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Protein

Unconventional myosin-If

Gene

MYO1F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi110 – 117ATPSequence analysis8

GO - Molecular functioni

  • actin binding Source: UniProtKB
  • ATP binding Source: UniProtKB
  • calmodulin binding Source: UniProtKB-KW
  • motor activity Source: InterPro

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-If
Alternative name(s):
Myosin-Ie
Gene namesi
Name:MYO1F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000142347.16
HGNCiHGNC:7600 MYO1F
MIMi601480 gene
neXtProtiNX_O00160

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Involvement in diseasei

Defects in MYO1F has been found in a patient with a form of non-syndromic sensorineural hearing loss.1 Publication

Keywords - Diseasei

Deafness, Disease mutation, Non-syndromic deafness

Organism-specific databases

DisGeNETi4542
OpenTargetsiENSG00000142347
PharmGKBiPA31402

Polymorphism and mutation databases

BioMutaiMYO1F

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234521 – 1098Unconventional myosin-IfAdd BLAST1098

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1023PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiO00160
MaxQBiO00160
PaxDbiO00160
PeptideAtlasiO00160
PRIDEiO00160
ProteomicsDBi47747

PTM databases

iPTMnetiO00160
PhosphoSitePlusiO00160

Expressioni

Gene expression databases

BgeeiENSG00000142347 Expressed in 188 organ(s), highest expression level in blood
CleanExiHS_MYO1F
ExpressionAtlasiO00160 baseline and differential
GenevisibleiO00160 HS

Organism-specific databases

HPAiHPA055242

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi110638, 13 interactors
IntActiO00160, 5 interactors
STRINGi9606.ENSP00000344871

Structurei

3D structure databases

ProteinModelPortaliO00160
SMRiO00160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 690Myosin motorPROSITE-ProRule annotationAdd BLAST674
Domaini693 – 722IQPROSITE-ProRule annotationAdd BLAST30
Domaini728 – 917TH1PROSITE-ProRule annotationAdd BLAST190
Domaini1041 – 1098SH3PROSITE-ProRule annotationAdd BLAST58

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni579 – 589Actin-bindingSequence analysisAdd BLAST11

Sequence similaritiesi

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810
HOVERGENiHBG100702
InParanoidiO00160
KOiK10356
OMAiGIMTPDY
OrthoDBiEOG091G0136
PhylomeDBiO00160
TreeFamiTF312960

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
cd11827 SH3_MyoIe_If_like, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035507 Ie/If_SH3
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00193 MYOSINHEAVY
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS50002 SH3, 1 hit
PS51757 TH1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

O00160-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSKERFHWQ SHNVKQSGVD DMVLLPQITE DAIAANLRKR FMDDYIFTYI
60 70 80 90 100
GSVLISVNPF KQMPYFTDRE IDLYQGAAQY ENPPHIYALT DNMYRNMLID
110 120 130 140 150
CENQCVIISG ESGAGKTVAA KYIMGYISKV SGGGEKVQHV KDIILQSNPL
160 170 180 190 200
LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG EPDGGKISNF LLEKSRVVMQ
210 220 230 240 250
NENERNFHIY YQLLEGASQE QRQNLGLMTP DYYYYLNQSD TYQVDGTDDR
260 270 280 290 300
SDFGETLSAM QVIGIPPSIQ QLVLQLVAGI LHLGNISFCE DGNYARVESV
310 320 330 340 350
DLLAFPAYLL GIDSGRLQEK LTSRKMDSRW GGRSESINVT LNVEQAAYTR
360 370 380 390 400
DALAKGLYAR LFDFLVEAIN RAMQKPQEEY SIGVLDIYGF EIFQKNGFEQ
410 420 430 440 450
FCINFVNEKL QQIFIELTLK AEQEEYVQEG IRWTPIQYFN NKVVCDLIEN
460 470 480 490 500
KLSPPGIMSV LDDVCATMHA TGGGADQTLL QKLQAAVGTH EHFNSWSAGF
510 520 530 540 550
VIHHYAGKVS YDVSGFCERN RDVLFSDLIE LMQTSEQAFL RMLFPEKLDG
560 570 580 590 600
DKKGRPSTAG SKIKKQANDL VATLMRCTPH YIRCIKPNET KRPRDWEENR
610 620 630 640 650
VKHQVEYLGL KENIRVRRAG FAYRRQFAKF LQRYAILTPE TWPRWRGDER
660 670 680 690 700
QGVQHLLRAV NMEPDQYQMG STKVFVKNPE SLFLLEEVRE RKFDGFARTI
710 720 730 740 750
QKAWRRHVAV RKYEEMREEA SNILLNKKER RRNSINRNFV GDYLGLEERP
760 770 780 790 800
ELRQFLGKRE RVDFADSVTK YDRRFKPIKR DLILTPKCVY VIGREKVKKG
810 820 830 840 850
PEKGQVCEVL KKKVDIQALR GVSLSTRQDD FFILQEDAAD SFLESVFKTE
860 870 880 890 900
FVSLLCKRFE EATRRPLPLT FSDTLQFRVK KEGWGGGGTR SVTFSRGFGD
910 920 930 940 950
LAVLKVGGRT LTVSVGDGLP KSSKPTRKGM AKGKPRRSSQ APTRAAPAPP
960 970 980 990 1000
RGMDRNGVPP SARGGPLPLE IMSGGGTHRP PRGPPSTSLG ASRRPRARPP
1010 1020 1030 1040 1050
SEHNTEFLNV PDQGMAGMQR KRSVGQRPVP GVGRPKPQPR THGPRCRALY
1060 1070 1080 1090
QYVGQDVDEL SFNVNEVIEI LMEDPSGWWK GRLHGQEGLF PGNYVEKI
Length:1,098
Mass (Da):124,844
Last modified:November 24, 2009 - v3
Checksum:i75C2B1306F74C7C5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QY89M0QY89_HUMAN
Unconventional myosin-If
MYO1F
134Annotation score:
M0QXU2M0QXU2_HUMAN
Unconventional myosin-If
MYO1F
117Annotation score:
M0QXU5M0QXU5_HUMAN
Unconventional myosin-If
MYO1F
76Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti259A → V in BAC03995 (PubMed:14702039).Curated1
Sequence conflicti534 – 536TSE → SSD in CAA67058 (PubMed:9119401).Curated3
Sequence conflicti592 – 593RP → HA in CAC83948 (PubMed:11804589).Curated2
Sequence conflicti592 – 593RP → HA in CAA67058 (PubMed:9119401).Curated2
Sequence conflicti602K → Q in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti759R → K in CAC83948 (PubMed:11804589).Curated1
Sequence conflicti759R → K in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti797V → M in CAC83948 (PubMed:11804589).Curated1
Sequence conflicti797V → M in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti805Q → P in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti809V → I in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti814V → L in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti922S → N in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti927R → G in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti930M → L in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti948 – 951APPR → GAPQ in CAA67058 (PubMed:9119401).Curated4
Sequence conflicti958 – 967VPPSARGGPL → APLCPQGGAPC in CAA67058 (PubMed:9119401).Curated10
Sequence conflicti971 – 990IMSGG…STSLG → KFIWPRGHPQASPALRPHPW D in CAA67058 (PubMed:9119401).CuratedAdd BLAST20
Sequence conflicti1031Missing in CAA67058 (PubMed:9119401).Curated1
Sequence conflicti1090 – 1098FPGNYVEKI → GSPSARSPA in BAC03995 (PubMed:14702039).Curated9

