFWEENFGCKLGSHGKRNSHIKKCTGLERIARDSSYEQEGKVQFVIDAVYSMAYALHNMH
KDLCPGYIGLCPRMSTIDGKELLGYIRAVNFNGSAGTPVTFNENGDAPGRYDIFQYQITN
KSTEYKVIGHWTNQLHLKVEDMQWAHREHTHPASVCSLPCKPGERKKTVKGVPCCWHCER
CEGYNYQVDELSCELCPLDQRPNMNRTGCQLIPIIKLEWHSPWAVVPVFVAILGIIATTF
VIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYSITFLMIAAPDTIICSFRRVFLGLGMC
FSYAALLTKTNRIHRIFEQGKKSVTAPKFISPASQLVITFSLISVQLLGVFVWFVVDPPH
IIIDYGEQRTLDPEKARGVLKCDISDLSLICSLGYSILLMVTCTVYAIKTRGVPETFNEA
KPIGFTMYTTCIIWLAFIPIFFGTAQSAEKMYIQTTTLTVSMSLSASVSLGMLYMPKVYI
IIFHPEQNVQKRKRSFKAVVTAATMQSKLIQKGNDRPNGEVKSELCESLETNTSSTKTTY
ISYSNHSI

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History
Entry version 170 (07 Nov 2018)
Sequence version 2 (01 Dec 2000)
Previous versions | rss
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Protein

Metabotropic glutamate receptor 8

Gene

GRM8

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	156	GlutamateBy similarity	1
Binding siteⁱ	227	GlutamateBy similarity	1
Binding siteⁱ	309	GlutamateBy similarity	1
Binding siteⁱ	401	GlutamateBy similarity	1

GO - Molecular functionⁱ

glutamate receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9473604
G protein-coupled receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9473604

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 9473604
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 11166323
G protein-coupled glutamate receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
G protein-coupled receptor signaling pathway Source: Reactome
regulation of synaptic transmission, glutamatergic
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
visual perception
Source: ProtInc
Traceable author statementⁱ
- 9473604

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer
Biological process	Sensory transduction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Metabotropic glutamate receptor 8 Short name: mGluR8
Gene namesⁱ	Name:GRM8 Synonyms:GPRC1H, MGLUR8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000179603.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4600 GRM8
MIMⁱ	601116 gene
neXtProtⁱ	NX_O00222

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	34 – 583	ExtracellularSequence analysisAdd BLAST	550
Transmembraneⁱ	584 – 608	Helical; Name=1Sequence analysisAdd BLAST	25
Topological domainⁱ	609 – 620	CytoplasmicSequence analysisAdd BLAST	12
Transmembraneⁱ	621 – 641	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	642 – 647	ExtracellularSequence analysis	6
Transmembraneⁱ	648 – 668	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	669 – 695	CytoplasmicSequence analysisAdd BLAST	27
Transmembraneⁱ	696 – 716	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	717 – 746	ExtracellularSequence analysisAdd BLAST	30
Transmembraneⁱ	747 – 768	Helical; Name=5Sequence analysisAdd BLAST	22
Topological domainⁱ	769 – 781	CytoplasmicSequence analysisAdd BLAST	13
Transmembraneⁱ	782 – 803	Helical; Name=6Sequence analysisAdd BLAST	22
Topological domainⁱ	804 – 818	ExtracellularSequence analysisAdd BLAST	15
Transmembraneⁱ	819 – 843	Helical; Name=7Sequence analysisAdd BLAST	25
Topological domainⁱ	844 – 908	CytoplasmicSequence analysisAdd BLAST	65

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2918
Open Targets More...OpenTargetsⁱ	ENSG00000179603
PharmGKBⁱ	PA28997

Chemistry databases

ChEMBLⁱ	CHEMBL3228
Drug and drug target database More...DrugBankⁱ	DB00142 L-Glutamic Acid
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	296

Polymorphism and mutation databases

BioMutaⁱ	GRM8

BioMutaⁱ

GRM8

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 33	Sequence analysisAdd BLAST		33
ChainⁱPRO_0000012941	34 – 908	Metabotropic glutamate receptor 8Add BLAST		875

