UniProtKB - O00213 (APBB1_HUMAN)
Amyloid beta precursor protein binding family B member 1
APBB1
Functioni
Transcription coregulator that can have both coactivator and corepressor functions (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469, PubMed:33938178).
Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469).
Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis (PubMed:15031292, PubMed:18468999, PubMed:18922798, PubMed:25342469).
May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1 (PubMed:19234442).
Required for histone H4 acetylation at double-strand breaks (DSBs) (PubMed:19234442).
Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:33938178).
Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4 (PubMed:19343227).
Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (PubMed:19343227).
Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning (By similarity).
Plays a role in the maintenance of lens transparency (By similarity).
May play a role in muscle cell strength (By similarity).
By similarity7 PublicationsGO - Molecular functioni
- amyloid-beta binding Source: GO_Central
- chromatin binding Source: UniProtKB
- histone binding Source: UniProtKB
- low-density lipoprotein particle receptor binding Source: ARUK-UCL
- proline-rich region binding Source: UniProtKB
- transcription coactivator activity Source: ARUK-UCL
- ubiquitin protein ligase binding Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- axonogenesis Source: UniProtKB
- cellular response to DNA damage stimulus Source: UniProtKB
- chromatin organization Source: UniProtKB-KW
- histone H4 acetylation Source: UniProtKB
- negative regulation of cell cycle G1/S phase transition Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- positive regulation of apoptotic process Source: UniProtKB
- positive regulation of protein secretion Source: ARUK-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: ARUK-UCL
- regulation of transcription, DNA-templated Source: GO_Central
- signal transduction Source: UniProtKB
- smooth muscle contraction Source: UniProtKB
Keywordsi
Molecular function | Activator, Chromatin regulator, Repressor |
Biological process | Apoptosis, DNA damage, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | O00213 |
Reactomei | R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
SignaLinki | O00213 |
SIGNORi | O00213 |
Names & Taxonomyi
Protein namesi | Recommended name: Amyloid beta precursor protein binding family B member 1ImportedAlternative name(s): Amyloid-beta A4 precursor protein-binding family B member 1By similarity Protein Fe65By similarity |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:581, APBB1 |
MIMi | 602709, gene |
neXtProti | NX_O00213 |
VEuPathDBi | HostDB:ENSG00000166313 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- Nucleus 4 Publications
- Nucleus speckle 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Other locations
- growth cone By similarity
Note: Colocalizes with TSHZ3 in axonal growth cone (By similarity). Colocalizes with TSHZ3 in the nucleus (PubMed:19343227). In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP (PubMed:18468999). Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus (PubMed:18468999). Nuclear translocation is under the regulation of APP (PubMed:18468999). Colocalizes with NEK6 at the nuclear speckles (PubMed:17512906). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (By similarity).By similarity3 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: HPA
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- growth cone Source: UniProtKB
- lamellipodium Source: UniProtKB
- synapse Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 117 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 204 | K → Q: Mimics acetylation; leading to increased transcription activator activity; when associated with Q-701. 1 Publication | 1 | |
Mutagenesisi | 204 | K → R: Abolished acetylation by KAT5, leading to decreased transcription activator activity; when associated with R-701. 1 Publication | 1 | |
Mutagenesisi | 234 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 269 – 271 | YYW → AAA: Impairs transcriptional activation and inhibits binding to ABL1. 1 Publication | 3 | |
Mutagenesisi | 269 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 270 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 403 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 467 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 546 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 547 | Y → F: Abrogates phosphorylation and stimulation of transcription by ABL1, and increases the interaction with RASD1/DEXRAS1. 2 Publications | 1 | |
Mutagenesisi | 658 | Y → F: No effect on phosphorylation by ABL1. 1 Publication | 1 | |
Mutagenesisi | 701 | K → Q: Mimics acetylation; leading to increased transcription activator activity; when associated with Q-204. 1 Publication | 1 | |
Mutagenesisi | 701 | K → R: Abolished acetylation by KAT5, leading to decreased transcription activator activity; when associated with R-204. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 322 |
MalaCardsi | APBB1 |
OpenTargetsi | ENSG00000166313 |
PharmGKBi | PA24873 |
Miscellaneous databases
Pharosi | O00213, Tbio |
Genetic variation databases
BioMutai | APBB1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076049 | 1 – 710 | Amyloid beta precursor protein binding family B member 1Add BLAST | 710 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 204 | N6-acetyllysine1 Publication | 1 | |
Modified residuei | 517 | PhosphoserineBy similarity | 1 | |
Modified residuei | 547 | Phosphotyrosine; by ABL12 Publications | 1 | |
Modified residuei | 610 | Phosphoserine; by SGK1By similarity | 1 | |
Modified residuei | 701 | N6-acetyllysine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O00213 |
MassIVEi | O00213 |
MaxQBi | O00213 |
PaxDbi | O00213 |
PeptideAtlasi | O00213 |
PRIDEi | O00213 |
ProteomicsDBi | 47783 [O00213-1] 47784 [O00213-2] 6474 |
PTM databases
GlyGeni | O00213, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O00213 |
PhosphoSitePlusi | O00213 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000166313, Expressed in right hemisphere of cerebellum and 214 other tissues |
ExpressionAtlasi | O00213, baseline and differential |
Genevisiblei | O00213, HS |
Organism-specific databases
HPAi | ENSG00000166313, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP (PubMed:18922798, PubMed:18833287, PubMed:18468999).
