UniProtKB - O00187 (MASP2_HUMAN)
Protein
Mannan-binding lectin serine protease 2
Gene
MASP2
Organism
Homo sapiens (Human)
Status
Functioni
Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.1 Publication
Catalytic activityi
- Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile). EC:3.4.21.104
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 67 | Calcium 1 | 1 | |
Metal bindingi | 75 | Calcium 1 | 1 | |
Metal bindingi | 120 | Calcium 1 | 1 | |
Metal bindingi | 122 | Calcium 1; via carbonyl oxygen | 1 | |
Metal bindingi | 123 | Calcium 1 | 1 | |
Metal bindingi | 138 | Calcium 2 | 1 | |
Metal bindingi | 139 | Calcium 2; via carbonyl oxygen | 1 | |
Metal bindingi | 141 | Calcium 2 | 1 | |
Metal bindingi | 158 | Calcium 2 | 1 | |
Metal bindingi | 159 | Calcium 2; via carbonyl oxygen | 1 | |
Metal bindingi | 162 | Calcium 2; via carbonyl oxygen | 1 | |
Active sitei | 483 | Charge relay system | 1 | |
Active sitei | 532 | Charge relay system | 1 | |
Active sitei | 633 | Charge relay system | 1 |
GO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- calcium ion binding Source: InterPro
- complement component C4b binding Source: BHF-UCL
- peptidase activity Source: UniProtKB
- serine-type endopeptidase activity Source: UniProtKB
GO - Biological processi
- complement activation Source: Reactome
- complement activation, classical pathway Source: UniProtKB-KW
- complement activation, lectin pathway Source: UniProtKB
Keywordsi
Molecular function | Hydrolase, Protease, Serine protease |
Biological process | Complement pathway, Immunity, Innate immunity |
Ligand | Calcium, Metal-binding |
Enzyme and pathway databases
BRENDAi | 3.4.21.104, 2681 |
PathwayCommonsi | O00187 |
Reactomei | R-HSA-166662, Lectin pathway of complement activation [O00187-1] R-HSA-166663, Initial triggering of complement [O00187-1] R-HSA-2855086, Ficolins bind to repetitive carbohydrate structures on the target cell surface [O00187-1] |
SABIO-RKi | O00187 |
Protein family/group databases
MEROPSi | S01.229 |
Names & Taxonomyi
Protein namesi | Recommended name: Mannan-binding lectin serine protease 2 (EC:3.4.21.104)Alternative name(s): MBL-associated serine protease 2 Mannose-binding protein-associated serine protease 2 Short name: MASP-2 Cleaved into the following 2 chains: |
Gene namesi | Name:MASP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000009724.16 |
HGNCi | HGNC:6902, MASP2 |
MIMi | 605102, gene |
neXtProti | NX_O00187 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Keywords - Cellular componenti
SecretedPathology & Biotechi
Involvement in diseasei
MASP2 deficiency (MASPD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025346 | 120 | D → G in MASPD; found in a patient suffering from frequent infections and chronic inflammatory disease; strongly decreases affinity for MBL2 and FCN2. 4 PublicationsCorresponds to variant dbSNP:rs72550870EnsemblClinVar. | 1 | |
