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UniProtKB - O00187 (MASP2_HUMAN)

Protein

Mannan-binding lectin serine protease 2

Gene

MASP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase.1 Publication

Catalytic activityi

Selective cleavage after Arg-223 in complement component C2 (-Ser-Leu-Gly-Arg-|-Lys-Ile-Gln-Ile) and after Arg-76 in complement component C4 (-Gly-Leu-Gln-Arg-|-Ala-Leu-Glu-Ile).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi67Calcium 11
Metal bindingi75Calcium 11
Metal bindingi120Calcium 11
Metal bindingi122Calcium 1; via carbonyl oxygen1
Metal bindingi123Calcium 11
Metal bindingi138Calcium 21
Metal bindingi139Calcium 2; via carbonyl oxygen1
Metal bindingi141Calcium 21
Metal bindingi158Calcium 21
Metal bindingi159Calcium 2; via carbonyl oxygen1
Metal bindingi162Calcium 2; via carbonyl oxygen1
Active sitei483Charge relay system1
Active sitei532Charge relay system1
Active sitei633Charge relay system1

GO - Molecular functioni

  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • complement component C4b binding Source: BHF-UCL
  • peptidase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processComplement pathway, Immunity, Innate immunity
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.4.21.104 2681
ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
SABIO-RKiO00187

Protein family/group databases

MEROPSiS01.229

Names & Taxonomyi

Protein namesi
Recommended name:
Mannan-binding lectin serine protease 2 (EC:3.4.21.104)
Alternative name(s):
MBL-associated serine protease 2
Mannose-binding protein-associated serine protease 2
Short name:
MASP-2
Cleaved into the following 2 chains:
Mannan-binding lectin serine protease 2 A chain
Mannan-binding lectin serine protease 2 B chain
Gene namesi
Name:MASP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000009724.16
HGNCiHGNC:6902 MASP2
MIMi605102 gene
neXtProtiNX_O00187

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Involvement in diseasei

MASP2 deficiency (MASPD)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder that results in autoimmune manifestations, recurrent severe infections, and chronic inflammatory disease.
See also OMIM:613791
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_025346120D → G in MASPD; found in a patient suffering from frequent infections and chronic inflammatory disease; strongly decreases affinity for MBL2 and FCN2. 4 PublicationsCorresponds to variant dbSNP:rs72550870EnsemblClinVar.1
Natural variantiVAR_025347126P → L in MASPD. 2 PublicationsCorresponds to variant dbSNP:rs56392418EnsemblClinVar.1
Natural variantiVAR_065814156C → CHNH in MASPD. 1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi74Y → A: Strongly decreases affinity for MBL2. Decreases affinity for FCN2. 1 Publication1
Mutagenesisi121Y → A: Strongly decreases affinity for MBL2, but not for FCN2. 1 Publication1
Mutagenesisi124E → A: Decreases affinity for MBL2. Slight decrease in affinity for FCN2. 1 Publication1
Mutagenesisi444R → Q: Abolishes autocatalytic cleavage. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10747
MalaCardsiMASP2
MIMi613791 phenotype
OpenTargetsiENSG00000009724
Orphaneti331187 Immunodeficiency due to MASP-2 deficiency
PharmGKBiPA30645

Chemistry databases

DrugBankiDB04527 Beta-Hydroxyasparagine

Polymorphism and mutation databases

BioMutaiMASP2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000002759816 – 686Mannan-binding lectin serine protease 2Add BLAST671
ChainiPRO_000002759916 – 444Mannan-binding lectin serine protease 2 A chainAdd BLAST429
ChainiPRO_0000027600445 – 686Mannan-binding lectin serine protease 2 B chainAdd BLAST242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi72 ↔ 90
Disulfide bondi142 ↔ 156
Disulfide bondi152 ↔ 165
Modified residuei158(3R)-3-hydroxyasparagineSequence analysis1
Disulfide bondi167 ↔ 180
Disulfide bondi184 ↔ 211By similarity
Disulfide bondi241 ↔ 259By similarity
Disulfide bondi300 ↔ 348By similarity
Disulfide bondi328 ↔ 361By similarity
Disulfide bondi366 ↔ 412
Disulfide bondi396 ↔ 430
Disulfide bondi434 ↔ 552Interchain (between A and B chains)
Disulfide bondi598 ↔ 618
Disulfide bondi629 ↔ 660

