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Entry version 142 (18 Sep 2019)
Sequence version 1 (01 Jul 1997)
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Protein

Small acidic protein

Gene

SMAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Small acidic protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMAP
Synonyms:C11orf58
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16990 C11orf58

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00193

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10944

Open Targets

More...
OpenTargetsi
ENSG00000110696

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485353

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C11orf58

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002636561 – 183Small acidic proteinAdd BLAST183

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki13Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei17PhosphoserineCombined sources1
Cross-linki62Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei63PhosphoserineCombined sources1
Cross-linki75Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei87PhosphoserineCombined sources1
Modified residuei127PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1
Modified residuei174N6-acetyllysineCombined sources1
Modified residuei179N6-acetyllysineCombined sources1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00193

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00193

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
O00193

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00193

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00193

PeptideAtlas

More...
PeptideAtlasi
O00193

PRoteomics IDEntifications database

More...
PRIDEi
O00193

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47772

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
O00193

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00193

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00193

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O00193

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110696 Expressed in 204 organ(s), highest expression level in cerebellar vermis

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00193 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00193 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036591
HPA076406

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116144, 47 interactors

Protein interaction database and analysis system

More...
IntActi
O00193, 22 interactors

Molecular INTeraction database

More...
MINTi
O00193

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000228136

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi109 – 139Asp-richAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SMAP family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVYQ Eukaryota
ENOG4111SCI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000687

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000247059

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00193

Identification of Orthologs from Complete Genome Data

More...
OMAi
GFSEFQE

Database of Orthologous Groups

More...
OrthoDBi
1443224at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00193

TreeFam database of animal gene trees

More...
TreeFami
TF328803

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026714 SMAP
IPR028124 SMAP_dom

The PANTHER Classification System

More...
PANTHERi
PTHR22175 PTHR22175, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15477 SMAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O00193-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAARESHPH GVKRSASPDD DLGSSNWEAA DLGNEERKQK FLRLMGAGKK
60 70 80 90 100
EHTGRLVIGD HKSTSHFRTG EEDKKINEEL ESQYQQSMDS KLSGRYRRHC
110 120 130 140 150
GLGFSEVEDH DGEGDVAGDD DDDDDDSPDP ESPDDSESDS ESEKEESAEE
160 170 180
LQAAEHPDEV EDPKNKKDAK SNYKMMFVKS SGS
Length:183
Mass (Da):20,333
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i509BA7377B699A74
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PM92E9PM92_HUMAN
Chromosome 11 open reading frame 58
C11orf58
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQA1E9PQA1_HUMAN
Chromosome 11 open reading frame 58
C11orf58
86Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRZ9E9PRZ9_HUMAN
Chromosome 11 open reading frame 58
C11orf58
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U51678 mRNA Translation: AAB99729.1
CR456882 mRNA Translation: CAG33163.1
AK315382 mRNA Translation: BAG37775.1
CH471064 Genomic DNA Translation: EAW68455.1
BC007103 mRNA Translation: AAH07103.1
BC016352 mRNA Translation: AAH16352.1
BC020937 mRNA Translation: AAH20937.1
BC103747 mRNA Translation: AAI03748.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7822.1

NCBI Reference Sequences

More...
RefSeqi
NP_055082.1, NM_014267.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000228136; ENSP00000228136; ENSG00000110696

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10944

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10944

UCSC genome browser

More...
UCSCi
uc001mmk.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51678 mRNA Translation: AAB99729.1
CR456882 mRNA Translation: CAG33163.1
AK315382 mRNA Translation: BAG37775.1
CH471064 Genomic DNA Translation: EAW68455.1
BC007103 mRNA Translation: AAH07103.1
BC016352 mRNA Translation: AAH16352.1
BC020937 mRNA Translation: AAH20937.1
BC103747 mRNA Translation: AAI03748.1
CCDSiCCDS7822.1
RefSeqiNP_055082.1, NM_014267.5

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi116144, 47 interactors
IntActiO00193, 22 interactors
MINTiO00193
STRINGi9606.ENSP00000228136

PTM databases

iPTMnetiO00193
PhosphoSitePlusiO00193
SwissPalmiO00193

Polymorphism and mutation databases

BioMutaiC11orf58

Proteomic databases

EPDiO00193
jPOSTiO00193
MassIVEiO00193
MaxQBiO00193
PaxDbiO00193
PeptideAtlasiO00193
PRIDEiO00193
ProteomicsDBi47772
TopDownProteomicsiO00193

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10944
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000228136; ENSP00000228136; ENSG00000110696
GeneIDi10944
KEGGihsa:10944
UCSCiuc001mmk.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10944
DisGeNETi10944

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C11orf58
HGNCiHGNC:16990 C11orf58
HPAiHPA036591
HPA076406
neXtProtiNX_O00193
OpenTargetsiENSG00000110696
PharmGKBiPA143485353

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IVYQ Eukaryota
ENOG4111SCI LUCA
GeneTreeiENSGT00390000000687
HOGENOMiHOG000247059
InParanoidiO00193
OMAiGFSEFQE
OrthoDBi1443224at2759
PhylomeDBiO00193
TreeFamiTF328803

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C11orf58 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C11orf58

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
10944

Pharos

More...
Pharosi
O00193

Protein Ontology

More...
PROi
PR:O00193

Gene expression databases

BgeeiENSG00000110696 Expressed in 204 organ(s), highest expression level in cerebellar vermis
ExpressionAtlasiO00193 baseline and differential
GenevisibleiO00193 HS

Family and domain databases

InterProiView protein in InterPro
IPR026714 SMAP
IPR028124 SMAP_dom
PANTHERiPTHR22175 PTHR22175, 1 hit
PfamiView protein in Pfam
PF15477 SMAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMAP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00193
Secondary accession number(s): B2RD28
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 1, 1997
Last modified: September 18, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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