TLR4

Functionⁱ

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:27022195).

Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:9237759, PubMed:10835634, PubMed:27022195,PubMed:21393102).

Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate, and Ni²⁺. Responses triggered by Ni²⁺ require non-conserved histidines and are, therefore, species-specific (PubMed:20711192).

Both M.tuberculosis HSP70 (dnaK) and HSP65 (groEL-2) act via this protein to stimulate NF-kappa-B expression (PubMed:15809303).

In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion. Binds electronegative LDL (LDL^-) and mediates the cytokine release induced by LDL^- (PubMed:23880187).

Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via TLR2, but also partially via this receptor (PubMed:16622205, PubMed:10835634, PubMed:15809303, PubMed:17478729, PubMed:20037584, PubMed:20711192, PubMed:23880187, PubMed:27022195, PubMed:9237759).

Activated by the signaling pathway regulator NMI which acts as damage-associated molecular patterns (DAMPs) in response to cell injury or pathogen invasion, therefore promoting nuclear factor NF-kappa-B activation (PubMed:29038465).

10 Publications

Miscellaneous

His-456 and His-458 are found in TLR4 of human and several other primate species and may be responsible for inflammatory responses triggered by nickel (Ni²⁺). Ni²⁺ may cross-link the two receptor monomers through specific histidines, triggering the formation of a dimer that structurally resembles that induced by LPS. This process may be the basis for the development of contact allergy to Ni²⁺. A mouse model of contact allergy to Ni²⁺ in which TLR4-deficient mice expresses human TLR4 has been proposed.1 Publication

Caution

In some plant proteins and in human SARM1, the TIR domain has NAD⁺ hydrolase (NADase) activity (PubMed:28334607). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (PubMed:28334607). Based on this, it is unlikely that Toll-like receptors have NADase activity.Curated1 Publication

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Immunity, Inflammatory response, Innate immunity
Ligand	NAD

Enzyme and pathway databases

PathwayCommonsⁱ	O00206
Reactomeⁱ	R-HSA-1236974, ER-Phagosome pathway R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166166, MyD88-independent TLR4 cascade R-HSA-2562578, TRIF-mediated programmed cell death R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-9707616, Heme signaling R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkⁱ	O00206
SIGNORⁱ	O00206

Protein family/group databases

TCDBⁱ	8.A.43.1.9, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

TCDBⁱ

8.A.43.1.9, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Toll-like receptor 4 Alternative name(s): hToll CD_antigen: CD284
Gene namesⁱ	Name:TLR4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11850, TLR4
MIMⁱ	603030, gene
neXtProtⁱ	NX_O00206
VEuPathDBⁱ	HostDB:ENSG00000136869

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 631	ExtracellularSequence analysisAdd BLAST	608
Transmembraneⁱ	632 – 652	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	653 – 839	CytoplasmicSequence analysisAdd BLAST	187

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Endosome, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	431	H → A: Partially diminishes NF-kappa-B activation induced by Ni(2+). Strongly reduces NF-kappa-B activation induced by Ni(2+); when associated with A-456 or A-458. 1 Publication	1
Mutagenesisⁱ	456	H → A: Partially diminishes NF-kappa-B activation induced by Ni(2+). Strongly reduces NF-kappa-B activation induced by Ni(2+); when associated with A-431. Suppresses NF-kappa-B activation induced by Ni(2+); when associated with A-458. 1 Publication	1
Mutagenesisⁱ	458	H → A: Partially diminishes NF-kappa-B activation induced by Ni(2+). Strongly reduces NF-kappa-B activation induced by Ni(2+); when associated with A-431. Suppresses NF-kappa-B activation induced by Ni(2+); when associated with A-456. 1 Publication	1
Mutagenesisⁱ	526	N → A: Abolishes LPS-response and prevents the cell surface expression. 1 Publication	1
Mutagenesisⁱ	575	N → A: Abolishes LPS-response and prevents the cell surface expression. 1 Publication	1
Mutagenesisⁱ	697	E → R: Abolishes LPS-response. 1 Publication	1
Mutagenesisⁱ	710	R → E: Abolishes LPS-response. 1 Publication	1
Mutagenesisⁱ	711	D → K: Abolishes LPS-response. 1 Publication	1
Mutagenesisⁱ	714	P → H, R or E: Abolishes MYD88-binding and LPS-response. 1 Publication	1

Keywords - Diseaseⁱ

Age-related macular degeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7099
MalaCards human disease database More...MalaCardsⁱ	TLR4
Open Targets More...OpenTargetsⁱ	ENSG00000136869
Orphanetⁱ	117, Behcet disease
PharmGKBⁱ	PA36552

Miscellaneous databases

Pharosⁱ	O00206, Tchem

Pharosⁱ

O00206, Tchem

Chemistry databases

ChEMBLⁱ	CHEMBL5255
Drug and drug target database More...DrugBankⁱ	DB02767, (R)-3-hydroxytetradecanoic acid DB00924, Cyclobenzaprine DB06447, E5531 DB04933, Eritoran DB05475, Golotimod DB03017, Lauric acid DB13615, Mifamurtide DB08231, Myristic acid DB01183, Naloxone DB11193, Papain
DrugCentral More...DrugCentralⁱ	O00206
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1754