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	64 ↔ 106	By similarity
Glycosylationⁱ	95	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	246 ↔ 534	By similarity
Glycosylationⁱ	298	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	369 ↔ 384	By similarity
Disulfide bondⁱ	424 ↔ 431	By similarity
Glycosylationⁱ	452	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	480	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	516 ↔ 535	By similarity
Disulfide bondⁱ	520 ↔ 538	By similarity
Disulfide bondⁱ	541 ↔ 553	By similarity
Disulfide bondⁱ	556 ↔ 569	By similarity
Glycosylationⁱ	565	N-linked (GlcNAc...) asparagineSequence analysis	1
Cross-linkⁱ	882	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbⁱ	O00222
PeptideAtlas More...PeptideAtlasⁱ	O00222
PRIDEⁱ	O00222
ProteomicsDBⁱ	47792 47793 [O00222-2] 47794 [O00222-3]

PTM databases

iPTMnetⁱ	O00222
PhosphoSitePlusⁱ	O00222

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000179603 Expressed in 138 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_GRM8
ExpressionAtlasⁱ	O00222 baseline and differential
Genevisibleⁱ	O00222 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA051481

HPAⁱ

HPA051481

Interactionⁱ

Subunit structureⁱ

Interacts with PICK1.By similarity

Protein-protein interaction databases

CORUMⁱ	O00222
STRINGⁱ	9606.ENSP00000344173

Chemistry databases

BindingDBⁱ

O00222

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	39 – 42	Combined sources	4
Beta strandⁱ	45 – 52	Combined sources	8
Beta strandⁱ	55 – 57	Combined sources	3
Beta strandⁱ	63 – 67	Combined sources	5
Turnⁱ	69 – 72	Combined sources	4
Helixⁱ	73 – 88	Combined sources	16
Turnⁱ	92 – 95	Combined sources	4
Beta strandⁱ	98 – 104	Combined sources	7
Helixⁱ	109 – 116	Combined sources	8
Helixⁱ	117 – 119	Combined sources	3
Beta strandⁱ	147 – 151	Combined sources	5
Helixⁱ	156 – 166	Combined sources	11
Turnⁱ	167 – 170	Combined sources	4
Beta strandⁱ	173 – 177	Combined sources	5
Helixⁱ	181 – 184	Combined sources	4
Turnⁱ	186 – 188	Combined sources	3
Beta strandⁱ	192 – 196	Combined sources	5
Helixⁱ	199 – 213	Combined sources	15
Beta strandⁱ	217 – 225	Combined sources	9
Helixⁱ	226 – 241	Combined sources	16
Beta strandⁱ	242 – 244	Combined sources	3
Beta strandⁱ	246 – 253	Combined sources	8
Helixⁱ	261 – 269	Combined sources	9
Beta strandⁱ	277 – 281	Combined sources	5
Helixⁱ	284 – 296	Combined sources	13
Turnⁱ	300 – 302	Combined sources	3
Beta strandⁱ	304 – 307	Combined sources	4
Turnⁱ	309 – 313	Combined sources	5
Turnⁱ	316 – 320	Combined sources	5
Turnⁱ	322 – 327	Combined sources	6
Beta strandⁱ	329 – 334	Combined sources	6
Helixⁱ	339 – 346	Combined sources	8
Turnⁱ	350 – 352	Combined sources	3
Helixⁱ	359 – 367	Combined sources	9
Turnⁱ	390 – 392	Combined sources	3
Helixⁱ	402 – 423	Combined sources	22
Beta strandⁱ	424 – 426	Combined sources	3
Helixⁱ	432 – 434	Combined sources	3
Helixⁱ	439 – 448	Combined sources	10
Beta strandⁱ	450 – 452	Combined sources	3
Beta strandⁱ	458 – 460	Combined sources	3
Beta strandⁱ	463 – 465	Combined sources	3
Beta strandⁱ	470 – 478	Combined sources	9
Beta strandⁱ	483 – 497	Combined sources	15
Helixⁱ	499 – 501	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	O00222
SMRⁱ	O00222
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	177 – 179	Glutamate bindingBy similarity		3

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 3 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118884
HOVERGENⁱ	HBG107965
InParanoidⁱ	O00222
KEGG Orthology (KO) More...KOⁱ	K04608
OMAⁱ	TYVHAIA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G177R
PhylomeDBⁱ	O00222
TreeFamⁱ	TF313240

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR000162 GPCR_3_mtglu_rcpt IPR000144 GPCR_3_mtglu_rcpt_8 IPR028082 Peripla_BP_I
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR PR01058 MTABOTROPC8R PR00593 MTABOTROPICR
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform A (identifier: O00222-1) [UniParc]FASTA Add to basket

