EYA2

Functionⁱ

Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:12500905, PubMed:23435380). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19351884). Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (PubMed:12500905).4 Publications

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.1 Publication

Cofactorⁱ

Mg²⁺1 PublicationNote: Binds 1 Mg²⁺ ion per subunit.1 Publication

Kineticsⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	274	Nucleophile1 Publication	1
Metal bindingⁱ	274	Magnesium1 Publication	1
Active siteⁱ	276	Proton donor1 Publication	1
Metal bindingⁱ	276	Magnesium; via carbonyl oxygen1 Publication	1
Metal bindingⁱ	502	Magnesium1 Publication	1

GO - Molecular functionⁱ

magnesium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19351884
protein tyrosine phosphatase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 19351884
transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

DNA repair Source: UniProtKB-KW
extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
histone dephosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 19351884
mesodermal cell fate specification
Source: ProtInc
Traceable author statementⁱ
- 9020840
mitochondrial outer membrane permeabilization Source: Ensembl
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: GO_Central
positive regulation of DNA repair Source: GO_Central
regulation of transcription, DNA-templated Source: UniProtKB-KW
striated muscle tissue development Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Chromatin regulator, Developmental protein, Hydrolase, Protein phosphatase
Biological process	DNA damage, DNA repair, Transcription, Transcription regulation
Ligand	Magnesium, Metal-binding

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
Reactomeⁱ	R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
SABIO-RKⁱ	O00167

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eyes absent homolog 2 (EC:3.1.3.481 Publication)
Gene namesⁱ	Name:EYA2 Synonyms:EAB1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000064655.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3520 EYA2
MIMⁱ	601654 gene
neXtProtⁱ	NX_O00167

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	516	P → R: Strongly reduces SIX1 binding. 1 Publication		1
Mutagenesisⁱ	532	A → R: Abolishes interaction with SIX1. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2139
Open Targets More...OpenTargetsⁱ	ENSG00000064655
PharmGKBⁱ	PA27932

Chemistry databases

ChEMBLⁱ	CHEMBL1293275

ChEMBLⁱ

CHEMBL1293275

Polymorphism and mutation databases

BioMutaⁱ	EYA2

BioMutaⁱ

EYA2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000218646	1 – 538	Eyes absent homolog 2Add BLAST		538

Proteomic databases

PaxDbⁱ	O00167
PeptideAtlas More...PeptideAtlasⁱ	O00167
PRIDEⁱ	O00167
ProteomicsDBⁱ	47756 47757 [O00167-2] 47758 [O00167-3]

PTM databases

DEPODⁱ	O00167
iPTMnetⁱ	O00167
PhosphoSitePlusⁱ	O00167

Expressionⁱ

Tissue specificityⁱ

Highest expression in muscle with lower levels in kidney, placenta, pancreas, brain and heart.1 Publication

Developmental stageⁱ

At the begin of fourth week of development detected in cytoplasm of somite cells. Between the sixth and eighth week of development detected in cytoplasm of limb bud cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000064655 Expressed in 147 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasⁱ	O00167 baseline and differential
Genevisibleⁱ	O00167 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027024 HPA059291

HPAⁱ

HPA027024
HPA059291

Interactionⁱ

Subunit structureⁱ

Interacts with DACH2 and SIX1, and probably with SIX2, SIX4 and SIX5. Interacts with CAPN8 (By similarity). Interacts with GNAZ and GNAI2; this precludes interaction with SIX1.By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
SIX1	Q15475	3	EBI-16038245,EBI-743675

With

Entry

#Exp.

