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Protein

Amyloid-beta A4 precursor protein-binding family B member 1

Gene

APBB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity. Function in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s).6 Publications

GO - Molecular functioni

  • amyloid-beta binding Source: UniProtKB
  • chromatin binding Source: UniProtKB
  • histone binding Source: UniProtKB
  • proline-rich region binding Source: UniProtKB
  • protein-containing complex binding Source: Ensembl
  • tau protein binding Source: Ensembl
  • transcription factor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Chromatin regulator, Repressor
Biological processApoptosis, DNA damage, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
SignaLinkiO00213
SIGNORiO00213

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 precursor protein-binding family B member 1
Alternative name(s):
Protein Fe65
Gene namesi
Name:APBB1
Synonyms:FE65, RIR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000166313.18
HGNCiHGNC:581 APBB1
MIMi602709 gene
neXtProtiNX_O00213

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi117Y → F: No effect on phosphorylation by ABL1. 1 Publication1
Mutagenesisi234Y → F: No effect on phosphorylation by ABL1. 1 Publication1
Mutagenesisi269 – 271YYW → AAA: Impairs transcriptional activation and inhibits binding to ABL1. 1 Publication3
Mutagenesisi269Y → F: No effect on phosphorylation by ABL1. 1 Publication1
Mutagenesisi270Y → F: No effect on phosphorylation by ABL1. 1 Publication1
Mutagenesisi403Y → F: No effect on phosphorylation by ABL1. 1 Publication1
Mutagenesisi467Y → F: No effect on phosphorylation by ABL1. 1 Publication1
Mutagenesisi546Y → F: No effect on phosphorylation by ABL1. 1 Publication1
Mutagenesisi547Y → F: Abrogates phosphorylation and stimulation of transcription by ABL1, and increases the interaction with RASD1/DEXRAS1. 2 Publications1
Mutagenesisi658Y → F: No effect on phosphorylation by ABL1. 1

Organism-specific databases

DisGeNETi322
OpenTargetsiENSG00000166313
PharmGKBiPA24873

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000760491 – 710Amyloid-beta A4 precursor protein-binding family B member 1Add BLAST710

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei517PhosphoserineBy similarity1
Modified residuei547Phosphotyrosine; by ABL12 Publications1
Modified residuei610Phosphoserine; by SGK1By similarity1

Post-translational modificationi

Polyubiquitination by RNF157 leads to degradation by the proteasome (PubMed:25342469).1 Publication
Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity). Phosphorylated following nuclear translocation. Phosphorylation at Tyr-547 by ABL1 enhances transcriptional activation activity and reduces the affinity for RASD1/DEXRAS1.By similarity2 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO00213
MaxQBiO00213
PaxDbiO00213
PeptideAtlasiO00213
PRIDEiO00213
ProteomicsDBi47783
47784 [O00213-2]

PTM databases

iPTMnetiO00213
PhosphoSitePlusiO00213

Expressioni

Tissue specificityi

Highly expressed in brain; strongly reduced in post-mortem elderly subjects with Alzheimer disease.1 Publication

Gene expression databases

BgeeiENSG00000166313 Expressed in 199 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_APBB1
ExpressionAtlasiO00213 baseline and differential
GenevisibleiO00213 HS

Organism-specific databases

HPAiCAB022104
HPA038521
HPA038522

Interactioni

Subunit structurei

Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts (via PID domain 2) with APP (with the intracellular domain of the amyloid-beta precursor protein). Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs the transcription activation activity. Interacts (via PID domain 1) with KAT5/TIP60. Interacts (via the WW domain) with the proline-rich region of APBB1IP. Interacts with TSHZ1 and TSHZ2 (By similarity). Interacts (via the WW domain) with histone H2AX (when phosphorylated on 'Tyr-142') and the proline-rich region of ENAH. Interacts with MAPK8. Interacts (via PID domain 1) with TSHZ3 (via homeobox domain). Interacts with SET. Found in a trimeric complex with HDAC1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Interacts (via WWW domain) with NEK6. Interacts (via WWW domain) with ABL1. Interacts with RNF157 (PubMed:25342469).By similarity9 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi106819, 99 interactors
CORUMiO00213
DIPiDIP-30903N
ELMiO00213
IntActiO00213, 17 interactors
MINTiO00213
STRINGi9606.ENSP00000299402

Structurei

Secondary structure

1710
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00213
SMRiO00213
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00213

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini253 – 285WWPROSITE-ProRule annotationAdd BLAST33
Domaini370 – 509PID 1PROSITE-ProRule annotationAdd BLAST140
Domaini542 – 699PID 2PROSITE-ProRule annotationAdd BLAST158

