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Entry version 187 (29 Sep 2021)
Sequence version 1 (01 Jul 1997)
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Protein

Potassium channel subfamily K member 1

Gene

KCNK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:15820677, PubMed:21653227).

Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel is selective for K+ ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na+ at subphysiological K+ levels and upon acidification of the extracellular medium (PubMed:21653227, PubMed:22431633).

The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (PubMed:8605869, PubMed:8978667, PubMed:15820677, PubMed:21653227, PubMed:22431633, PubMed:23169818, PubMed:25001086).

Channel activity is modulated by activation of serotonin receptors (By similarity).

Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity).

Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (PubMed:23169818).

Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (PubMed:23169818).

Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity).

Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity).

In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G-protein coupled receptors, such as F2R and CNR1 (By similarity).

Required for normal ion and water transport in the kidney (By similarity).

Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity).

The low channel activity of homodimeric KCNK1 may be due to sumoylation (PubMed:15820677, PubMed:20498050, PubMed:23169818).

The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (PubMed:19959478).

By similarity11 Publications

Miscellaneous

When the external K+ concentration is lowered to subphysiological levels, it takes several minutes till the channel has reached a new, stable state characterized by increased Na+ permeability (PubMed:21653227). Likewise, when the external pH is lowered to values below 6.5, it takes several minutes till the channel has reached a new, stable state characterized by increased Na+ permeability (PubMed:22431633). When raising the K+ concentration back to 5 mM, it takes 40 to 70 minutes for the channel to regain its original selectivity for K+ (PubMed:21653227). Likewise, it takes more that 25 minutes for the channel to regain its original K+ selectivity when the pH is raised back to 7.4 (PubMed:22431633).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by Ba2+ ions and quinidine (PubMed:8605869). Inhibited by quinine (PubMed:8605869, PubMed:21653227). Is slightly inhibited by 10 mM tetraethylammonium (TEA), and only marginally inhibited by 4-aminopyridine, charybdotoxin and dendrotoxin (PubMed:8605869). Lowering the extracellular pH to below 6.5 transiently activates the channel, and then inhibits channel activity (PubMed:15820677, PubMed:22431633). Inhibited when the intracellular pH is decreased down to pH 6.0, but this may be due to indirect effects (PubMed:8605869).4 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Has a unit conductance of 34 pS. Both activation and channel closure are very rapid. Is not voltage-gated. The relationship between voltage and current is nearly linear. Has a mean open time of 0.3 msec at a membrane potential of -80 mV, and 1.9 msec at +80 mV (PubMed:8605869).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei118Important for increased permeability to Na(+) when K(+) levels are subphysiological1 Publication1
Sitei146Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability2 Publications1
Sitei261Part of a hydrophobic barrier that is stochastically dewetted and limits ion permeability1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Potassium channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
O00180

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1299308, Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
R-HSA-5576886, Phase 4 - resting membrane potential

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium channel subfamily K member 1
Alternative name(s):
Inward rectifying potassium channel protein TWIK-11 Publication
Potassium channel K2P11 Publication
Potassium channel KCNO1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KCNK1
Synonyms:HOHO11 Publication, KCNO1, TWIK1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6272, KCNK1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601745, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_O00180

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000135750

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 20Cytoplasmic1 PublicationAdd BLAST20
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei21 – 41Helical1 PublicationAdd BLAST21
Topological domaini42 – 103Extracellular1 Publication1 PublicationAdd BLAST62
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei104 – 116Helical; Name=Pore helix 11 PublicationAdd BLAST13
Intramembranei117 – 1221 Publication6
Topological domaini123 – 132Extracellular1 Publication10
Transmembranei133 – 156Helical1 PublicationAdd BLAST24
Topological domaini157 – 181Cytoplasmic1 PublicationAdd BLAST25
Transmembranei182 – 202Helical1 PublicationAdd BLAST21
Topological domaini203 – 211Extracellular1 Publication9
Intramembranei212 – 224Helical; Name=Pore helix 21 PublicationAdd BLAST13
Intramembranei225 – 2311 Publication7
Topological domaini232 – 243Extracellular1 PublicationAdd BLAST12
Transmembranei244 – 267Helical1 PublicationAdd BLAST24
Topological domaini268 – 336Cytoplasmic1 PublicationAdd BLAST69

