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Protein

Tumor necrosis factor receptor superfamily member 10A

Gene

TNFRSF10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • death receptor activity Source: ProtInc
  • protease binding Source: UniProtKB
  • signaling receptor activity Source: UniProtKB
  • TRAIL binding Source: UniProtKB
  • transcription factor binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-140534 Caspase activation via Death Receptors in the presence of ligand
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3371378 Regulation by c-FLIP
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218900 CASP8 activity is inhibited
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-69416 Dimerization of procaspase-8
R-HSA-75158 TRAIL signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
O00220

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O00220

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor receptor superfamily member 10A
Alternative name(s):
Death receptor 4
TNF-related apoptosis-inducing ligand receptor 1
Short name:
TRAIL receptor 1
Short name:
TRAIL-R1
CD_antigen: CD261
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TNFRSF10A
Synonyms:APO2, DR4, TRAILR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000104689.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11904 TNFRSF10A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
603611 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00220

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 239ExtracellularSequence analysisAdd BLAST216
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei240 – 262HelicalSequence analysisAdd BLAST23
Topological domaini263 – 468CytoplasmicSequence analysisAdd BLAST206

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8797

Open Targets

More...
OpenTargetsi
ENSG00000104689

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36597

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3551

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
1879

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TNFRSF10A

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003457924 – 468Tumor necrosis factor receptor superfamily member 10AAdd BLAST445

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei52Omega-N-methylarginineCombined sources1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi132 ↔ 145PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi148 ↔ 164PROSITE-ProRule annotationCombined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi167 ↔ 180PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi170 ↔ 188PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi190 ↔ 204PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi207 ↔ 221PROSITE-ProRule annotationCombined sources1 Publication
Disulfide bondi211 ↔ 229PROSITE-ProRule annotationCombined sources1 Publication
Modified residuei424PhosphoserineCombined sources1
Modified residuei463PhosphoserineCombined sources1
Modified residuei466PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00220

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00220

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00220

PeptideAtlas

More...
PeptideAtlasi
O00220

PRoteomics IDEntifications database

More...
PRIDEi
O00220

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47790

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00220

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00220

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O00220

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000104689 Expressed in 187 organ(s), highest expression level in buccal mucosa cell

CleanEx database of gene expression profiles

More...
CleanExi
HS_TNFRSF10A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00220 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00220 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA050958
HPA054475

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer (PubMed:26457518). Three TNFRSF10A molecules interact with the TNFSF10 homotrimer (PubMed:26457518). Can interact with TRADD and RIPK1. Interacts with ARAP1. Interacts with HCMV protein UL141; this interaction prevents TNFRSF10A cell surface expression.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114325, 50 interactors

Protein interaction database and analysis system

More...
IntActi
O00220, 11 interactors

Molecular INTeraction database

More...
MINTi
O00220

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000221132

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O00220

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1468
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00220

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00220

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati107 – 145TNFR-Cys 1Add BLAST39
Repeati147 – 188TNFR-Cys 2Add BLAST42
Repeati189 – 229TNFR-Cys 3Add BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini365 – 448DeathPROSITE-ProRule annotationAdd BLAST84

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi29 – 32Poly-Ala4

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162957

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000142423

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG061626

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00220

KEGG Orthology (KO)

More...
KOi
K04722

Identification of Orthologs from Complete Genome Data

More...
OMAi
CTPWSDL

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0MOV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00220

TreeFam database of animal gene trees

More...
TreeFami
TF333916

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08315 Death_TRAILR_DR4_DR5, 1 hit
cd10580 TNFRSF10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
IPR034029 TNFRSF10A/B_death

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037867 CD261_antigen, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01956 TNFACTORR10

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47986 SSF47986, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O00220-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPPPARVHL GAFLAVTPNP GSAASGTEAA AATPSKVWGS SAGRIEPRGG
60 70 80 90 100
GRGALPTSMG QHGPSARARA GRAPGPRPAR EASPRLRVHK TFKFVVVGVL
110 120 130 140 150
LQVVPSSAAT IKLHDQSIGT QQWEHSPLGE LCPPGSHRSE HPGACNRCTE
160 170 180 190 200
GVGYTNASNN LFACLPCTAC KSDEEERSPC TTTRNTACQC KPGTFRNDNS
210 220 230 240 250
AEMCRKCSRG CPRGMVKVKD CTPWSDIECV HKESGNGHNI WVILVVTLVV
260 270 280 290 300
PLLLVAVLIV CCCIGSGCGG DPKCMDRVCF WRLGLLRGPG AEDNAHNEIL
310 320 330 340 350
SNADSLSTFV SEQQMESQEP ADLTGVTVQS PGEAQCLLGP AEAEGSQRRR
360 370 380 390 400
LLVPANGADP TETLMLFFDK FANIVPFDSW DQLMRQLDLT KNEIDVVRAG
410 420 430 440 450
TAGPGDALYA MLMKWVNKTG RNASIHTLLD ALERMEERHA REKIQDLLVD
460
SGKFIYLEDG TGSAVSLE
Length:468
Mass (Da):50,089
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E96619D0BDC0CD4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8U8C0F8U8C0_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF10A
310Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RFH1E5RFH1_HUMAN
Tumor necrosis factor receptor supe...
TNFRSF10A
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti281W → C in BAF83988 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05234911G → V. Corresponds to variant dbSNP:rs34737614Ensembl.1
Natural variantiVAR_01614933T → I. Corresponds to variant dbSNP:rs20577Ensembl.1
Natural variantiVAR_052350105P → R. Corresponds to variant dbSNP:rs11986840Ensembl.1
Natural variantiVAR_016150141H → R2 PublicationsCorresponds to variant dbSNP:rs17620Ensembl.1
Natural variantiVAR_016151209R → T2 PublicationsCorresponds to variant dbSNP:rs20575Ensembl.1
Natural variantiVAR_016152228E → A. Corresponds to variant dbSNP:rs20576Ensembl.1
Natural variantiVAR_052351297N → H. Corresponds to variant dbSNP:rs17088980Ensembl.1
Natural variantiVAR_052352441R → K5 PublicationsCorresponds to variant dbSNP:rs2230229Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U90875 mRNA Translation: AAC51226.1
BT006906 mRNA Translation: AAP35552.1
AK291299 mRNA Translation: BAF83988.1
EF064713 Genomic DNA Translation: ABK41896.1
AC100861 Genomic DNA No translation available.
BC012866 mRNA Translation: AAH12866.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6039.1