IntAct

Notes

SIX1

Q15475

3

EBI-16038245,EBI-743675

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	108440, 83 interactors
Database of interacting proteins More...DIPⁱ	DIP-40707N
IntActⁱ	O00167, 35 interactors
Molecular INTeraction database More...MINTⁱ	O00167
STRINGⁱ	9606.ENSP00000333640

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	269 – 273	Combined sources	5
Turnⁱ	277 – 279	Combined sources	3
Helixⁱ	283 – 287	Combined sources	5
Helixⁱ	289 – 294	Combined sources	6
Helixⁱ	298 – 319	Combined sources	22
Helixⁱ	322 – 325	Combined sources	4
Helixⁱ	326 – 328	Combined sources	3
Turnⁱ	333 – 336	Combined sources	4
Helixⁱ	337 – 339	Combined sources	3
Helixⁱ	350 – 352	Combined sources	3
Helixⁱ	374 – 394	Combined sources	21
Helixⁱ	398 – 402	Combined sources	5
Helixⁱ	406 – 420	Combined sources	15
Turnⁱ	421 – 423	Combined sources	3
Helixⁱ	424 – 436	Combined sources	13
Beta strandⁱ	441 – 449	Combined sources	9
Helixⁱ	451 – 460	Combined sources	10
Turnⁱ	464 – 466	Combined sources	3
Helixⁱ	469 – 471	Combined sources	3
Beta strandⁱ	472 – 474	Combined sources	3
Turnⁱ	476 – 478	Combined sources	3
Helixⁱ	480 – 491	Combined sources	12
Beta strandⁱ	493 – 503	Combined sources	11
Helixⁱ	504 – 512	Combined sources	9
Beta strandⁱ	517 – 519	Combined sources	3
Helixⁱ	523 – 534	Combined sources	12

Show more details

3D structure databases

ProteinModelPortalⁱ	O00167
SMRⁱ	O00167
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O00167

EvolutionaryTraceⁱ

O00167

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the HAD-like hydrolase superfamily. EYA family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3107 Eukaryota ENOG410XT12 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000008860
HOVERGENⁱ	HBG002447
InParanoidⁱ	O00167
KEGG Orthology (KO) More...KOⁱ	K17620
OMAⁱ	SADGFHS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G04YD
PhylomeDBⁱ	O00167
TreeFamⁱ	TF319337

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02601 HAD_Eya, 1 hit
Gene3Dⁱ	3.40.50.12350, 1 hit
InterProⁱ	View protein in InterPro IPR028473 EYA2 IPR006545 EYA_dom IPR038102 EYA_dom_sf IPR028472 EYA_fam IPR036412 HAD-like_sf
PANTHERⁱ	PTHR10190 PTHR10190, 1 hit PTHR10190:SF7 PTHR10190:SF7, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit
TIGRFAMsⁱ	TIGR01658 EYA-cons_domain, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

Note: Experimental confirmation may be lacking for some isoforms.

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: O00167-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF 
        60         70         80         90        100
SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS 
       110        120        130        140        150
IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL 
       160        170        180        190        200
GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS 
       210        220        230        240        250
TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR 
       260        270        280        290        300
GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT 
       310        320        330        340        350
SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF 
       360        370        380        390        400
SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG 
       410        420        430        440        450
LIGTPKRETW LQLRAELEAL TDLWLTHSLK ALNLINSRPN CVNVLVTTTQ 
       460        470        480        490        500
LIPALAKVLL YGLGSVFPIE NIYSATKTGK ESCFERIMQR FGRKAVYVVI 
       510        520        530 
GDGVEEEQGA KKHNMPFWRI SCHADLEALR HALELEYL

Length:538

Mass (Da):59,232

Last modified:May 2, 2002 - v2

Checksum:ⁱ3DBFC31D8BE1E85D

GO

Isoform 2 (identifier: O00167-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
99-122: Missing.

