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Protein

Galectin-9

Gene

LGALS9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth (By similarity). Ligand for P4HB; the interaction retains P4HB at the cell surface of Th2 T-helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). Ligand for CD44; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function (By similarity). Promotes ability of mesenchymal stromal cells to suppress T-cell proliferation (PubMed:23817958). Expands regulatory T-cells and induces cytotoxic T-cell apoptosis following virus infection (PubMed:20209097). Activates ERK1/2 phosphorylation inducing cytokine (IL-6, IL-8, IL-12) and chemokine (CCL2) production in mast and dendritic cells (PubMed:24465902, PubMed:16116184). Inhibits degranulation and induces apoptosis of mast cells (PubMed:24465902). Induces maturation and migration of dendritic cells (PubMed:25754930, PubMed:16116184). Inhibits natural killer (NK) cell function (PubMed:23408620). Can transform NK cell phenotype from peripheral to decidual during pregnancy (PubMed:25578313). Astrocyte derived galectin-9 enhances microglial TNF production (By similarity). May play a role in thymocyte-epithelial interactions relevant to the biology of the thymus. May provide the molecular basis for urate flux across cell membranes, allowing urate that is formed during purine metabolism to efflux from cells and serving as an electrogenic transporter that plays an important role in renal and gastrointestinal urate excretion (By similarity). Highly selective to the anion urate (By similarity).By similarity11 Publications
Isoform 2: Acts as an eosinophil chemoattractant (PubMed:9642261). It also inhibits angiogenesis (PubMed:24333696). Suppresses IFNG production by natural killer cells (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei48Beta-galactoside 11
Binding sitei61Beta-galactoside 11
Binding sitei65Beta-galactoside 11
Binding sitei75Beta-galactoside 11
Binding sitei267Beta-galactoside 21
Binding sitei271Beta-galactoside 21
Binding sitei281Beta-galactoside 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB
  • disaccharide binding Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • galactose binding Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processChemotaxis, Immunity
LigandLectin

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-451927 Interleukin-2 family signaling

Protein family/group databases

UniLectin database of carbohydrate-binding proteins

More...
UniLectini
O00182

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Galectin-9
Short name:
Gal-9
Alternative name(s):
Ecalectin
Tumor antigen HOM-HD-21
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:LGALS9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000168961.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6570 LGALS9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601879 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00182

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3965

Open Targets

More...
OpenTargetsi
ENSG00000168961

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30347

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5474

Drug and drug target database

More...
DrugBanki
DB04472 (R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
LGALS9

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000769461 – 355Galectin-9Add BLAST355

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00182

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
O00182

MaxQB - The MaxQuant DataBase

More...
MaxQBi
O00182

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00182

PeptideAtlas

More...
PeptideAtlasi
O00182

PRoteomics IDEntifications database

More...
PRIDEi
O00182

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47764
47765 [O00182-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00182

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00182

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells in decidua and placenta in pregnancy (at protein level) (PubMed:23242525, PubMed:25578313). Isoform 2 is the most abundant isoform expressed in endothelial cells (PubMed:24333696). Upon endothelial cell activation isoform 2 expression decreases while expression of isoform 3 and isoform 5 increases (PubMed:24333696). Isoform 4 decreases in pathological pregnancy (PubMed:23242525).3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By toll-like receptor ligands zymosan (TLR2 ligand), polyinosinic:polycytidylic acid (poly I:C) (TLR3 ligand) and lipopolysaccharides (LPS) (TLR4 ligand) and by proinflammatory cytokines IFNG, TNFA, IL1A and IL1B in mesenchymal stromal cells (PubMed:23817958). By IFNG in macrophages (PubMed:20209097). Up-regulated in dendritic cells following infection with dengue virus (PubMed:25754930). Up-regulated in Kupffer cells following infection with hepatitis C virus (PubMed:20209097). Up-regulated in plasma following infection with HIV-1 (PubMed:24786365).4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000168961 Expressed in 201 organ(s), highest expression level in mucosa of transverse colon

CleanEx database of gene expression profiles

More...
CleanExi
HS_LGALS9

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00182 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00182 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046876
HPA047218

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110156, 79 interactors

Protein interaction database and analysis system

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IntActi
O00182, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378856