NCBI Reference Sequences

More...
RefSeqi
NP_003835.3, NM_003844.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.213467
Hs.591834

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000221132; ENSP00000221132; ENSG00000104689

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8797

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8797

UCSC genome browser

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UCSCi
uc003xda.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U90875 mRNA Translation: AAC51226.1
BT006906 mRNA Translation: AAP35552.1
AK291299 mRNA Translation: BAF83988.1
EF064713 Genomic DNA Translation: ABK41896.1
AC100861 Genomic DNA No translation available.
BC012866 mRNA Translation: AAH12866.1
CCDSiCCDS6039.1
RefSeqiNP_003835.3, NM_003844.3
UniGeneiHs.213467
Hs.591834

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5CIRX-ray3.00E/F/G125-232[»]
ProteinModelPortaliO00220
SMRiO00220
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114325, 50 interactors
IntActiO00220, 11 interactors
MINTiO00220
STRINGi9606.ENSP00000221132

Chemistry databases

BindingDBiO00220
ChEMBLiCHEMBL3551
GuidetoPHARMACOLOGYi1879

PTM databases

iPTMnetiO00220
PhosphoSitePlusiO00220
SwissPalmiO00220

Polymorphism and mutation databases

BioMutaiTNFRSF10A

Proteomic databases

EPDiO00220
MaxQBiO00220
PaxDbiO00220
PeptideAtlasiO00220
PRIDEiO00220
ProteomicsDBi47790

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
8797
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221132; ENSP00000221132; ENSG00000104689
GeneIDi8797
KEGGihsa:8797
UCSCiuc003xda.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
8797
DisGeNETi8797
EuPathDBiHostDB:ENSG00000104689.9

GeneCards: human genes, protein and diseases

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GeneCardsi
TNFRSF10A

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0022944
HGNCiHGNC:11904 TNFRSF10A
HPAiHPA050958
HPA054475
MIMi603611 gene
neXtProtiNX_O00220
OpenTargetsiENSG00000104689
PharmGKBiPA36597

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IZX0 Eukaryota
ENOG4111ZZM LUCA
GeneTreeiENSGT00940000162957
HOGENOMiHOG000142423
HOVERGENiHBG061626
InParanoidiO00220
KOiK04722
OMAiCTPWSDL
OrthoDBiEOG091G0MOV
PhylomeDBiO00220
TreeFamiTF333916

Enzyme and pathway databases

ReactomeiR-HSA-140534 Caspase activation via Death Receptors in the presence of ligand
R-HSA-202733 Cell surface interactions at the vascular wall
R-HSA-3371378 Regulation by c-FLIP
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218900 CASP8 activity is inhibited
R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-HSA-69416 Dimerization of procaspase-8
R-HSA-75158 TRAIL signaling
SignaLinkiO00220
SIGNORiO00220

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
TNFRSF10A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
8797

Protein Ontology

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PROi
PR:O00220

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000104689 Expressed in 187 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_TNFRSF10A
ExpressionAtlasiO00220 baseline and differential
GenevisibleiO00220 HS

Family and domain databases

CDDicd08315 Death_TRAILR_DR4_DR5, 1 hit
cd10580 TNFRSF10, 1 hit
InterProiView protein in InterPro
IPR011029 DEATH-like_dom_sf
IPR000488 Death_domain
IPR001368 TNFR/NGFR_Cys_rich_reg
IPR020465 TNFR_10
IPR034024 TNFRSF10_N
IPR034029 TNFRSF10A/B_death
PfamiView protein in Pfam
PF00531 Death, 1 hit
PF00020 TNFR_c6, 2 hits
PIRSFiPIRSF037867 CD261_antigen, 1 hit
PRINTSiPR01956 TNFACTORR10
SMARTiView protein in SMART
SM00005 DEATH, 1 hit
SM00208 TNFR, 2 hits
SUPFAMiSSF47986 SSF47986, 1 hit
PROSITEiView protein in PROSITE
PS50017 DEATH_DOMAIN, 1 hit
PS00652 TNFR_NGFR_1, 2 hits
PS50050 TNFR_NGFR_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTR10A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00220
Secondary accession number(s): A8K5I4, Q53Y72, Q96E62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 30, 2010
Last modified: December 5, 2018
This is version 183 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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