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Protein

GTP-binding protein 1

Gene

GTPBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 174GTPSequence analysis8
Nucleotide bindingi252 – 256GTPSequence analysis5
Nucleotide bindingi308 – 311GTPSequence analysis4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • translation elongation factor activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTP-binding protein 1
Short name:
G-protein 1
Short name:
GP-1
Short name:
GP1
Gene namesi
Name:GTPBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100226.15
HGNCiHGNC:4669 GTPBP1
MIMi602245 gene
neXtProtiNX_O00178

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi9567
OpenTargetsiENSG00000100226
PharmGKBiPA29057

Polymorphism and mutation databases

BioMutaiGTPBP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224691 – 669GTP-binding protein 1Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei6PhosphoserineBy similarity1
Modified residuei8PhosphoserineBy similarity1
Modified residuei12PhosphoserineCombined sources1
Modified residuei24PhosphoserineBy similarity1
Modified residuei25PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1
Modified residuei47PhosphoserineCombined sources1
Modified residuei69PhosphoserineCombined sources1
Modified residuei580PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00178
MaxQBiO00178
PaxDbiO00178
PeptideAtlasiO00178
PRIDEiO00178
ProteomicsDBi47762

PTM databases

iPTMnetiO00178
PhosphoSitePlusiO00178

Expressioni

Gene expression databases

BgeeiENSG00000100226 Expressed in 215 organ(s), highest expression level in blood
CleanExiHS_GTPBP1
ExpressionAtlasiO00178 baseline and differential
GenevisibleiO00178 HS

Organism-specific databases

HPAiHPA003166
HPA064702

Interactioni

Subunit structurei

Interacts with EXOSC2/RRP4, EXOSC3/RRP40, EXOSC5/RRP46, HNRNPD, HNRNPR and SYNCRIP. Identified in a complex with AANAT mRNA, but does not bind mRNA by itself (By similarity).By similarity

Protein-protein interaction databases

BioGridi114937, 36 interactors
IntActiO00178, 17 interactors
MINTiO00178
STRINGi9606.ENSP00000216044

Structurei

3D structure databases

ProteinModelPortaliO00178
SMRiO00178
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 389tr-type GPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni167 – 174G1PROSITE-ProRule annotation8
Regioni206 – 210G2PROSITE-ProRule annotation5
Regioni252 – 255G3PROSITE-ProRule annotation4
Regioni308 – 311G4PROSITE-ProRule annotation4
Regioni366 – 368G5PROSITE-ProRule annotation3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 36Poly-Ala9

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0463 Eukaryota
COG5258 LUCA
GeneTreeiENSGT00730000110829
HOGENOMiHOG000176635
HOVERGENiHBG004471
InParanoidiO00178
OMAiYLRKGMV
OrthoDBiEOG091G06LY
PhylomeDBiO00178
TreeFamiTF350446

Family and domain databases

CDDicd04165 GTPBP1_like, 1 hit
InterProiView protein in InterPro
IPR039263 GTPB1
IPR035531 GTPBP1-like
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PANTHERiPTHR43721:SF14 PTHR43721:SF14, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

O00178-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATERSRSAM DSPVPASMFA PEPSSPGAAR AAAAAARLHG GFDSDCSEDG
60 70 80 90 100
EALNGEPELD LTSKLVLVSP TSEQYDSLLR QMWERMDEGC GETIYVIGQG
110 120 130 140 150
SDGTEYGLSE ADMEASYATV KSMAEQIEAD VILLRERQEA GGRVRDYLVR
160 170 180 190 200
KRVGDNDFLE VRVAVVGNVD AGKSTLLGVL THGELDNGRG FARQKLFRHK
210 220 230 240 250
HEIESGRTSS VGNDILGFDS EGNVVNKPDS HGGSLEWTKI CEKSTKVITF
260 270 280 290 300
IDLAGHEKYL KTTVFGMTGH LPDFCMLMVG SNAGIVGMTK EHLGLALALN
310 320 330 340 350
VPVFVVVTKI DMCPANILQE TLKLLQRLLK SPGCRKIPVL VQSKDDVIVT
360 370 380 390 400
ASNFSSERMC PIFQISNVTG ENLDLLKMFL NLLSPRTSYR EEEPAEFQID
410 420 430 440 450
DTYSVPGVGT VVSGTTLRGL IKLNDTLLLG PDPLGNFLSI AVKSIHRKRM
460 470 480 490 500
PVKEVRGGQT ASFALKKIKR SSIRKGMVMV SPRLNPQASW EFEAEILVLH
510 520 530 540 550
HPTTISPRYQ AMVHCGSIRQ TATILSMDKD CLRTGDKATV HFRFIKTPEY
560 570 580 590 600
LHIDQRLVFR EGRTKAVGTI TKLLQTTNNS PMNSKPQQIK MQSTKKGPLT
610 620 630 640 650
KRDEGGPSGG PAVGAPPPGD EASSVGAGQP AASSNLQPQP KPSSGGRRRG
660
GQRHKVKSQG ACVTPASGC
Length:669
Mass (Da):72,454
Last modified:July 10, 2007 - v3
Checksum:i0814F4DC03740ABE
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H716F5H716_HUMAN
GTP-binding protein 1
GTPBP1
152Annotation score:
B0QY59B0QY59_HUMAN
GTP-binding protein 1
GTPBP1
349Annotation score:
F5H257F5H257_HUMAN
GTP-binding protein 1
GTPBP1
86Annotation score:
F8WAZ4F8WAZ4_HUMAN
GTP-binding protein 1
GTPBP1
70Annotation score:
F5H7C0F5H7C0_HUMAN
GTP-binding protein 1
GTPBP1
39Annotation score:
H0YGA8H0YGA8_HUMAN
GTP-binding protein 1
GTPBP1
30Annotation score:
H0YH10H0YH10_HUMAN
GTP-binding protein 1
GTPBP1
90Annotation score:
H0YF75H0YF75_HUMAN
GTP-binding protein 1
GTPBP1
40Annotation score:

Sequence cautioni

The sequence AAB51273 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAG30387 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04949691G → R. Corresponds to variant dbSNP:rs11547402Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021707 Genomic DNA No translation available.
BC014075 mRNA Translation: AAH14075.3
CR456501 mRNA Translation: CAG30387.1 Different initiation.
U87964 mRNA Translation: AAB51273.1 Different initiation.
CCDSiCCDS13977.2
PIRiJC5291
RefSeqiNP_004277.2, NM_004286.4
UniGeneiHs.276925

Genome annotation databases

EnsembliENST00000216044; ENSP00000216044; ENSG00000100226
GeneIDi9567
KEGGihsa:9567
UCSCiuc003awg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL021707 Genomic DNA No translation available.
BC014075 mRNA Translation: AAH14075.3
CR456501 mRNA Translation: CAG30387.1 Different initiation.
U87964 mRNA Translation: AAB51273.1 Different initiation.
CCDSiCCDS13977.2
PIRiJC5291
RefSeqiNP_004277.2, NM_004286.4
UniGeneiHs.276925

3D structure databases

ProteinModelPortaliO00178
SMRiO00178
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114937, 36 interactors
IntActiO00178, 17 interactors
MINTiO00178
STRINGi9606.ENSP00000216044

PTM databases

iPTMnetiO00178
PhosphoSitePlusiO00178

Polymorphism and mutation databases

BioMutaiGTPBP1

Proteomic databases

EPDiO00178
MaxQBiO00178
PaxDbiO00178
PeptideAtlasiO00178
PRIDEiO00178
ProteomicsDBi47762

Protocols and materials databases

DNASUi9567
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216044; ENSP00000216044; ENSG00000100226
GeneIDi9567
KEGGihsa:9567
UCSCiuc003awg.4 human

Organism-specific databases

CTDi9567
DisGeNETi9567
EuPathDBiHostDB:ENSG00000100226.15
GeneCardsiGTPBP1
H-InvDBiHIX0016477
HGNCiHGNC:4669 GTPBP1
HPAiHPA003166
HPA064702
MIMi602245 gene
neXtProtiNX_O00178
OpenTargetsiENSG00000100226
PharmGKBiPA29057
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0463 Eukaryota
COG5258 LUCA
GeneTreeiENSGT00730000110829
HOGENOMiHOG000176635
HOVERGENiHBG004471
InParanoidiO00178
OMAiYLRKGMV
OrthoDBiEOG091G06LY
PhylomeDBiO00178
TreeFamiTF350446

Miscellaneous databases

ChiTaRSiGTPBP1 human
GeneWikiiGTPBP1
GenomeRNAii9567
PROiPR:O00178
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100226 Expressed in 215 organ(s), highest expression level in blood
CleanExiHS_GTPBP1
ExpressionAtlasiO00178 baseline and differential
GenevisibleiO00178 HS

Family and domain databases

CDDicd04165 GTPBP1_like, 1 hit
InterProiView protein in InterPro
IPR039263 GTPB1
IPR035531 GTPBP1-like
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PANTHERiPTHR43721:SF14 PTHR43721:SF14, 1 hit
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGTPB1_HUMAN
AccessioniPrimary (citable) accession number: O00178
Secondary accession number(s): Q6IC67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 10, 2007
Last modified: November 7, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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