Interacts (via PID domain 2) with APP (with the intracellular domain of the amyloid-beta precursor protein) (PubMed:18833287, PubMed:18468999).
Interacts (via PID domain 2) with RASD1/DEXRAS1; impairs the transcription activation activity (PubMed:18922798).
Interacts (via PID domain 1) with KAT5/TIP60 (PubMed:33938178).
Interacts (via the WW domain) with the proline-rich region of APBB1IP (By similarity).
Interacts with TSHZ1 and TSHZ2 (By similarity).
Interacts (via the WW domain) with histone H2AX (when phosphorylated on 'Tyr-142') and the proline-rich region of ENAH (PubMed:17686488).
Interacts with MAPK8 (PubMed:19234442).
Interacts (via PID domain 1) with TSHZ3 (via homeobox domain) (PubMed:19343227).
Interacts with SET (PubMed:19343227).
Found in a trimeric complex with HDAC1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3 (PubMed:19343227).
Interacts (via WWW domain) with NEK6 (PubMed:17512906).
Interacts (via WWW domain) with ABL1 (PubMed:15031292).
Interacts with RNF157 (PubMed:25342469).
By similarity10 PublicationsBinary interactionsi
O00213
Isoform 2 [O00213-2]
GO - Molecular functioni
- histone binding Source: UniProtKB
- low-density lipoprotein particle receptor binding Source: ARUK-UCL
- proline-rich region binding Source: UniProtKB
- ubiquitin protein ligase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 106819, 156 interactors |
CORUMi | O00213 |
DIPi | DIP-30903N |
ELMi | O00213 |
IntActi | O00213, 168 interactors |
MINTi | O00213 |
STRINGi | 9606.ENSP00000477213 |
Miscellaneous databases
RNActi | O00213, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | O00213 |
SMRi | O00213 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O00213 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 253 – 285 | WWPROSITE-ProRule annotationAdd BLAST | 33 | |
Domaini | 370 – 509 | PID 1PROSITE-ProRule annotationAdd BLAST | 140 | |
Domaini | 542 – 699 | PID 2PROSITE-ProRule annotationAdd BLAST | 158 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 24 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 131 – 254 | DisorderedSequence analysisAdd BLAST | 124 | |
Regioni | 276 – 299 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 340 – 365 | DisorderedSequence analysisAdd BLAST | 26 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 17 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 152 – 175 | Acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 208 – 249 | Polar residuesSequence analysisAdd BLAST | 42 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502QT08, Eukaryota |
GeneTreei | ENSGT00390000000002 |
HOGENOMi | CLU_021196_0_0_1 |
InParanoidi | O00213 |
OMAi | QVYYLGS |
OrthoDBi | 437627at2759 |
PhylomeDBi | O00213 |
TreeFami | TF314331 |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039576, Fe65 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR14058, PTHR14058, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 2 hits PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSVPSSLSQS AINANSHGGP ALSLPLPLHA AHNQLLNAKL QATAVGPKDL
60 70 80 90 100
RSAMGEGGGP EPGPANAKWL KEGQNQLRRA ATAHRDQNRN VTLTLAEEAS
110 120 130 140 150
QEPEMAPLGP KGLIHLYSEL ELSAHNAANR GLRGPGLIIS TQEQGPDEGE
160 170 180 190 200
EKAAGEAEEE EEDDDDEEEE EDLSSPPGLP EPLESVEAPP RPQALTDGPR
210 220 230 240 250
