AP4M1

Functionⁱ

Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways (PubMed:10436028, PubMed:11139587, PubMed:10066790, PubMed:11802162, PubMed:20230749). AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system (PubMed:11139587, PubMed:20230749). It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons (By similarity). Within AP-4, the mu-type subunit AP4M1 is directly involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos (PubMed:10436028, PubMed:11139587, PubMed:26544806, PubMed:20230749). The adaptor protein complex 4 (AP-4) may also recognize other types of sorting signal (By similarity).By similarity6 Publications

GO - Molecular functionⁱ

protein domain specific binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11139587
- 26544806

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

Golgi to endosome transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20230749
Golgi to lysosome transport
Source: UniProtKB
Inferred from direct assayⁱ
- 11139587
intracellular protein transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20230749
protein localization Source: UniProtKB
protein localization to basolateral plasma membrane Source: UniProtKB
protein targeting
Source: UniProtKB
Inferred from direct assayⁱ
- 20230749
protein targeting to lysosome
Source: UniProtKB
Inferred from direct assayⁱ
- 11139587

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432720 Lysosome Vesicle Biogenesis
SignaLinkⁱ	O00189

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: AP-4 complex subunit mu-1Curated Alternative name(s): AP-4 adaptor complex mu subunit Adaptor-related protein complex 4 subunit mu-1 Mu subunit of AP-4 Mu-adaptin-related protein 2 Short name: mu-ARP2 Mu4-adaptin Short name: mu4
Gene namesⁱ	Name:AP4M1Imported Synonyms:MUARP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000221838.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:574 AP4M1
MIMⁱ	602296 gene
neXtProtⁱ	NX_O00189

Keywords - Cellular componentⁱ

Endosome, Golgi apparatus, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Spastic paraplegia 50, autosomal recessive (SPG50)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. SPG50 affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	255	F → A: Abolishes interaction with APP. 1 Publication		1
Mutagenesisⁱ	283	R → D: Strongly reduced interaction with APP. 1 Publication		1

Keywords - Diseaseⁱ

Hereditary spastic paraplegia, Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9179
MalaCards human disease database More...MalaCardsⁱ	AP4M1
MIMⁱ	612936 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000221838
Orphanetⁱ	280763 Severe intellectual disability and progressive spastic paraplegia
PharmGKBⁱ	PA24866

Polymorphism and mutation databases

BioMutaⁱ	AP4M1

BioMutaⁱ

AP4M1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000193787	1 – 453	AP-4 complex subunit mu-1Add BLAST		453

Proteomic databases

EPDⁱ	O00189
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00189
PaxDbⁱ	O00189
PeptideAtlas More...PeptideAtlasⁱ	O00189
PRIDEⁱ	O00189
ProteomicsDBⁱ	47769
TopDownProteomicsⁱ	O00189

PTM databases

iPTMnetⁱ	O00189
PhosphoSitePlusⁱ	O00189

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highly expressed in testis and lowly expressed in brain and lung.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000221838 Expressed in 136 organ(s), highest expression level in right testis
CleanExⁱ	HS_AP4M1
ExpressionAtlasⁱ	O00189 baseline and differential
Genevisibleⁱ	O00189 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA066774

HPAⁱ

HPA066774

Interactionⁱ

Subunit structureⁱ

Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin (sigma-type AP4S1) (PubMed:10436028, PubMed:10066790, PubMed:11802162). Interacts with tyrosine-based sorting signals on the cytoplasmic tail of cargo proteins such as APP, LAMP2 and NAGPA (PubMed:11139587, PubMed:26544806, PubMed:20230749). Interacts with the C-terminal domain of GRID2 (By similarity). Interacts with GRIA1 and GRIA2; the interaction is indirect via CACNG3 (By similarity). Interacts with CACNG3; CACNG3 associates GRIA1 and GRIA2 with the adaptor protein complex 4 (AP-4) to target them to the somatodendritic compartment of neurons (By similarity).By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
USP47	Q96K76	3	EBI-3914106,EBI-2514143

With

Entry

#Exp.

