SNAP23

Functionⁱ

Essential component of the high affinity receptor for the general membrane fusion machinery and an important regulator of transport vesicle docking and fusion.

GO - Molecular functionⁱ

SNAP receptor activity Source: GO_Central
syntaxin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16677249

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Source: Reactome
histamine secretion by mast cell
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 18253931
membrane fusion
Source: ProtInc
Traceable author statementⁱ
- 10839363
neutrophil degranulation Source: Reactome
post-Golgi vesicle-mediated transport
Source: ProtInc
Traceable author statementⁱ
- 9727496
protein transport Source: UniProtKB-KW
synaptic vesicle fusion to presynaptic active zone membrane Source: GO_Central
synaptic vesicle priming Source: GO_Central
vesicle targeting
Source: ProtInc
Traceable author statementⁱ
- 8663154

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Protein transport, Transport

Biological process

Protein transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-421837 Clathrin derived vesicle budding R-HSA-6798695 Neutrophil degranulation
SIGNORⁱ	O00161

Protein family/group databases

TCDBⁱ	1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

TCDBⁱ

1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synaptosomal-associated protein 23 Short name: SNAP-23 Alternative name(s): Vesicle-membrane fusion protein SNAP-23
Gene namesⁱ	Name:SNAP23
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000092531.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11131 SNAP23
MIMⁱ	602534 gene
neXtProtⁱ	NX_O00161

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Synapse, Synaptosome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	8773
Open Targets More...OpenTargetsⁱ	ENSG00000092531
PharmGKBⁱ	PA35979

Polymorphism and mutation databases

BioMutaⁱ	SNAP23

BioMutaⁱ

SNAP23

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000213598	1 – 211	Synaptosomal-associated protein 23Add BLAST		211

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources2 Publications	1
Modified residueⁱ	5	PhosphoserineCombined sources	1
Modified residueⁱ	6	PhosphoserineCombined sources	1
Modified residueⁱ	20	PhosphoserineCombined sources	1
Modified residueⁱ	23	PhosphoserineBy similarity	1
Modified residueⁱ	34	PhosphoserineCombined sources	1
Lipidationⁱ	79	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	80	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	83	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	85	S-palmitoyl cysteine1 Publication	1
Lipidationⁱ	87	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	110	PhosphoserineCombined sources	1
Lipidationⁱ	112	S-palmitoyl cysteine1 Publication	1
Modified residueⁱ	161	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDⁱ	O00161
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	O00161
PaxDbⁱ	O00161
PeptideAtlas More...PeptideAtlasⁱ	O00161
PRIDEⁱ	O00161
ProteomicsDBⁱ	47748 47749 [O00161-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	O00161

OGPⁱ

O00161

PTM databases

iPTMnetⁱ	O00161
PhosphoSitePlusⁱ	O00161
SwissPalmⁱ	O00161

Miscellaneous databases

PMAP-CutDBⁱ	O00161

PMAP-CutDBⁱ

O00161

Expressionⁱ

Tissue specificityⁱ

Ubiquitous. Highest levels where found in placenta.

Gene expression databases

Bgeeⁱ	ENSG00000092531 Expressed in 234 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_SNAP23
ExpressionAtlasⁱ	O00161 baseline and differential
Genevisibleⁱ	O00161 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037083 CAB037317 HPA001214

HPAⁱ

CAB037083
CAB037317
HPA001214

Interactionⁱ

Subunit structureⁱ

Homotetramer (via coiled-coil domain), also forms heterotetramers with STX4 and VAMP3 (PubMed:12556468). Found in a complex with VAMP8 and STX1A (PubMed:12130530). Found in a complex with VAMP8 and STX4 in pancreas (By similarity). Interacts simultaneously with SNAPIN and SYN4 (By similarity). Interacts with STX1A (By similarity). Interacts with STX12 (By similarity). Interacts tightly to multiple syntaxins and synaptobrevins/VAMPs (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (PubMed:28882895).By similarity3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
NAPA	P54920	2	EBI-745000,EBI-749652
NAPB	Q9H115	3	EBI-745000,EBI-3921185
STX11	O75558	7	EBI-745000,EBI-714135
VAMP3	Q15836	2	EBI-745000,EBI-722343
ZDHHC17	Q8IUH5	4	EBI-745000,EBI-524753

