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Protein

C-C motif chemokine 24

Gene

CCL24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic for resting T-lymphocytes, and eosinophils. Has lower chemotactic activity for neutrophils but none for monocytes and activated lymphocytes. Is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. Binds to CCR3.

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: CAFA
  • CCR chemokine receptor binding Source: GO_Central
  • chemokine activity Source: UniProtKB
  • receptor ligand activity Source: CAFA

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 24
Alternative name(s):
CK-beta-6
Eosinophil chemotactic protein 2
Eotaxin-2
Myeloid progenitor inhibitory factor 2
Short name:
MPIF-2
Small-inducible cytokine A24
Gene namesi
Name:CCL24
Synonyms:MPIF2, SCYA24
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106178.6
HGNCiHGNC:10623 CCL24
MIMi602495 gene
neXtProtiNX_O00175

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6369
OpenTargetsiENSG00000106178
PharmGKBiPA35555

Polymorphism and mutation databases

BioMutaiCCL24

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 263 PublicationsAdd BLAST26
ChainiPRO_000000523227 – 119C-C motif chemokine 24Add BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 58
Disulfide bondi34 ↔ 74
Glycosylationi115N-linked (GlcNAc...) asparagine1

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiO00175
PeptideAtlasiO00175
PRIDEiO00175
ProteomicsDBi47761

Miscellaneous databases

PMAP-CutDBiO00175

Expressioni

Tissue specificityi

Activated monocytes and activated T lymphocytes.

Gene expression databases

BgeeiENSG00000106178 Expressed in 78 organ(s), highest expression level in spleen
CleanExiHS_CCL24
GenevisibleiO00175 HS

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5876N
IntActiO00175, 5 interactors
STRINGi9606.ENSP00000222902

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00175
SMRiO00175
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00175

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JCGF Eukaryota
ENOG41119KC LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO00175
KOiK21097
OMAiGQKFCGD
OrthoDBiEOG091G1251
PhylomeDBiO00175
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00175-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGLMTIVTS LLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY
60 70 80 90 100
QLSSRSTCLK AGVIFTTKKG QQFCGDPKQE WVQRYMKNLD AKQKKASPRA
110
RAVAVKGPVQ RYPGNQTTC
Length:119
Mass (Da):13,134
Last modified:May 30, 2000 - v2
Checksum:i6CAACA61731FB393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61A → G in AAB51135 (PubMed:9104803).Curated1
Sequence conflicti73F → S AA sequence (PubMed:9104803).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01840429I → L1 PublicationCorresponds to variant dbSNP:rs2302006Ensembl.1
Natural variantiVAR_04871031S → F. Corresponds to variant dbSNP:rs11465293Ensembl.1
Natural variantiVAR_048711102A → T. Corresponds to variant dbSNP:rs11465312Ensembl.1
Natural variantiVAR_048712110Q → E. Corresponds to variant dbSNP:rs11465313Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85768 mRNA Translation: AAB51135.1
AK312216 mRNA Translation: BAG35149.1
AC005102 Genomic DNA Translation: AAD15410.1
BC069072 mRNA Translation: AAH69072.1
BC069391 mRNA Translation: AAH69391.1
AJ223461 mRNA Translation: CAA11383.1
CCDSiCCDS34670.1
RefSeqiNP_002982.2, NM_002991.2
XP_011514761.1, XM_011516459.2
XP_011514762.1, XM_011516460.2
UniGeneiHs.247838

Genome annotation databases

EnsembliENST00000222902; ENSP00000222902; ENSG00000106178
ENST00000416943; ENSP00000400533; ENSG00000106178
GeneIDi6369
KEGGihsa:6369
UCSCiuc011kga.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CCL24 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U85768 mRNA Translation: AAB51135.1
AK312216 mRNA Translation: BAG35149.1
AC005102 Genomic DNA Translation: AAD15410.1
BC069072 mRNA Translation: AAH69072.1
BC069391 mRNA Translation: AAH69391.1
AJ223461 mRNA Translation: CAA11383.1
CCDSiCCDS34670.1
RefSeqiNP_002982.2, NM_002991.2
XP_011514761.1, XM_011516459.2
XP_011514762.1, XM_011516460.2
UniGeneiHs.247838

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EIGNMR-A27-99[»]
1EIHNMR-A27-99[»]
ProteinModelPortaliO00175
SMRiO00175
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5876N
IntActiO00175, 5 interactors
STRINGi9606.ENSP00000222902

Polymorphism and mutation databases

BioMutaiCCL24

Proteomic databases

PaxDbiO00175
PeptideAtlasiO00175
PRIDEiO00175
ProteomicsDBi47761

Protocols and materials databases

DNASUi6369
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222902; ENSP00000222902; ENSG00000106178
ENST00000416943; ENSP00000400533; ENSG00000106178
GeneIDi6369
KEGGihsa:6369
UCSCiuc011kga.3 human

Organism-specific databases

CTDi6369
DisGeNETi6369
EuPathDBiHostDB:ENSG00000106178.6
GeneCardsiCCL24
HGNCiHGNC:10623 CCL24
MIMi602495 gene
neXtProtiNX_O00175
OpenTargetsiENSG00000106178
PharmGKBiPA35555
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JCGF Eukaryota
ENOG41119KC LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiO00175
KOiK21097
OMAiGQKFCGD
OrthoDBiEOG091G1251
PhylomeDBiO00175
TreeFamiTF334888

Miscellaneous databases

EvolutionaryTraceiO00175
GenomeRNAii6369
PMAP-CutDBiO00175
PROiPR:O00175
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106178 Expressed in 78 organ(s), highest expression level in spleen
CleanExiHS_CCL24
GenevisibleiO00175 HS

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL24_HUMAN
AccessioniPrimary (citable) accession number: O00175
Secondary accession number(s): B2R5K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 158 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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