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi158 – 171Glu-richAdd BLAST14

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEKA Eukaryota
ENOG410YEVS LUCA
GeneTreeiENSGT00390000000002
HOGENOMiHOG000033983
HOVERGENiHBG050524
InParanoidiO00213
KOiK04529
PhylomeDBiO00213
TreeFamiTF314331

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039576 Fe65
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR14058 PTHR14058, 1 hit
PfamiView protein in Pfam
PF00640 PID, 2 hits
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

Sequences (6+)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00213-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSVPSSLSQS AINANSHGGP ALSLPLPLHA AHNQLLNAKL QATAVGPKDL
60 70 80 90 100
RSAMGEGGGP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS
110 120 130 140 150
QEPEMAPLGP KGLIHLYSEL ELSAHNAANR GLRGPGLIIS TQEQGPDEGE
160 170 180 190 200
EKAAGEAEEE EEDDDDEEEE EDLSSPPGLP EPLESVEAPP RPQALTDGPR
210 220 230 240 250
EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE
260 270 280 290 300
TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL
310 320 330 340 350
TWTGFAHGEG FEDGEFWKDE PSDEAPMELG LKEPEEGTLT FPAQSLSPEP
360 370 380 390 400
LPQEEEKLPP RNTNPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ
410 420 430 440 450
LSYHKNNLHD PMSGGWGEGK DLLLQLEDET LKLVEPQSQA LLHAQPIISI
460 470 480 490 500
RVWGVGRDSG RERDFAYVAR DKLTQMLKCH VFRCEAPAKN IATSLHEICS
510 520 530 540 550
KIMAERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV QKFQVYYLGN
560 570 580 590 600
VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV
610 620 630 640 650
LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV
660 670 680 690 700
QAACMLRYQK CLDARSQAST SCLPAPPAES VARRVGWTVR RGVQSLWGSL
710
KPKRLGAHTP
Length:710
Mass (Da):77,244
Last modified:June 1, 1998 - v2
Checksum:iFD4A2EF7E8D8E884
GO
Isoform 2 (identifier: O00213-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     462-463: Missing.

Show »
Length:708
Mass (Da):76,959
Checksum:iFC578B7688BCC1A0
GO
Isoform 3 (identifier: O00213-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-213: Missing.
     214-240: NSAASDEDSSWATLSQGSPSYGSPEDT → MSAMFSQDFFLAIILQDSSA
     462-463: Missing.

Show »
Length:488
Mass (Da):53,927
Checksum:i72DB1DFEA0886C91
GO
Isoform 4 (identifier: O00213-4) [UniParc]FASTAAdd to basket
Also known as: p60Fe65

The sequence of this isoform differs from the canonical sequence as follows:
     1-259: Missing.

Note: Expressed preferentially in the brain.
Show »
Length:451
Mass (Da):49,857
Checksum:i14AE683C4BD3A6D5
GO
Isoform 5 (identifier: O00213-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-213: Missing.
     214-240: NSAASDEDSSWATLSQGSPSYGSPEDT → MSAMFSQDFFLAIILQDSSA

Note: No experimental confirmation available.
Show »
Length:490
Mass (Da):54,212
Checksum:i1996107B7E50C0B0
GO
Isoform 6 (identifier: O00213-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-240: MSVPSSLSQS...SPSYGSPEDT → MTQMR

Note: No experimental confirmation available.
Show »
Length:475
Mass (Da):52,656
Checksum:iC01AD5CED5941D94
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPL8J3KPL8_HUMAN
Amyloid-beta A4 precursor protein-b...
APBB1
710Annotation score:
V9GY97V9GY97_HUMAN
Amyloid-beta A4 precursor protein-b...
APBB1
261Annotation score:
A0A087WYH9A0A087WYH9_HUMAN
Amyloid-beta A4 precursor protein-b...
APBB1
475Annotation score:
A0A087X0V7A0A087X0V7_HUMAN
Amyloid-beta A4 precursor protein-b...
APBB1
451Annotation score:
A0A075B7G8A0A075B7G8_HUMAN
Amyloid-beta A4 precursor protein-b...
APBB1
706Annotation score:
V9GYR7V9GYR7_HUMAN
Amyloid-beta A4 precursor protein-b...
APBB1
235Annotation score:
V9GYD5V9GYD5_HUMAN
Amyloid-beta A4 precursor protein-b...
APBB1
87Annotation score:

Sequence cautioni

The sequence CAD98057 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti367I → T in BAH11532 (PubMed:14702039).Curated1
Sequence conflicti493T → A in BAH11532 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014444327M → V. Corresponds to variant dbSNP:rs1800423Ensembl.1
Natural variantiVAR_014445396N → S. Corresponds to variant dbSNP:rs1800425Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0474591 – 259Missing in isoform 4. 2 PublicationsAdd BLAST259
Alternative sequenceiVSP_0547091 – 240MSVPS…SPEDT → MTQMR in isoform 6. 1 PublicationAdd BLAST240
Alternative sequenceiVSP_0453261 – 213Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST213
Alternative sequenceiVSP_045327214 – 240NSAAS…SPEDT → MSAMFSQDFFLAIILQDSSA in isoform 3 and isoform 5. 2 PublicationsAdd BLAST27
Alternative sequenceiVSP_011658462 – 463Missing in isoform 2 and isoform 3. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77864 mRNA Translation: AAB93631.1
AF029234, AF047835 Genomic DNA Translation: AAC79942.1
EF103274 mRNA Translation: ABL07489.3
AK293550 mRNA Translation: BAH11531.1
AK293554 mRNA Translation: BAH11532.1
AK293643 mRNA Translation: BAH11554.1
AK295241 mRNA Translation: BAH12016.1
BX538185 mRNA Translation: CAD98057.1 Different initiation.
AC068733 Genomic DNA No translation available.
AC084337 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68723.1
CH471064 Genomic DNA Translation: EAW68724.1
BC010854 mRNA Translation: AAH10854.1
CCDSiCCDS31410.1 [O00213-2]
CCDS58114.1 [O00213-3]
CCDS66015.1 [O00213-4]
CCDS66016.1 [O00213-6]
CCDS66017.1 [O00213-5]
CCDS66018.1 [O00213-1]
RefSeqiNP_001155.1, NM_001164.4 [O00213-1]
NP_001244248.1, NM_001257319.2 [O00213-5]
NP_001244249.1, NM_001257320.2 [O00213-4]
NP_001244250.1, NM_001257321.2 [O00213-4]
NP_001244252.1, NM_001257323.2 [O00213-3]
NP_001244254.1, NM_001257325.2 [O00213-6]
NP_001244255.1, NM_001257326.2 [O00213-4]
NP_663722.1, NM_145689.2 [O00213-2]
XP_011518342.1, XM_011520040.2 [O00213-4]
XP_016873130.1, XM_017017641.1 [O00213-2]
UniGeneiHs.372840

Genome annotation databases

EnsembliENST00000299402; ENSP00000299402; ENSG00000166313 [O00213-2]
ENST00000311051; ENSP00000311912; ENSG00000166313 [O00213-2]
ENST00000530885; ENSP00000433338; ENSG00000166313 [O00213-3]
ENST00000608394; ENSP00000476442; ENSG00000166313 [O00213-4]
ENST00000608645; ENSP00000476646; ENSG00000166313 [O00213-4]
ENST00000608655; ENSP00000476846; ENSG00000166313 [O00213-5]
ENST00000608704; ENSP00000476871; ENSG00000166313 [O00213-4]
ENST00000609331; ENSP00000477069; ENSG00000166313 [O00213-6]
ENST00000609360; ENSP00000477213; ENSG00000166313 [O00213-1]
GeneIDi322
KEGGihsa:322
UCSCiuc001mdb.4 human [O00213-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77864 mRNA Translation: AAB93631.1
AF029234, AF047835 Genomic DNA Translation: AAC79942.1
EF103274 mRNA Translation: ABL07489.3
AK293550 mRNA Translation: BAH11531.1
AK293554 mRNA Translation: BAH11532.1
AK293643 mRNA Translation: BAH11554.1
AK295241 mRNA Translation: BAH12016.1
BX538185 mRNA Translation: CAD98057.1 Different initiation.
AC068733 Genomic DNA No translation available.
AC084337 Genomic DNA No translation available.
CH471064 Genomic DNA Translation: EAW68723.1
CH471064 Genomic DNA Translation: EAW68724.1
BC010854 mRNA Translation: AAH10854.1
CCDSiCCDS31410.1 [O00213-2]
CCDS58114.1 [O00213-3]
CCDS66015.1 [O00213-4]
CCDS66016.1 [O00213-6]
CCDS66017.1 [O00213-5]
CCDS66018.1 [O00213-1]
RefSeqiNP_001155.1, NM_001164.4 [O00213-1]
NP_001244248.1, NM_001257319.2 [O00213-5]
NP_001244249.1, NM_001257320.2 [O00213-4]
NP_001244250.1, NM_001257321.2 [O00213-4]
NP_001244252.1, NM_001257323.2 [O00213-3]
NP_001244254.1, NM_001257325.2 [O00213-6]
NP_001244255.1, NM_001257326.2 [O00213-4]
NP_663722.1, NM_145689.2 [O00213-2]
XP_011518342.1, XM_011520040.2 [O00213-4]
XP_016873130.1, XM_017017641.1 [O00213-2]
UniGeneiHs.372840