Natural variantiVAR_025347 | 126 | P → L in MASPD. 2 PublicationsCorresponds to variant dbSNP:rs56392418EnsemblClinVar. | 1 | |
Natural variantiVAR_065814 | 156 | C → CHNH in MASPD. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 74 | Y → A: Strongly decreases affinity for MBL2. Decreases affinity for FCN2. 1 Publication | 1 | |
Mutagenesisi | 121 | Y → A: Strongly decreases affinity for MBL2, but not for FCN2. 1 Publication | 1 | |
Mutagenesisi | 124 | E → A: Decreases affinity for MBL2. Slight decrease in affinity for FCN2. 1 Publication | 1 | |
Mutagenesisi | 444 | R → Q: Abolishes autocatalytic cleavage. 1 Publication | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 10747 |
MalaCardsi | MASP2 |
MIMi | 613791, phenotype |
OpenTargetsi | ENSG00000009724 |
Orphaneti | 331187, Immunodeficiency due to MASP-2 deficiency |
PharmGKBi | PA30645 |
Miscellaneous databases
Pharosi | O00187, Tbio |
Chemistry databases
ChEMBLi | CHEMBL4295646 |
DrugBanki | DB04527, beta-Hydroxyasparagine |
Polymorphism and mutation databases
BioMutai | MASP2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 15 | Sequence analysisAdd BLAST | 15 | |
ChainiPRO_0000027598 | 16 – 686 | Mannan-binding lectin serine protease 2Add BLAST | 671 | |
ChainiPRO_0000027599 | 16 – 444 | Mannan-binding lectin serine protease 2 A chainAdd BLAST | 429 | |
ChainiPRO_0000027600 | 445 – 686 | Mannan-binding lectin serine protease 2 B chainAdd BLAST | 242 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 72 ↔ 90 | |||
Disulfide bondi | 142 ↔ 156 | |||
Disulfide bondi | 152 ↔ 165 | |||
Modified residuei | 158 | (3R)-3-hydroxyasparagineSequence analysis | 1 | |
Disulfide bondi | 167 ↔ 180 | |||
Disulfide bondi | 184 ↔ 211 | By similarity | ||
Disulfide bondi | 241 ↔ 259 | By similarity | ||
Disulfide bondi | 300 ↔ 348 | By similarity | ||
Disulfide bondi | 328 ↔ 361 | By similarity | ||
Disulfide bondi | 366 ↔ 412 | |||
Disulfide bondi | 396 ↔ 430 | |||
Disulfide bondi | 434 ↔ 552 | Interchain (between A and B chains) | ||
Disulfide bondi | 598 ↔ 618 | |||
Disulfide bondi | 629 ↔ 660 |
Post-translational modificationi
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity
Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 444 – 445 | Cleavage; by autolysis1 Publication | 2 |
Keywords - PTMi
Autocatalytic cleavage, Disulfide bond, HydroxylationProteomic databases
CPTACi | non-CPTAC-2683 |
jPOSTi | O00187 |
MassIVEi | O00187 |
PaxDbi | O00187 |
PeptideAtlasi | O00187 |
PRIDEi | O00187 |
ProteomicsDBi | 47767 [O00187-1] 47768 [O00187-2] |
PTM databases
GlyGeni | O00187, 1 site |
iPTMneti | O00187 |
PhosphoSitePlusi | O00187 |
Expressioni
Tissue specificityi
Plasma.
Gene expression databases
Bgeei | ENSG00000009724, Expressed in right lobe of liver and 122 other tissues |
Genevisiblei | O00187, HS |
Organism-specific databases
HPAi | ENSG00000009724, Tissue enriched (liver) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1. Dimerization and MBL2 binding requires calcium ions.