Post-translational modificationi

The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.By similarity
Activated by cleavage after Arg-444. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei444 – 445Cleavage; by autolysis1 Publication2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Hydroxylation

Proteomic databases

PaxDbiO00187
PeptideAtlasiO00187
PRIDEiO00187
ProteomicsDBi47767
47768 [O00187-2]

PTM databases

iPTMnetiO00187
PhosphoSitePlusiO00187

Expressioni

Tissue specificityi

Plasma.

Gene expression databases

BgeeiENSG00000009724 Expressed in 101 organ(s), highest expression level in right lobe of liver
GenevisibleiO00187 HS

Organism-specific databases

HPAiHPA029313
HPA029314

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Binds MBL2. Isoform 2 binds to MASP1. Binds SERPING1. Dimerization and MBL2 binding requires calcium ions.3 Publications

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi115970, 4 interactors
IntActiO00187, 1 interactor
MINTiO00187
STRINGi9606.ENSP00000383690

Structurei

Secondary structure

1686
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00187
SMRiO00187
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00187

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 137CUB 1PROSITE-ProRule annotationAdd BLAST122
Domaini138 – 181EGF-like; calcium-bindingAdd BLAST44
Domaini184 – 296CUB 2PROSITE-ProRule annotationAdd BLAST113
Domaini298 – 363Sushi 1PROSITE-ProRule annotationAdd BLAST66
Domaini364 – 432Sushi 2PROSITE-ProRule annotationAdd BLAST69
Domaini445 – 684Peptidase S1PROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Belongs to the peptidase S1 family.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118890
HOVERGENiHBG000559
InParanoidiO00187
KOiK03993
OMAiMFVDIPI
OrthoDBiEOG091G02DS
PhylomeDBiO00187
TreeFamiTF330373

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00041 CUB, 2 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037571 MASP2
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR033116 TRYPSIN_SER
PANTHERiPTHR24255:SF10 PTHR24255:SF10, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF07645 EGF_CA, 1 hit
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00042 CUB, 2 hits
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50494 SSF50494, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01180 CUB, 2 hits
PS01186 EGF_2, 1 hit
PS01187 EGF_CA, 1 hit
PS50923 SUSHI, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: O00187-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLTLLGLL CGSVATPLGP KWPEPVFGRL ASPGFPGEYA NDQERRWTLT 
        60         70         80         90        100
APPGYRLRLY FTHFDLELSH LCEYDFVKLS SGAKVLATLC GQESTDTERA 
       110        120        130        140        150
PGKDTFYSLG SSLDITFRSD YSNEKPFTGF EAFYAAEDID ECQVAPGEAP 
       160        170        180        190        200
TCDHHCHNHL GGFYCSCRAG YVLHRNKRTC SALCSGQVFT QRSGELSSPE 
       210        220        230        240        250
YPRPYPKLSS CTYSISLEEG FSVILDFVES FDVETHPETL CPYDFLKIQT 
       260        270        280        290        300
DREEHGPFCG KTLPHRIETK SNTVTITFVT DESGDHTGWK IHYTSTAQPC 
       310        320        330        340        350
PYPMAPPNGH VSPVQAKYIL KDSFSIFCET GYELLQGHLP LKSFTAVCQK 
       360        370        380        390        400
DGSWDRPMPA CSIVDCGPPD DLPSGRVEYI TGPGVTTYKA VIQYSCEETF 
       410        420        430        440        450
YTMKVNDGKY VCEADGFWTS SKGEKSLPVC EPVCGLSART TGGRIYGGQK 
       460        470        480        490        500
AKPGDFPWQV LILGGTTAAG ALLYDNWVLT AAHAVYEQKH DASALDIRMG 
       510        520        530        540        550
TLKRLSPHYT QAWSEAVFIH EGYTHDAGFD NDIALIKLNN KVVINSNITP 
       560        570        580        590        600
ICLPRKEAES FMRTDDIGTA SGWGLTQRGF LARNLMYVDI PIVDHQKCTA 
       610        620        630        640        650
AYEKPPYPRG SVTANMLCAG LESGGKDSCR GDSGGALVFL DSETERWFVG 
       660        670        680 
GIVSWGSMNC GEAGQYGVYT KVINYIPWIE NIISDF
Length:686
Mass (Da):75,702
Last modified:January 11, 2011 - v4
Checksum:iED952085FA115E21
GO
Isoform 2 (identifier: O00187-2) [UniParc]FASTAAdd to basket
Also known as: MAp19, Small MBL-associated protein, sMAP