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi69C → A: Abolishes channel activity and formation of disulfide-linked homodimers. 1 Publication1
Mutagenesisi95N → A: Abolishes N-glycosylation. 1 Publication1
Mutagenesisi108 – 109LF → FY: Impairs selectivity for K(+) ions and increases permeability to Na(+) ions, both at pH 7.4 and at pH 6. 1 Publication2
Mutagenesisi118T → I: Abolishes change in ion selectivity in the presence of subphysiological K(+) levels. 1 Publication1
Mutagenesisi122H → K: Increases channel activity, and has only a minor effect on the inhibition by acidification of the extracellular medium. 1 Publication1
Mutagenesisi122H → N: Decreases channel activity and abolishes inhibition by acidification of the extracellular medium. 3 Publications1
Mutagenesisi146L → A or V: Does not increase the low intrinsic channel activity. 1 Publication1
Mutagenesisi146L → D: Increases channel activity. 2 Publications1
Mutagenesisi146L → N or T: Increases channel activity. 1 Publication1
Mutagenesisi146L → S: Increases channel activity. Strongly increases channel activity; when associated with S-261. 1 Publication1
Mutagenesisi161T → A: No effect on channel activity. 1 Publication1
Mutagenesisi228L → F: No effect on selectivity for K(+) ions. 1 Publication1
Mutagenesisi231Y → F: Strongly decreases activity of homodimeric channels and of heterodimeric channels formed with KCNK3 and with KCNK9. No effect on location at the cell membrane. 1 Publication1
Mutagenesisi250T → L: Slighly decreases the increased permeability to Na(+) ions at pH 6. 1 Publication1
Mutagenesisi261L → D or N: Increases channel activity. 1 Publication1
Mutagenesisi261L → S: Increases channel activity. Strongly increases channel activity; when associated with S-146. 1 Publication1
Mutagenesisi274K → A, C, D, Q or R: Converts the electrically silent channel that is present at the cell membrane to an active channel. 1 Publication1
Mutagenesisi274K → E: Converts the electrically silent channel that is present at the cell membrane to an active channel. No effect on retention in recycling endosomes. 6 Publications1
Mutagenesisi293 – 294II → AA: Strongly increases location at the cell membrane. 1 Publication2
Mutagenesisi299 – 336Missing : No effect on intracellular retention in recycling endosomes. 1 PublicationAdd BLAST38

Organism-specific databases

DisGeNET

More...
DisGeNETi
3775

Open Targets

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OpenTargetsi
ENSG00000135750

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA219

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
O00180, Tbio

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00308, Ibutilide
DB00908, Quinidine
DB01346, Quinidine barbiturate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KCNK1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001017401 – 336Potassium channel subfamily K member 1Add BLAST336

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69Interchain2 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi95N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki274Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)2 Publications
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei326PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylation is controversial. Sumoylated by UBE2I (PubMed:15820677). Not sumoylated when expressed in xenopus oocytes or mammalian cells (PubMed:17693262). Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane (PubMed:15820677). Sumoylation of a single subunit is sufficient to silence the dimeric channel (PubMed:20498050, PubMed:23169818). Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9 (PubMed:23169818). Desumoylated by SENP1; this activates the channel (PubMed:15820677, PubMed:20498050, PubMed:23169818). Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9 (PubMed:23169818). SENP1 treatment has no effect (PubMed:17693262).4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
O00180