3 PublicationsGO - Molecular functioni
- calcium-dependent protein binding Source: UniProtKB
- complement component C4b binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 115970, 17 interactors |
IntActi | O00187, 4 interactors |
MINTi | O00187 |
STRINGi | 9606.ENSP00000383690 |
Miscellaneous databases
RNActi | O00187, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | O00187 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O00187 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 16 – 137 | CUB 1PROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 138 – 181 | EGF-like; calcium-bindingAdd BLAST | 44 | |
Domaini | 184 – 296 | CUB 2PROSITE-ProRule annotationAdd BLAST | 113 | |
Domaini | 298 – 363 | Sushi 1PROSITE-ProRule annotationAdd BLAST | 66 | |
Domaini | 364 – 432 | Sushi 2PROSITE-ProRule annotationAdd BLAST | 69 | |
Domaini | 445 – 684 | Peptidase S1PROSITE-ProRule annotationAdd BLAST | 240 |
Sequence similaritiesi
Belongs to the peptidase S1 family.PROSITE-ProRule annotation
Keywords - Domaini
EGF-like domain, Repeat, Signal, SushiPhylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00950000183084 |
HOGENOMi | CLU_006842_14_1_1 |
InParanoidi | O00187 |
OMAi | QWPKPVF |
OrthoDBi | 156878at2759 |
PhylomeDBi | O00187 |
TreeFami | TF330373 |
Family and domain databases
CDDi | cd00033, CCP, 2 hits cd00041, CUB, 2 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR037571, MASP2 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR001254, Trypsin_dom IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24255:SF10, PTHR24255:SF10, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF07645, EGF_CA, 1 hit PF00084, Sushi, 2 hits PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00032, CCP, 2 hits SM00042, CUB, 2 hits SM00181, EGF, 1 hit SM00179, EGF_CA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50494, SSF50494, 1 hit SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01180, CUB, 2 hits PS01186, EGF_2, 1 hit PS01187, EGF_CA, 1 hit PS50923, SUSHI, 2 hits PS50240, TRYPSIN_DOM, 1 hit PS00135, TRYPSIN_SER, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: O00187-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRLLTLLGLL CGSVATPLGP KWPEPVFGRL ASPGFPGEYA NDQERRWTLT
60 70 80 90 100
APPGYRLRLY FTHFDLELSH LCEYDFVKLS SGAKVLATLC GQESTDTERA
110 120 130 140 150
PGKDTFYSLG SSLDITFRSD YSNEKPFTGF EAFYAAEDID ECQVAPGEAP
160 170 180 190 200
TCDHHCHNHL GGFYCSCRAG YVLHRNKRTC SALCSGQVFT QRSGELSSPE
210 220 230 240 250
YPRPYPKLSS CTYSISLEEG FSVILDFVES FDVETHPETL CPYDFLKIQT
260 270 280 290 300
DREEHGPFCG KTLPHRIETK SNTVTITFVT DESGDHTGWK IHYTSTAQPC
310 320 330 340 350
PYPMAPPNGH VSPVQAKYIL KDSFSIFCET GYELLQGHLP LKSFTAVCQK
360 370 380 390 400
DGSWDRPMPA CSIVDCGPPD DLPSGRVEYI TGPGVTTYKA VIQYSCEETF
410 420 430 440 450
YTMKVNDGKY VCEADGFWTS SKGEKSLPVC EPVCGLSART TGGRIYGGQK
460 470 480 490 500
AKPGDFPWQV LILGGTTAAG ALLYDNWVLT AAHAVYEQKH DASALDIRMG
510 520 530 540 550
TLKRLSPHYT QAWSEAVFIH EGYTHDAGFD NDIALIKLNN KVVINSNITP
560 570 580 590 600
ICLPRKEAES FMRTDDIGTA SGWGLTQRGF LARNLMYVDI PIVDHQKCTA
610 620 630 640 650
AYEKPPYPRG SVTANMLCAG LESGGKDSCR GDSGGALVFL DSETERWFVG
660 670 680