IntAct

Notes

USP47

Q96K76

3

EBI-3914106,EBI-2514143

GO - Molecular functionⁱ

protein domain specific binding
Source: UniProtKB
Inferred from direct assayⁱ
- 11139587
- 26544806

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114616, 34 interactors
CORUMⁱ	O00189
IntActⁱ	O00189, 31 interactors
Molecular INTeraction database More...MINTⁱ	O00189
STRINGⁱ	9606.ENSP00000352603

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	186 – 199	Combined sources	14
Beta strandⁱ	205 – 218	Combined sources	14
Beta strandⁱ	225 – 230	Combined sources	6
Beta strandⁱ	235 – 237	Combined sources	3
Turnⁱ	240 – 242	Combined sources	3
Beta strandⁱ	246 – 256	Combined sources	11
Helixⁱ	264 – 267	Combined sources	4
Beta strandⁱ	269 – 272	Combined sources	4
Beta strandⁱ	276 – 286	Combined sources	11
Beta strandⁱ	295 – 304	Combined sources	10
Turnⁱ	306 – 308	Combined sources	3
Beta strandⁱ	309 – 319	Combined sources	11
Beta strandⁱ	326 – 335	Combined sources	10
Beta strandⁱ	341 – 349	Combined sources	9
Beta strandⁱ	353 – 357	Combined sources	5
Beta strandⁱ	360 – 365	Combined sources	6
Beta strandⁱ	373 – 381	Combined sources	9
Beta strandⁱ	405 – 412	Combined sources	8
Beta strandⁱ	421 – 427	Combined sources	7
Beta strandⁱ	437 – 451	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	O00189
SMRⁱ	O00189
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O00189

EvolutionaryTraceⁱ

O00189

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	184 – 452	MHDPROSITE-ProRule annotationAdd BLAST		269

Sequence similaritiesⁱ

Belongs to the adaptor complexes medium subunit family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0937 Eukaryota ENOG410XPFS LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062779
HOGENOMⁱ	HOG000173245
HOVERGENⁱ	HBG102734
InParanoidⁱ	O00189
KEGG Orthology (KO) More...KOⁱ	K12402
PhylomeDBⁱ	O00189
TreeFamⁱ	TF329745

Family and domain databases

InterProⁱ	View protein in InterPro IPR036168 AP2_Mu_C_sf IPR022775 AP_mu_sigma_su IPR001392 Clathrin_mu IPR018240 Clathrin_mu_CS IPR011012 Longin-like_dom_sf IPR028565 MHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00928 Adap_comp_sub, 1 hit PF01217 Clat_adaptor_s, 1 hit
PIRSFⁱ	PIRSF005992 Clathrin_mu, 1 hit
PRINTSⁱ	PR00314 CLATHRINADPT
SUPFAMⁱ	SSF49447 SSF49447, 1 hit SSF64356 SSF64356, 1 hit
PROSITEⁱ	View protein in PROSITE PS00991 CLAT_ADAPTOR_M_2, 1 hit PS51072 MHD, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show all Align All

O00189-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGDESPVVMH 
        60         70         80         90        100
HHGRHFIHIR HSGLYLVVTT SENVSPFSLL ELLSRLATLL GDYCGSLGEG 
       110        120        130        140        150
TISRNVALVY ELLDEVLDYG YVQTTSTEML RNFIQTEAVV SKPFSLFDLS 
       160        170        180        190        200
SVGLFGAETQ QSKVAPSSAA SRPVLSSRSD QSQKNEVFLD VVERLSVLIA 
       210        220        230        240        250
SNGSLLKVDV QGEIRLKSFL PSGSEMRIGL TEEFCVGKSE LRGYGPGIRV 
       260        270        280        290        300
DEVSFHSSVN LDEFESHRIL RLQPPQGELT VMRYQLSDDL PSPLPFRLFP 
       310        320        330        340        350
SVQWDRGSGR LQVYLKLRCD LLSKSQALNV RLHLPLPRGV VSLSQELSSP 
       360        370        380        390        400
EQKAELAEGA LRWDLPRVQG GSQLSGLFQM DVPGPPGPPS HGLSTSASPL 
       410        420        430        440        450
GLGPASLSFE LPRHTCSGLQ VRFLRLAFRP CGNANPHKWV RHLSHSDAYV 