Genetic variation databases

BioMutaⁱ	TLR4

BioMutaⁱ

TLR4

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	1 PublicationAdd BLAST		23
ChainⁱPRO_0000034722	24 – 839	Toll-like receptor 4Add BLAST		816

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	29 ↔ 40	2 Publications
Glycosylationⁱ	35	N-linked (GlcNAc...) asparagine3 Publications	1
Glycosylationⁱ	173	N-linked (GlcNAc...) asparagine4 Publications	1
Glycosylationⁱ	205	N-linked (GlcNAc...) asparagine3 Publications	1
Disulfide bondⁱ	281 ↔ 306	1 Publication
Glycosylationⁱ	282	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	309	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	390 ↔ 391	1 Publication
Glycosylationⁱ	497	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	526	N-linked (GlcNAc...) asparagine2 Publications	1
Glycosylationⁱ	575	N-linked (GlcNAc...) asparagine2 Publications	1
Disulfide bondⁱ	583 ↔ 609	1 Publication
Disulfide bondⁱ	585 ↔ 627	1 Publication
Glycosylationⁱ	624	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	630	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated. Glycosylation of Asn-526 and Asn-575 seems to be necessary for the expression of TLR4 on the cell surface and the LPS-response. Likewise, mutants lacking two or more of the other N-glycosylation sites were deficient in interaction with LPS.4 Publications

Phosphorylated on tyrosine residues by LYN after binding lipopolysaccharide.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MassIVEⁱ	O00206
PaxDbⁱ	O00206
PeptideAtlas More...PeptideAtlasⁱ	O00206
PRIDEⁱ	O00206
ProteomicsDBⁱ	47779 [O00206-1] 47780 [O00206-2] 47781 [O00206-3]

PTM databases

GlyGenⁱ	O00206, 10 sites
iPTMnetⁱ	O00206
PhosphoSitePlusⁱ	O00206

Expressionⁱ

Tissue specificityⁱ

Highly expressed in placenta, spleen and peripheral blood leukocytes (PubMed:9435236, PubMed:9237759). Detected in monocytes, macrophages, dendritic cells and several types of T-cells (PubMed:9237759, PubMed:27022195).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000136869, Expressed in leukocyte and 199 other tissues
ExpressionAtlasⁱ	O00206, baseline and differential
Genevisibleⁱ	O00206, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000136869, Low tissue specificity

HPAⁱ

ENSG00000136869, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binding to bacterial LPS leads to homodimerization.

Interacts with LY96 via the extracellular domain (PubMed:17803912, PubMed:19252480).

Interacts with MYD88 and TIRAP via their respective TIR domains (By similarity).

Interacts with TICAM2 (PubMed:14519765, PubMed:25736436).

Interacts with NOX4 (PubMed:15356101).

Interacts with CNPY3 (By similarity).

Interacts with HSP90B1. The interaction with both CNPY3 and HSP90B1 is required for proper folding in the endoplasmic reticulum.

Interacts with MAP3K21; this interaction leads to negative regulation of TLR4 signaling (PubMed:21602844).

Interacts with CD36, following CD36 stimulation by oxLDL or amyloid-beta 42, and forms a heterodimer with TLR6 (PubMed:20037584). The trimeric complex is internalized and triggers inflammatory response. LYN kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation.

Interacts with TICAM1 in response to LPS in a WDFY1-dependent manner (PubMed:25736436).

Interacts with WDFY1 in response to LPS (By similarity).

Interacts with SMPDL3B (By similarity).

Interacts with CEACAM1; upon lipopolysaccharide stimulation, forms a complex including TLR4 and the phosphorylated form of SYK and CEACAM1, which in turn, recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome (By similarity).

Interacts with RFTN1; the interaction occurs in response to lipopolysaccharide stimulation (PubMed:27022195).

Interacts with SCIMP; the interaction occurs in response to lipopolysaccharide stimulation and is enhanced by phosphorylation of SCIMP by LYN (By similarity). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (By similarity).

Interacts with TRAF3IP3 (PubMed:30573680).

Interacts with TREM1; this interaction enhances TLR4-mediated inflammatory response (PubMed:21393102, PubMed:17098818).

By similarity13 Publications

(Microbial infection) In case of infection, interacts with uropathogenic E.coli protein TcpC.

