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UniProtKB - O00161 (SNP23_HUMAN)

Entry version 212 (23 Feb 2022)
Sequence version 1 (01 Jul 1997)
Previous versions | rss
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Protein

Synaptosomal-associated protein 23

Gene

SNAP23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		O00161

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1236974, ER-Phagosome pathway
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-199992, trans-Golgi Network Vesicle Budding
R-HSA-6798695, Neutrophil degranulation
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9013026, RHOB GTPase cycle
R-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013406, RHOQ GTPase cycle
R-HSA-9013409, RHOJ GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
R-HSA-9035034, RHOF GTPase cycle

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		O00161

SIGNOR Signaling Network Open Resource

More...SIGNORi		O00161

Protein family/group databases

Transport Classification Database

More...TCDBi		1.F.1.1.1, the synaptosomal vesicle fusion pore (svf-pore) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Synaptosomal-associated protein 23
Short name:
SNAP-23
Alternative name(s):
Vesicle-membrane fusion protein SNAP-23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SNAP23
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11131, SNAP23

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602534, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00161

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000092531

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		8773

Open Targets

More...OpenTargetsi		ENSG00000092531

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA35979

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		O00161, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SNAP23

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002135981 – 211Synaptosomal-associated protein 23Add BLAST211

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources2 Publications1
Modified residuei5PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei20PhosphoserineCombined sources1
Modified residuei23PhosphoserineBy similarity1
Modified residuei34PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi79S-palmitoyl cysteine1 Publication1
Lipidationi80S-palmitoyl cysteine1 Publication1
Lipidationi83S-palmitoyl cysteine1 Publication1
Lipidationi85S-palmitoyl cysteine1 Publication1
Lipidationi87S-palmitoyl cysteine1 Publication1
Modified residuei110PhosphoserineCombined sources1
Lipidationi112S-palmitoyl cysteine1 Publication1
Modified residuei161PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00161

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00161

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		O00161

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00161

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00161

PeptideAtlas

More...PeptideAtlasi		O00161

PRoteomics IDEntifications database

More...PRIDEi		O00161

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		47748 [O00161-1]
47749 [O00161-2]

2D gel databases

USC-OGP 2-DE database

More...OGPi		O00161

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00161

MetOSite database of methionine sulfoxide sites

More...MetOSitei		O00161

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00161

SwissPalm database of S-palmitoylation events

More...SwissPalmi		O00161

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Highest levels where found in placenta.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000092531, Expressed in chorionic villus and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00161, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00161, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000092531, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (PubMed:12556468).

Found in a complex with VAMP8 and STX1A (PubMed:12130530).

Found in a complex with VAMP8 and STX4 in pancreas (By similarity).

Interacts simultaneously with SNAPIN and SYN4 (By similarity).

Interacts with STX1A (By similarity).

Interacts with STX12 (By similarity).

Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity).

Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		114303, 138 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		O00161

Protein interaction database and analysis system

More...IntActi		O00161, 59 interactors

Molecular INTeraction database

More...MINTi		O00161

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000249647

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		O00161, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1211
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00161

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		O00161

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 76t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST63
Domaini146 – 208t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST63

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili23 – 761 PublicationAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNAP-25 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3065, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182843

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_096939_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00161

Identification of Orthologs from Complete Genome Data

More...OMAi		NYAVHKA

Database of Orthologous Groups

More...OrthoDBi		1358184at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00161

TreeFam database of animal gene trees

More...TreeFami		TF315125

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000928, SNAP-25_dom
IPR000727, T_SNARE_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00835, SNAP-25, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00397, t_SNARE, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50192, T_SNARE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform SNAP-23a (identifier: O00161-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE 
        60         70         80         90        100
QLNRIEEGLD QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK 
       110        120        130        140        150
TTWGDGGENS PCNVVSKQPG PVTNGQLQQP TTGAASGGYI KRITNDARED 
       160        170        180        190        200
EMEENLTQVG SILGNLKDMA LNIGNEIDAQ NPQIKRITDK ADTNRDRIDI 
       210 
ANARAKKLID S
Length:211
Mass (Da):23,354
Last modified:July 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAC378E9786C3A239
GO
Isoform SNAP-23b (identifier: O00161-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     89-89: R → S
     90-142: Missing.

Show »
Length:158
Mass (Da):17,789
Checksum:i985F775F40884E07
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BV99H3BV99_HUMAN
Synaptosomal-associated protein
SNAP23
142Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BP15H3BP15_HUMAN
Synaptosomal-associated protein
SNAP23
149Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BQY9H3BQY9_HUMAN
Synaptosomal-associated protein
SNAP23
154Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM38H3BM38_HUMAN
Synaptosomal-associated protein
SNAP23
125Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR18H3BR18_HUMAN
Synaptosomal-associated protein
SNAP23
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BU94H3BU94_HUMAN
Synaptosomal-associated protein 23
SNAP23
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BPJ0H3BPJ0_HUMAN
Synaptosomal-associated protein 23
SNAP23
127Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BR99H3BR99_HUMAN
Synaptosomal-associated protein 23
SNAP23
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNE1H3BNE1_HUMAN
Synaptosomal-associated protein 23
SNAP23
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNG6H3BNG6_HUMAN
Synaptosomal-associated protein 23
SNAP23
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti135A → V in AAC50537 (PubMed:8663154).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00618789R → S in isoform SNAP-23b. 1 Publication1
Alternative sequenceiVSP_00618890 – 142Missing in isoform SNAP-23b. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U55936 mRNA Translation: AAC50537.1
Y09567 mRNA Translation: CAA70760.1
Y09568 mRNA Translation: CAA70761.1
AJ011915 mRNA Translation: CAA09864.1
AJ278972, AJ278973, AJ278974 Genomic DNA Translation: CAC07504.1
BT006916 mRNA Translation: AAP35562.1
CR457212 mRNA Translation: CAG33493.1
BC000148 mRNA Translation: AAH00148.1
BC003686 mRNA Translation: AAH03686.1
BC022890 mRNA Translation: AAH22890.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10087.1 [O00161-1]
CCDS10088.1 [O00161-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5296
JC5297