Also known as: mGluR8a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG 
        60         70         80         90        100
LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV 
       110        120        130        140        150
RILDTCSRDT YALEQSLTFV QALIEKDASD VKCANGDPPI FTKPDKISGV 
       160        170        180        190        200
IGAAASSVSI MVANILRLFK IPQISYASTA PELSDNTRYD FFSRVVPPDS 
       210        220        230        240        250
YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR EIGGVCIAQS 
       260        270        280        290        300
QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 
       310        320        330        340        350
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL 
       360        370        380        390        400
ANNRRNVWFA EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG 
       410        420        430        440        450
KVQFVIDAVY SMAYALHNMH KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN 
       460        470        480        490        500
FNGSAGTPVT FNENGDAPGR YDIFQYQITN KSTEYKVIGH WTNQLHLKVE 
       510        520        530        540        550
DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER CEGYNYQVDE 
       560        570        580        590        600
LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 
       610        620        630        640        650
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF 
       660        670        680        690        700
RRVFLGLGMC FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF 
       710        720        730        740        750
SLISVQLLGV FVWFVVDPPH IIIDYGEQRT LDPEKARGVL KCDISDLSLI 
       760        770        780        790        800
CSLGYSILLM VTCTVYAIKT RGVPETFNEA KPIGFTMYTT CIIWLAFIPI 
       810        820        830        840        850
FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI IIFHPEQNVQ 
       860        870        880        890        900
KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNTSSTKTTY 

ISYSNHSI

Length:908

Mass (Da):101,741

Last modified:December 1, 2000 - v2

Checksum:ⁱ95C2D5883DAF6FDE

Isoform B (identifier: O00222-2) [UniParc]FASTA Add to basket

Also known as: mGluR8b

The sequence of this isoform differs from the canonical sequence as follows:
893-908: TSSTKTTYISYSNHSI → SKSSVEFPMVKSGSTS

« Hide

        10         20         30         40         50
MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG 
        60         70         80         90        100
LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV 
       110        120        130        140        150
RILDTCSRDT YALEQSLTFV QALIEKDASD VKCANGDPPI FTKPDKISGV 
       160        170        180        190        200
IGAAASSVSI MVANILRLFK IPQISYASTA PELSDNTRYD FFSRVVPPDS 
       210        220        230        240        250
YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR EIGGVCIAQS 
       260        270        280        290        300
QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 
       310        320        330        340        350
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL 
       360        370        380        390        400
ANNRRNVWFA EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG 
       410        420        430        440        450
KVQFVIDAVY SMAYALHNMH KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN 
       460        470        480        490        500
FNGSAGTPVT FNENGDAPGR YDIFQYQITN KSTEYKVIGH WTNQLHLKVE 
       510        520        530        540        550
DMQWAHREHT HPASVCSLPC KPGERKKTVK GVPCCWHCER CEGYNYQVDE 
       560        570        580        590        600
LSCELCPLDQ RPNMNRTGCQ LIPIIKLEWH SPWAVVPVFV AILGIIATTF 
       610        620        630        640        650
VIVTFVRYND TPIVRASGRE LSYVLLTGIF LCYSITFLMI AAPDTIICSF 
       660        670        680        690        700
RRVFLGLGMC FSYAALLTKT NRIHRIFEQG KKSVTAPKFI SPASQLVITF 
       710        720        730        740        750
SLISVQLLGV FVWFVVDPPH IIIDYGEQRT LDPEKARGVL KCDISDLSLI 
       760        770        780        790        800
CSLGYSILLM VTCTVYAIKT RGVPETFNEA KPIGFTMYTT CIIWLAFIPI 
       810        820        830        840        850
FFGTAQSAEK MYIQTTTLTV SMSLSASVSL GMLYMPKVYI IIFHPEQNVQ 
       860        870        880        890        900
KRKRSFKAVV TAATMQSKLI QKGNDRPNGE VKSELCESLE TNSKSSVEFP 

MVKSGSTS

Show »

Length:908

Mass (Da):101,608

Checksum:ⁱ9F0D1EDB226C16D6

Isoform C (identifier: O00222-3) [UniParc]FASTA Add to basket

Also known as: mGluR8c

The sequence of this isoform differs from the canonical sequence as follows:
454-501: SAGTPVTFNE...TNQLHLKVED → CRRGIQMSLP...LDVMISSSIK
502-908: Missing.