1 Publication

Binary interactionsⁱ

Hide details

O00206

With	#Exp.	IntAct
ADIPOR1 [Q96A54]	2	EBI-528701,EBI-1632076
LY96 [Q9Y6Y9]	7	EBI-528701,EBI-1539247
MBL2 [P11226]	2	EBI-528701,EBI-5325353
MYD88 [Q99836]	4	EBI-528701,EBI-447677
NOX4 [Q9NPH5]	4	EBI-528701,EBI-11301574
SIGLEC5 [O15389]	2	EBI-528701,EBI-750381
SIGLEC6 - isoform 3 [O43699-3]	2	EBI-528701,EBI-12161783
SIGLEC9 [Q9Y336]	2	EBI-528701,EBI-12857926
TICAM2 [Q86XR7]	3	EBI-528701,EBI-525927
TIRAP [P58753]	6	EBI-528701,EBI-528644
itself	2	EBI-528701,EBI-528701
TLR6 [Q9Y2C9]	2	EBI-528701,EBI-13940779
TNC [P24821]	4	EBI-528701,EBI-9979894

Isoform 1 [O00206-1]

With	#Exp.	IntAct
LY96 [Q9Y6Y9]	5	EBI-15745059,EBI-1539247
DERP2 [P49278] from Dermatophagoides pteronyssinus.	3	EBI-15745059,EBI-15745025

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	112954, 41 interactors
ComplexPortalⁱ	CPX-2545, LY96-TLR4 toll-like receptor complex CPX-945, TLR4-TLR6 toll-like receptor complex
CORUMⁱ	O00206
Database of interacting proteins More...DIPⁱ	DIP-34769N
ELMⁱ	O00206
IntActⁱ	O00206, 33 interactors
Molecular INTeraction database More...MINTⁱ	O00206
STRINGⁱ	9606.ENSP00000363089

Chemistry databases

BindingDBⁱ

O00206

Miscellaneous databases

RNActⁱ	O00206, protein

RNActⁱ

O00206, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 33	Combined sources	5
Turnⁱ	34 – 36	Combined sources	3
Beta strandⁱ	37 – 39	Combined sources	3
Beta strandⁱ	50 – 52	Combined sources	3
Beta strandⁱ	58 – 60	Combined sources	3
Turnⁱ	71 – 76	Combined sources	6
Beta strandⁱ	81 – 84	Combined sources	4
Turnⁱ	95 – 100	Combined sources	6
Beta strandⁱ	106 – 108	Combined sources	3
Beta strandⁱ	115 – 117	Combined sources	3
Turnⁱ	119 – 124	Combined sources	6
Beta strandⁱ	130 – 132	Combined sources	3
Helixⁱ	141 – 143	Combined sources	3
Turnⁱ	145 – 148	Combined sources	4
Beta strandⁱ	154 – 156	Combined sources	3
Helixⁱ	169 – 173	Combined sources	5
Beta strandⁱ	179 – 181	Combined sources	3
Helixⁱ	192 – 195	Combined sources	4
Helixⁱ	196 – 199	Combined sources	4
Beta strandⁱ	206 – 209	Combined sources	4
Turnⁱ	220 – 225	Combined sources	6
Beta strandⁱ	227 – 235	Combined sources	9
Helixⁱ	242 – 248	Combined sources	7
Turnⁱ	249 – 252	Combined sources	4
Beta strandⁱ	254 – 262	Combined sources	9
Turnⁱ	274 – 277	Combined sources	4
Helixⁱ	278 – 282	Combined sources	5
Beta strandⁱ	283 – 292	Combined sources	10
Beta strandⁱ	295 – 298	Combined sources	4
Turnⁱ	301 – 304	Combined sources	4
Helixⁱ	305 – 307	Combined sources	3
Beta strandⁱ	311 – 317	Combined sources	7
Beta strandⁱ	319 – 322	Combined sources	4
Helixⁱ	324 – 327	Combined sources	4
Beta strandⁱ	333 – 339	Combined sources	7
Beta strandⁱ	341 – 344	Combined sources	4
Beta strandⁱ	355 – 360	Combined sources	6
Beta strandⁱ	377 – 379	Combined sources	3
Beta strandⁱ	387 – 392	Combined sources	6
Helixⁱ	393 – 396	Combined sources	4
Beta strandⁱ	403 – 405	Combined sources	3
Beta strandⁱ	410 – 419	Combined sources	10
Beta strandⁱ	426 – 428	Combined sources	3
Beta strandⁱ	432 – 437	Combined sources	6
Turnⁱ	438 – 445	Combined sources	8
Beta strandⁱ	451 – 453	Combined sources	3
Turnⁱ	464 – 469	Combined sources	6
Beta strandⁱ	475 – 477	Combined sources	3
Helixⁱ	484 – 486	Combined sources	3
Beta strandⁱ	500 – 502	Combined sources	3
Turnⁱ	513 – 518	Combined sources	6
Beta strandⁱ	524 – 526	Combined sources	3
Helixⁱ	538 – 540	Combined sources	3
Beta strandⁱ	548 – 550	Combined sources	3
Beta strandⁱ	560 – 563	Combined sources	4
Beta strandⁱ	573 – 575	Combined sources	3
Helixⁱ	585 – 587	Combined sources	3
Helixⁱ	588 – 596	Combined sources	9
Helixⁱ	597 – 600	Combined sources	4
Helixⁱ	604 – 606	Combined sources	3
Beta strandⁱ	608 – 612	Combined sources	5
Helixⁱ	613 – 615	Combined sources	3
Beta strandⁱ	617 – 619	Combined sources	3
Helixⁱ	620 – 622	Combined sources	3
Beta strandⁱ	627 – 629	Combined sources	3
Helixⁱ	630 – 662	Combined sources	33

