UniProtKB - O00142 (KITM_HUMAN)
Protein
Thymidine kinase 2, mitochondrial
Gene
TK2
Organism
Homo sapiens (Human)
Status
Functioni
Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents.1 Publication
Catalytic activityi
- EC:2.7.1.21
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 81 | SubstrateBy similarity | 1 | |
Binding sitei | 99 | SubstrateBy similarity | 1 | |
Binding sitei | 110 | SubstrateBy similarity | 1 | |
Active sitei | 133 | Proton acceptorSequence analysis | 1 | |
Binding sitei | 134 | SubstrateBy similarity | 1 | |
Binding sitei | 201 | SubstrateBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 57 – 65 | ATPBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- deoxynucleoside kinase activity Source: GO_Central
- thymidine kinase activity Source: ProtInc
GO - Biological processi
- DNA biosynthetic process Source: UniProtKB-KW
- nucleobase-containing compound metabolic process Source: ProtInc
- pyrimidine nucleoside salvage Source: Reactome
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | DNA synthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS09420-MONOMER |
BRENDAi | 2.7.1.21, 2681 |
PathwayCommonsi | O00142 |
Reactomei | R-HSA-73614, Pyrimidine salvage |
SABIO-RKi | O00142 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:TK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11831, TK2 |
MIMi | 188250, gene |
neXtProti | NX_O00142 |
VEuPathDBi | HostDB:ENSG00000166548.15 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: Reactome
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Mitochondrial DNA depletion syndrome 2 (MTDPS2)5 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder due to mitochondrial dysfunction characterized by childhood onset of muscle weakness associated with depletion of mtDNA in skeletal muscle. There is wide clinical variability; some patients have onset in infancy and show a rapidly progressive course with early death due to respiratory failure, whereas others have later onset of a slowly progressive myopathy.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019419 | 53 | I → M in MTDPS2. 1 PublicationCorresponds to variant dbSNP:rs137854432EnsemblClinVar. | 1 | |
Natural variantiVAR_023790 | 64 | T → M in MTDPS2. 1 PublicationCorresponds to variant dbSNP:rs281865487EnsemblClinVar. | 1 | |
Natural variantiVAR_019420 | 108 | T → M in MTDPS2; reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs137854431EnsemblClinVar. | 1 | |
Natural variantiVAR_072789 | 117 | M → V in MTDPS2; severe form of combined brain and muscular atrophy; depletion of mtDNA in skeletal muscle; normal residual mtDNA in blood and fibroblasts. 1 Publication | 1 | |
Natural variantiVAR_019421 | 121 | H → N in MTDPS2; reduction of activity in muscles. 2 PublicationsCorresponds to variant dbSNP:rs137854429EnsemblClinVar. | 1 | |
Natural variantiVAR_072790 | 139 | A → V in MTDPS2; severe form of combined brain and muscular atrophy; depletion of mtDNA in skeletal muscle; normal residual mtDNA in blood and fibroblasts. 1 PublicationCorresponds to variant dbSNP:rs281865494EnsemblClinVar. | 1 | |
Natural variantiVAR_023791 | 183 | R → W in MTDPS2 and PEOB3; reduction of activity; reduced affinity for ATP. 2 PublicationsCorresponds to variant dbSNP:rs137886900EnsemblClinVar. | 1 | |
Natural variantiVAR_023792 | 192 | R → K in MTDPS2; reduction of activity. 1 PublicationCorresponds to variant dbSNP:rs281865496EnsemblClinVar. | 1 | |
Natural variantiVAR_019422 | 212 | I → N in MTDPS2; reduction of activity in muscles. 1 PublicationCorresponds to variant dbSNP:rs137854430EnsemblClinVar. | 1 |
Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 3 (PEOB3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of progressive external ophthalmoplegia, a mitochondrial myopathy characterized by progressive paralysis of the levator palpebrae, orbicularis oculi, and extraocular muscles. PEOB3 patients manifest adult-onset progressive external ophthalmoplegia and progressive proximal muscle weakness associated with muscle atrophy.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023791 | 183 | R → W in MTDPS2 and PEOB3; reduction of activity; reduced affinity for ATP. 2 PublicationsCorresponds to variant dbSNP:rs137886900EnsemblClinVar. | 1 | |
Natural variantiVAR_076984 | 188 | T → A in PEOB3; reduction of activity; reduced affinity for ATP. 1 PublicationCorresponds to variant dbSNP:rs281865495EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Primary mitochondrial disease, Progressive external ophthalmoplegiaOrganism-specific databases
DisGeNETi | 7084 |
GeneReviewsi | TK2 |
MalaCardsi | TK2 |
MIMi | 609560, phenotype 617069, phenotype |
OpenTargetsi | ENSG00000166548 |
Orphaneti | 254886, Autosomal recessive progressive external ophthalmoplegia 254875, Mitochondrial DNA depletion syndrome, myopathic form |
PharmGKBi | PA36535 |
Miscellaneous databases
Pharosi | O00142, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4580 |
DrugBanki | DB02594, 2'-Deoxycytidine DB03312, Brivudine DB04485, Thymidine DB02452, Thymidine 5'-triphosphate |
DrugCentrali | O00142 |
Genetic variation databases
BioMutai | TK2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 33 | MitochondrionAdd BLAST | 33 | |
ChainiPRO_0000016842 | 34 – 265 | Thymidine kinase 2, mitochondrialAdd BLAST | 232 |
Proteomic databases
jPOSTi | O00142 |
MassIVEi | O00142 |
MaxQBi | O00142 |
PaxDbi | O00142 |
PeptideAtlasi | O00142 |
PRIDEi | O00142 |
ProteomicsDBi | 20434 47731 [O00142-1] 47732 [O00142-2] 47733 [O00142-3] 5605 |
PTM databases
iPTMneti | O00142 |
PhosphoSitePlusi | O00142 |
Expressioni
Tissue specificityi
Predominantly expressed in liver, pancreas, muscle, and brain.
Gene expression databases
Bgeei | ENSG00000166548, Expressed in testis and 223 other tissues |
ExpressionAtlasi | O00142, baseline and differential |
Genevisiblei | O00142, HS |
Organism-specific databases
HPAi | ENSG00000166548, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
2 PublicationsProtein-protein interaction databases
BioGRIDi | 112939, 9 interactors |
IntActi | O00142, 4 interactors |
STRINGi | 9606.ENSP00000299697 |
Chemistry databases
BindingDBi | O00142 |
Miscellaneous databases
RNActi | O00142, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the DCK/DGK family.
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG4235, Eukaryota |
GeneTreei | ENSGT00940000158005 |
HOGENOMi | CLU_030466_1_0_1 |
InParanoidi | O00142 |
OMAi | IFAKYLH |
PhylomeDBi | O00142 |
TreeFami | TF324413 |
Family and domain databases
CDDi | cd01673, dNK, 1 hit |
InterProi | View protein in InterPro IPR002624, DCK/DGK IPR031314, DNK_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01712, dNK, 1 hit |
PIRSFi | PIRSF000705, DNK, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 20 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: O00142-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLLWPLRGWA ARALRCFGPG SRGSPASGPG PRRVQRRAWP PDKEQEKEKK
60 70 80 90 100
SVICVEGNIA SGKTTCLEFF SNATDVEVLT EPVSKWRNVR GHNPLGLMYH
110 120 130 140 150
DASRWGLTLQ TYVQLTMLDR HTRPQVSSVR LMERSIHSAR YIFVENLYRS
160 170 180 190 200
GKMPEVDYVV LSEWFDWILR NMDVSVDLIV YLRTNPETCY QRLKKRCREE
210 220 230 240 250
EKVIPLEYLE AIHHLHEEWL IKGSLFPMAA PVLVIEADHH MERMLELFEQ
260
NRDRILTPEN RKHCP