« Hide

        10         20         30         40         50
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF 
        60         70         80         90        100
SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSFS 
       110        120        130        140        150
TSPTGQSPYT YQMHGTTGFY QGGNGLGNAA GFGSVHQDYP SYPGFPQSQY 
       160        170        180        190        200
PQYYGSSYNP PYVPASSICP SPLSTSTYVL QEASHNVPNQ SSESLAGEYN 
       210        220        230        240        250
THNGPSTPAK EGDTDRPHRA SDGKLRGRSK RSSDPSPAGD NEIERVFVWD 
       260        270        280        290        300
LDETIIIFHS LLTGTFASRY GKDTTTSVRI GLMMEEMIFN LADTHLFFND 
       310        320        330        340        350
LEDCDQIHVD DVSSDDNGQD LSTYNFSADG FHSSAPGANL CLGSGVHGGV 
       360        370        380        390        400
DWMRKLAFRY RRVKEMYNTY KNNVGGLIGT PKRETWLQLR AELEALTDLW 
       410        420        430        440        450
LTHSLKALNL INSRPNCVNV LVTTTQLIPA LAKVLLYGLG SVFPIENIYS 
       460        470        480        490        500
ATKTGKESCF ERIMQRFGRK AVYVVIGDGV EEEQGAKKHN MPFWRISCHA 
       510 
DLEALRHALE LEYL

Show »

Length:514

Mass (Da):56,688

Checksum:ⁱ970E63DB345E484A

GO

Isoform 3 (identifier: O00167-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
401-479: Missing.

« Hide

        10         20         30         40         50
MVELVISPSL TVNSDCLDKL KFNRADAAVW TLSDRQGITK SAPLRVSQLF 
        60         70         80         90        100
SRSCPRVLPR QPSTAMAAYG QTQYSAGIQQ ATPYTAYPPP AQAYGIPSYS 
       110        120        130        140        150
IKTEDSLNHS PGQSGFLSYG SSFSTSPTGQ SPYTYQMHGT TGFYQGGNGL 
       160        170        180        190        200
GNAAGFGSVH QDYPSYPGFP QSQYPQYYGS SYNPPYVPAS SICPSPLSTS 
       210        220        230        240        250
TYVLQEASHN VPNQSSESLA GEYNTHNGPS TPAKEGDTDR PHRASDGKLR 
       260        270        280        290        300
GRSKRSSDPS PAGDNEIERV FVWDLDETII IFHSLLTGTF ASRYGKDTTT 
       310        320        330        340        350
SVRIGLMMEE MIFNLADTHL FFNDLEDCDQ IHVDDVSSDD NGQDLSTYNF 
       360        370        380        390        400
SADGFHSSAP GANLCLGSGV HGGVDWMRKL AFRYRRVKEM YNTYKNNVGG 
       410        420        430        440        450
KESCFERIMQ RFGRKAVYVV IGDGVEEEQG AKKHNMPFWR ISCHADLEAL 

RHALELEYL

Show »

Length:459

Mass (Da):50,533

Checksum:ⁱ774885A6F04CA6B2

GO

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E7ETN2	E7ETN2_HUMAN	Eyes absent homolog Eyes absent homolog, EC 3.1.3.48	EYA2	508	Annotation score:
B1AKW3	B1AKW3_HUMAN	Eyes absent homolog Eyes absent homolog, EC 3.1.3.48	EYA2	197	Annotation score:

Sequence cautionⁱ

The sequence AAH13882 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	296	K → E in AAB42065 (PubMed:9049631).Curated	1
Sequence conflictⁱ	361	G → A in AAP35328 (Ref. 3) Curated	1
Sequence conflictⁱ	361	G → A in AAH08803 (PubMed:15489334).Curated	1
Sequence conflictⁱ	381	A → S in AAB42065 (PubMed:9049631).Curated	1
Sequence conflictⁱ	419	A → V in CAA07815 (PubMed:9887327).Curated	1
Sequence conflictⁱ	525	D → N in AAB51120 (PubMed:9195991).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_048964	83	P → S. Corresponds to variant dbSNP:rs2275596Ensembl.		1
Natural variantⁱVAR_048965	238	T → A. Corresponds to variant dbSNP:rs866936Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001490	99 – 122	Missing in isoform 2. 2 PublicationsAdd BLAST		24
Alternative sequenceⁱVSP_001491	401 – 479	Missing in isoform 3. 1 PublicationAdd BLAST		79