Show more details

3D structure databases

AlphaFoldDBⁱ	O00206
SMRⁱ	O00206
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O00206

EvolutionaryTraceⁱ

O00206

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	55 – 76	LRR 1Add BLAST	22
Repeatⁱ	79 – 100	LRR 2Add BLAST	22
Repeatⁱ	103 – 124	LRR 3Add BLAST	22
Repeatⁱ	127 – 148	LRR 4Add BLAST	22
Repeatⁱ	151 – 172	LRR 5Add BLAST	22
Repeatⁱ	176 – 199	LRR 6Add BLAST	24
Repeatⁱ	205 – 225	LRR 7Add BLAST	21
Repeatⁱ	227 – 247	LRR 8Add BLAST	21
Repeatⁱ	331 – 351	LRR 9Add BLAST	21
Repeatⁱ	352 – 373	LRR 10Add BLAST	22
Repeatⁱ	374 – 394	LRR 11Add BLAST	21
Repeatⁱ	400 – 422	LRR 12Add BLAST	23
Repeatⁱ	423 – 444	LRR 13Add BLAST	22
Repeatⁱ	448 – 456	LRR 14	9
Repeatⁱ	472 – 495	LRR 15Add BLAST	24
Repeatⁱ	497 – 518	LRR 16Add BLAST	22
Repeatⁱ	521 – 542	LRR 17Add BLAST	22
Repeatⁱ	545 – 565	LRR 18Add BLAST	21
Domainⁱ	579 – 629	LRRCTAdd BLAST	51
Domainⁱ	672 – 815	TIRPROSITE-ProRule annotationAdd BLAST	144

Domainⁱ

The TIR domain mediates interaction with NOX4.1 Publication

Sequence similaritiesⁱ

Belongs to the Toll-like receptor family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4641, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000160778
HOGENOMⁱ	CLU_006000_5_0_1
InParanoidⁱ	O00206
OMAⁱ	CKHSAER
Database of Orthologous Groups More...OrthoDBⁱ	282372at2759
PhylomeDBⁱ	O00206
TreeFamⁱ	TF351113

Family and domain databases

Gene3Dⁱ	3.40.50.10140, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR24365, PTHR24365, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13855, LRR_8, 3 hits PF01582, TIR, 1 hit
PIRSFⁱ	PIRSF037595, Toll-like_receptor, 1 hit
SMARTⁱ	View protein in SMART SM00369, LRR_TYP, 11 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit
SUPFAMⁱ	SSF52200, SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450, LRR, 11 hits PS50104, TIR, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: O00206-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMSASRLAGT LIPAMAFLSC VRPESWEPCV EVVPNITYQC MELNFYKIPD 
        60         70         80         90        100
NLPFSTKNLD LSFNPLRHLG SYSFFSFPEL QVLDLSRCEI QTIEDGAYQS 
       110        120        130        140        150
LSHLSTLILT GNPIQSLALG AFSGLSSLQK LVAVETNLAS LENFPIGHLK 
       160        170        180        190        200
TLKELNVAHN LIQSFKLPEY FSNLTNLEHL DLSSNKIQSI YCTDLRVLHQ 
       210        220        230        240        250
MPLLNLSLDL SLNPMNFIQP GAFKEIRLHK LTLRNNFDSL NVMKTCIQGL 
       260        270        280        290        300
AGLEVHRLVL GEFRNEGNLE KFDKSALEGL CNLTIEEFRL AYLDYYLDDI 
       310        320        330        340        350
IDLFNCLTNV SSFSLVSVTI ERVKDFSYNF GWQHLELVNC KFGQFPTLKL 
       360        370        380        390        400
KSLKRLTFTS NKGGNAFSEV DLPSLEFLDL SRNGLSFKGC CSQSDFGTTS 
       410        420        430        440        450
LKYLDLSFNG VITMSSNFLG LEQLEHLDFQ HSNLKQMSEF SVFLSLRNLI 
       460        470        480        490        500
YLDISHTHTR VAFNGIFNGL SSLEVLKMAG NSFQENFLPD IFTELRNLTF 
       510        520        530        540        550
LDLSQCQLEQ LSPTAFNSLS SLQVLNMSHN NFFSLDTFPY KCLNSLQVLD 
       560        570        580        590        600
YSLNHIMTSK KQELQHFPSS LAFLNLTQND FACTCEHQSF LQWIKDQRQL 
       610        620        630        640        650
LVEVERMECA TPSDKQGMPV LSLNITCQMN KTIIGVSVLS VLVVSVVAVL 
       660        670        680        690        700
VYKFYFHLML LAGCIKYGRG ENIYDAFVIY SSQDEDWVRN ELVKNLEEGV 
       710        720        730        740        750
PPFQLCLHYR DFIPGVAIAA NIIHEGFHKS RKVIVVVSQH FIQSRWCIFE 
       760        770        780        790        800
YEIAQTWQFL SSRAGIIFIV LQKVEKTLLR QQVELYRLLS RNTYLEWEDS 
       810        820        830 
VLGRHIFWRR LRKALLDGKS WNPEGTVGTG CNWQEATSI

