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Protein

AH receptor-interacting protein

Gene

AIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.
Cellular negative regulator of the hepatitis B virus (HBV) X protein.

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: Ensembl
  • GAF domain binding Source: UniProtKB
  • transcription coactivator activity Source: ProtInc
  • transcription factor binding Source: ProtInc
  • unfolded protein binding Source: HGNC

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-8937144 Aryl hydrocarbon receptor signalling
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SIGNORiO00170

Names & Taxonomyi

Protein namesi
Recommended name:
AH receptor-interacting protein
Short name:
AIP
Alternative name(s):
Aryl-hydrocarbon receptor-interacting protein
HBV X-associated protein 2
Short name:
XAP-2
Immunophilin homolog ARA9
Gene namesi
Name:AIP
Synonyms:XAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000110711.9
HGNCiHGNC:358 AIP
MIMi605555 gene
neXtProtiNX_O00170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Pituitary adenoma 1, multiple types (PITA1)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete: growth hormone (GH)-secreting, prolactin (PRL)-secreting, adrenocorticotropin (ACTH)-secreting, thyroid- stimulating hormone (TSH)-secreting, and plurihormonal (GH and TSH) tumors. Familial and sporadic forms have been reported.
See also OMIM:102200
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05840747 – 54Missing in PITA1; unknown pathological significance. 1 Publication8
Natural variantiVAR_043910241K → E in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043911248Missing in PITA1; ACTH-secreting pituitary adenoma; unknown pathological significance. 1 Publication1
Natural variantiVAR_043912271R → W in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043913304R → Q in PITA1; ACTH-secreting pituitary adenoma. 1 Publication1
Prolactin-secreting pituitary adenoma (PSPA)1 Publication1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionMost common type of hormonally active pituitary adenoma.
See also OMIM:600634

Keywords - Diseasei

Cushing syndrome

Organism-specific databases

DisGeNETi9049
GeneReviewsiAIP
MalaCardsiAIP
MIMi102200 phenotype
600634 phenotype
Orphaneti963 Acromegaly
314777 Familial isolated pituitary adenoma
PharmGKBiPA24652

Polymorphism and mutation databases

BioMutaiAIP

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000753391 – 330AH receptor-interacting proteinAdd BLAST330

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei43PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00170
MaxQBiO00170
PaxDbiO00170
PeptideAtlasiO00170
PRIDEiO00170
ProteomicsDBi47760

PTM databases

iPTMnetiO00170
PhosphoSitePlusiO00170

Expressioni

Tissue specificityi

Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.

Gene expression databases

BgeeiENSG00000110711
CleanExiHS_AIP
ExpressionAtlasiO00170 baseline and differential
GenevisibleiO00170 HS

Organism-specific databases

HPAiCAB033674
CAB069477
HPA050217

Interactioni

Subunit structurei

Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • aryl hydrocarbon receptor binding Source: Ensembl
  • GAF domain binding Source: UniProtKB
  • transcription factor binding Source: ProtInc
  • unfolded protein binding Source: HGNC

Protein-protein interaction databases

BioGridi114511, 54 interactors
DIPiDIP-34068N
IntActiO00170, 33 interactors
MINTiO00170
STRINGi9606.ENSP00000279146

Structurei

Secondary structure

1330
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 9Combined sources6
Beta strandi17 – 19Combined sources3
Beta strandi33 – 37Combined sources5
Beta strandi39 – 41Combined sources3
Beta strandi43 – 46Combined sources4
Beta strandi49 – 53Combined sources5
Turni54 – 57Combined sources4
Beta strandi60 – 67Combined sources8
Helixi72 – 77Combined sources6
Beta strandi85 – 89Combined sources5
Helixi92 – 95Combined sources4
Helixi98 – 105Combined sources8
Helixi108 – 110Combined sources3
Turni113 – 117Combined sources5
Turni137 – 139Combined sources3
Helixi140 – 143Combined sources4
Beta strandi149 – 158Combined sources10
Turni160 – 162Combined sources3
Helixi173 – 176Combined sources4
Helixi178 – 192Combined sources15
Helixi195 – 213Combined sources19
Helixi221 – 243Combined sources23
Helixi248 – 260Combined sources13
Helixi265 – 277Combined sources13
Helixi281 – 294Combined sources14
Helixi296 – 298Combined sources3
Helixi299 – 311Combined sources13
Helixi314 – 324Combined sources11