GIVSWGSMNC GEAGQYGVYT KVINYIPWIE NIISDF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 41 | N → S in BAF83512 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 225 | L → P in BAF83512 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 298 – 299 | QP → HA in CAA71059 (PubMed:9087411).Curated | 2 | |
Sequence conflicti | 298 – 299 | QP → HA in CAB50733 (PubMed:10092804).Curated | 2 | |
Sequence conflicti | 298 – 299 | QP → HA in CAB50735 (PubMed:10092804).Curated | 2 | |
Sequence conflicti | 298 – 299 | QP → HA in CAA67050 (Ref. 4) Curated | 2 | |
Sequence conflicti | 298 – 299 | QP → HA in AAG50274 (Ref. 6) Curated | 2 | |
Sequence conflicti | 361 – 362 | Missing in CAB50733 (PubMed:10092804).Curated | 2 | |
Sequence conflicti | 361 – 362 | Missing in CAB50735 (PubMed:10092804).Curated | 2 | |
Sequence conflicti | 372 | L → LCS in CAB50733 (PubMed:10092804).Curated | 1 | |
Sequence conflicti | 372 | L → LCS in CAB50735 (PubMed:10092804).Curated | 1 | |
Sequence conflicti | 399 | T → A in BAF83512 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 442 | G → E in AAG50274 (Ref. 6) Curated | 1 | |
Sequence conflicti | 447 | G → E in AAG50274 (Ref. 6) Curated | 1 | |
Sequence conflicti | 461 – 462 | Missing in CAB50733 (PubMed:10092804).Curated | 2 | |
Sequence conflicti | 461 – 462 | Missing in CAB50735 (PubMed:10092804).Curated | 2 | |
Sequence conflicti | 473 | L → LIL in CAB50733 (PubMed:10092804).Curated | 1 | |
Sequence conflicti | 473 | L → LIL in CAB50735 (PubMed:10092804).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_025344 | 99 | R → Q2 PublicationsCorresponds to variant dbSNP:rs61735600EnsemblClinVar. | 1 | |
Natural variantiVAR_025345 | 118 | R → C2 PublicationsCorresponds to variant dbSNP:rs147270785Ensembl. | 1 | |
Natural variantiVAR_025346 | 120 | D → G in MASPD; found in a patient suffering from frequent infections and chronic inflammatory disease; strongly decreases affinity for MBL2 and FCN2. 4 PublicationsCorresponds to variant dbSNP:rs72550870EnsemblClinVar. | 1 | |
Natural variantiVAR_025347 | 126 | P → L in MASPD. 2 PublicationsCorresponds to variant dbSNP:rs56392418EnsemblClinVar. | 1 | |
Natural variantiVAR_075087 | 128 | T → M1 PublicationCorresponds to variant dbSNP:rs141145402EnsemblClinVar. | 1 | |
Natural variantiVAR_028784 | 155 | H → R. Corresponds to variant dbSNP:rs2273343Ensembl. | 1 | |
Natural variantiVAR_065814 | 156 | C → CHNH in MASPD. | 1 | |
Natural variantiVAR_028785 | 371 | D → Y1 PublicationCorresponds to variant dbSNP:rs12711521EnsemblClinVar. | 1 | |
Natural variantiVAR_028786 | 377 | V → A Associated with reduced MASP2 levels in plasma; no effect on catalytic activity. 2 PublicationsCorresponds to variant dbSNP:rs2273346EnsemblClinVar. | 1 | |
Natural variantiVAR_075088 | 405 | V → M1 PublicationCorresponds to variant dbSNP:rs61735594Ensembl. | 1 | |
Natural variantiVAR_028787 | 439 | R → H. Corresponds to variant dbSNP:rs12085877EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005383 | 182 – 185 | ALCS → EQSL in isoform 2. 2 Publications | 4 | |