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O00180

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
O00180

MaxQB - The MaxQuant DataBase

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MaxQBi
O00180

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
O00180

PeptideAtlas

More...
PeptideAtlasi
O00180

PRoteomics IDEntifications database

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PRIDEi
O00180

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
47763

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

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GlyGeni
O00180, 1 site

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
O00180

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
O00180

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
O00180

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in bronchial epithelial cells (PubMed:21964404). Detected in heart left atrium and left ventricle (PubMed:17478540). Detected in cardiac myocytes (at protein level) (PubMed:21653227). Widely expressed with high levels in heart, brain and kidney, and lower levels in colon, ovary, placenta, lung and liver (PubMed:8605869, PubMed:9362344). Highly expressed in cerebellum, and detected at lower levels in amygdala, caudate nucleus, brain cortex, hippocampus, putamen, substantia nigra, thalamus, dorsal root ganglion, spinal cord, pituitary, heart, kidney, lung, placenta, pancreas, stomach, small intestine, uterus and prostate (PubMed:11165377). Detected in right and left heart ventricle and atrium, and in heart Purkinje fibers (PubMed:17478540). Detected in bronchial epithelial cells (PubMed:21964404).6 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000135750, Expressed in cerebellum and 232 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
O00180, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
O00180, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000135750, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (PubMed:8978667, PubMed:22282804). Heterodimer with KCNK2; disulfide-linked (By similarity). In astrocytes, forms mostly heterodimeric potassium channels with KCNK2, with only a minor proportion of functional channels containing homodimeric KCNK1 (By similarity).

Interacts with KCNK3 and KCNK9, forming functional heterodimeric channels (PubMed:23169818).

Interacts with GNG4 (By similarity).

Identified in a complex with PSD and ARF6; interacts only with PSD that is bound to ARF6 (By similarity).

Interacts with UBE2I (PubMed:15820677).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109976, 13 interactors

Database of interacting proteins

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DIPi
DIP-59532N

Protein interaction database and analysis system

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IntActi
O00180, 11 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000355580

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
O00180, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1336
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
O00180

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni117 – 122Selectivity filter 11 Publication1 Publication6
Regioni225 – 230Selectivity filter 21 Publication6
Regioni293 – 299Important for intracellular retention in recycling endosomes1 Publication7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1418, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155293

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_022504_6_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
O00180

Identification of Orthologs from Complete Genome Data

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OMAi
NHKSTWY

Database of Orthologous Groups

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OrthoDBi
1211599at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O00180

TreeFam database of animal gene trees

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TreeFami
TF313947

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR003280, 2pore_dom_K_chnl
IPR003092, 2pore_dom_K_chnl_TASK
IPR005408, 2pore_dom_K_chnl_TWIK
IPR001779, 2pore_dom_K_chnl_TWIK1
IPR013099, K_chnl_dom

Pfam protein domain database

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Pfami
View protein in Pfam
PF07885, Ion_trans_2, 2 hits

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF038061, K_channel_subfamily_K_type, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01333, 2POREKCHANEL
PR01096, TWIK1CHANNEL
PR01586, TWIKCHANNEL

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O00180-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLQSLAGSSC VRLVERHRSA WCFGFLVLGY LLYLVFGAVV FSSVELPYED
60 70 80 90 100
LLRQELRKLK RRFLEEHECL SEQQLEQFLG RVLEASNYGV SVLSNASGNW
110 120 130 140 150
NWDFTSALFF ASTVLSTTGY GHTVPLSDGG KAFCIIYSVI GIPFTLLFLT
160 170 180 190 200
AVVQRITVHV TRRPVLYFHI RWGFSKQVVA IVHAVLLGFV TVSCFFFIPA
210 220 230 240 250
AVFSVLEDDW NFLESFYFCF ISLSTIGLGD YVPGEGYNQK FRELYKIGIT
260 270 280 290 300
CYLLLGLIAM LVVLETFCEL HELKKFRKMF YVKKDKDEDQ VHIIEHDQLS
310 320 330
FSSITDQAAG MKEDQKQNEP FVATQSSACV DGPANH
Length:336
Mass (Da):38,143
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A41D9501323215D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5T5E6Q5T5E6_HUMAN
Potassium channel subfamily K membe...
KCNK1
242Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U33632 mRNA Translation: AAB01688.1
U76996 mRNA Translation: AAB97878.1
U90065 mRNA Translation: AAB51147.1
AL356357 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69989.1
BC018051 mRNA Translation: AAH18051.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS1599.1