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
O00182

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1355
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAKX-ray1.97A/B/C1-148[»]
2EALX-ray1.85A/B1-148[»]
2YY1X-ray2.17A1-147[»]
2ZHKX-ray1.80A/B1-148[»]
2ZHLX-ray1.75A/B/C/D1-148[»]
2ZHMX-ray1.84A/B/C/D1-148[»]
2ZHNX-ray1.30A1-148[»]
3LSDX-ray2.03A6-148[»]
3LSEX-ray2.69A6-148[»]
3NV1X-ray1.50A218-355[»]
3NV2X-ray2.34A218-355[»]
3NV3X-ray1.57A218-355[»]
3NV4X-ray1.99A218-355[»]
3WLUX-ray1.40A/B/C/D5-148[»]
3WV6X-ray1.95A/B1-355[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00182

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00182

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
O00182

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini17 – 148Galectin 1PROSITE-ProRule annotationAdd BLAST132
Domaini227 – 355Galectin 2PROSITE-ProRule annotationAdd BLAST129

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni82 – 88Beta-galactoside binding 17
Regioni287 – 293Beta-galactoside binding 2By similarity7

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains two homologous but distinct carbohydrate-binding domains.

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3587 Eukaryota
ENOG4111EA0 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162701

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290194

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG002412

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00182

KEGG Orthology (KO)

More...
KOi
K10093

Identification of Orthologs from Complete Genome Data

More...
OMAi
DYEHRLP

Database of Orthologous Groups

More...
OrthoDBi
829777at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
O00182

TreeFam database of animal gene trees

More...
TreeFami
TF315551

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00070 GLECT, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00337 Gal-bind_lectin, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00908 Gal-bind_lectin, 2 hits
SM00276 GLECT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51304 GALECTIN, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00182-1) [UniParc]FASTAAdd to basket
Also known as: Long, Gal-9FL1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFSGSQAPY LSPAVPFSGT IQGGLQDGLQ ITVNGTVLSS SGTRFAVNFQ
60 70 80 90 100
TGFSGNDIAF HFNPRFEDGG YVVCNTRQNG SWGPEERKTH MPFQKGMPFD
110 120 130 140 150
LCFLVQSSDF KVMVNGILFV QYFHRVPFHR VDTISVNGSV QLSYISFQNP
160 170 180 190 200
RTVPVQPAFS TVPFSQPVCF PPRPRGRRQK PPGVWPANPA PITQTVIHTV
210 220 230 240 250
QSAPGQMFST PAIPPMMYPH PAYPMPFITT ILGGLYPSKS ILLSGTVLPS
260 270 280 290 300
AQRFHINLCS GNHIAFHLNP RFDENAVVRN TQIDNSWGSE ERSLPRKMPF
310 320 330 340 350
VRGQSFSVWI LCEAHCLKVA VDGQHLFEYY HRLRNLPTIN RLEVGGDIQL

THVQT
Length:355
Mass (Da):39,518
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4748C22FCAFA536A
GO
Isoform 2 (identifier: O00182-2) [UniParc]FASTAAdd to basket
Also known as: Medium, Gal-9delta51 Publication, D51 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.

Show »
Length:323
Mass (Da):35,888
Checksum:i1A3EB2941FC7F377
GO
Isoform 3 (identifier: O00182-3) [UniParc]FASTAAdd to basket
Also known as: Short, Gal-9delta5/61 Publication, D5/61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.
     181-192: Missing.

Show »
Length:311
Mass (Da):34,691
Checksum:i3D00232FE39D776C
GO
Isoform 4 (identifier: O00182-4) [UniParc]FASTAAdd to basket
Also known as: Gal-9delta5/101 Publication, D5/101 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.
     254-355: FHINLCSGNH...GDIQLTHVQT → CGSCVKLTASRWPWMVSTCLNTTIA

Show »
Length:246
Mass (Da):26,777
Checksum:i414EB1F6493EE81E
GO
Isoform 5 (identifier: O00182-5) [UniParc]FASTAAdd to basket
Also known as: Gal-9delta5/6/101 Publication, D5/6/101 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     149-180: Missing.
     181-192: Missing.
     254-355: FHINLCSGNH...GDIQLTHVQT → CGSCVKLTASRWPWMVSTCLNTTIA

Show »
Length:234
Mass (Da):25,579
Checksum:i29B8BF54B3F32BC3
GO
Isoform 6 (identifier: O00182-6) [UniParc]FASTAAdd to basket
Also known as: D61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     181-192: Missing.