IRI

Length:453

Mass (Da):49,977

Last modified:April 17, 2007 - v2

Checksum:ⁱAE3DCA8C5AED08B7

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JC87	C9JC87_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	460	Annotation score:
C9JWL4	C9JWL4_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	311	Annotation score:
C9IZL5	C9IZL5_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	325	Annotation score:
C9JMG3	C9JMG3_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	265	Annotation score:
H7BZV3	H7BZV3_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	160	Annotation score:
F8WCR6	F8WCR6_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	218	Annotation score:
H0Y6K1	H0Y6K1_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	193	Annotation score:
H7C0A0	H7C0A0_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	138	Annotation score:
F8WCC5	F8WCC5_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	97	Annotation score:
F8WDR3	F8WDR3_HUMAN	AP-4 complex subunit mu-1 AP-4 complex subunit mu-1	AP4M1	64	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	338	R → G in AAD43328 (PubMed:10436028).Curated	1
Sequence conflictⁱ	345	Q → R in CAA69667 (PubMed:9013859).Curated	1
Sequence conflictⁱ	345	Q → R in AAD25869 (PubMed:11139587).Curated	1
Sequence conflictⁱ	400	L → M in AAD43328 (PubMed:10436028).Curated	1
Sequence conflictⁱ	417	S → C in AAD43328 (PubMed:10436028).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08387 mRNA Translation: CAA69667.1 AF155158 mRNA Translation: AAD43328.1 AF020796 mRNA Translation: AAD25869.1 CH471091 Genomic DNA Translation: EAW76594.1 CH471091 Genomic DNA Translation: EAW76597.1 BC018705 mRNA Translation: AAH18705.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5685.1
NCBI Reference Sequences More...RefSeqⁱ	NP_004713.2, NM_004722.3
UniGeneⁱ	Hs.632317

Genome annotation databases

Ensemblⁱ	ENST00000359593; ENSP00000352603; ENSG00000221838 ENST00000421755; ENSP00000412185; ENSG00000221838
GeneIDⁱ	9179
KEGGⁱ	hsa:9179
UCSC genome browser More...UCSCⁱ	uc003utb.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00189	cDNA FLJ55579, highly similar to Adapter-relatedprotein complex 4 mu-1 subunit		HUMAN		405	UniRef100_O00189

Protein	Similar proteins		Species	Score	Length	Source
O00189	AP-4 complex subunit mu-1		BOVIN		452	UniRef90_O00189
AP-4 complex subunit mu-1		CANLF		452
AP-4 complex subunit mu-1		MOUSE		449
cDNA FLJ55579, highly similar to Adapter-relatedprotein complex 4 mu-1 subunit		HUMAN		405
Uncharacterized protein		PAPAN		460
+132

Protein	Similar proteins		Species	Score	Length	Source
O00189	AP-4 complex subunit mu-1		CANLF		452	UniRef50_O00189
AP-4 complex subunit mu-1		BOVIN		452
AP-4 complex subunit mu-1		MOUSE		449
AP-4 complex subunit mu-1		RAT		453
cDNA FLJ55579, highly similar to Adapter-relatedprotein complex 4 mu-1 subunit		HUMAN		405
+236

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08387 mRNA Translation: CAA69667.1 AF155158 mRNA Translation: AAD43328.1 AF020796 mRNA Translation: AAD25869.1 CH471091 Genomic DNA Translation: EAW76594.1 CH471091 Genomic DNA Translation: EAW76597.1 BC018705 mRNA Translation: AAH18705.1
CCDSⁱ	CCDS5685.1
RefSeqⁱ	NP_004713.2, NM_004722.3
UniGeneⁱ	Hs.632317