The sequence of this isoform differs from the canonical sequence as follows:
     182-185: ALCS → EQSL
     186-686: Missing.

Show »
Length:185
Mass (Da):20,629
Checksum:i73B133D56FB229C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41N → S in BAF83512 (PubMed:14702039).Curated1
Sequence conflicti225L → P in BAF83512 (PubMed:14702039).Curated1
Sequence conflicti298 – 299QP → HA in CAA71059 (PubMed:9087411).Curated2
Sequence conflicti298 – 299QP → HA in CAB50733 (PubMed:10092804).Curated2
Sequence conflicti298 – 299QP → HA in CAB50735 (PubMed:10092804).Curated2
Sequence conflicti298 – 299QP → HA in CAA67050 (Ref. 4) Curated2
Sequence conflicti298 – 299QP → HA in AAG50274 (Ref. 6) Curated2
Sequence conflicti361 – 362Missing in CAB50733 (PubMed:10092804).Curated2
Sequence conflicti361 – 362Missing in CAB50735 (PubMed:10092804).Curated2
Sequence conflicti372L → LCS in CAB50733 (PubMed:10092804).Curated1
Sequence conflicti372L → LCS in CAB50735 (PubMed:10092804).Curated1
Sequence conflicti399T → A in BAF83512 (PubMed:14702039).Curated1
Sequence conflicti442G → E in AAG50274 (Ref. 6) Curated1
Sequence conflicti447G → E in AAG50274 (Ref. 6) Curated1
Sequence conflicti461 – 462Missing in CAB50733 (PubMed:10092804).Curated2
Sequence conflicti461 – 462Missing in CAB50735 (PubMed:10092804).Curated2
Sequence conflicti473L → LIL in CAB50733 (PubMed:10092804).Curated1
Sequence conflicti473L → LIL in CAB50735 (PubMed:10092804).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02534499R → Q2 PublicationsCorresponds to variant dbSNP:rs61735600EnsemblClinVar.1
Natural variantiVAR_025345118R → C2 PublicationsCorresponds to variant dbSNP:rs147270785Ensembl.1
Natural variantiVAR_025346120D → G in MASPD; found in a patient suffering from frequent infections and chronic inflammatory disease; strongly decreases affinity for MBL2 and FCN2. 4 PublicationsCorresponds to variant dbSNP:rs72550870EnsemblClinVar.1
Natural variantiVAR_025347126P → L in MASPD. 2 PublicationsCorresponds to variant dbSNP:rs56392418EnsemblClinVar.1
Natural variantiVAR_075087128T → M1 PublicationCorresponds to variant dbSNP:rs141145402EnsemblClinVar.1
Natural variantiVAR_028784155H → R. Corresponds to variant dbSNP:rs2273343Ensembl.1
Natural variantiVAR_065814156C → CHNH in MASPD. 1
Natural variantiVAR_028785371D → Y1 PublicationCorresponds to variant dbSNP:rs12711521EnsemblClinVar.1
Natural variantiVAR_028786377V → A Associated with reduced MASP2 levels in plasma; no effect on catalytic activity. 2 PublicationsCorresponds to variant dbSNP:rs2273346EnsemblClinVar.1
Natural variantiVAR_075088405V → M1 PublicationCorresponds to variant dbSNP:rs61735594Ensembl.1
Natural variantiVAR_028787439R → H. Corresponds to variant dbSNP:rs12085877EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_005383182 – 185ALCS → EQSL in isoform 2. 2 Publications4
Alternative sequenceiVSP_005384186 – 686Missing in isoform 2. 2 PublicationsAdd BLAST501