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079873502I → V Probable disease-associated mutation found in a patient with non-syndromic sensorineural hearing loss. 1 PublicationCorresponds to variant dbSNP:rs200797032Ensembl.1
Natural variantiVAR_056179960P → L. Corresponds to variant dbSNP:rs2288411Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310570 mRNA Translation: CAC83948.1
AK092877 mRNA Translation: BAC03995.1
AC092298 Genomic DNA No translation available.
AC092316 Genomic DNA No translation available.
AC124902 Genomic DNA No translation available.
AC130469 Genomic DNA No translation available.
BC028071 mRNA Translation: AAH28071.1
X98411 mRNA Translation: CAA67058.1
CCDSiCCDS42494.1
RefSeqiNP_036467.2, NM_012335.3
UniGeneiHs.465818

Genome annotation databases

EnsembliENST00000338257; ENSP00000344871; ENSG00000142347
ENST00000613525; ENSP00000481682; ENSG00000142347
ENST00000644032; ENSP00000494550; ENSG00000142347
GeneIDi4542
KEGGihsa:4542
UCSCiuc002mkg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ310570 mRNA Translation: CAC83948.1
AK092877 mRNA Translation: BAC03995.1
AC092298 Genomic DNA No translation available.
AC092316 Genomic DNA No translation available.
AC124902 Genomic DNA No translation available.
AC130469 Genomic DNA No translation available.
BC028071 mRNA Translation: AAH28071.1
X98411 mRNA Translation: CAA67058.1
CCDSiCCDS42494.1
RefSeqiNP_036467.2, NM_012335.3
UniGeneiHs.465818

3D structure databases

ProteinModelPortaliO00160
SMRiO00160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110638, 13 interactors
IntActiO00160, 5 interactors
STRINGi9606.ENSP00000344871

PTM databases

iPTMnetiO00160
PhosphoSitePlusiO00160

Polymorphism and mutation databases

BioMutaiMYO1F

Proteomic databases

EPDiO00160
MaxQBiO00160
PaxDbiO00160
PeptideAtlasiO00160
PRIDEiO00160
ProteomicsDBi47747

Protocols and materials databases

DNASUi4542
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338257; ENSP00000344871; ENSG00000142347
ENST00000613525; ENSP00000481682; ENSG00000142347
ENST00000644032; ENSP00000494550; ENSG00000142347
GeneIDi4542
KEGGihsa:4542
UCSCiuc002mkg.4 human

Organism-specific databases

CTDi4542
DisGeNETi4542
EuPathDBiHostDB:ENSG00000142347.16
GeneCardsiMYO1F
H-InvDBiHIX0014717
HGNCiHGNC:7600 MYO1F
HPAiHPA055242
MIMi601480 gene
neXtProtiNX_O00160
OpenTargetsiENSG00000142347
PharmGKBiPA31402
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810
HOVERGENiHBG100702
InParanoidiO00160
KOiK10356
OMAiGIMTPDY
OrthoDBiEOG091G0136
PhylomeDBiO00160
TreeFamiTF312960

Miscellaneous databases

ChiTaRSiMYO1F human
GeneWikiiMYO1F
GenomeRNAii4542
PROiPR:O00160
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000142347 Expressed in 188 organ(s), highest expression level in blood
CleanExiHS_MYO1F
ExpressionAtlasiO00160 baseline and differential
GenevisibleiO00160 HS

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
cd11827 SH3_MyoIe_If_like, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR035507 Ie/If_SH3
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00193 MYOSINHEAVY
PR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00242 MYSc, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS50002 SH3, 1 hit
PS51757 TH1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1F_HUMAN
AccessioniPrimary (citable) accession number: O00160
Secondary accession number(s): Q8WWN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 24, 2009
Last modified: November 7, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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