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Protein

Rho-related GTP-binding protein RhoD

Gene

RHOD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi24 – 31GTPBy similarity8
Nucleotide bindingi71 – 75GTPBy similarity5
Nucleotide bindingi129 – 132GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: GO_Central
  • protein kinase binding Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-5663220 RHO GTPases Activate Formins
SignaLinkiO00212

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein RhoD
Alternative name(s):
Rho-related protein HP1
Short name:
RhoHP1
Gene namesi
Name:RHOD
Synonyms:ARHD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000173156.6
HGNCiHGNC:670 RHOD
MIMi605781 gene
neXtProtiNX_O00212

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi207C → S: Abolishes endosomal localization. 1 Publication1

Organism-specific databases

DisGeNETi29984
PharmGKBiPA24952

Polymorphism and mutation databases

BioMutaiRHOD

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988631 – 207Rho-related GTP-binding protein RhoDAdd BLAST207
PropeptideiPRO_0000223365208 – 210Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei207Cysteine methyl esterBy similarity1
Lipidationi207S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO00212
MaxQBiO00212
PaxDbiO00212
PeptideAtlasiO00212
PRIDEiO00212
ProteomicsDBi47782

PTM databases

iPTMnetiO00212
PhosphoSitePlusiO00212

Expressioni

Tissue specificityi

Heart, placenta, liver, skeletal muscle, and pancreas and, with weaker intensity, in several other tissues.

Gene expression databases

BgeeiENSG00000173156 Expressed in 172 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_RHOD
ExpressionAtlasiO00212 baseline and differential
GenevisibleiO00212 HS

Interactioni

Subunit structurei

Interacts (in GTP-bound form) with DIAPH2 isoform 3, DAPK3, FILIP1 and WHAMM. Interacts with PAK5. Interacts (independent of GTP-loaded status) with ANKFY1.5 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119010, 16 interactors
CORUMiO00212
IntActiO00212, 6 interactors
STRINGi9606.ENSP00000308576

Structurei

Secondary structure

1210
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00212
SMRiO00212
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00212

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi46 – 54Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiO00212
KOiK07530
OrthoDBiEOG091G0KNI
PhylomeDBiO00212
TreeFamiTF331746

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O00212-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTAAQAAGEE APPGVRSVKV VLVGDGGCGK TSLLMVFADG AFPESYTPTV
60 70 80 90 100
FERYMVNLQV KGKPVHLHIW DTAGQDDYDR LRPLFYPDAS VLLLCFDVTS
110 120 130 140 150
PNSFDNIFNR WYPEVNHFCK KVPIIVVGCK TDLCKDKSLV NKLRRNGLEP
160 170 180 190 200
VTYHRGQEMA RSVGAVAYLE CSARLHDNVH AVFQEAAEVA LSSRGRNFWR
210
RITQGFCVVT
Length:210
Mass (Da):23,413
Last modified:July 28, 2009 - v2
Checksum:i7B8A7AE8933C78B0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIG5E9PIG5_HUMAN
Rho-related GTP-binding protein Rho...
RHOD
144Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_058408134C → R3 PublicationsCorresponds to variant dbSNP:rs4930409Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85815 Genomic DNA Translation: BAA19652.1
AF498973 mRNA Translation: AAM21120.1
AP000729 Genomic DNA No translation available.
BC001338 mRNA Translation: AAH01338.1
CCDSiCCDS8155.1
RefSeqiNP_055393.1, NM_014578.3
UniGeneiHs.15114

Genome annotation databases

EnsembliENST00000308831; ENSP00000308576; ENSG00000173156
GeneIDi29984
KEGGihsa:29984
UCSCiuc001ojv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D85815 Genomic DNA Translation: BAA19652.1
AF498973 mRNA Translation: AAM21120.1
AP000729 Genomic DNA No translation available.
BC001338 mRNA Translation: AAH01338.1
CCDSiCCDS8155.1
RefSeqiNP_055393.1, NM_014578.3
UniGeneiHs.15114

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2J1LX-ray2.50A7-197[»]
ProteinModelPortaliO00212
SMRiO00212
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119010, 16 interactors
CORUMiO00212
IntActiO00212, 6 interactors
STRINGi9606.ENSP00000308576

PTM databases

iPTMnetiO00212
PhosphoSitePlusiO00212

Polymorphism and mutation databases

BioMutaiRHOD

Proteomic databases

EPDiO00212
MaxQBiO00212
PaxDbiO00212
PeptideAtlasiO00212
PRIDEiO00212
ProteomicsDBi47782

Protocols and materials databases

DNASUi29984
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308831; ENSP00000308576; ENSG00000173156
GeneIDi29984
KEGGihsa:29984
UCSCiuc001ojv.4 human

Organism-specific databases

CTDi29984
DisGeNETi29984
EuPathDBiHostDB:ENSG00000173156.6
GeneCardsiRHOD
HGNCiHGNC:670 RHOD
MIMi605781 gene
neXtProtiNX_O00212
PharmGKBiPA24952
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiO00212
KOiK07530
OrthoDBiEOG091G0KNI
PhylomeDBiO00212
TreeFamiTF331746

Enzyme and pathway databases

ReactomeiR-HSA-194840 Rho GTPase cycle
R-HSA-5663220 RHO GTPases Activate Formins
SignaLinkiO00212

Miscellaneous databases

ChiTaRSiRHOD human
EvolutionaryTraceiO00212
GeneWikiiRhoD
GenomeRNAii29984
PROiPR:O00212
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173156 Expressed in 172 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_RHOD
ExpressionAtlasiO00212 baseline and differential
GenevisibleiO00212 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRHOD_HUMAN
AccessioniPrimary (citable) accession number: O00212
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 28, 2009
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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