Length:839

Mass (Da):95,680

Last modified:January 1, 1998 - v2

Checksum:ⁱ92C48F55821133E8

GO

Isoform 2 (identifier: O00206-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-40: Missing.

« Hide

        10         20         30         40         50
MELNFYKIPD NLPFSTKNLD LSFNPLRHLG SYSFFSFPEL QVLDLSRCEI 
        60         70         80         90        100
QTIEDGAYQS LSHLSTLILT GNPIQSLALG AFSGLSSLQK LVAVETNLAS 
       110        120        130        140        150
LENFPIGHLK TLKELNVAHN LIQSFKLPEY FSNLTNLEHL DLSSNKIQSI 
       160        170        180        190        200
YCTDLRVLHQ MPLLNLSLDL SLNPMNFIQP GAFKEIRLHK LTLRNNFDSL 
       210        220        230        240        250
NVMKTCIQGL AGLEVHRLVL GEFRNEGNLE KFDKSALEGL CNLTIEEFRL 
       260        270        280        290        300
AYLDYYLDDI IDLFNCLTNV SSFSLVSVTI ERVKDFSYNF GWQHLELVNC 
       310        320        330        340        350
KFGQFPTLKL KSLKRLTFTS NKGGNAFSEV DLPSLEFLDL SRNGLSFKGC 
       360        370        380        390        400
CSQSDFGTTS LKYLDLSFNG VITMSSNFLG LEQLEHLDFQ HSNLKQMSEF 
       410        420        430        440        450
SVFLSLRNLI YLDISHTHTR VAFNGIFNGL SSLEVLKMAG NSFQENFLPD 
       460        470        480        490        500
IFTELRNLTF LDLSQCQLEQ LSPTAFNSLS SLQVLNMSHN NFFSLDTFPY 
       510        520        530        540        550
KCLNSLQVLD YSLNHIMTSK KQELQHFPSS LAFLNLTQND FACTCEHQSF 
       560        570        580        590        600
LQWIKDQRQL LVEVERMECA TPSDKQGMPV LSLNITCQMN KTIIGVSVLS 
       610        620        630        640        650
VLVVSVVAVL VYKFYFHLML LAGCIKYGRG ENIYDAFVIY SSQDEDWVRN 
       660        670        680        690        700
ELVKNLEEGV PPFQLCLHYR DFIPGVAIAA NIIHEGFHKS RKVIVVVSQH 
       710        720        730        740        750
FIQSRWCIFE YEIAQTWQFL SSRAGIIFIV LQKVEKTLLR QQVELYRLLS 
       760        770        780        790 
RNTYLEWEDS VLGRHIFWRR LRKALLDGKS WNPEGTVGTG CNWQEATSI

Show »

Length:799

Mass (Da):91,296

Checksum:ⁱ82F70995E7F2AF9D

GO

Isoform 3 (identifier: O00206-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-200: Missing.

« Hide

        10         20         30         40         50
MPLLNLSLDL SLNPMNFIQP GAFKEIRLHK LTLRNNFDSL NVMKTCIQGL 
        60         70         80         90        100
AGLEVHRLVL GEFRNEGNLE KFDKSALEGL CNLTIEEFRL AYLDYYLDDI 
       110        120        130        140        150
IDLFNCLTNV SSFSLVSVTI ERVKDFSYNF GWQHLELVNC KFGQFPTLKL 
       160        170        180        190        200
KSLKRLTFTS NKGGNAFSEV DLPSLEFLDL SRNGLSFKGC CSQSDFGTTS 
       210        220        230        240        250
LKYLDLSFNG VITMSSNFLG LEQLEHLDFQ HSNLKQMSEF SVFLSLRNLI 
       260        270        280        290        300
YLDISHTHTR VAFNGIFNGL SSLEVLKMAG NSFQENFLPD IFTELRNLTF 
       310        320        330        340        350
LDLSQCQLEQ LSPTAFNSLS SLQVLNMSHN NFFSLDTFPY KCLNSLQVLD 
       360        370        380        390        400
YSLNHIMTSK KQELQHFPSS LAFLNLTQND FACTCEHQSF LQWIKDQRQL 
       410        420        430        440        450
LVEVERMECA TPSDKQGMPV LSLNITCQMN KTIIGVSVLS VLVVSVVAVL 
       460        470        480        490        500
VYKFYFHLML LAGCIKYGRG ENIYDAFVIY SSQDEDWVRN ELVKNLEEGV 
       510        520        530        540        550
PPFQLCLHYR DFIPGVAIAA NIIHEGFHKS RKVIVVVSQH FIQSRWCIFE 
       560        570        580        590        600
YEIAQTWQFL SSRAGIIFIV LQKVEKTLLR QQVELYRLLS RNTYLEWEDS 
       610        620        630 
VLGRHIFWRR LRKALLDGKS WNPEGTVGTG CNWQEATSI

