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Protein

Sulfotransferase family cytosolic 2B member 1

Gene

SULT2B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10.9 µM for DHEA (at 37 degrees Celsius, in the presence of 1 mM MgCl2)2 Publications
  2. KM=3.8 µM for DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2)2 Publications
  3. KM=11.8 µM for pregnenolone (at 37 degrees Celsius, in the presence of 1 mM MgCl2)2 Publications
  4. KM=0.6 µM for PAPS (at 37 degrees Celsius, in the presence of 1 mM MgCl2)2 Publications
  1. Vmax=1752 pmol/min/mg enzyme toward DHEA (at 37 degrees Celsius, in the presence of 10 mM MgCl2)2 Publications

Temperature dependencei

Optimum temperature is 37 degrees Celsius. Retains 70% and 20% of activity when incubated at 42 degrees Celsius for 45 and 120 minutes, respectively. Activity is lost after 200 minutes incubation at 42 degrees Celsius.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei98Substrate1
Binding sitei103Substrate1
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei125Proton acceptor1
Binding sitei125Substrate1
Binding sitei147PAPS1
Binding sitei155PAPS1
Binding sitei210PAPS1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi70 – 75PAPS6
Nucleotide bindingi244 – 249PAPS6
Nucleotide bindingi274 – 276PAPS3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • alcohol sulfotransferase activity Source: Reactome
  • cholesterol binding Source: CAFA
  • nucleic acid binding Source: CAFA
  • steroid hormone binding Source: CAFA
  • steroid sulfotransferase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processLipid metabolism, Steroid metabolism

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-156584 Cytosolic sulfonation of small molecules

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
O00204 Predicted

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001653 [O00204-1]
SLP:000001654 [O00204-2]

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfotransferase family cytosolic 2B member 1 (EC:2.8.2.2)
Short name:
ST2B1
Short name:
Sulfotransferase 2B1
Alternative name(s):
Alcohol sulfotransferase
Hydroxysteroid sulfotransferase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SULT2B1
Synonyms:HSST2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000088002.11

Human Gene Nomenclature Database

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HGNCi
HGNC:11459 SULT2B1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604125 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00204

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Microsome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Ichthyosis, congenital, autosomal recessive 14 (ARCI14)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs.
See also OMIM:617571
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079210149P → L in ARCI14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1114167424Ensembl.1
Natural variantiVAR_079211274R → Q in ARCI14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs762765702EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1 – 23Missing : Loss of the cholesterol sulfotransferase activity. 1 PublicationAdd BLAST23
Mutagenesisi1 – 18Missing : Increases the cholesterol sulfotransferase activity. 1 PublicationAdd BLAST18
Mutagenesisi19D → A: Increases the cholesterol sulfotransferase activity. 1 Publication1
Mutagenesisi20I → A: Loss of the cholesterol sulfotransferase activity. 1 Publication1
Mutagenesisi21S → A: Increases the cholesterol sulfotransferase activity. 1 Publication1
Mutagenesisi22E → A: Increases the cholesterol sulfotransferase activity. 1 Publication1
Mutagenesisi23I → A: Loss of the cholesterol sulfotransferase activity. 1 Publication1
Mutagenesisi347S → A: No change in subcellular localization. 1 Publication1
Mutagenesisi348S → D: 10-fold increase in specific activity for DHEA sulfation. 10-fold increase in substrate affinity for DHEA and pregnenolone. No effect on substrate affinity for PAPS. Increases enzyme stability. 1 Publication1
Mutagenesisi348S → G: Abolishes nuclear localization. 1 Publication1
Mutagenesisi352S → G: No change in subcellular localization. 1 Publication1
Mutagenesisi357S → G: No change in subcellular localization. 1 Publication1

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

DisGeNET

More...
DisGeNETi
6820

MalaCards human disease database

More...
MalaCardsi
SULT2B1
MIMi617571 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000088002

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
313 Lamellar ichthyosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA36249

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL1743297

Drug and drug target database

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DrugBanki
DB01812 Adenosine-3'-5'-Diphosphate
DB03309 N-Cyclohexyltaurine
DB01708 Prasterone
DB02789 Pregnenolone

