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Protein

Ras-related protein Rab-27B

Gene

RAB27B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the associaton of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 24GTP9
Nucleotide bindingi74 – 78GTPBy similarity5
Nucleotide bindingi133 – 136GTP4
Nucleotide bindingi163 – 165GTP3

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB
  • myosin V binding Source: UniProtKB
  • protein domain specific binding Source: UniProtKB

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-27B
Alternative name(s):
C25KG
Gene namesi
Name:RAB27B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

EuPathDBiHostDB:ENSG00000041353.9
HGNCiHGNC:9767 RAB27B
MIMi603869 gene
neXtProtiNX_O00194

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5874
OpenTargetsiENSG00000041353
PharmGKBiPA34118

Polymorphism and mutation databases

BioMutaiRAB27B

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001212242 – 218Ras-related protein Rab-27BAdd BLAST217

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonine1 Publication1
Disulfide bondi123 ↔ 1881 Publication
Lipidationi216S-geranylgeranyl cysteineBy similarity1
Modified residuei218Cysteine methyl esterBy similarity1
Lipidationi218S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiO00194
MaxQBiO00194
PaxDbiO00194
PeptideAtlasiO00194
PRIDEiO00194
ProteomicsDBi47773

2D gel databases

OGPiO00194

PTM databases

iPTMnetiO00194
PhosphoSitePlusiO00194

Expressioni

Tissue specificityi

Expressed primarily in testis.

Gene expression databases

BgeeiENSG00000041353 Expressed in 187 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_RAB27B
ExpressionAtlasiO00194 baseline and differential
GenevisibleiO00194 HS

Organism-specific databases

HPAiCAB017712
HPA019849

Interactioni

Subunit structurei

Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111812, 14 interactors
DIPiDIP-48948N
IntActiO00194, 8 interactors
STRINGi9606.ENSP00000262094

Structurei

Secondary structure

1218
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00194
SMRiO00194
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00194

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0081 Eukaryota
ENOG410XQ3T LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiO00194
KOiK07886
OMAiAEKKCAC
OrthoDBiEOG091G0I51
PhylomeDBiO00194
TreeFamiTF312895

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O00194-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDGDYDYLI KLLALGDSGV GKTTFLYRYT DNKFNPKFIT TVGIDFREKR
60 70 80 90 100
VVYNAQGPNG SSGKAFKVHL QLWDTAGQER FRSLTTAFFR DAMGFLLMFD
110 120 130 140 150
LTSQQSFLNV RNWMSQLQAN AYCENPDIVL IGNKADLPDQ REVNERQARE
160 170 180 190 200
LADKYGIPYF ETSAATGQNV EKAVETLLDL IMKRMEQCVE KTQIPDTVNG
210
GNSGNLDGEK PPEKKCIC
Length:218
Mass (Da):24,608
Last modified:January 23, 2007 - v4
Checksum:i8ED640F0C15EDCD3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ES41K7ES41_HUMAN
Ras-related protein Rab-27B
RAB27B
87Annotation score:
K7EJ38K7EJ38_HUMAN
Ras-related protein Rab-27B
RAB27B
131Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05171492A → T. Corresponds to variant dbSNP:rs9966265Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57093 mRNA Translation: AAC51194.2
AF329499 mRNA Translation: AAK11243.1
AF498954 mRNA Translation: AAM21102.1
AK314115 mRNA Translation: BAG36807.1
CH471096 Genomic DNA Translation: EAW63010.1
BC027474 mRNA Translation: AAH27474.1
CCDSiCCDS11958.1
RefSeqiNP_004154.2, NM_004163.4
XP_005266790.1, XM_005266733.1
XP_016881402.1, XM_017025913.1
XP_016881403.1, XM_017025914.1
UniGeneiHs.25318

Genome annotation databases

EnsembliENST00000262094; ENSP00000262094; ENSG00000041353
GeneIDi5874
KEGGihsa:5874
UCSCiuc002lfr.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57093 mRNA Translation: AAC51194.2
AF329499 mRNA Translation: AAK11243.1
AF498954 mRNA Translation: AAM21102.1
AK314115 mRNA Translation: BAG36807.1
CH471096 Genomic DNA Translation: EAW63010.1
BC027474 mRNA Translation: AAH27474.1
CCDSiCCDS11958.1
RefSeqiNP_004154.2, NM_004163.4
XP_005266790.1, XM_005266733.1
XP_016881402.1, XM_017025913.1
XP_016881403.1, XM_017025914.1
UniGeneiHs.25318

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F7SX-ray2.70A/B4-201[»]
ProteinModelPortaliO00194
SMRiO00194
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111812, 14 interactors
DIPiDIP-48948N
IntActiO00194, 8 interactors
STRINGi9606.ENSP00000262094

PTM databases

iPTMnetiO00194
PhosphoSitePlusiO00194

Polymorphism and mutation databases

BioMutaiRAB27B

2D gel databases

OGPiO00194

Proteomic databases

EPDiO00194
MaxQBiO00194
PaxDbiO00194
PeptideAtlasiO00194
PRIDEiO00194
ProteomicsDBi47773

Protocols and materials databases

DNASUi5874
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262094; ENSP00000262094; ENSG00000041353
GeneIDi5874
KEGGihsa:5874
UCSCiuc002lfr.4 human

Organism-specific databases

CTDi5874
DisGeNETi5874
EuPathDBiHostDB:ENSG00000041353.9
GeneCardsiRAB27B
HGNCiHGNC:9767 RAB27B
HPAiCAB017712
HPA019849
MIMi603869 gene
neXtProtiNX_O00194
OpenTargetsiENSG00000041353
PharmGKBiPA34118
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0081 Eukaryota
ENOG410XQ3T LUCA
GeneTreeiENSGT00890000139330
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiO00194
KOiK07886
OMAiAEKKCAC
OrthoDBiEOG091G0I51
PhylomeDBiO00194
TreeFamiTF312895

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation
R-HSA-8873719 RAB geranylgeranylation
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

EvolutionaryTraceiO00194
GenomeRNAii5874
PROiPR:O00194
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000041353 Expressed in 187 organ(s), highest expression level in Brodmann (1909) area 23
CleanExiHS_RAB27B
ExpressionAtlasiO00194 baseline and differential
GenevisibleiO00194 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRB27B_HUMAN
AccessioniPrimary (citable) accession number: O00194
Secondary accession number(s): B2RAB0, Q9BZB6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 176 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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