« Hide

        10         20         30         40         50
MVCEGKRSAS CPCFFLLTAK FYWILTMMQR THSQEYAHSI RVDGDIILGG 
        60         70         80         90        100
LFPVHAKGER GVPCGELKKE KGIHRLEAML YAIDQINKDP DLLSNITLGV 
       110        120        130        140        150
RILDTCSRDT YALEQSLTFV QALIEKDASD VKCANGDPPI FTKPDKISGV 
       160        170        180        190        200
IGAAASSVSI MVANILRLFK IPQISYASTA PELSDNTRYD FFSRVVPPDS 
       210        220        230        240        250
YQAQAMVDIV TALGWNYVST LASEGNYGES GVEAFTQISR EIGGVCIAQS 
       260        270        280        290        300
QKIPREPRPG EFEKIIKRLL ETPNARAVIM FANEDDIRRI LEAAKKLNQS 
       310        320        330        340        350
GHFLWIGSDS WGSKIAPVYQ QEEIAEGAVT ILPKRASIDG FDRYFRSRTL 
       360        370        380        390        400
ANNRRNVWFA EFWEENFGCK LGSHGKRNSH IKKCTGLERI ARDSSYEQEG 
       410        420        430        440        450
KVQFVIDAVY SMAYALHNMH KDLCPGYIGL CPRMSTIDGK ELLGYIRAVN 
       460        470        480        490        500
FNGCRRGIQM SLPWPTLFTP SFSSSWAVLA LLSLLMKTEM LLDVMISSSI 

K

Show »

Length:501

Mass (Da):55,948

Checksum:ⁱCF684628F8123919

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A0A0MT06	A0A0A0MT06_HUMAN	Metabotropic glutamate receptor 8 Metabotropic glutamate receptor 8	GRM8	416	Annotation score:
E7ETK3	E7ETK3_HUMAN	Metabotropic glutamate receptor 8 Metabotropic glutamate receptor 8	GRM8	293	Annotation score:
H7C4V5	H7C4V5_HUMAN	Metabotropic glutamate receptor 8 Metabotropic glutamate receptor 8	GRM8	91	Annotation score:
C9J7I1	C9J7I1_HUMAN	Metabotropic glutamate receptor 8 Metabotropic glutamate receptor 8	GRM8	20	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	194	R → A in AAB72040 (PubMed:9299241).Curated	1
Sequence conflictⁱ	460	T → I in AAB72040 (PubMed:9299241).Curated	1
Sequence conflictⁱ	591	A → V in ABY87924 (Ref. 5) Curated	1
Sequence conflictⁱ	642	A → G in AAB72040 (PubMed:9299241).Curated	1
Sequence conflictⁱ	904	S → T in AAB72040 (PubMed:9299241).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_014446	10	S → C1 PublicationCorresponds to variant dbSNP:rs769194Ensembl.	1
Natural variantⁱVAR_014447	21	F → C. Corresponds to variant dbSNP:rs769202Ensembl.	1
Natural variantⁱVAR_049278	265	I → T1 PublicationCorresponds to variant dbSNP:rs17150343Ensembl.	1
Natural variantⁱVAR_054752	343	R → Q1 PublicationCorresponds to variant dbSNP:rs13309334Ensembl.	1
Natural variantⁱVAR_054477	362	F → Y1 PublicationCorresponds to variant dbSNP:rs78124913Ensembl.	1
Natural variantⁱVAR_054478	368	G → D1 PublicationCorresponds to variant dbSNP:rs78947184Ensembl.	1
Natural variantⁱVAR_014448	392	R → Q. Corresponds to variant dbSNP:rs2234947Ensembl.	1
Natural variantⁱVAR_054479	430	L → F1 PublicationCorresponds to variant dbSNP:rs75863532Ensembl.	1
Natural variantⁱVAR_014449	548	V → G. Corresponds to variant dbSNP:rs2234948Ensembl.	1
Natural variantⁱVAR_054753	768	I → N1 PublicationCorresponds to variant dbSNP:rs1051433Ensembl.	1
Natural variantⁱVAR_054754	902	S → I. Corresponds to variant dbSNP:rs10225567Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_002033	454 – 501	SAGTP…LKVED → CRRGIQMSLPWPTLFTPSFS SSWAVLALLSLLMKTEMLLD VMISSSIK in isoform C. 1 PublicationAdd BLAST	48
Alternative sequenceⁱVSP_002034	502 – 908	Missing in isoform C. 1 PublicationAdd BLAST	407
Alternative sequenceⁱVSP_002032	893 – 908	TSSTK…SNHSI → SKSSVEFPMVKSGSTS in isoform B. 2 PublicationsAdd BLAST	16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U95025 mRNA Translation: AAB72040.1 U92459 mRNA Translation: AAB51764.1 AJ236921 mRNA Translation: CAB36968.1 AJ236922 mRNA Translation: CAB36969.1 AY608335 mRNA Translation: AAT37959.1 EU432125 mRNA Translation: ABY87924.1 EU368948 Genomic DNA Translation: ABY59657.1 CH236947 Genomic DNA Translation: EAL24322.1 BC093725 mRNA Translation: AAH93725.1 BC101675 mRNA Translation: AAI01676.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47696.1 [O00222-2] CCDS5794.1 [O00222-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_000836.2, NM_000845.2 [O00222-1] NP_001120795.1, NM_001127323.1 [O00222-2] XP_006716001.1, XM_006715938.3 [O00222-1] XP_011514393.1, XM_011516091.1 [O00222-1] XP_011514394.1, XM_011516092.2 [O00222-2] XP_016867563.1, XM_017012074.1 [O00222-1]
UniGeneⁱ	Hs.449625

