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Protein

Activator of apoptosis harakiri

Gene

HRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes apoptosis.2 Publications

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of protein homooligomerization Source: BHF-UCL
  • positive regulation of release of cytochrome c from mitochondria Source: BHF-UCL

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

SIGNORiO00198

Names & Taxonomyi

Protein namesi
Recommended name:
Activator of apoptosis harakiri
Alternative name(s):
BH3-interacting domain-containing protein 3
Neuronal death protein DP5
Gene namesi
Name:HRK
Synonyms:BID3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000135116.9
HGNCiHGNC:5185 HRK
MIMi603447 gene
neXtProtiNX_O00198

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei69 – 87HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi8739
OpenTargetsiENSG00000135116
PharmGKBiPA29459

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001431061 – 91Activator of apoptosis harakiriAdd BLAST91

Proteomic databases

PaxDbiO00198
PRIDEiO00198
ProteomicsDBi47774

Expressioni

Gene expression databases

BgeeiENSG00000135116 Expressed in 106 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_HRK
ExpressionAtlasiO00198 baseline and differential
GenevisibleiO00198 HS

Organism-specific databases

HPAiCAB025973

Interactioni

Subunit structurei

Interacts with BCL2 and BCL2L1. Interacts with C1QBP.3 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi114276, 6 interactors
ELMiO00198
IntActiO00198, 7 interactors
STRINGi9606.ENSP00000257572

Structurei

Secondary structure

191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00198
SMRiO00198
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00198

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 47BH3Add BLAST15

Domaini

The BH3 motif is required for the induction of cell death.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J2PJ Eukaryota
ENOG41113ZW LUCA
GeneTreeiENSGT00390000007050
HOGENOMiHOG000112951
HOVERGENiHBG005990
InParanoidiO00198
KOiK02512
OMAiAVCACSS
OrthoDBiEOG091G16Q4
PhylomeDBiO00198
TreeFamiTF338168

Family and domain databases

InterProiView protein in InterPro
IPR017249 Apoptosis_activator_harakiri
IPR020728 Bcl2_BH3_motif_CS
PANTHERiPTHR15056 PTHR15056, 1 hit
PfamiView protein in Pfam
PF15196 Harakiri, 1 hit
PIRSFiPIRSF037635 BID3, 1 hit
PROSITEiView protein in PROSITE
PS01259 BH3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O00198-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCPCPLHRGR GPPAVCACSA GRLGLRSSAA QLTAARLKAL GDELHQRTMW
60 70 80 90
RRRARSRRAP APGALPTYWP WLCAAAQVAA LAAWLLGRRN L
Length:91
Mass (Da):9,884
Last modified:July 1, 1997 - v1
Checksum:i22E45FA2B0B7AA00
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJY7K7EJY7_HUMAN
Activator of apoptosis harakiri
HRK
18Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76376 mRNA Translation: AAC34931.1
AC083806 Genomic DNA No translation available.
CCDSiCCDS9181.1
RefSeqiNP_003797.1, NM_003806.2
XP_016875635.1, XM_017020146.1
UniGeneiHs.26605
Hs.87247

Genome annotation databases

EnsembliENST00000257572; ENSP00000257572; ENSG00000135116
GeneIDi8739
KEGGihsa:8739
UCSCiuc001twe.5 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U76376 mRNA Translation: AAC34931.1
AC083806 Genomic DNA No translation available.
CCDSiCCDS9181.1
RefSeqiNP_003797.1, NM_003806.2
XP_016875635.1, XM_017020146.1
UniGeneiHs.26605
Hs.87247

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L58NMR-A22-53[»]
2L5BNMR-A61-91[»]
ProteinModelPortaliO00198
SMRiO00198
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114276, 6 interactors
ELMiO00198
IntActiO00198, 7 interactors
STRINGi9606.ENSP00000257572

Proteomic databases

PaxDbiO00198
PRIDEiO00198
ProteomicsDBi47774

Protocols and materials databases

DNASUi8739
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257572; ENSP00000257572; ENSG00000135116
GeneIDi8739
KEGGihsa:8739
UCSCiuc001twe.5 human

Organism-specific databases

CTDi8739
DisGeNETi8739
EuPathDBiHostDB:ENSG00000135116.9
GeneCardsiHRK
HGNCiHGNC:5185 HRK
HPAiCAB025973
MIMi603447 gene
neXtProtiNX_O00198
OpenTargetsiENSG00000135116
PharmGKBiPA29459
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2PJ Eukaryota
ENOG41113ZW LUCA
GeneTreeiENSGT00390000007050
HOGENOMiHOG000112951
HOVERGENiHBG005990
InParanoidiO00198
KOiK02512
OMAiAVCACSS
OrthoDBiEOG091G16Q4
PhylomeDBiO00198
TreeFamiTF338168

Enzyme and pathway databases

SIGNORiO00198

Miscellaneous databases

ChiTaRSiHRK human
EvolutionaryTraceiO00198
GeneWikiiHRK_(gene)
GenomeRNAii8739
PROiPR:O00198
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135116 Expressed in 106 organ(s), highest expression level in buccal mucosa cell
CleanExiHS_HRK
ExpressionAtlasiO00198 baseline and differential
GenevisibleiO00198 HS

Family and domain databases

InterProiView protein in InterPro
IPR017249 Apoptosis_activator_harakiri
IPR020728 Bcl2_BH3_motif_CS
PANTHERiPTHR15056 PTHR15056, 1 hit
PfamiView protein in Pfam
PF15196 Harakiri, 1 hit
PIRSFiPIRSF037635 BID3, 1 hit
PROSITEiView protein in PROSITE
PS01259 BH3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiHRK_HUMAN
AccessioniPrimary (citable) accession number: O00198
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 1, 1997
Last modified: September 12, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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