3D structure databases

ProteinModelPortaliO00170
SMRiO00170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 121PPIase FKBP-typePROSITE-ProRule annotationAdd BLAST91
Repeati179 – 212TPR 1Add BLAST34
Repeati231 – 264TPR 2Add BLAST34
Repeati265 – 298TPR 3Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0545 Eukaryota
ENOG410YGYV LUCA
HOVERGENiHBG004198
InParanoidiO00170
KOiK17767
OrthoDBiEOG091G0C69
PhylomeDBiO00170
TreeFamiTF314507

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR031208 AIP
IPR001179 PPIase_FKBP_dom
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PANTHERiPTHR11242:SF3 PTHR11242:SF3, 1 hit
PfamiView protein in Pfam
PF00254 FKBP_C, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
PROSITEiView protein in PROSITE
PS50059 FKBP_PPIASE, 1 hit
PS50005 TPR, 1 hit
PS50293 TPR_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

O00170-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADIIARLRE DGIQKRVIQE GRGELPDFQD GTKATFHYRT LHSDDEGTVL
60 70 80 90 100
DDSRARGKPM ELIIGKKFKL PVWETIVCTM REGEIAQFLC DIKHVVLYPL
110 120 130 140 150
VAKSLRNIAV GKDPLEGQRH CCGVAQMREH SSLGHADLDA LQQNPQPLIF
160 170 180 190 200
HMEMLKVESP GTYQQDPWAM TDEEKAKAVP LIHQEGNRLY REGHVKEAAA
210 220 230 240 250
KYYDAIACLK NLQMKEQPGS PEWIQLDQQI TPLLLNYCQC KLVVEEYYEV
260 270 280 290 300
LDHCSSILNK YDDNVKAYFK RGKAHAAVWN AQEAQADFAK VLELDPALAP
310 320 330
VVSRELQALE ARIRQKDEED KARFRGIFSH
Length:330
Mass (Da):37,636
Last modified:July 28, 2009 - v2
Checksum:i9302AA6D0F8D8F51
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04390816R → H2 PublicationsCorresponds to variant dbSNP:rs145047094EnsemblClinVar.1
Natural variantiVAR_05840747 – 54Missing in PITA1; unknown pathological significance. 1 Publication8
Natural variantiVAR_043909228Q → KCombined sources4 PublicationsCorresponds to variant dbSNP:rs641081EnsemblClinVar.1
Natural variantiVAR_043910241K → E in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043911248Missing in PITA1; ACTH-secreting pituitary adenoma; unknown pathological significance. 1 Publication1
Natural variantiVAR_043912271R → W in PITA1; unknown pathological significance. 1 Publication1
Natural variantiVAR_043913304R → Q in PITA1; ACTH-secreting pituitary adenoma. 1 Publication1
Natural variantiVAR_061545307Q → R4 PublicationsCorresponds to variant dbSNP:rs4930199Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31913 mRNA Translation: AAB39923.1
U78521 mRNA Translation: AAB59004.1
AM236341 Genomic DNA Translation: CAJ85657.1
EF066502 Genomic DNA Translation: ABK60081.1
EF066504 Genomic DNA Translation: ABK60082.1
EF066505 Genomic DNA Translation: ABK60083.1
EF066510 Genomic DNA Translation: ABK60084.1
BC104827 mRNA Translation: AAI04828.1
BC104797 mRNA Translation: AAI04798.1
CCDSiCCDS8168.1
RefSeqiNP_001289888.1, NM_001302959.1
NP_001289889.1, NM_001302960.1
NP_003968.3, NM_003977.3
UniGeneiHs.412433

Genome annotation databases

EnsembliENST00000279146; ENSP00000279146; ENSG00000110711
GeneIDi9049
KEGGihsa:9049
UCSCiuc001olv.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAIP_HUMAN
AccessioniPrimary (citable) accession number: O00170
Secondary accession number(s): A0SZW3
, A0SZW4, A0SZW5, A0SZW6, Q2M3Q2, Q99606
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 28, 2009
Last modified: June 20, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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