Genome annotation databases

Ensemblⁱ	ENST00000339582; ENSP00000344173; ENSG00000179603 [O00222-1] ENST00000341617; ENSP00000345747; ENSG00000179603 [O00222-3] ENST00000358373; ENSP00000351142; ENSG00000179603 [O00222-2] ENST00000472701; ENSP00000419832; ENSG00000179603 [O00222-2]
GeneIDⁱ	2918
KEGGⁱ	hsa:2918
UCSC genome browser More...UCSCⁱ	uc003vlr.3 human [O00222-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00222	Glutamate receptor metabotropic 8 (Fragment)		PIG		216	UniRef100_O00222
UPI0007DC700B		HUMAN		703

Protein	Similar proteins		Species	Score	Length	Source
O00222	Metabotropic glutamate receptor 8		RAT		908	UniRef90_P70579
Metabotropic glutamate receptor 8		MOUSE		908
Glutamate metabotropic receptor 8		ORNAN		911
Glutamate metabotropic receptor 8		MONDO		911
Uncharacterized protein		MACMU		910
+294
O00222-3	GRM8 isoform 6		PONAB		501	UniRef90_O00222-3
GRM8 isoform 6		PANTR		501
metabotropic glutamate receptor 8-like		DELLE		468
metabotropic glutamate receptor 8-like		TURTR		403
UPI00067DACDA		MICOH		494
+1

Protein	Similar proteins		Species	Score	Length	Source
O00222	Metabotropic glutamate receptor 8		RAT		908	UniRef50_P70579
Metabotropic glutamate receptor 8		MOUSE		908
Glutamate metabotropic receptor 8		ORNAN		911
Glutamate metabotropic receptor 8		MONDO		911
Glutamate metabotropic receptor 8		OTOGA		910
+492
O00222-3	GRM8 isoform 6		PANTR		501	UniRef50_O00222-3
GRM8 isoform 6		PONAB		501
metabotropic glutamate receptor 8-like		DELLE		468
metabotropic glutamate receptor 8-like		TURTR		403
metabotropic glutamate receptor 7-like		Austrofundulus limnaeus		426
+20

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U95025 mRNA Translation: AAB72040.1 U92459 mRNA Translation: AAB51764.1 AJ236921 mRNA Translation: CAB36968.1 AJ236922 mRNA Translation: CAB36969.1 AY608335 mRNA Translation: AAT37959.1 EU432125 mRNA Translation: ABY87924.1 EU368948 Genomic DNA Translation: ABY59657.1 CH236947 Genomic DNA Translation: EAL24322.1 BC093725 mRNA Translation: AAH93725.1 BC101675 mRNA Translation: AAI01676.1
CCDSⁱ	CCDS47696.1 [O00222-2] CCDS5794.1 [O00222-1]
RefSeqⁱ	NP_000836.2, NM_000845.2 [O00222-1] NP_001120795.1, NM_001127323.1 [O00222-2] XP_006716001.1, XM_006715938.3 [O00222-1] XP_011514393.1, XM_011516091.1 [O00222-1] XP_011514394.1, XM_011516092.2 [O00222-2] XP_016867563.1, XM_017012074.1 [O00222-1]
UniGeneⁱ	Hs.449625