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09926 mRNA Translation: CAA71059.1
AB008047 mRNA Translation: BAA78616.1
Y18281 mRNA Translation: CAB50728.1
Y18282 mRNA Translation: CAB50729.1
Y18283 mRNA Translation: CAB50730.1
Y18284 mRNA Translation: CAB50731.1
Y18286 Genomic DNA Translation: CAB50732.1
Y18286 Genomic DNA Translation: CAB50733.1
Y18287 Genomic DNA Translation: CAB50734.1
Y18287 Genomic DNA Translation: CAB50735.1
X98400 mRNA Translation: CAA67050.1
AB033742 Genomic DNA Translation: BAA85658.1
AB033742 Genomic DNA Translation: BAA85659.1
AF321558 Genomic DNA Translation: AAG50275.1
AF321562
, AF321558, AF321559, AF321560, AF321561 Genomic DNA Translation: AAG50274.1
AK290823 mRNA Translation: BAF83512.1
AL109811 Genomic DNA No translation available.
AJ297949 Genomic DNA Translation: CAC17138.1
AJ297949 Genomic DNA Translation: CAC17139.1
AJ300188 Genomic DNA Translation: CAC15568.1
CCDSiCCDS123.1 [O00187-1]
CCDS124.1 [O00187-2]
PIRiA59271
RefSeqiNP_006601.2, NM_006610.3 [O00187-1]
NP_631947.1, NM_139208.2 [O00187-2]
UniGeneiHs.655645

Genome annotation databases

EnsembliENST00000400897; ENSP00000383690; ENSG00000009724 [O00187-1]
ENST00000400898; ENSP00000383691; ENSG00000009724 [O00187-2]
GeneIDi10747
KEGGihsa:10747
UCSCiuc001aru.4 human [O00187-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

MASP2base

MASP2 mutation db

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09926 mRNA Translation: CAA71059.1
AB008047 mRNA Translation: BAA78616.1
Y18281 mRNA Translation: CAB50728.1
Y18282 mRNA Translation: CAB50729.1
Y18283 mRNA Translation: CAB50730.1
Y18284 mRNA Translation: CAB50731.1
Y18286 Genomic DNA Translation: CAB50732.1
Y18286 Genomic DNA Translation: CAB50733.1
Y18287 Genomic DNA Translation: CAB50734.1
Y18287 Genomic DNA Translation: CAB50735.1
X98400 mRNA Translation: CAA67050.1
AB033742 Genomic DNA Translation: BAA85658.1
AB033742 Genomic DNA Translation: BAA85659.1
AF321558 Genomic DNA Translation: AAG50275.1
AF321562
, AF321558, AF321559, AF321560, AF321561 Genomic DNA Translation: AAG50274.1
AK290823 mRNA Translation: BAF83512.1
AL109811 Genomic DNA No translation available.
AJ297949 Genomic DNA Translation: CAC17138.1
AJ297949 Genomic DNA Translation: CAC17139.1
AJ300188 Genomic DNA Translation: CAC15568.1
CCDSiCCDS123.1 [O00187-1]
CCDS124.1 [O00187-2]
PIRiA59271
RefSeqiNP_006601.2, NM_006610.3 [O00187-1]
NP_631947.1, NM_139208.2 [O00187-2]
UniGeneiHs.655645