Alternative sequenceiVSP_005384 | 186 – 686 | Missing in isoform 2. 2 PublicationsAdd BLAST | 501 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09926 mRNA Translation: CAA71059.1 AB008047 mRNA Translation: BAA78616.1 Y18281 mRNA Translation: CAB50728.1 Y18282 mRNA Translation: CAB50729.1 Y18283 mRNA Translation: CAB50730.1 Y18284 mRNA Translation: CAB50731.1 Y18286 Genomic DNA Translation: CAB50732.1 Y18286 Genomic DNA Translation: CAB50733.1 Y18287 Genomic DNA Translation: CAB50734.1 Y18287 Genomic DNA Translation: CAB50735.1 X98400 mRNA Translation: CAA67050.1 AB033742 Genomic DNA Translation: BAA85658.1 AB033742 Genomic DNA Translation: BAA85659.1 AF321558 Genomic DNA Translation: AAG50275.1 AF321562 , AF321558, AF321559, AF321560, AF321561 Genomic DNA Translation: AAG50274.1 AK290823 mRNA Translation: BAF83512.1 AL109811 Genomic DNA No translation available. AJ297949 Genomic DNA Translation: CAC17138.1 AJ297949 Genomic DNA Translation: CAC17139.1 AJ300188 Genomic DNA Translation: CAC15568.1 |
CCDSi | CCDS123.1 [O00187-1] CCDS124.1 [O00187-2] |
PIRi | A59271 |
RefSeqi | NP_006601.2, NM_006610.3 [O00187-1] NP_631947.1, NM_139208.2 [O00187-2] |
Genome annotation databases
Ensembli | ENST00000400897; ENSP00000383690; ENSG00000009724 [O00187-1] ENST00000400898; ENSP00000383691; ENSG00000009724 [O00187-2] |
GeneIDi | 10747 |
KEGGi | hsa:10747 |
UCSCi | uc001aru.4, human [O00187-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
MASP2base MASP2 mutation db |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09926 mRNA Translation: CAA71059.1 AB008047 mRNA Translation: BAA78616.1 Y18281 mRNA Translation: CAB50728.1 Y18282 mRNA Translation: CAB50729.1 Y18283 mRNA Translation: CAB50730.1 Y18284 mRNA Translation: CAB50731.1 Y18286 Genomic DNA Translation: CAB50732.1 Y18286 Genomic DNA Translation: CAB50733.1 Y18287 Genomic DNA Translation: CAB50734.1 Y18287 Genomic DNA Translation: CAB50735.1 X98400 mRNA Translation: CAA67050.1 AB033742 Genomic DNA Translation: BAA85658.1 AB033742 Genomic DNA Translation: BAA85659.1 AF321558 Genomic DNA Translation: AAG50275.1 AF321562 , AF321558, AF321559, AF321560, AF321561 Genomic DNA Translation: AAG50274.1 AK290823 mRNA Translation: BAF83512.1 AL109811 Genomic DNA No translation available. AJ297949 Genomic DNA Translation: CAC17138.1 AJ297949 Genomic DNA Translation: CAC17139.1 AJ300188 Genomic DNA Translation: CAC15568.1 |
CCDSi | CCDS123.1 [O00187-1] CCDS124.1 [O00187-2] |
PIRi | A59271 |
RefSeqi | NP_006601.2, NM_006610.3 [O00187-1] NP_631947.1, NM_139208.2 [O00187-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1Q3X | X-ray | 2.23 | A/B | 363-686 | [»] | |
1SZB | X-ray | 2.50 | A/B | 16-181 | [»] | |
1ZJK | X-ray | 2.18 | A | 287-686 | [»] | |
3TVJ | X-ray | 1.28 | A | 363-444 | [»] | |
B | 445-686 | [»] | ||||
4FXG | X-ray | 3.75 | G/I | 291-444 | [»] | |
H/J | 445-686 | [»] | ||||
5JPM | X-ray | 3.75 | G/I | 291-444 | [»] | |
H/J | 445-686 | [»] | ||||
SMRi | O00187 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115970, 17 interactors |
IntActi | O00187, 4 interactors |
MINTi | O00187 |
STRINGi | 9606.ENSP00000383690 |
Chemistry databases
ChEMBLi | CHEMBL4295646 |
DrugBanki | DB04527, beta-Hydroxyasparagine |
Protein family/group databases
MEROPSi | S01.229 |
PTM databases
GlyGeni | O00187, 1 site |
iPTMneti | O00187 |
PhosphoSitePlusi | O00187 |
Polymorphism and mutation databases
BioMutai | MASP2 |
Proteomic databases
CPTACi | non-CPTAC-2683 |
jPOSTi | O00187 |
MassIVEi | O00187 |
PaxDbi | O00187 |
PeptideAtlasi | O00187 |
PRIDEi | O00187 |
ProteomicsDBi | 47767 [O00187-1] 47768 [O00187-2] |