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U71207 mRNA Translation: AAB51120.1 Y10261 Genomic DNA Translation: CAA71310.1 BT006682 mRNA Translation: AAP35328.1 AL049540 , AL121776, AL359434, AL022342 Genomic DNA Translation: CAI23166.1 BC000289 mRNA Translation: AAH00289.2 BC008803 mRNA Translation: AAH08803.1 BC013882 mRNA Translation: AAH13882.2 Different initiation. U81601 mRNA Translation: AAB42065.1 AJ007992 mRNA Translation: CAA07815.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13403.1 [O00167-1] CCDS54471.1 [O00167-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_005235.3, NM_005244.4 [O00167-1] NP_742108.2, NM_172110.3 [O00167-3]
UniGeneⁱ	Hs.472877 Hs.722040 Hs.722415 Hs.722416

Genome annotation databases

Ensemblⁱ	ENST00000327619; ENSP00000333640; ENSG00000064655 [O00167-1] ENST00000357410; ENSP00000349986; ENSG00000064655 [O00167-3] ENST00000497062; ENSP00000417105; ENSG00000064655 [O00167-2]
GeneIDⁱ	2139
KEGGⁱ	hsa:2139
UCSC genome browser More...UCSCⁱ	uc002xsm.3 human [O00167-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00167	Eyes absent homolog (Fragment)		HUMAN		434	UniRef100_O00167

Protein	Similar proteins		Species	Score	Length	Source
O00167	Eyes absent homolog (Fragment)		HUMAN		434	UniRef90_O00167
Eyes absent homolog		AOTNA		543
Eyes absent homolog		PANTR		538
Eyes absent homolog		MACMU		538
Eyes absent homolog (Fragment)		MACFA		543
+24
O00167-2	Eyes absent homolog		SAIBB		507	UniRef90_O00167-2
Eyes absent homolog		PAPAN		499
Eyes absent homolog		MACNE		499
Eyes absent homolog (Fragment)		MUSPF		418
Eyes absent homolog		LOXAF		417
+2
O00167-3	Eyes absent homolog		PROCO		460	UniRef90_O00167-3
Eyes absent homolog		TARSY		460
Eyes absent homolog		PANTR		459
Eyes absent homolog		SAIBB		459
Eyes absent homolog		MACMU		459
+30

Protein	Similar proteins		Species	Score	Length	Source
O00167	Isoform 2 of Eyes absent homolog 1		MOUSE		553	UniRef50_P97767-2
Eyes absent homolog 4		HUMAN		639
Eyes absent homolog 4 (Fragment)		TAKRU		119
Eyes absent homolog		MONDO		678
Eyes absent homolog		MACFA		591
+1589
O00167-2	Eyes absent homolog		SAIBB		507	UniRef50_O00167-2
Eyes absent homolog		PAPAN		499
Eyes absent homolog		MACNE		499
Eyes absent homolog (Fragment)		MUSPF		418
Eyes absent homolog		LOXAF		417
+16
O00167-3	Eyes absent homolog		PROCO		460	UniRef50_O00167-3
Eyes absent homolog		TARSY		460
Eyes absent homolog		ODORO		459
Eyes absent homolog		PANPA		459
Eyes absent homolog		GORGO		459
+112

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U71207 mRNA Translation: AAB51120.1 Y10261 Genomic DNA Translation: CAA71310.1 BT006682 mRNA Translation: AAP35328.1 AL049540 , AL121776, AL359434, AL022342 Genomic DNA Translation: CAI23166.1 BC000289 mRNA Translation: AAH00289.2 BC008803 mRNA Translation: AAH08803.1 BC013882 mRNA Translation: AAH13882.2 Different initiation. U81601 mRNA Translation: AAB42065.1 AJ007992 mRNA Translation: CAA07815.1
CCDSⁱ	CCDS13403.1 [O00167-1] CCDS54471.1 [O00167-3]
RefSeqⁱ	NP_005235.3, NM_005244.4 [O00167-1] NP_742108.2, NM_172110.3 [O00167-3]
UniGeneⁱ	Hs.472877 Hs.722040 Hs.722415 Hs.722416