Protein sequence database of the Protein Information Resource

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PIRi
S65566

NCBI Reference Sequences

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RefSeqi
NP_002236.1, NM_002245.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000366621; ENSP00000355580; ENSG00000135750

Database of genes from NCBI RefSeq genomes

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GeneIDi
3775

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3775

UCSC genome browser

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UCSCi
uc010pxo.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33632 mRNA Translation: AAB01688.1
U76996 mRNA Translation: AAB97878.1
U90065 mRNA Translation: AAB51147.1
AL356357 Genomic DNA No translation available.
CH471098 Genomic DNA Translation: EAW69989.1
BC018051 mRNA Translation: AAH18051.1
CCDSiCCDS1599.1
PIRiS65566
RefSeqiNP_002236.1, NM_002245.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3UKMX-ray3.40A/B/C/D19-288[»]
SMRiO00180
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109976, 13 interactors
DIPiDIP-59532N
IntActiO00180, 11 interactors
STRINGi9606.ENSP00000355580

Chemistry databases

DrugBankiDB00308, Ibutilide
DB00908, Quinidine
DB01346, Quinidine barbiturate

PTM databases

GlyGeniO00180, 1 site
iPTMnetiO00180
PhosphoSitePlusiO00180
SwissPalmiO00180

Genetic variation databases

BioMutaiKCNK1

Proteomic databases

EPDiO00180
jPOSTiO00180
MassIVEiO00180
MaxQBiO00180
PaxDbiO00180
PeptideAtlasiO00180
PRIDEiO00180
ProteomicsDBi47763

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
20802, 310 antibodies

The DNASU plasmid repository

More...
DNASUi
3775

Genome annotation databases

EnsembliENST00000366621; ENSP00000355580; ENSG00000135750
GeneIDi3775
KEGGihsa:3775
UCSCiuc010pxo.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3775
DisGeNETi3775

GeneCards: human genes, protein and diseases

More...
GeneCardsi
KCNK1
HGNCiHGNC:6272, KCNK1
HPAiENSG00000135750, Tissue enhanced (brain)
MIMi601745, gene
neXtProtiNX_O00180
OpenTargetsiENSG00000135750
PharmGKBiPA219
VEuPathDBiHostDB:ENSG00000135750

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1418, Eukaryota
GeneTreeiENSGT00940000155293
HOGENOMiCLU_022504_6_0_1
InParanoidiO00180
OMAiNHKSTWY
OrthoDBi1211599at2759
PhylomeDBiO00180
TreeFamiTF313947

Enzyme and pathway databases

PathwayCommonsiO00180
ReactomeiR-HSA-1299308, Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)
R-HSA-5576886, Phase 4 - resting membrane potential

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
3775, 3 hits in 1011 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
KCNK1, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
KCNK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
3775
PharosiO00180, Tbio

Protein Ontology

More...
PROi
PR:O00180
RNActiO00180, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000135750, Expressed in cerebellum and 232 other tissues
ExpressionAtlasiO00180, baseline and differential
GenevisibleiO00180, HS

Family and domain databases

InterProiView protein in InterPro
IPR003280, 2pore_dom_K_chnl
IPR003092, 2pore_dom_K_chnl_TASK
IPR005408, 2pore_dom_K_chnl_TWIK
IPR001779, 2pore_dom_K_chnl_TWIK1
IPR013099, K_chnl_dom
PfamiView protein in Pfam
PF07885, Ion_trans_2, 2 hits
PIRSFiPIRSF038061, K_channel_subfamily_K_type, 1 hit
PRINTSiPR01333, 2POREKCHANEL
PR01096, TWIK1CHANNEL
PR01586, TWIKCHANNEL

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKCNK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00180
Secondary accession number(s): Q13307, Q5T5E8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 1, 1997
Last modified: September 29, 2021
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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