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SULT2B1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000851491 – 365Sulfotransferase family cytosolic 2B member 1Add BLAST365

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei348Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O00204

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00204

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O00204

PeptideAtlas

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PeptideAtlasi
O00204

PRoteomics IDEntifications database

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PRIDEi
O00204

ProteomicsDB human proteome resource

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ProteomicsDBi
47777
47778 [O00204-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O00204

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O00204

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088002 Expressed in 146 organ(s), highest expression level in lower esophagus mucosa

CleanEx database of gene expression profiles

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CleanExi
HS_SULT2B1

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00204 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033013
HPA041724
HPA043539

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112689, 15 interactors

Protein interaction database and analysis system

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IntActi
O00204, 12 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000201586

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1365
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q1QX-ray2.91A24-365[»]
1Q1ZX-ray2.40A19-312[»]
1Q20X-ray2.30A19-312[»]
1Q22X-ray2.50A19-312[»]

Database of protein disorder

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DisProti
DP00404
DP01099

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
O00204

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O00204

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
O00204

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi305 – 365Pro/Ser-richAdd BLAST61

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sulfotransferase 1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1584 Eukaryota
ENOG4111H56 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000159269

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000037209

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG001195

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O00204

KEGG Orthology (KO)

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KOi
K01015

Identification of Orthologs from Complete Genome Data

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OMAi
RMQGKEN

Database of Orthologous Groups

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OrthoDBi
780670at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O00204

TreeFam database of animal gene trees

More...
TreeFami
TF321745

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00685 Sulfotransfer_1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O00204-1) [UniParc]FASTAAdd to basket
Also known as: SULT2B1b, B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDGPAEPQIP GLWDTYEDDI SEISQKLPGE YFRYKGVPFP VGLYSLESIS
60 70 80 90 100
LAENTQDVRD DDIFIITYPK SGTTWMIEII CLILKEGDPS WIRSVPIWER
110 120 130 140 150
APWCETIVGA FSLPDQYSPR LMSSHLPIQI FTKAFFSSKA KVIYMGRNPR
160 170 180 190 200
DVVVSLYHYS KIAGQLKDPG TPDQFLRDFL KGEVQFGSWF DHIKGWLRMK
210 220 230 240 250
GKDNFLFITY EELQQDLQGS VERICGFLGR PLGKEALGSV VAHSTFSAMK
260 270 280 290 300
ANTMSNYTLL PPSLLDHRRG AFLRKGVCGD WKNHFTVAQS EAFDRAYRKQ
310 320 330 340 350
MRGMPTFPWD EDPEEDGSPD PEPSPEPEPK PSLEPNTSLE REPRPNSSPS
360
PSPGQASETP HPRPS
Length:365
Mass (Da):41,308
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13E95248DD40DF91
GO
Isoform 2 (identifier: O00204-2) [UniParc]FASTAAdd to basket
Also known as: SULT2B1a, A

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MDGPAEPQIPGLWDTYEDDISEI → MASPPPFH

Show »
Length:350
Mass (Da):39,599
Checksum:iCE5BAA8F8874E3A4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350S → N in AAC78498 (PubMed:9799594).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02088751L → S. Corresponds to variant dbSNP:rs16982149Ensembl.1
Natural variantiVAR_079210149P → L in ARCI14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1114167424Ensembl.1
Natural variantiVAR_021988240V → I. Corresponds to variant dbSNP:rs2302947Ensembl.1
Natural variantiVAR_079211274R → Q in ARCI14; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs762765702EnsemblClinVar.1
Natural variantiVAR_020888345P → L. Corresponds to variant dbSNP:rs17842463Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0125101 – 23MDGPA…DISEI → MASPPPFH in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U92314 mRNA Translation: AAC78498.1
U92315 mRNA Translation: AAC78499.1
U92322
, U92316, U92318, U92319, U92320, U92321 Genomic DNA Translation: AAC78553.1
U92322
, U92316, U92317, U92318, U92319, U92320, U92321 Genomic DNA Translation: AAC78554.1
AC008403 Genomic DNA No translation available.
BC034694 mRNA Translation: AAH34694.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS12723.1 [O00204-1]
CCDS12724.1 [O00204-2]