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E45NMR-A241-290[»]
2HO2X-ray1.33A253-289[»]
2IDHX-ray2.28A/B/C/D/E/F/G/H253-289[»]
2OEIX-ray1.35A253-289[»]
3D8DX-ray2.20A/B366-505[»]
3D8EX-ray2.80A/B/C/D366-505[»]
3D8FX-ray2.70A/B/C/D366-505[»]
3DXCX-ray2.10A/C534-667[»]
3DXDX-ray2.20A/C534-667[»]
3DXEX-ray2.00A/C534-667[»]
5NQHX-ray2.60A/B/C/D534-667[»]
ProteinModelPortaliO00213
SMRiO00213
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106819, 99 interactors
CORUMiO00213
DIPiDIP-30903N
ELMiO00213
IntActiO00213, 17 interactors
MINTiO00213
STRINGi9606.ENSP00000299402

PTM databases

iPTMnetiO00213
PhosphoSitePlusiO00213

Proteomic databases

EPDiO00213
MaxQBiO00213
PaxDbiO00213
PeptideAtlasiO00213
PRIDEiO00213
ProteomicsDBi47783
47784 [O00213-2]

Protocols and materials databases

DNASUi322
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299402; ENSP00000299402; ENSG00000166313 [O00213-2]
ENST00000311051; ENSP00000311912; ENSG00000166313 [O00213-2]
ENST00000530885; ENSP00000433338; ENSG00000166313 [O00213-3]
ENST00000608394; ENSP00000476442; ENSG00000166313 [O00213-4]
ENST00000608645; ENSP00000476646; ENSG00000166313 [O00213-4]
ENST00000608655; ENSP00000476846; ENSG00000166313 [O00213-5]
ENST00000608704; ENSP00000476871; ENSG00000166313 [O00213-4]
ENST00000609331; ENSP00000477069; ENSG00000166313 [O00213-6]
ENST00000609360; ENSP00000477213; ENSG00000166313 [O00213-1]
GeneIDi322
KEGGihsa:322
UCSCiuc001mdb.4 human [O00213-1]

Organism-specific databases

CTDi322
DisGeNETi322
EuPathDBiHostDB:ENSG00000166313.18
GeneCardsiAPBB1
H-InvDBiHIX0009398
HGNCiHGNC:581 APBB1
HPAiCAB022104
HPA038521
HPA038522
MIMi602709 gene
neXtProtiNX_O00213
OpenTargetsiENSG00000166313
PharmGKBiPA24873
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IEKA Eukaryota
ENOG410YEVS LUCA
GeneTreeiENSGT00390000000002
HOGENOMiHOG000033983
HOVERGENiHBG050524
InParanoidiO00213
KOiK04529
PhylomeDBiO00213
TreeFamiTF314331

Enzyme and pathway databases

ReactomeiR-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
SignaLinkiO00213
SIGNORiO00213

Miscellaneous databases

ChiTaRSiAPBB1 human
EvolutionaryTraceiO00213
GeneWikiiAPBB1
GenomeRNAii322
PROiPR:O00213
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000166313 Expressed in 199 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_APBB1
ExpressionAtlasiO00213 baseline and differential
GenevisibleiO00213 HS

Family and domain databases

CDDicd00201 WW, 1 hit
Gene3Di2.30.29.30, 2 hits
InterProiView protein in InterPro
IPR039576 Fe65
IPR011993 PH-like_dom_sf
IPR006020 PTB/PI_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PANTHERiPTHR14058 PTHR14058, 1 hit
PfamiView protein in Pfam
PF00640 PID, 2 hits
PF00397 WW, 1 hit
SMARTiView protein in SMART
SM00462 PTB, 2 hits
SM00456 WW, 1 hit
SUPFAMiSSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS01179 PID, 2 hits
PS01159 WW_DOMAIN_1, 1 hit
PS50020 WW_DOMAIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAPBB1_HUMAN
AccessioniPrimary (citable) accession number: O00213
Secondary accession number(s): A1E379
, A6NH82, A6NL69, B7Z1J5, B7Z1J6, B7Z2Y0, D3DQT2, Q7Z324, Q96A93, V9GYK0, V9GYT4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: June 1, 1998
Last modified: November 7, 2018
This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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