GO - Molecular functionⁱ

SNAP receptor activity Source: GO_Central
syntaxin binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 16677249

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	114303, 65 interactors
CORUMⁱ	O00161
IntActⁱ	O00161, 35 interactors
Molecular INTeraction database More...MINTⁱ	O00161
STRINGⁱ	9606.ENSP00000249647

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Helixⁱ	24 – 74	Combined sources		51

Show more details

3D structure databases

ProteinModelPortalⁱ	O00161
SMRⁱ	O00161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	O00161

EvolutionaryTraceⁱ

O00161

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	14 – 76	t-SNARE coiled-coil homology 1PROSITE-ProRule annotationAdd BLAST		63
Domainⁱ	146 – 208	t-SNARE coiled-coil homology 2PROSITE-ProRule annotationAdd BLAST		63

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	23 – 76	1 PublicationAdd BLAST		54

Sequence similaritiesⁱ

Belongs to the SNAP-25 family.Curated

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG3065 Eukaryota ENOG410Y3Y0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000012186
HOGENOMⁱ	HOG000231599
HOVERGENⁱ	HBG056971
InParanoidⁱ	O00161
KEGG Orthology (KO) More...KOⁱ	K08508
OMAⁱ	TNKDRID
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0N7J
PhylomeDBⁱ	O00161
TreeFamⁱ	TF315125

Family and domain databases

InterProⁱ	View protein in InterPro IPR000928 SNAP-25 IPR000727 T_SNARE_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00835 SNAP-25, 1 hit
SMARTⁱ	View protein in SMART SM00397 t_SNARE, 2 hits
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform SNAP-23a (identifier: O00161-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE 
        60         70         80         90        100
QLNRIEEGLD QINKDMRETE KTLTELNKCC GLCVCPCNRT KNFESGKAYK 
       110        120        130        140        150
TTWGDGGENS PCNVVSKQPG PVTNGQLQQP TTGAASGGYI KRITNDARED 
       160        170        180        190        200
EMEENLTQVG SILGNLKDMA LNIGNEIDAQ NPQIKRITDK ADTNRDRIDI 
       210 
ANARAKKLID S

Length:211

Mass (Da):23,354

Last modified:July 1, 1997 - v1

Checksum:ⁱAC378E9786C3A239

GO

Isoform SNAP-23b (identifier: O00161-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
89-89: R → S
90-142: Missing.

« Hide

        10         20         30         40         50
MDNLSSEEIQ QRAHQITDES LESTRRILGL AIESQDAGIK TITMLDEQKE 
        60         70         80         90        100
QLNRIEEGLD QINKDMRETE KTLTELNKCC GLCVCPCNSI TNDAREDEME 
       110        120        130        140        150
ENLTQVGSIL GNLKDMALNI GNEIDAQNPQ IKRITDKADT NRDRIDIANA 

RAKKLIDS

Show »

Length:158

Mass (Da):17,789

Checksum:ⁱ985F775F40884E07

GO

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H3BP15	H3BP15_HUMAN	Synaptosomal-associated protein Synaptosomal-associated protein	SNAP23	149	Annotation score:
H3BQY9	H3BQY9_HUMAN	Synaptosomal-associated protein Synaptosomal-associated protein	SNAP23	154	Annotation score:
H3BV99	H3BV99_HUMAN	Synaptosomal-associated protein Synaptosomal-associated protein	SNAP23	142	Annotation score:
H3BM38	H3BM38_HUMAN	Synaptosomal-associated protein Synaptosomal-associated protein	SNAP23	125	Annotation score:
H3BR18	H3BR18_HUMAN	Synaptosomal-associated protein Synaptosomal-associated protein	SNAP23	109	Annotation score:
H3BU94	H3BU94_HUMAN	Synaptosomal-associated protein 23 Synaptosomal-associated protein 23	SNAP23	53	Annotation score:
H3BPJ0	H3BPJ0_HUMAN	Synaptosomal-associated protein 23 Synaptosomal-associated protein 23	SNAP23	127	Annotation score:
H3BR99	H3BR99_HUMAN	Synaptosomal-associated protein 23 Synaptosomal-associated protein 23	SNAP23	90	Annotation score:
H3BNE1	H3BNE1_HUMAN	Synaptosomal-associated protein 23 Synaptosomal-associated protein 23	SNAP23	97	Annotation score:
H3BNG6	H3BNG6_HUMAN	Synaptosomal-associated protein 23 Synaptosomal-associated protein 23	SNAP23	44	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	135	A → V in AAC50537 (PubMed:8663154).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006187	89	R → S in isoform SNAP-23b. 1 Publication		1
Alternative sequenceⁱVSP_006188	90 – 142	Missing in isoform SNAP-23b. 1 PublicationAdd BLAST		53