Show »
Length:343
Mass (Da):38,321
Checksum:i79BEC0B506CFA9DF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KS82J3KS82_HUMAN
Galectin
LGALS9
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS92J3QS92_HUMAN
Galectin
LGALS9
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPS0K7EPS0_HUMAN
Galectin
LGALS9
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KSA0J3KSA0_HUMAN
Galectin
LGALS9
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKK6J3QKK6_HUMAN
Galectin-9
LGALS9
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti48N → D in CAB93851 (Ref. 6) Curated1
Sequence conflicti79 – 81NGS → KGR in CAB93851 (Ref. 6) Curated3
Sequence conflicti88K → R in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti89T → M in CAB93851 (Ref. 6) Curated1
Sequence conflicti93F → S in BAD96952 (Ref. 7) Curated1
Sequence conflicti135S → F in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti270P → L in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti313E → G in CAA88922 (PubMed:9045665).Curated1
Sequence conflicti326L → V in CAB93851 (Ref. 6) Curated1
Sequence conflicti341R → K in CAB93851 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0204535G → S2 PublicationsCorresponds to variant dbSNP:rs3751093Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_003096149 – 180Missing in isoform 2, isoform 3, isoform 4 and isoform 5. 5 Publications1 PublicationAdd BLAST32
Alternative sequenceiVSP_057842181 – 192Missing in isoform 3, isoform 5 and isoform 6. 2 PublicationsAdd BLAST12
Alternative sequenceiVSP_057843254 – 355FHINL…THVQT → CGSCVKLTASRWPWMVSTCL NTTIA in isoform 4 and isoform 5. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49107 mRNA Translation: CAA88922.1
AB006782 mRNA Translation: BAA22166.1
AB005894 mRNA Translation: BAA31542.1
AB003517 mRNA Translation: BAF76327.1
AB008492 mRNA Translation: BAF76328.1
AB040130 Genomic DNA Translation: BAB83623.1
AB040130 Genomic DNA Translation: BAB83625.1
AB040130 Genomic DNA Translation: BAB83624.1
AJ288083
, AJ288084, AJ288085, AJ288086, AJ288087, AJ288088, AJ288089, AJ288090 Genomic DNA Translation: CAB93851.1
AK223232 mRNA Translation: BAD96952.1
AC015688 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51037.1
CH471159 Genomic DNA Translation: EAW51038.1
CH471159 Genomic DNA Translation: EAW51039.1
CH471159 Genomic DNA Translation: EAW51044.1
BC105942 mRNA Translation: AAI05943.1
BC105944 mRNA Translation: AAI05945.1
BC110340 mRNA Translation: AAI10341.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11222.1 [O00182-1]
CCDS32592.1 [O00182-2]
CCDS82093.1 [O00182-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001317092.1, NM_001330163.1 [O00182-4]
NP_002299.2, NM_002308.3 [O00182-2]
NP_033665.1, NM_009587.2 [O00182-1]
XP_006721955.1, XM_006721892.2 [O00182-3]
XP_006721958.1, XM_006721895.3 [O00182-5]
XP_016880112.1, XM_017024623.1 [O00182-6]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.81337

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000302228; ENSP00000306228; ENSG00000168961 [O00182-2]
ENST00000313648; ENSP00000318214; ENSG00000168961 [O00182-4]
ENST00000395473; ENSP00000378856; ENSG00000168961 [O00182-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3965