Show »

Length:639

Mass (Da):73,301

Checksum:ⁱ23C1406CE32427EC

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A2R8Y7P4	A0A2R8Y7P4_HUMAN		Toll-like receptor 4 Toll-like receptor 4	TLR4	32	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	73	S → R in ABU41664 (Ref. 11) Curated	1
Sequence conflictⁱ	400	S → C in BAF82742 (PubMed:14702039).Curated	1
Sequence conflictⁱ	581	F → S in BAG64706 (PubMed:14702039).Curated	1

Polymorphismⁱ

Allele TLR4*B (Gly-299, Ile-399) is associated with a blunted response to inhaled LPS.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_021977	175	T → A. Corresponds to variant dbSNP:rs16906079Ensembl.	1
Natural variantⁱVAR_018729	188	Q → R1 PublicationCorresponds to variant dbSNP:rs5030713Ensembl.	1
Natural variantⁱVAR_018730	246	C → S1 PublicationCorresponds to variant dbSNP:rs5030714Ensembl.	1
Natural variantⁱVAR_074187	287	E → D1 Publication	1
Natural variantⁱVAR_012739	299	D → G in allele TLR4*B; reduced LPS-response; associated with an increased risk for age-related macular degeneration in Caucasian carriers. 5 PublicationsCorresponds to variant dbSNP:rs4986790EnsemblClinVar.	1
Natural variantⁱVAR_047563	306	C → W. Corresponds to variant dbSNP:rs2770145Ensembl.	1
Natural variantⁱVAR_047564	310	V → G. Corresponds to variant dbSNP:rs2770144Ensembl.	1
Natural variantⁱVAR_018731	329	N → S1 PublicationCorresponds to variant dbSNP:rs5030715Ensembl.	1
Natural variantⁱVAR_020334	342	F → Y. Corresponds to variant dbSNP:rs5031050Ensembl.	1
Natural variantⁱVAR_037668	385	L → F. Corresponds to variant dbSNP:rs11536884Ensembl.	1
Natural variantⁱVAR_012740	399	T → I in allele TLR4*B; reduced LPS-response. 4 PublicationsCorresponds to variant dbSNP:rs4986791EnsemblClinVar.	1
Natural variantⁱVAR_020335	400	S → N. Corresponds to variant dbSNP:rs4987233Ensembl.	1
Natural variantⁱVAR_018732	443	F → L1 PublicationCorresponds to variant dbSNP:rs5030716Ensembl.	1
Natural variantⁱVAR_018733	474	E → K1 PublicationCorresponds to variant dbSNP:rs5030718Ensembl.	1
Natural variantⁱVAR_018734	510	Q → H1 PublicationCorresponds to variant dbSNP:rs5030719Ensembl.	1
Natural variantⁱVAR_018735	694	K → R1 PublicationCorresponds to variant dbSNP:rs5030722Ensembl.	1
Natural variantⁱVAR_018736	763	R → H1 PublicationCorresponds to variant dbSNP:rs5030723Ensembl.	1
Natural variantⁱVAR_018737	834	Q → H1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_035793	1 – 200	Missing in isoform 3. 1 PublicationAdd BLAST		200
Alternative sequenceⁱVSP_035794	1 – 40	Missing in isoform 2. 2 PublicationsAdd BLAST		40

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U93091 mRNA Translation: AAC80227.1 AB445638 mRNA Translation: BAG55035.1 DQ018107 Genomic DNA Translation: AAY82267.1 DQ018108 Genomic DNA Translation: AAY82268.1 DQ018109 Genomic DNA Translation: AAY82269.1 AK290053 mRNA Translation: BAF82742.1 AK293068 mRNA Translation: BAF85757.1 AK303730 mRNA Translation: BAG64706.1 AL160272 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87448.1 CH471090 Genomic DNA Translation: EAW87451.1 BC117422 mRNA Translation: AAI17423.1 EF535831 Genomic DNA Translation: ABU41662.1 EF535832 Genomic DNA Translation: ABU41663.1 EF535833 Genomic DNA Translation: ABU41664.1 AF177765 Genomic DNA Translation: AAF05316.1 AF177766 Genomic DNA Translation: AAF07823.1 AF172171, AF172169, AF172170 Genomic DNA Translation: AAF89753.1 U88880 mRNA Translation: AAC34135.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6818.1 [O00206-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_003257.1, NM_003266.3 [O00206-2] NP_612564.1, NM_138554.4 [O00206-1] NP_612567.1, NM_138557.2 [O00206-3]