NCBI Reference Sequences

More...RefSeqi		NP_003816.2, NM_003825.3 [O00161-1]
NP_570710.1, NM_130798.2 [O00161-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000249647; ENSP00000249647; ENSG00000092531
ENST00000349777; ENSP00000207062; ENSG00000092531 [O00161-2]
ENST00000397138; ENSP00000380327; ENSG00000092531 [O00161-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		8773

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:8773

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000249647.8; ENSP00000249647.3; NM_003825.4; NP_003816.2

UCSC genome browser

More...UCSCi		uc001zpz.3, human [O00161-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U55936 mRNA Translation: AAC50537.1
Y09567 mRNA Translation: CAA70760.1
Y09568 mRNA Translation: CAA70761.1
AJ011915 mRNA Translation: CAA09864.1
AJ278972, AJ278973, AJ278974 Genomic DNA Translation: CAC07504.1
BT006916 mRNA Translation: AAP35562.1
CR457212 mRNA Translation: CAG33493.1
BC000148 mRNA Translation: AAH00148.1
BC003686 mRNA Translation: AAH03686.1
BC022890 mRNA Translation: AAH22890.1
CCDSiCCDS10087.1 [O00161-1]
CCDS10088.1 [O00161-2]
PIRiJC5296
JC5297
RefSeqiNP_003816.2, NM_003825.3 [O00161-1]
NP_570710.1, NM_130798.2 [O00161-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1NHLX-ray2.30A23-76[»]
3ZUSX-ray2.95A/B/C/D150-211[»]
SMRiO00161
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi114303, 138 interactors
CORUMiO00161
IntActiO00161, 59 interactors
MINTiO00161
STRINGi9606.ENSP00000249647

Protein family/group databases

TCDBi1.F.1.1.1, the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetiO00161
MetOSiteiO00161
PhosphoSitePlusiO00161
SwissPalmiO00161

Genetic variation databases

BioMutaiSNAP23

2D gel databases

OGPiO00161

Proteomic databases

EPDiO00161
jPOSTiO00161
MassIVEiO00161
MaxQBiO00161
PaxDbiO00161
PeptideAtlasiO00161
PRIDEiO00161
ProteomicsDBi47748 [O00161-1]
47749 [O00161-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		712, 431 antibodies from 36 providers

The DNASU plasmid repository

More...DNASUi		8773

Genome annotation databases

EnsembliENST00000249647; ENSP00000249647; ENSG00000092531
ENST00000349777; ENSP00000207062; ENSG00000092531 [O00161-2]
ENST00000397138; ENSP00000380327; ENSG00000092531 [O00161-2]
GeneIDi8773
KEGGihsa:8773
MANE-SelectiENST00000249647.8; ENSP00000249647.3; NM_003825.4; NP_003816.2
UCSCiuc001zpz.3, human [O00161-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		8773
DisGeNETi8773

GeneCards: human genes, protein and diseases

More...GeneCardsi		SNAP23
HGNCiHGNC:11131, SNAP23
HPAiENSG00000092531, Low tissue specificity
MIMi602534, gene
neXtProtiNX_O00161
OpenTargetsiENSG00000092531
PharmGKBiPA35979
VEuPathDBiHostDB:ENSG00000092531

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3065, Eukaryota
GeneTreeiENSGT00950000182843
HOGENOMiCLU_096939_0_0_1
InParanoidiO00161
OMAiNYAVHKA
OrthoDBi1358184at2759
PhylomeDBiO00161
TreeFamiTF315125

Enzyme and pathway databases

PathwayCommonsiO00161
ReactomeiR-HSA-1236974, ER-Phagosome pathway
R-HSA-1445148, Translocation of SLC2A4 (GLUT4) to the plasma membrane
R-HSA-199992, trans-Golgi Network Vesicle Budding
R-HSA-6798695, Neutrophil degranulation
R-HSA-8980692, RHOA GTPase cycle
R-HSA-9013026, RHOB GTPase cycle
R-HSA-9013148, CDC42 GTPase cycle
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013406, RHOQ GTPase cycle
R-HSA-9013409, RHOJ GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle
R-HSA-9035034, RHOF GTPase cycle
SignaLinkiO00161
SIGNORiO00161

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		8773, 417 hits in 1055 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		SNAP23, human
EvolutionaryTraceiO00161

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SNAP23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		8773
PharosiO00161, Tbio

Protein Ontology

More...PROi		PR:O00161
RNActiO00161, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000092531, Expressed in chorionic villus and 244 other tissues
ExpressionAtlasiO00161, baseline and differential
GenevisibleiO00161, HS

Family and domain databases

InterProiView protein in InterPro
IPR000928, SNAP-25_dom
IPR000727, T_SNARE_dom
PfamiView protein in Pfam
PF00835, SNAP-25, 1 hit
SMARTiView protein in SMART
SM00397, t_SNARE, 2 hits
PROSITEiView protein in PROSITE
PS50192, T_SNARE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSNP23_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00161
Secondary accession number(s): O00162, Q13602, Q6IAE3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: July 1, 1997
Last modified: February 23, 2022
This is version 212 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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