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	6BSZ	X-ray	2.65	A/B	37-514	[»]
	6BT5	X-ray	2.92	A/B	37-514	[»]
ProteinModelPortalⁱ	O00222
SMRⁱ	O00222
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	O00222
STRINGⁱ	9606.ENSP00000344173

Chemistry databases

BindingDBⁱ	O00222
ChEMBLⁱ	CHEMBL3228
DrugBankⁱ	DB00142 L-Glutamic Acid
GuidetoPHARMACOLOGYⁱ	296

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	O00222
PhosphoSitePlusⁱ	O00222

Polymorphism and mutation databases

BioMutaⁱ	GRM8

BioMutaⁱ

GRM8

Proteomic databases

PaxDbⁱ	O00222
PeptideAtlasⁱ	O00222
PRIDEⁱ	O00222
ProteomicsDBⁱ	47792 47793 [O00222-2] 47794 [O00222-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000339582; ENSP00000344173; ENSG00000179603 [O00222-1] ENST00000341617; ENSP00000345747; ENSG00000179603 [O00222-3] ENST00000358373; ENSP00000351142; ENSG00000179603 [O00222-2] ENST00000472701; ENSP00000419832; ENSG00000179603 [O00222-2]
GeneIDⁱ	2918
KEGGⁱ	hsa:2918
UCSCⁱ	uc003vlr.3 human [O00222-1]

Organism-specific databases

CTDⁱ	2918
DisGeNETⁱ	2918
EuPathDBⁱ	HostDB:ENSG00000179603.17
GeneCardsⁱ	GRM8
H-InvDBⁱ	HIX0025292
HGNCⁱ	HGNC:4600 GRM8
HPAⁱ	HPA051481
MIMⁱ	601116 gene
neXtProtⁱ	NX_O00222
OpenTargetsⁱ	ENSG00000179603
PharmGKBⁱ	PA28997
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1056 Eukaryota ENOG410XR6W LUCA
GeneTreeⁱ	ENSGT00760000118884
HOVERGENⁱ	HBG107965
InParanoidⁱ	O00222
KOⁱ	K04608
OMAⁱ	TYVHAIA
OrthoDBⁱ	EOG091G177R
PhylomeDBⁱ	O00222
TreeFamⁱ	TF313240

Enzyme and pathway databases

Reactomeⁱ	R-HSA-418594 G alpha (i) signalling events R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Reactomeⁱ

R-HSA-418594 G alpha (i) signalling events
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)

Miscellaneous databases

ChiTaRSⁱ	GRM8 human
GeneWikiⁱ	Metabotropic_glutamate_receptor_8
GenomeRNAiⁱ	2918
Protein Ontology More...PROⁱ	PR:O00222
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000179603 Expressed in 138 organ(s), highest expression level in anterior cingulate cortex
CleanExⁱ	HS_GRM8
ExpressionAtlasⁱ	O00222 baseline and differential
Genevisibleⁱ	O00222 HS

Family and domain databases

Gene3Dⁱ	2.10.50.30, 1 hit
InterProⁱ	View protein in InterPro IPR001828 ANF_lig-bd_rcpt IPR000337 GPCR_3 IPR011500 GPCR_3_9-Cys_dom IPR038550 GPCR_3_9-Cys_sf IPR017978 GPCR_3_C IPR017979 GPCR_3_CS IPR000162 GPCR_3_mtglu_rcpt IPR000144 GPCR_3_mtglu_rcpt_8 IPR028082 Peripla_BP_I
Pfamⁱ	View protein in Pfam PF00003 7tm_3, 1 hit PF01094 ANF_receptor, 1 hit PF07562 NCD3G, 1 hit
PRINTSⁱ	PR00248 GPCRMGR PR01058 MTABOTROPC8R PR00593 MTABOTROPICR
SUPFAMⁱ	SSF53822 SSF53822, 1 hit
PROSITEⁱ	View protein in PROSITE PS00979 G_PROTEIN_RECEP_F3_1, 1 hit PS00980 G_PROTEIN_RECEP_F3_2, 1 hit PS00981 G_PROTEIN_RECEP_F3_3, 1 hit PS50259 G_PROTEIN_RECEP_F3_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GRM8_HUMAN
Accessionⁱ	O00222Primary (citable) accession number: O00222 Secondary accession number(s): A4D0Y3 Q6J165
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	December 1, 2000
	Last modified:	November 7, 2018
	This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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Metabotropic glutamate receptor 8

GRM8

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3D structure databases

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

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Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