Genome annotation databases

Ensemblⁱ	ENST00000355622.8; ENSP00000363089.5; ENSG00000136869.16 ENST00000394487.5; ENSP00000377997.4; ENSG00000136869.16 [O00206-2]
GeneIDⁱ	7099
KEGGⁱ	hsa:7099
MANE-Selectⁱ	ENST00000355622.8; ENSP00000363089.5; NM_138554.5; NP_612564.1
UCSC genome browser More...UCSCⁱ	uc004bjz.5, human [O00206-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00206	Isoform 2 of Toll-like receptor 4		HUMAN		799	UniRef100_O00206
Toll-like receptor 4 (Fragment)		Pan troglodytes ellioti		55
Toll-like receptor 4 (Fragment)		Pan troglodytes troglodytes		55
Toll-like receptor 4 (Fragment)		western gorilla		55
Toll-like receptor 4 (Fragment)		Pan troglodytes verus		55
+10

Protein	Similar proteins		Species	Score	Length	Source
O00206	Toll-like receptor 4		PANPA		839	UniRef90_O00206
Toll-like receptor 4		GORGO		837
Toll-like receptor 4		PONPY		828
Toll-like receptor 4		PAPAN		826
Isoform 2 of Toll-like receptor 4		HUMAN		799
+109

Protein	Similar proteins		Species	Score	Length	Source
O00206	Toll-like receptor 4	)	MOUSE		835	UniRef50_Q9QUK6
Toll-like receptor 4		RAT		835
Toll-like receptor 4		PIG		841
Toll-like receptor 4		CRIGR		838
Toll-like receptor 4		PANPA		839
+658

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

Zips, necklaces and mobile telephones - Issue 134 of December 2011

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U93091 mRNA Translation: AAC80227.1 AB445638 mRNA Translation: BAG55035.1 DQ018107 Genomic DNA Translation: AAY82267.1 DQ018108 Genomic DNA Translation: AAY82268.1 DQ018109 Genomic DNA Translation: AAY82269.1 AK290053 mRNA Translation: BAF82742.1 AK293068 mRNA Translation: BAF85757.1 AK303730 mRNA Translation: BAG64706.1 AL160272 Genomic DNA No translation available. CH471090 Genomic DNA Translation: EAW87448.1 CH471090 Genomic DNA Translation: EAW87451.1 BC117422 mRNA Translation: AAI17423.1 EF535831 Genomic DNA Translation: ABU41662.1 EF535832 Genomic DNA Translation: ABU41663.1 EF535833 Genomic DNA Translation: ABU41664.1 AF177765 Genomic DNA Translation: AAF05316.1 AF177766 Genomic DNA Translation: AAF07823.1 AF172171, AF172169, AF172170 Genomic DNA Translation: AAF89753.1 U88880 mRNA Translation: AAC34135.1
CCDSⁱ	CCDS6818.1 [O00206-1]
RefSeqⁱ	NP_003257.1, NM_003266.3 [O00206-2] NP_612564.1, NM_138554.4 [O00206-1] NP_612567.1, NM_138557.2 [O00206-3]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2Z62	X-ray	1.70	A	27-228	[»]
	2Z63	X-ray	2.00	A	27-527	[»]
	2Z65	X-ray	2.70	A/B	27-228	[»]
	2Z66	X-ray	1.90	A/B/C/D	381-627	[»]
	3FXI	X-ray	3.10	A/B	27-631	[»]
	3UL7	X-ray	2.37	A	28-226	[»]
	3UL8	X-ray	2.50	A	27-228	[»]
	3UL9	X-ray	2.45	A	28-228	[»]
	3ULA	X-ray	3.60	A/C	27-228	[»]
	4G8A	X-ray	2.40	A/B	23-629	[»]
	5NAM	NMR	-	A	623-670	[»]
	5NAO	NMR	-	A	623-657	[»]
AlphaFoldDBⁱ	O00206
SMRⁱ	O00206
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	112954, 41 interactors
ComplexPortalⁱ	CPX-2545, LY96-TLR4 toll-like receptor complex CPX-945, TLR4-TLR6 toll-like receptor complex
CORUMⁱ	O00206
DIPⁱ	DIP-34769N
ELMⁱ	O00206
IntActⁱ	O00206, 33 interactors
MINTⁱ	O00206
STRINGⁱ	9606.ENSP00000363089

Chemistry databases

BindingDBⁱ	O00206
ChEMBLⁱ	CHEMBL5255
DrugBankⁱ	DB02767, (R)-3-hydroxytetradecanoic acid DB00924, Cyclobenzaprine DB06447, E5531 DB04933, Eritoran DB05475, Golotimod DB03017, Lauric acid DB13615, Mifamurtide DB08231, Myristic acid DB01183, Naloxone DB11193, Papain
DrugCentralⁱ	O00206
GuidetoPHARMACOLOGYⁱ	1754