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Q3XX-ray2.23A/B363-686[»]
1SZBX-ray2.50A/B16-181[»]
1ZJKX-ray2.18A287-686[»]
3TVJX-ray1.28A363-444[»]
B445-686[»]
4FXGX-ray3.75G/I291-444[»]
H/J445-686[»]
5JPMX-ray3.75G/I291-444[»]
H/J445-686[»]
ProteinModelPortaliO00187
SMRiO00187
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115970, 4 interactors
IntActiO00187, 1 interactor
MINTiO00187
STRINGi9606.ENSP00000383690

Chemistry databases

DrugBankiDB04527 Beta-Hydroxyasparagine

Protein family/group databases

MEROPSiS01.229

PTM databases

iPTMnetiO00187
PhosphoSitePlusiO00187

Polymorphism and mutation databases

BioMutaiMASP2

Proteomic databases

PaxDbiO00187
PeptideAtlasiO00187
PRIDEiO00187
ProteomicsDBi47767
47768 [O00187-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400897; ENSP00000383690; ENSG00000009724 [O00187-1]
ENST00000400898; ENSP00000383691; ENSG00000009724 [O00187-2]
GeneIDi10747
KEGGihsa:10747
UCSCiuc001aru.4 human [O00187-1]

Organism-specific databases

CTDi10747
DisGeNETi10747
EuPathDBiHostDB:ENSG00000009724.16
GeneCardsiMASP2
HGNCiHGNC:6902 MASP2
HPAiHPA029313
HPA029314
MalaCardsiMASP2
MIMi605102 gene
613791 phenotype
neXtProtiNX_O00187
OpenTargetsiENSG00000009724
Orphaneti331187 Immunodeficiency due to MASP-2 deficiency
PharmGKBiPA30645
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118890
HOVERGENiHBG000559
InParanoidiO00187
KOiK03993
OMAiMFVDIPI
OrthoDBiEOG091G02DS
PhylomeDBiO00187
TreeFamiTF330373

Enzyme and pathway databases

BRENDAi3.4.21.104 2681
ReactomeiR-HSA-166662 Lectin pathway of complement activation
R-HSA-166663 Initial triggering of complement
R-HSA-2855086 Ficolins bind to repetitive carbohydrate structures on the target cell surface
SABIO-RKiO00187

Miscellaneous databases

EvolutionaryTraceiO00187
GenomeRNAii10747
PROiPR:O00187
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000009724 Expressed in 101 organ(s), highest expression level in right lobe of liver
GenevisibleiO00187 HS

Family and domain databases

CDDicd00033 CCP, 2 hits
cd00041 CUB, 2 hits
cd00190 Tryp_SPc, 1 hit
Gene3Di2.60.120.290, 2 hits
InterProiView protein in InterPro
IPR000859 CUB_dom
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037571 MASP2
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR035914 Sperma_CUB_dom_sf
IPR035976 Sushi/SCR/CCP_sf
IPR000436 Sushi_SCR_CCP_dom
IPR001254 Trypsin_dom
IPR033116 TRYPSIN_SER
PANTHERiPTHR24255:SF10 PTHR24255:SF10, 1 hit
PfamiView protein in Pfam
PF00431 CUB, 2 hits
PF07645 EGF_CA, 1 hit
PF00084 Sushi, 2 hits
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00032 CCP, 2 hits
SM00042 CUB, 2 hits
SM00181 EGF, 1 hit
SM00179 EGF_CA, 1 hit
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF49854 SSF49854, 2 hits
SSF50494 SSF50494, 1 hit
SSF57535 SSF57535, 2 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS01180 CUB, 2 hits
PS01186 EGF_2, 1 hit
PS01187 EGF_CA, 1 hit
PS50923 SUSHI, 2 hits
PS50240 TRYPSIN_DOM, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMASP2_HUMAN
AccessioniPrimary (citable) accession number: O00187
Secondary accession number(s): A8K458
, A8MWJ2, O75754, Q5TEQ5, Q5TER0, Q96QG4, Q9BZH0, Q9H498, Q9H499, Q9UBP3, Q9UC48, Q9ULC7, Q9UMV3, Q9Y270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: January 11, 2011
Last modified: November 7, 2018
This is version 200 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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