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3L81	X-ray	1.60	A	160-453	[»]
	4MDR	X-ray	1.85	A	160-453	[»]
ProteinModelPortalⁱ	O00189
SMRⁱ	O00189
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114616, 34 interactors
CORUMⁱ	O00189
IntActⁱ	O00189, 31 interactors
MINTⁱ	O00189
STRINGⁱ	9606.ENSP00000352603

PTM databases

iPTMnetⁱ	O00189
PhosphoSitePlusⁱ	O00189

Polymorphism and mutation databases

BioMutaⁱ	AP4M1

BioMutaⁱ

AP4M1

Proteomic databases

EPDⁱ	O00189
MaxQBⁱ	O00189
PaxDbⁱ	O00189
PeptideAtlasⁱ	O00189
PRIDEⁱ	O00189
ProteomicsDBⁱ	47769
TopDownProteomicsⁱ	O00189

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9179
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000359593; ENSP00000352603; ENSG00000221838 ENST00000421755; ENSP00000412185; ENSG00000221838
GeneIDⁱ	9179
KEGGⁱ	hsa:9179
UCSCⁱ	uc003utb.5 human

Organism-specific databases

CTDⁱ	9179
DisGeNETⁱ	9179
EuPathDBⁱ	HostDB:ENSG00000221838.9
GeneCardsⁱ	AP4M1
HGNCⁱ	HGNC:574 AP4M1
HPAⁱ	HPA066774
MalaCardsⁱ	AP4M1
MIMⁱ	602296 gene 612936 phenotype
neXtProtⁱ	NX_O00189
OpenTargetsⁱ	ENSG00000221838
Orphanetⁱ	280763 Severe intellectual disability and progressive spastic paraplegia
PharmGKBⁱ	PA24866
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0937 Eukaryota ENOG410XPFS LUCA
GeneTreeⁱ	ENSGT00530000062779
HOGENOMⁱ	HOG000173245
HOVERGENⁱ	HBG102734
InParanoidⁱ	O00189
KOⁱ	K12402
PhylomeDBⁱ	O00189
TreeFamⁱ	TF329745

Enzyme and pathway databases

Reactomeⁱ	R-HSA-432720 Lysosome Vesicle Biogenesis
SignaLinkⁱ	O00189

Miscellaneous databases

ChiTaRSⁱ	AP4M1 human
EvolutionaryTraceⁱ	O00189
GeneWikiⁱ	AP4M1
GenomeRNAiⁱ	9179
Protein Ontology More...PROⁱ	PR:O00189
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000221838 Expressed in 136 organ(s), highest expression level in right testis
CleanExⁱ	HS_AP4M1
ExpressionAtlasⁱ	O00189 baseline and differential
Genevisibleⁱ	O00189 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR036168 AP2_Mu_C_sf IPR022775 AP_mu_sigma_su IPR001392 Clathrin_mu IPR018240 Clathrin_mu_CS IPR011012 Longin-like_dom_sf IPR028565 MHD
Pfamⁱ	View protein in Pfam PF00928 Adap_comp_sub, 1 hit PF01217 Clat_adaptor_s, 1 hit
PIRSFⁱ	PIRSF005992 Clathrin_mu, 1 hit
PRINTSⁱ	PR00314 CLATHRINADPT
SUPFAMⁱ	SSF49447 SSF49447, 1 hit SSF64356 SSF64356, 1 hit
PROSITEⁱ	View protein in PROSITE PS00991 CLAT_ADAPTOR_M_2, 1 hit PS51072 MHD, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AP4M1_HUMAN
Accessionⁱ	O00189Primary (citable) accession number: O00189 Secondary accession number(s): D6W5U1, Q8WV65, Q9UHK9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	April 17, 2007
	Last modified:	September 12, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

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UniProtKB - O00189 (AP4M1_HUMAN)

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AP-4 complex subunit mu-1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endosome

Golgi apparatus

Cytosol

Endosome

Extracellular region or secreted

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