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Protein

Frizzled-9

Gene

FZD9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity).By similarity1 Publication

Miscellaneous

Authors show that FZD9 is responsible for the cellular phenotype found in neural progenitor cells (NPCs) derived from Williams syndrome patients namely increased apoptosis of neural progenitor cells (NPCs).1 Publication

Caution

Has been first described as FZD3 in literature.Curated

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
SignaLinkiO00144
SIGNORiO00144

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-9
Short name:
Fz-9
Short name:
hFz9
Alternative name(s):
FzE6
CD_antigen: CD349
Gene namesi
Name:FZD9
Synonyms:FZD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000188763.4
HGNCiHGNC:4047 FZD9
MIMi601766 gene
neXtProtiNX_O00144

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 229ExtracellularSequence analysisAdd BLAST207
Transmembranei230 – 250Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini251 – 266CytoplasmicSequence analysisAdd BLAST16
Transmembranei267 – 287Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini288 – 315ExtracellularSequence analysisAdd BLAST28
Transmembranei316 – 336Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini337 – 355CytoplasmicSequence analysisAdd BLAST19
Transmembranei356 – 376Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini377 – 400ExtracellularSequence analysisAdd BLAST24
Transmembranei401 – 421Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini422 – 447CytoplasmicSequence analysisAdd BLAST26
Transmembranei448 – 468Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini469 – 508ExtracellularSequence analysisAdd BLAST40
Transmembranei509 – 529Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini530 – 591CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi8326
OpenTargetsiENSG00000188763
PharmGKBiPA28464

Polymorphism and mutation databases

BioMutaiFZD9

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001300323 – 591Frizzled-9Add BLAST569

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 100PROSITE-ProRule annotation
Disulfide bondi47 ↔ 93PROSITE-ProRule annotation
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi84 ↔ 122PROSITE-ProRule annotation
Disulfide bondi111 ↔ 152PROSITE-ProRule annotation
Disulfide bondi115 ↔ 139PROSITE-ProRule annotation
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbiO00144
PeptideAtlasiO00144
PRIDEiO00144
ProteomicsDBi47734

PTM databases

iPTMnetiO00144
PhosphoSitePlusiO00144

Expressioni

Tissue specificityi

Expressed predominantly in adult and fetal brain, testis, eye, skeletal muscle and kidney. Moderately expressed in pancreas, thyroid, adrenal cortex, small intestine and stomach. Detected in fetal liver and kidney. Expressed in neural progenitor cells (PubMed:27509850).1 Publication

Gene expression databases

BgeeiENSG00000188763 Expressed in 78 organ(s), highest expression level in cartilage tissue
CleanExiHS_FZD3
HS_FZD9
GenevisibleiO00144 HS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113922, 3 interactors
STRINGi9606.ENSP00000345785

Structurei

3D structure databases

ProteinModelPortaliO00144
SMRiO00144
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 155FZPROSITE-ProRule annotationAdd BLAST122

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni58 – 172Required for Wnt-activated receptor activityBy similarityAdd BLAST115
Regioni554 – 591Required for CTNNB1 accumulation and TCF transcription factor activityBy similarityAdd BLAST38

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi532 – 537Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
HOGENOMiHOG000233236
HOVERGENiHBG006977
InParanoidiO00144
KOiK02842
OMAiCVIVCYF
OrthoDBiEOG091G0N5M
PhylomeDBiO00144
TreeFamiTF317907

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

O00144-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAPLRGAL LLWQLLAAGG AALEIGRFDP ERGRGAAPCQ AVEIPMCRGI
60 70 80 90 100
GYNLTRMPNL LGHTSQGEAA AELAEFAPLV QYGCHSHLRF FLCSLYAPMC
110 120 130 140 150
TDQVSTPIPA CRPMCEQARL RCAPIMEQFN FGWPDSLDCA RLPTRNDPHA
160 170 180 190 200
LCMEAPENAT AGPAEPHKGL GMLPVAPRPA RPPGDLGPGA GGSGTCENPE
210 220 230 240 250
KFQYVEKSRS CAPRCGPGVE VFWSRRDKDF ALVWMAVWSA LCFFSTAFTV
260 270 280 290 300
LTFLLEPHRF QYPERPIIFL SMCYNVYSLA FLIRAVAGAQ SVACDQEAGA
310 320 330 340 350
LYVIQEGLEN TGCTLVFLLL YYFGMASSLW WVVLTLTWFL AAGKKWGHEA
360 370 380 390 400
IEAHGSYFHM AAWGLPALKT IVILTLRKVA GDELTGLCYV ASTDAAALTG
410 420 430 440 450
FVLVPLSGYL VLGSSFLLTG FVALFHIRKI MKTGGTNTEK LEKLMVKIGV
460 470 480 490 500
FSILYTVPAT CVIVCYVYER LNMDFWRLRA TEQPCAAAAG PGGRRDCSLP
510 520 530 540 550
GGSVPTVAVF MLKIFMSLVV GITSGVWVWS SKTFQTWQSL CYRKIAAGRA
560 570 580 590
RAKACRAPGS YGRGTHCHYK APTVVLHMTK TDPSLENPTH L
Length:591
Mass (Da):64,466
Last modified:July 1, 1997 - v1
Checksum:i0D3784A78DF0B2E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82169 mRNA Translation: AAC51174.1
AC005049 Genomic DNA Translation: AAQ93359.1
CCDSiCCDS5548.1
RefSeqiNP_003499.1, NM_003508.2
UniGeneiHs.647029

Genome annotation databases

EnsembliENST00000344575; ENSP00000345785; ENSG00000188763
GeneIDi8326
KEGGihsa:8326
UCSCiuc003tyb.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82169 mRNA Translation: AAC51174.1
AC005049 Genomic DNA Translation: AAQ93359.1
CCDSiCCDS5548.1
RefSeqiNP_003499.1, NM_003508.2
UniGeneiHs.647029

3D structure databases

ProteinModelPortaliO00144
SMRiO00144
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113922, 3 interactors
STRINGi9606.ENSP00000345785

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiO00144
PhosphoSitePlusiO00144

Polymorphism and mutation databases

BioMutaiFZD9

Proteomic databases

PaxDbiO00144
PeptideAtlasiO00144
PRIDEiO00144
ProteomicsDBi47734

Protocols and materials databases

DNASUi8326
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000344575; ENSP00000345785; ENSG00000188763
GeneIDi8326
KEGGihsa:8326
UCSCiuc003tyb.4 human

Organism-specific databases

CTDi8326
DisGeNETi8326
EuPathDBiHostDB:ENSG00000188763.4
GeneCardsiFZD9
HGNCiHGNC:4047 FZD9
MIMi601766 gene
neXtProtiNX_O00144
OpenTargetsiENSG00000188763
PharmGKBiPA28464
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00760000118864
HOGENOMiHOG000233236
HOVERGENiHBG006977
InParanoidiO00144
KOiK02842
OMAiCVIVCYF
OrthoDBiEOG091G0N5M
PhylomeDBiO00144
TreeFamiTF317907

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
SignaLinkiO00144
SIGNORiO00144

Miscellaneous databases

GeneWikiiFZD9
GenomeRNAii8326
PROiPR:O00144
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188763 Expressed in 78 organ(s), highest expression level in cartilage tissue
CleanExiHS_FZD3
HS_FZD9
GenevisibleiO00144 HS

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR017981 GPCR_2-like
PANTHERiPTHR11309 PTHR11309, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFZD9_HUMAN
AccessioniPrimary (citable) accession number: O00144
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: July 1, 1997
Last modified: November 7, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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