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Entry version 170 (13 Feb 2019)
Sequence version 2 (28 Jul 2009)
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Protein

AH receptor-interacting protein

Gene

AIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Cellular negative regulator of the hepatitis B virus (HBV) X protein.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: Ensembl
  • GAF domain binding Source: UniProtKB
  • transcription coactivator activity Source: ProtInc
  • transcription factor binding Source: ProtInc
  • unfolded protein binding Source: HGNC

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-8937144 Aryl hydrocarbon receptor signalling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
O00170

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AH receptor-interacting protein
Short name:
AIP
Alternative name(s):
Aryl-hydrocarbon receptor-interacting protein
HBV X-associated protein 2
Short name:
XAP-2
Immunophilin homolog ARA9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AIP
Synonyms:XAP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000110711.9

Human Gene Nomenclature Database

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HGNCi
HGNC:358 AIP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605555 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_O00170

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pituitary adenoma 1, multiple types (PITA1)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported.
See also OMIM:102200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05840747 – 54Missing in PITA1; unknown pathological significance. 1 Publication8
Natural variantiVAR_043910241K → E in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043911248Missing in PITA1; ACTH-secreting pituitary adenoma; unknown pathological significance. 1 Publication1
Natural variantiVAR_043912271R → W in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043913304R → Q in PITA1; ACTH-secreting pituitary adenoma. 1 Publication1
Prolactin-secreting pituitary adenoma (PSPA)1 Publication1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionMost common type of hormonally active pituitary adenoma.
See also OMIM:600634

Keywords - Diseasei

Cushing syndrome

Organism-specific databases

DisGeNET

More...
DisGeNETi
9049

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
AIP

MalaCards human disease database

More...
MalaCardsi
AIP
MIMi102200 phenotype
600634 phenotype

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
963 Acromegaly
314777 Familial isolated pituitary adenoma
314790 Null pituitary adenoma
2965 Prolactinoma
314786 Silent pituitary adenoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24652

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AIP

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000753391 – 330AH receptor-interacting proteinAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
O00170

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
O00170

MaxQB - The MaxQuant DataBase

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MaxQBi
O00170

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
O00170

PeptideAtlas

More...
PeptideAtlasi
O00170

PRoteomics IDEntifications database

More...
PRIDEi
O00170

ProteomicsDB human proteome resource

More...
ProteomicsDBi
47760

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
O00170

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
O00170

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000110711 Expressed in 199 organ(s), highest expression level in popliteal artery

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
O00170 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
O00170 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033674
CAB069477
HPA050217

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114511, 56 interactors

Database of interacting proteins

More...
DIPi
DIP-34068N

Protein interaction database and analysis system

More...
IntActi
O00170, 34 interactors

Molecular INTeraction database

More...
MINTi
O00170

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000279146

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LKNNMR-A2-166[»]
4AIFX-ray2.01A/B172-315[»]
4APOX-ray1.90A/B166-330[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
O00170

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
O00170

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini31 – 121PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST91
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati179 – 212TPR 1Add BLAST34
Repeati231 – 264TPR 2Add BLAST34
Repeati265 – 298TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0545 Eukaryota
ENOG410YGYV LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG004198

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
O00170

KEGG Orthology (KO)

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KOi
K17767

Database of Orthologous Groups

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OrthoDBi
1278789at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
O00170

TreeFam database of animal gene trees

More...
TreeFami
TF314507

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031208 AIP
IPR039663 AIP/AIPL1
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR11242 PTHR11242, 1 hit
PTHR11242:SF3 PTHR11242:SF3, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00254 FKBP_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