NCBI Reference Sequences

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RefSeqi
NP_004596.2, NM_004605.2 [O00204-2]
NP_814444.1, NM_177973.1 [O00204-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.369331

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000201586; ENSP00000201586; ENSG00000088002 [O00204-1]
ENST00000323090; ENSP00000312880; ENSG00000088002 [O00204-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6820

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6820

UCSC genome browser

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UCSCi
uc002pjl.4 human [O00204-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U92314 mRNA Translation: AAC78498.1
U92315 mRNA Translation: AAC78499.1
U92322
, U92316, U92318, U92319, U92320, U92321 Genomic DNA Translation: AAC78553.1
U92322
, U92316, U92317, U92318, U92319, U92320, U92321 Genomic DNA Translation: AAC78554.1
AC008403 Genomic DNA No translation available.
BC034694 mRNA Translation: AAH34694.1
CCDSiCCDS12723.1 [O00204-1]
CCDS12724.1 [O00204-2]
RefSeqiNP_004596.2, NM_004605.2 [O00204-2]
NP_814444.1, NM_177973.1 [O00204-1]
UniGeneiHs.369331

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q1QX-ray2.91A24-365[»]
1Q1ZX-ray2.40A19-312[»]
1Q20X-ray2.30A19-312[»]
1Q22X-ray2.50A19-312[»]
DisProtiDP00404
DP01099
ProteinModelPortaliO00204
SMRiO00204
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112689, 15 interactors
IntActiO00204, 12 interactors
STRINGi9606.ENSP00000201586

Chemistry databases

ChEMBLiCHEMBL1743297
DrugBankiDB01812 Adenosine-3'-5'-Diphosphate
DB03309 N-Cyclohexyltaurine
DB01708 Prasterone
DB02789 Pregnenolone
SwissLipidsiSLP:000001653 [O00204-1]
SLP:000001654 [O00204-2]

Protein family/group databases

MoonDBiO00204 Predicted

PTM databases

iPTMnetiO00204
PhosphoSitePlusiO00204

Polymorphism and mutation databases

BioMutaiSULT2B1

Proteomic databases

jPOSTiO00204
MaxQBiO00204
PaxDbiO00204
PeptideAtlasiO00204
PRIDEiO00204
ProteomicsDBi47777
47778 [O00204-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6820
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000201586; ENSP00000201586; ENSG00000088002 [O00204-1]
ENST00000323090; ENSP00000312880; ENSG00000088002 [O00204-2]
GeneIDi6820
KEGGihsa:6820
UCSCiuc002pjl.4 human [O00204-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6820
DisGeNETi6820
EuPathDBiHostDB:ENSG00000088002.11

GeneCards: human genes, protein and diseases

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GeneCardsi
SULT2B1
HGNCiHGNC:11459 SULT2B1
HPAiCAB033013
HPA041724
HPA043539
MalaCardsiSULT2B1
MIMi604125 gene
617571 phenotype
neXtProtiNX_O00204
OpenTargetsiENSG00000088002
Orphaneti313 Lamellar ichthyosis
PharmGKBiPA36249

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1584 Eukaryota
ENOG4111H56 LUCA
GeneTreeiENSGT00940000159269
HOGENOMiHOG000037209
HOVERGENiHBG001195
InParanoidiO00204
KOiK01015
OMAiRMQGKEN
OrthoDBi780670at2759
PhylomeDBiO00204
TreeFamiTF321745

Enzyme and pathway databases

ReactomeiR-HSA-156584 Cytosolic sulfonation of small molecules

Miscellaneous databases

EvolutionaryTraceiO00204

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SULT2B1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6820

Protein Ontology

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PROi
PR:O00204

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088002 Expressed in 146 organ(s), highest expression level in lower esophagus mucosa
CleanExiHS_SULT2B1
GenevisibleiO00204 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000863 Sulfotransferase_dom
PfamiView protein in Pfam
PF00685 Sulfotransfer_1, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiST2B1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00204
Secondary accession number(s): O00205, O75814
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: January 4, 2005
Last modified: January 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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