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3GEB	X-ray	2.40	A/B/C/D	268-538	[»]
	3HB0	X-ray	2.50	A/B/C/D	268-538	[»]
	3HB1	X-ray	2.51	A/B/C/D	268-538	[»]
	4EGC	X-ray	1.99	B	253-538	[»]
ProteinModelPortalⁱ	O00167
SMRⁱ	O00167
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108440, 83 interactors
DIPⁱ	DIP-40707N
IntActⁱ	O00167, 35 interactors
MINTⁱ	O00167
STRINGⁱ	9606.ENSP00000333640

Chemistry databases

ChEMBLⁱ	CHEMBL1293275

ChEMBLⁱ

CHEMBL1293275

PTM databases

DEPODⁱ	O00167
iPTMnetⁱ	O00167
PhosphoSitePlusⁱ	O00167

Polymorphism and mutation databases

BioMutaⁱ	EYA2

BioMutaⁱ

EYA2

Proteomic databases

PaxDbⁱ	O00167
PeptideAtlasⁱ	O00167
PRIDEⁱ	O00167
ProteomicsDBⁱ	47756 47757 [O00167-2] 47758 [O00167-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2139
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000327619; ENSP00000333640; ENSG00000064655 [O00167-1] ENST00000357410; ENSP00000349986; ENSG00000064655 [O00167-3] ENST00000497062; ENSP00000417105; ENSG00000064655 [O00167-2]
GeneIDⁱ	2139
KEGGⁱ	hsa:2139
UCSCⁱ	uc002xsm.3 human [O00167-1]

Organism-specific databases

CTDⁱ	2139
DisGeNETⁱ	2139
EuPathDBⁱ	HostDB:ENSG00000064655.18
GeneCardsⁱ	EYA2
HGNCⁱ	HGNC:3520 EYA2
HPAⁱ	HPA027024 HPA059291
MIMⁱ	601654 gene
neXtProtⁱ	NX_O00167
OpenTargetsⁱ	ENSG00000064655
PharmGKBⁱ	PA27932
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3107 Eukaryota ENOG410XT12 LUCA
GeneTreeⁱ	ENSGT00390000008860
HOVERGENⁱ	HBG002447
InParanoidⁱ	O00167
KOⁱ	K17620
OMAⁱ	SADGFHS
OrthoDBⁱ	EOG091G04YD
PhylomeDBⁱ	O00167
TreeFamⁱ	TF319337

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
Reactomeⁱ	R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
SABIO-RKⁱ	O00167

Miscellaneous databases

ChiTaRSⁱ	EYA2 human
EvolutionaryTraceⁱ	O00167
GeneWikiⁱ	EYA2
GenomeRNAiⁱ	2139
Protein Ontology More...PROⁱ	PR:O00167
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000064655 Expressed in 147 organ(s), highest expression level in nasal cavity epithelium
ExpressionAtlasⁱ	O00167 baseline and differential
Genevisibleⁱ	O00167 HS

Family and domain databases

CDDⁱ	cd02601 HAD_Eya, 1 hit
Gene3Dⁱ	3.40.50.12350, 1 hit
InterProⁱ	View protein in InterPro IPR028473 EYA2 IPR006545 EYA_dom IPR038102 EYA_dom_sf IPR028472 EYA_fam IPR036412 HAD-like_sf
PANTHERⁱ	PTHR10190 PTHR10190, 1 hit PTHR10190:SF7 PTHR10190:SF7, 1 hit
SUPFAMⁱ	SSF56784 SSF56784, 1 hit
TIGRFAMsⁱ	TIGR01658 EYA-cons_domain, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EYA2_HUMAN
Accessionⁱ	O00167Primary (citable) accession number: O00167 Secondary accession number(s): Q5JSW8 Q9UIX7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
	Last sequence update:	May 2, 2002
	Last modified:	September 12, 2018
	This is version 175 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - O00167 (EYA2_HUMAN)

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Eyes absent homolog 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