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U55936 mRNA Translation: AAC50537.1 Y09567 mRNA Translation: CAA70760.1 Y09568 mRNA Translation: CAA70761.1 AJ011915 mRNA Translation: CAA09864.1 AJ278972, AJ278973, AJ278974 Genomic DNA Translation: CAC07504.1 BT006916 mRNA Translation: AAP35562.1 CR457212 mRNA Translation: CAG33493.1 BC000148 mRNA Translation: AAH00148.1 BC003686 mRNA Translation: AAH03686.1 BC022890 mRNA Translation: AAH22890.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10087.1 [O00161-1] CCDS10088.1 [O00161-2]
PIRⁱ	JC5296 JC5297
NCBI Reference Sequences More...RefSeqⁱ	NP_003816.2, NM_003825.3 [O00161-1] NP_570710.1, NM_130798.2 [O00161-2]
UniGeneⁱ	Hs.511149

Genome annotation databases

Ensemblⁱ	ENST00000249647; ENSP00000249647; ENSG00000092531 [O00161-1] ENST00000349777; ENSP00000207062; ENSG00000092531 [O00161-2] ENST00000397138; ENSP00000380327; ENSG00000092531 [O00161-2]
GeneIDⁱ	8773
KEGGⁱ	hsa:8773
UCSC genome browser More...UCSCⁱ	uc001zpz.3 human [O00161-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
O00161	Synaptosomal-associated protein		HUMAN		211	UniRef100_O00161
Synaptosomal-associated protein		PANTR		211
Synaptosomal-associated protein		PANPA		211
O00161-2	Synaptosomal-associated protein, 23kDa, isoform CRA_b		HUMAN		158	UniRef100_A0A024R9R8
SNAP23 isoform 19		PANTR		158
Uncharacterized protein		PANPA		158
Synaptosome associated protein 23		GORGO		158

Protein	Similar proteins		Species	Score	Length	Source
O00161	Synaptosomal-associated protein		HUMAN		211	UniRef90_O00161
Synaptosomal-associated protein		PANTR		211
Synaptosomal-associated protein		PANPA		211
Synaptosomal-associated protein		GORGO		198
Synaptosomal-associated protein		Cebus capucinus imitator		195
+10
O00161-2	Synaptosomal-associated protein, 23kDa, isoform CRA_b		HUMAN		158	UniRef90_A0A024R9R8
SNAP23 isoform 19		PANTR		158
Uncharacterized protein		PANPA		158
Synaptosome associated protein 23		GORGO		158
SNAP23 isoform 10		PONAB		158
+3

Protein	Similar proteins		Species	Score	Length	Source
O00161	Synaptosomal-associated protein		HUMAN		211	UniRef50_O00161
Synaptosomal-associated protein		PANTR		211
Synaptosomal-associated protein		PANPA		211
Synaptosomal-associated protein		GORGO		198
Synaptosomal-associated protein		Cebus capucinus imitator		195
+54
O00161-2	Uncharacterized protein		MACMU		158	UniRef50_A0A1D5Q6X8
Uncharacterized protein		COLAP		158
Uncharacterized protein		CERAT		158
Uncharacterized protein		RHIRO		158
Uncharacterized protein		PAPAN		158
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U55936 mRNA Translation: AAC50537.1 Y09567 mRNA Translation: CAA70760.1 Y09568 mRNA Translation: CAA70761.1 AJ011915 mRNA Translation: CAA09864.1 AJ278972, AJ278973, AJ278974 Genomic DNA Translation: CAC07504.1 BT006916 mRNA Translation: AAP35562.1 CR457212 mRNA Translation: CAG33493.1 BC000148 mRNA Translation: AAH00148.1 BC003686 mRNA Translation: AAH03686.1 BC022890 mRNA Translation: AAH22890.1
CCDSⁱ	CCDS10087.1 [O00161-1] CCDS10088.1 [O00161-2]
PIRⁱ	JC5296 JC5297
RefSeqⁱ	NP_003816.2, NM_003825.3 [O00161-1] NP_570710.1, NM_130798.2 [O00161-2]
UniGeneⁱ	Hs.511149