EHSKSASLLF GMRNSAASDE DSSWATLSQG SPSYGSPEDT DSFWNPNAFE
260 270 280 290 300
TDSDLPAGWM RVQDTSGTYY WHIPTGTTQW EPPGRASPSQ GSSPQEESQL
310 320 330 340 350
TWTGFAHGEG FEDGEFWKDE PSDEAPMELG LKEPEEGTLT FPAQSLSPEP
360 370 380 390 400
LPQEEEKLPP RNTNPGIKCF AVRSLGWVEM TEEELAPGRS SVAVNNCIRQ
410 420 430 440 450
LSYHKNNLHD PMSGGWGEGK DLLLQLEDET LKLVEPQSQA LLHAQPIISI
460 470 480 490 500
RVWGVGRDSG RERDFAYVAR DKLTQMLKCH VFRCEAPAKN IATSLHEICS
510 520 530 540 550
KIMAERRNAR CLVNGLSLDH SKLVDVPFQV EFPAPKNELV QKFQVYYLGN
560 570 580 590 600
VPVAKPVGVD VINGALESVL SSSSREQWTP SHVSVAPATL TILHQQTEAV
610 620 630 640 650
LGECRVRFLS FLAVGRDVHT FAFIMAAGPA SFCCHMFWCE PNAASLSEAV
660 670 680 690 700
QAACMLRYQK CLDARSQAST SCLPAPPAES VARRVGWTVR RGVQSLWGSL
710
KPKRLGAHTP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KPL8 | J3KPL8_HUMAN | Amyloid beta precursor protein-bind... | APBB1 | 710 | Annotation score: | ||
V9GY97 | V9GY97_HUMAN | Amyloid beta precursor protein-bind... | APBB1 | 261 | Annotation score: | ||
A0A087X0V7 | A0A087X0V7_HUMAN | Amyloid beta precursor protein-bind... | APBB1 | 451 | Annotation score: | ||
A0A087WYH9 | A0A087WYH9_HUMAN | Amyloid beta precursor protein-bind... | APBB1 | 475 | Annotation score: | ||
A0A075B7G8 | A0A075B7G8_HUMAN | Amyloid beta precursor protein-bind... | APBB1 | 706 | Annotation score: | ||
V9GYD5 | V9GYD5_HUMAN | Amyloid beta precursor protein-bind... | APBB1 | 87 | Annotation score: | ||
V9GYR7 | V9GYR7_HUMAN | Amyloid beta precursor protein-bind... | APBB1 | 235 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 367 | I → T in BAH11532 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 493 | T → A in BAH11532 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014444 | 327 | M → V. Corresponds to variant dbSNP:rs1800423EnsemblClinVar. | 1 | |
Natural variantiVAR_014445 | 396 | N → S. Corresponds to variant dbSNP:rs1800425Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047459 | 1 – 259 | Missing in isoform 4. 2 PublicationsAdd BLAST | 259 | |
Alternative sequenceiVSP_054709 | 1 – 240 | MSVPS…SPEDT → MTQMR in isoform 6. 1 PublicationAdd BLAST | 240 | |
Alternative sequenceiVSP_045326 | 1 – 213 | Missing in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 213 | |
Alternative sequenceiVSP_045327 | 214 – 240 | NSAAS…SPEDT → MSAMFSQDFFLAIILQDSSA in isoform 3 and isoform 5. 2 PublicationsAdd BLAST | 27 | |
Alternative sequenceiVSP_011658 | 462 – 463 | Missing in isoform 2 and isoform 3. 2 Publications | 2 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000299402; ENSP00000299402; ENSG00000166313 [O00213-2] ENST00000311051; ENSP00000311912; ENSG00000166313 [O00213-2] ENST00000530885; ENSP00000433338; ENSG00000166313 [O00213-3] ENST00000608394; ENSP00000476442; ENSG00000166313 [O00213-4] ENST00000608645; ENSP00000476646; ENSG00000166313 [O00213-4] ENST00000608655; ENSP00000476846; ENSG00000166313 [O00213-5] ENST00000608704; ENSP00000476871; ENSG00000166313 [O00213-4] ENST00000609331; ENSP00000477069; ENSG00000166313 [O00213-6] ENST00000609360; ENSP00000477213; ENSG00000166313 |
GeneIDi | 322 |
KEGGi | hsa:322 |
MANE-Selecti | ENST00000609360.6; ENSP00000477213.1; NM_001164.5; NP_001155.1 |
UCSCi | uc001mdb.4, human [O00213-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E45 | NMR | - | A | 241-290 | [»] | |