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3965

UCSC genome browser

More...
UCSCi
uc002gzp.4 human [O00182-1]
uc060cvd.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Galectin-9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49107 mRNA Translation: CAA88922.1
AB006782 mRNA Translation: BAA22166.1
AB005894 mRNA Translation: BAA31542.1
AB003517 mRNA Translation: BAF76327.1
AB008492 mRNA Translation: BAF76328.1
AB040130 Genomic DNA Translation: BAB83623.1
AB040130 Genomic DNA Translation: BAB83625.1
AB040130 Genomic DNA Translation: BAB83624.1
AJ288083
, AJ288084, AJ288085, AJ288086, AJ288087, AJ288088, AJ288089, AJ288090 Genomic DNA Translation: CAB93851.1
AK223232 mRNA Translation: BAD96952.1
AC015688 Genomic DNA No translation available.
CH471159 Genomic DNA Translation: EAW51037.1
CH471159 Genomic DNA Translation: EAW51038.1
CH471159 Genomic DNA Translation: EAW51039.1
CH471159 Genomic DNA Translation: EAW51044.1
BC105942 mRNA Translation: AAI05943.1
BC105944 mRNA Translation: AAI05945.1
BC110340 mRNA Translation: AAI10341.1
CCDSiCCDS11222.1 [O00182-1]
CCDS32592.1 [O00182-2]
CCDS82093.1 [O00182-4]
RefSeqiNP_001317092.1, NM_001330163.1 [O00182-4]
NP_002299.2, NM_002308.3 [O00182-2]
NP_033665.1, NM_009587.2 [O00182-1]
XP_006721955.1, XM_006721892.2 [O00182-3]
XP_006721958.1, XM_006721895.3 [O00182-5]
XP_016880112.1, XM_017024623.1 [O00182-6]
UniGeneiHs.81337

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2EAKX-ray1.97A/B/C1-148[»]
2EALX-ray1.85A/B1-148[»]
2YY1X-ray2.17A1-147[»]
2ZHKX-ray1.80A/B1-148[»]
2ZHLX-ray1.75A/B/C/D1-148[»]
2ZHMX-ray1.84A/B/C/D1-148[»]
2ZHNX-ray1.30A1-148[»]
3LSDX-ray2.03A6-148[»]
3LSEX-ray2.69A6-148[»]
3NV1X-ray1.50A218-355[»]
3NV2X-ray2.34A218-355[»]
3NV3X-ray1.57A218-355[»]
3NV4X-ray1.99A218-355[»]
3WLUX-ray1.40A/B/C/D5-148[»]
3WV6X-ray1.95A/B1-355[»]
ProteinModelPortaliO00182
SMRiO00182
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110156, 79 interactors
IntActiO00182, 13 interactors
STRINGi9606.ENSP00000378856

Chemistry databases

BindingDBiO00182
ChEMBLiCHEMBL5474
DrugBankiDB04472 (R)-1-Para-Nitro-Phenyl-2-Azido-Ethanol

Protein family/group databases

UniLectiniO00182

PTM databases

iPTMnetiO00182
PhosphoSitePlusiO00182

Polymorphism and mutation databases

BioMutaiLGALS9

Proteomic databases

EPDiO00182
jPOSTiO00182
MaxQBiO00182
PaxDbiO00182
PeptideAtlasiO00182
PRIDEiO00182
ProteomicsDBi47764
47765 [O00182-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302228; ENSP00000306228; ENSG00000168961 [O00182-2]
ENST00000313648; ENSP00000318214; ENSG00000168961 [O00182-4]
ENST00000395473; ENSP00000378856; ENSG00000168961 [O00182-1]
GeneIDi3965
KEGGihsa:3965
UCSCiuc002gzp.4 human [O00182-1]
uc060cvd.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3965
DisGeNETi3965
EuPathDBiHostDB:ENSG00000168961.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
LGALS9
HGNCiHGNC:6570 LGALS9
HPAiHPA046876
HPA047218
MIMi601879 gene
neXtProtiNX_O00182
OpenTargetsiENSG00000168961
PharmGKBiPA30347

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00940000162701
HOGENOMiHOG000290194
HOVERGENiHBG002412
InParanoidiO00182
KOiK10093
OMAiDYEHRLP
OrthoDBi829777at2759
PhylomeDBiO00182
TreeFamiTF315551

Enzyme and pathway databases

ReactomeiR-HSA-451927 Interleukin-2 family signaling

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
LGALS9 human
EvolutionaryTraceiO00182

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
LGALS9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3965

Protein Ontology

More...
PROi
PR:O00182

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000168961 Expressed in 201 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_LGALS9
ExpressionAtlasiO00182 baseline and differential
GenevisibleiO00182 HS

Family and domain databases

CDDicd00070 GLECT, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR001079 Galectin_CRD
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 2 hits
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 2 hits
SM00276 GLECT, 2 hits
SUPFAMiSSF49899 SSF49899, 2 hits
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLEG9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00182
Secondary accession number(s): A7VJG6
, F8W9W4, O14532, O75028, Q3B8N1, Q53FQ0, Q8WYQ7, Q9NQ58
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: January 16, 2019
This is version 179 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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