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1NHL	X-ray	2.30	A	23-76	[»]
	3ZUS	X-ray	2.95	A/B/C/D	150-209	[»]
ProteinModelPortalⁱ	O00161
SMRⁱ	O00161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114303, 65 interactors
CORUMⁱ	O00161
IntActⁱ	O00161, 35 interactors
MINTⁱ	O00161
STRINGⁱ	9606.ENSP00000249647

Protein family/group databases

TCDBⁱ	1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

TCDBⁱ

1.F.1.1.1 the synaptosomal vesicle fusion pore (svf-pore) family

PTM databases

iPTMnetⁱ	O00161
PhosphoSitePlusⁱ	O00161
SwissPalmⁱ	O00161

Polymorphism and mutation databases

BioMutaⁱ	SNAP23

BioMutaⁱ

SNAP23

2D gel databases

OGPⁱ	O00161

OGPⁱ

O00161

Proteomic databases

EPDⁱ	O00161
MaxQBⁱ	O00161
PaxDbⁱ	O00161
PeptideAtlasⁱ	O00161
PRIDEⁱ	O00161
ProteomicsDBⁱ	47748 47749 [O00161-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	8773
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000249647; ENSP00000249647; ENSG00000092531 [O00161-1] ENST00000349777; ENSP00000207062; ENSG00000092531 [O00161-2] ENST00000397138; ENSP00000380327; ENSG00000092531 [O00161-2]
GeneIDⁱ	8773
KEGGⁱ	hsa:8773
UCSCⁱ	uc001zpz.3 human [O00161-1]

Organism-specific databases

CTDⁱ	8773
DisGeNETⁱ	8773
EuPathDBⁱ	HostDB:ENSG00000092531.9
GeneCardsⁱ	SNAP23
HGNCⁱ	HGNC:11131 SNAP23
HPAⁱ	CAB037083 CAB037317 HPA001214
MIMⁱ	602534 gene
neXtProtⁱ	NX_O00161
OpenTargetsⁱ	ENSG00000092531
PharmGKBⁱ	PA35979
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3065 Eukaryota ENOG410Y3Y0 LUCA
GeneTreeⁱ	ENSGT00390000012186
HOGENOMⁱ	HOG000231599
HOVERGENⁱ	HBG056971
InParanoidⁱ	O00161
KOⁱ	K08508
OMAⁱ	TNKDRID
OrthoDBⁱ	EOG091G0N7J
PhylomeDBⁱ	O00161
TreeFamⁱ	TF315125

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1236974 ER-Phagosome pathway R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane R-HSA-421837 Clathrin derived vesicle budding R-HSA-6798695 Neutrophil degranulation
SIGNORⁱ	O00161

Miscellaneous databases

ChiTaRSⁱ	SNAP23 human
EvolutionaryTraceⁱ	O00161
GeneWikiⁱ	SNAP23
GenomeRNAiⁱ	8773
PMAP-CutDBⁱ	O00161
Protein Ontology More...PROⁱ	PR:O00161
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000092531 Expressed in 234 organ(s), highest expression level in chorionic villus
CleanExⁱ	HS_SNAP23
ExpressionAtlasⁱ	O00161 baseline and differential
Genevisibleⁱ	O00161 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR000928 SNAP-25 IPR000727 T_SNARE_dom
Pfamⁱ	View protein in Pfam PF00835 SNAP-25, 1 hit
SMARTⁱ	View protein in SMART SM00397 t_SNARE, 2 hits
PROSITEⁱ	View protein in PROSITE PS50192 T_SNARE, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SNP23_HUMAN
Accessionⁱ	O00161Primary (citable) accession number: O00161 Secondary accession number(s): O00162, Q13602, Q6IAE3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	July 1, 1997
	Last modified:	September 12, 2018
	This is version 191 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - O00161 (SNP23_HUMAN)

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Synaptosomal-associated protein 23

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Other locations

Extracellular region or secreted

Lysosome

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