Protein family/group databases

TCDBⁱ	8.A.43.1.9, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

TCDBⁱ

8.A.43.1.9, the neat-domain containing methaemoglobin heme sequestration (n-mhs) family

PTM databases

GlyGenⁱ	O00206, 10 sites
iPTMnetⁱ	O00206
PhosphoSitePlusⁱ	O00206

Genetic variation databases

BioMutaⁱ	TLR4

BioMutaⁱ

TLR4

Proteomic databases

MassIVEⁱ	O00206
PaxDbⁱ	O00206
PeptideAtlasⁱ	O00206
PRIDEⁱ	O00206
ProteomicsDBⁱ	47779 [O00206-1] 47780 [O00206-2] 47781 [O00206-3]

Protocols and materials databases

ABCDⁱ	O00206, 25 sequenced antibodies
Antibodypediaⁱ	3410, 1901 antibodies from 51 providers
The DNASU plasmid repository More...DNASUⁱ	7099

Genome annotation databases

Ensemblⁱ	ENST00000355622.8; ENSP00000363089.5; ENSG00000136869.16 ENST00000394487.5; ENSP00000377997.4; ENSG00000136869.16 [O00206-2]
GeneIDⁱ	7099
KEGGⁱ	hsa:7099
MANE-Selectⁱ	ENST00000355622.8; ENSP00000363089.5; NM_138554.5; NP_612564.1
UCSCⁱ	uc004bjz.5, human [O00206-1]

Organism-specific databases

CTDⁱ	7099
DisGeNETⁱ	7099
GeneCardsⁱ	TLR4
HGNCⁱ	HGNC:11850, TLR4
HPAⁱ	ENSG00000136869, Low tissue specificity
MalaCardsⁱ	TLR4
MIMⁱ	603030, gene
neXtProtⁱ	NX_O00206
OpenTargetsⁱ	ENSG00000136869
Orphanetⁱ	117, Behcet disease
PharmGKBⁱ	PA36552
VEuPathDBⁱ	HostDB:ENSG00000136869
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4641, Eukaryota
GeneTreeⁱ	ENSGT00940000160778
HOGENOMⁱ	CLU_006000_5_0_1
InParanoidⁱ	O00206
OMAⁱ	CKHSAER
OrthoDBⁱ	282372at2759
PhylomeDBⁱ	O00206
TreeFamⁱ	TF351113

Enzyme and pathway databases

PathwayCommonsⁱ	O00206
Reactomeⁱ	R-HSA-1236974, ER-Phagosome pathway R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-166166, MyD88-independent TLR4 cascade R-HSA-2562578, TRIF-mediated programmed cell death R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-5686938, Regulation of TLR by endogenous ligand R-HSA-936964, Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon R-HSA-937041, IKK complex recruitment mediated by RIP1 R-HSA-937072, TRAF6-mediated induction of TAK1 complex within TLR4 complex R-HSA-9707616, Heme signaling R-HSA-975163, IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
SignaLinkⁱ	O00206
SIGNORⁱ	O00206

Miscellaneous databases

BioGRID-ORCSⁱ	7099, 6 hits in 1065 CRISPR screens
EvolutionaryTraceⁱ	O00206
GeneWikiⁱ	TLR_4
GenomeRNAiⁱ	7099
Pharosⁱ	O00206, Tchem
Protein Ontology More...PROⁱ	PR:O00206
RNActⁱ	O00206, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000136869, Expressed in leukocyte and 199 other tissues
ExpressionAtlasⁱ	O00206, baseline and differential
Genevisibleⁱ	O00206, HS

Family and domain databases

Gene3Dⁱ	3.40.50.10140, 1 hit 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR032675, LRR_dom_sf IPR000157, TIR_dom IPR017241, Toll-like_receptor IPR035897, Toll_tir_struct_dom_sf
PANTHERⁱ	PTHR24365, PTHR24365, 1 hit
Pfamⁱ	View protein in Pfam PF13855, LRR_8, 3 hits PF01582, TIR, 1 hit
PIRSFⁱ	PIRSF037595, Toll-like_receptor, 1 hit
SMARTⁱ	View protein in SMART SM00369, LRR_TYP, 11 hits SM00082, LRRCT, 1 hit SM00255, TIR, 1 hit
SUPFAMⁱ	SSF52200, SSF52200, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450, LRR, 11 hits PS50104, TIR, 1 hit
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TLR4_HUMAN
Accessionⁱ	O00206Primary (citable) accession number: O00206 Secondary accession number(s): A8K1Y8 Q9UM57
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 11, 2002
	Last sequence update:	January 1, 1998
	Last modified:	May 25, 2022
	This is version 220 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Direct protein sequencing, Reference proteome

Documents

Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O00206 (TLR4_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Toll-like receptor 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Plasma membrane

Other locations

Endosome

Golgi apparatus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

O00206

Isoform 1 [O00206-1]

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Genetic variation databases

Proteomic databases

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