2HO2 | X-ray | 1.33 | A | 253-289 | [»] | |
2IDH | X-ray | 2.28 | A/B/C/D/E/F/G/H | 253-289 | [»] | |
2OEI | X-ray | 1.35 | A | 253-289 | [»] | |
3D8D | X-ray | 2.20 | A/B | 366-505 | [»] | |
3D8E | X-ray | 2.80 | A/B/C/D | 366-505 | [»] | |
3D8F | X-ray | 2.70 | A/B/C/D | 366-505 | [»] | |
3DXC | X-ray | 2.10 | A/C | 534-667 | [»] | |
3DXD | X-ray | 2.20 | A/C | 534-667 | [»] | |
3DXE | X-ray | 2.00 | A/C | 534-667 | [»] | |
5NQH | X-ray | 2.60 | A/B/C/D | 534-667 | [»] | |
BMRBi | O00213 | |||||
SMRi | O00213 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 106819, 156 interactors |
CORUMi | O00213 |
DIPi | DIP-30903N |
ELMi | O00213 |
IntActi | O00213, 168 interactors |
MINTi | O00213 |
STRINGi | 9606.ENSP00000477213 |
PTM databases
GlyGeni | O00213, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | O00213 |
PhosphoSitePlusi | O00213 |
Genetic variation databases
BioMutai | APBB1 |
Proteomic databases
jPOSTi | O00213 |
MassIVEi | O00213 |
MaxQBi | O00213 |
PaxDbi | O00213 |
PeptideAtlasi | O00213 |
PRIDEi | O00213 |
ProteomicsDBi | 47783 [O00213-1] 47784 [O00213-2] 6474 |
Protocols and materials databases
Antibodypediai | 23808, 401 antibodies from 39 providers |
DNASUi | 322 |
Genome annotation databases
Organism-specific databases
CTDi | 322 |
DisGeNETi | 322 |
GeneCardsi | APBB1 |
HGNCi | HGNC:581, APBB1 |
HPAi | ENSG00000166313, Tissue enhanced (brain) |
MalaCardsi | APBB1 |
MIMi | 602709, gene |
neXtProti | NX_O00213 |
OpenTargetsi | ENSG00000166313 |
PharmGKBi | PA24873 |
VEuPathDBi | HostDB:ENSG00000166313 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QT08, Eukaryota |
GeneTreei | ENSGT00390000000002 |
HOGENOMi | CLU_021196_0_0_1 |
InParanoidi | O00213 |
OMAi | QVYYLGS |
OrthoDBi | 437627at2759 |
PhylomeDBi | O00213 |
TreeFami | TF314331 |
Enzyme and pathway databases
PathwayCommonsi | O00213 |
Reactomei | R-HSA-5693565, Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
SignaLinki | O00213 |
SIGNORi | O00213 |
Miscellaneous databases
BioGRID-ORCSi | 322, 2 hits in 1047 CRISPR screens |
ChiTaRSi | APBB1, human |
EvolutionaryTracei | O00213 |
GeneWikii | APBB1 |
GenomeRNAii | 322 |
Pharosi | O00213, Tbio |
PROi | PR:O00213 |
RNActi | O00213, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166313, Expressed in right hemisphere of cerebellum and 214 other tissues |
ExpressionAtlasi | O00213, baseline and differential |
Genevisiblei | O00213, HS |
Family and domain databases
CDDi | cd00201, WW, 1 hit |
Gene3Di | 2.30.29.30, 2 hits |
InterProi | View protein in InterPro IPR039576, Fe65 IPR011993, PH-like_dom_sf IPR006020, PTB/PI_dom IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR14058, PTHR14058, 1 hit |
Pfami | View protein in Pfam PF00640, PID, 2 hits PF00397, WW, 1 hit |
SMARTi | View protein in SMART SM00462, PTB, 2 hits SM00456, WW, 1 hit |
SUPFAMi | SSF51045, SSF51045, 1 hit |
PROSITEi | View protein in PROSITE PS01179, PID, 2 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | APBB1_HUMAN | |
Accessioni | O00213Primary (citable) accession number: O00213 Secondary accession number(s): A1E379 V9GYT4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | June 1, 1998 | |
Last modified: | February 23, 2022 | |
This is version 197 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references