Protocols and materials databases
ABCDi | O00187, 10 sequenced antibodies |
Antibodypediai | 27998, 337 antibodies |
Genome annotation databases
Ensembli | ENST00000400897; ENSP00000383690; ENSG00000009724 [O00187-1] ENST00000400898; ENSP00000383691; ENSG00000009724 [O00187-2] |
GeneIDi | 10747 |
KEGGi | hsa:10747 |
UCSCi | uc001aru.4, human [O00187-1] |
Organism-specific databases
CTDi | 10747 |
DisGeNETi | 10747 |
EuPathDBi | HostDB:ENSG00000009724.16 |
GeneCardsi | MASP2 |
HGNCi | HGNC:6902, MASP2 |
HPAi | ENSG00000009724, Tissue enriched (liver) |
MalaCardsi | MASP2 |
MIMi | 605102, gene 613791, phenotype |
neXtProti | NX_O00187 |
OpenTargetsi | ENSG00000009724 |
Orphaneti | 331187, Immunodeficiency due to MASP-2 deficiency |
PharmGKBi | PA30645 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3627, Eukaryota |
GeneTreei | ENSGT00950000183084 |
HOGENOMi | CLU_006842_14_1_1 |
InParanoidi | O00187 |
OMAi | QWPKPVF |
OrthoDBi | 156878at2759 |
PhylomeDBi | O00187 |
TreeFami | TF330373 |
Enzyme and pathway databases
BRENDAi | 3.4.21.104, 2681 |
PathwayCommonsi | O00187 |
Reactomei | R-HSA-166662, Lectin pathway of complement activation [O00187-1] R-HSA-166663, Initial triggering of complement [O00187-1] R-HSA-2855086, Ficolins bind to repetitive carbohydrate structures on the target cell surface [O00187-1] |
SABIO-RKi | O00187 |
Miscellaneous databases
BioGRID-ORCSi | 10747, 8 hits in 845 CRISPR screens |
EvolutionaryTracei | O00187 |
GenomeRNAii | 10747 |
Pharosi | O00187, Tbio |
PROi | PR:O00187 |
RNActi | O00187, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000009724, Expressed in right lobe of liver and 122 other tissues |
Genevisiblei | O00187, HS |
Family and domain databases
CDDi | cd00033, CCP, 2 hits cd00041, CUB, 2 hits cd00190, Tryp_SPc, 1 hit |
Gene3Di | 2.40.10.10, 2 hits 2.60.120.290, 2 hits |
InterProi | View protein in InterPro IPR000859, CUB_dom IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR037571, MASP2 IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR001314, Peptidase_S1A IPR035914, Sperma_CUB_dom_sf IPR035976, Sushi/SCR/CCP_sf IPR000436, Sushi_SCR_CCP_dom IPR001254, Trypsin_dom IPR033116, TRYPSIN_SER |
PANTHERi | PTHR24255:SF10, PTHR24255:SF10, 1 hit |
Pfami | View protein in Pfam PF00431, CUB, 2 hits PF07645, EGF_CA, 1 hit PF00084, Sushi, 2 hits PF00089, Trypsin, 1 hit |
PRINTSi | PR00722, CHYMOTRYPSIN |
SMARTi | View protein in SMART SM00032, CCP, 2 hits SM00042, CUB, 2 hits SM00181, EGF, 1 hit SM00179, EGF_CA, 1 hit SM00020, Tryp_SPc, 1 hit |
SUPFAMi | SSF49854, SSF49854, 2 hits SSF50494, SSF50494, 1 hit SSF57535, SSF57535, 2 hits |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 1 hit PS01180, CUB, 2 hits PS01186, EGF_2, 1 hit PS01187, EGF_CA, 1 hit PS50923, SUSHI, 2 hits PS50240, TRYPSIN_DOM, 1 hit PS00135, TRYPSIN_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MASP2_HUMAN | |
Accessioni | O00187Primary (citable) accession number: O00187 Secondary accession number(s): A8K458 Q9Y270 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | January 11, 2011 | |
Last modified: | December 2, 2020 | |
This is version 215 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Peptidase families
Classification of peptidase families and list of entries