O00170-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL
60 70 80 90 100
DDSRARGKPM ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL
110 120 130 140 150
VAKSLRNIAV GKDPLEGQRH CCGVAQMREH SSLGHADLDA LQQNPQPLIF
160 170 180 190 200
HMEMLKVESP GTYQQDPWAM TDEEKAKAVP LIHQEGNRLY REGHVKEAAA
210 220 230 240 250
KYYDAIACLK NLQMKEQPGS PEWIQLDQQI TPLLLNYCQC KLVVEEYYEV
260 270 280 290 300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
310 320 330
VVSRELQALE ARIRQKDEED KARFRGIFSH
Length:330
Mass (Da):37,636
Last modified:July 28, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9302AA6D0F8D8F51
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PMH2E9PMH2_HUMAN
Peptidylprolyl isomerase
AIP
232Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GYQ3V9GYQ3_HUMAN
AH receptor-interacting protein
AIP
188Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04390816R → H2 PublicationsCorresponds to variant dbSNP:rs145047094EnsemblClinVar.1
Natural variantiVAR_05840747 – 54Missing in PITA1; unknown pathological significance. 1 Publication8
Natural variantiVAR_043909228Q → KCombined sources4 PublicationsCorresponds to variant dbSNP:rs641081EnsemblClinVar.1
Natural variantiVAR_043910241K → E in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043911248Missing in PITA1; ACTH-secreting pituitary adenoma; unknown pathological significance. 1 Publication1
Natural variantiVAR_043912271R → W in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043913304R → Q in PITA1; ACTH-secreting pituitary adenoma. 1 Publication1
Natural variantiVAR_061545307Q → R4 PublicationsCorresponds to variant dbSNP:rs4930199Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U31913 mRNA Translation: AAB39923.1
U78521 mRNA Translation: AAB59004.1
AM236341 Genomic DNA Translation: CAJ85657.1
EF066502 Genomic DNA Translation: ABK60081.1
EF066504 Genomic DNA Translation: ABK60082.1
EF066505 Genomic DNA Translation: ABK60083.1
EF066510 Genomic DNA Translation: ABK60084.1
BC104827 mRNA Translation: AAI04828.1
BC104797 mRNA Translation: AAI04798.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS8168.1

NCBI Reference Sequences

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RefSeqi
NP_001289888.1, NM_001302959.1
NP_001289889.1, NM_001302960.1
NP_003968.3, NM_003977.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.412433

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000279146; ENSP00000279146; ENSG00000110711

Database of genes from NCBI RefSeq genomes

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GeneIDi
9049

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9049

UCSC genome browser

More...
UCSCi
uc001olv.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31913 mRNA Translation: AAB39923.1
U78521 mRNA Translation: AAB59004.1
AM236341 Genomic DNA Translation: CAJ85657.1
EF066502 Genomic DNA Translation: ABK60081.1
EF066504 Genomic DNA Translation: ABK60082.1
EF066505 Genomic DNA Translation: ABK60083.1
EF066510 Genomic DNA Translation: ABK60084.1
BC104827 mRNA Translation: AAI04828.1
BC104797 mRNA Translation: AAI04798.1
CCDSiCCDS8168.1
RefSeqiNP_001289888.1, NM_001302959.1
NP_001289889.1, NM_001302960.1
NP_003968.3, NM_003977.3
UniGeneiHs.412433

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LKNNMR-A2-166[»]
4AIFX-ray2.01A/B172-315[»]
4APOX-ray1.90A/B166-330[»]
ProteinModelPortaliO00170
SMRiO00170
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114511, 56 interactors
DIPiDIP-34068N
IntActiO00170, 34 interactors
MINTiO00170
STRINGi9606.ENSP00000279146

PTM databases

iPTMnetiO00170
PhosphoSitePlusiO00170

Polymorphism and mutation databases

BioMutaiAIP

Proteomic databases

EPDiO00170
jPOSTiO00170
MaxQBiO00170
PaxDbiO00170
PeptideAtlasiO00170
PRIDEiO00170
ProteomicsDBi47760

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000279146; ENSP00000279146; ENSG00000110711
GeneIDi9049
KEGGihsa:9049
UCSCiuc001olv.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9049
DisGeNETi9049
EuPathDBiHostDB:ENSG00000110711.9

GeneCards: human genes, protein and diseases

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GeneCardsi
AIP
GeneReviewsiAIP
HGNCiHGNC:358 AIP
HPAiCAB033674
CAB069477
HPA050217
MalaCardsiAIP
MIMi102200 phenotype
600634 phenotype
605555 gene
neXtProtiNX_O00170
Orphaneti963 Acromegaly
314777 Familial isolated pituitary adenoma
314790 Null pituitary adenoma
2965 Prolactinoma
314786 Silent pituitary adenoma
PharmGKBiPA24652

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0545 Eukaryota
ENOG410YGYV LUCA
HOVERGENiHBG004198
InParanoidiO00170
KOiK17767
OrthoDBi1278789at2759
PhylomeDBiO00170
TreeFamiTF314507

Enzyme and pathway databases

ReactomeiR-HSA-8937144 Aryl hydrocarbon receptor signalling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiO00170

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AH_receptor-interacting_protein

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9049

Protein Ontology

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PROi
PR:O00170

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000110711 Expressed in 199 organ(s), highest expression level in popliteal artery
ExpressionAtlasiO00170 baseline and differential
GenevisibleiO00170 HS

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031208 AIP
IPR039663 AIP/AIPL1
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11242 PTHR11242, 1 hit
PTHR11242:SF3 PTHR11242:SF3, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAIP_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00170
Secondary accession number(s): A0SZW3
, A0SZW4, A0SZW5, A0SZW6, Q2M3Q2, Q99606
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 28, 2009
Last modified: February 13, 2019
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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