Computationally mapped potential isoform sequencesi
There are 20 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BP77 | H3BP77_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 282 | Annotation score: | ||
A0A0A0MSY7 | A0A0A0MSY7_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 289 | Annotation score: | ||
J3QRP0 | J3QRP0_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 146 | Annotation score: | ||
J3KS73 | J3KS73_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 130 | Annotation score: | ||
J3QL12 | J3QL12_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 88 | Annotation score: | ||
H3BV57 | H3BV57_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 78 | Annotation score: | ||
J3KSZ2 | J3KSZ2_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 22 | Annotation score: | ||
A0A7I2V2L8 | A0A7I2V2L8_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 45 | Annotation score: | ||
A0A7I2V304 | A0A7I2V304_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 52 | Annotation score: | ||
A0A7I2V3A3 | A0A7I2V3A3_HUMAN | Thymidine kinase 2, mitochondrial | TK2 | 32 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 37 | R → Y AA sequence (PubMed:9989599).Curated | 1 | |
Sequence conflicti | 49 | K → E in BAG57808 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 61 | S → G in AAC51167 (PubMed:9079672).Curated | 1 | |
Sequence conflicti | 206 | L → P in BAG57808 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 238 | D → DH in CAA71523 (PubMed:9989599).Curated | 1 | |
Sequence conflicti | 241 | Missing in AAC51167 (PubMed:9079672).Curated | 1 | |
Sequence conflicti | 251 | N → S in BAG57808 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019419 | 53 | I → M in MTDPS2. 1 PublicationCorresponds to variant dbSNP:rs137854432EnsemblClinVar. | 1 | |
Natural variantiVAR_023790 | 64 | T → M in MTDPS2. 1 PublicationCorresponds to variant dbSNP:rs281865487EnsemblClinVar. | 1 | |
Natural variantiVAR_019420 | 108 | T → M in MTDPS2; reduction of activity. 2 PublicationsCorresponds to variant dbSNP:rs137854431EnsemblClinVar. | 1 | |
Natural variantiVAR_072789 | 117 | M → V in MTDPS2; severe form of combined brain and muscular atrophy; depletion of mtDNA in skeletal muscle; normal residual mtDNA in blood and fibroblasts. 1 Publication | 1 | |
Natural variantiVAR_019421 | 121 | H → N in MTDPS2; reduction of activity in muscles. 2 PublicationsCorresponds to variant dbSNP:rs137854429EnsemblClinVar. | 1 | |
Natural variantiVAR_072790 | 139 | A → V in MTDPS2; severe form of combined brain and muscular atrophy; depletion of mtDNA in skeletal muscle; normal residual mtDNA in blood and fibroblasts. 1 PublicationCorresponds to variant dbSNP:rs281865494EnsemblClinVar. | 1 | |
Natural variantiVAR_023791 | 183 | R → W in MTDPS2 and PEOB3; reduction of activity; reduced affinity for ATP. 2 PublicationsCorresponds to variant dbSNP:rs137886900EnsemblClinVar. | 1 | |
Natural variantiVAR_076984 | 188 | T → A in PEOB3; reduction of activity; reduced affinity for ATP. 1 PublicationCorresponds to variant dbSNP:rs281865495EnsemblClinVar. | 1 | |
Natural variantiVAR_023792 | 192 | R → K in MTDPS2; reduction of activity. 1 PublicationCorresponds to variant dbSNP:rs281865496EnsemblClinVar. | 1 | |
Natural variantiVAR_019422 | 212 | I → N in MTDPS2; reduction of activity in muscles. 1 PublicationCorresponds to variant dbSNP:rs137854430EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054606 | 1 – 97 | Missing in isoform 5. 1 PublicationAdd BLAST | 97 | |
Alternative sequenceiVSP_003028 | 1 – 41 | MLLWP…RAWPP → MGAFCQRPSS in isoform 2. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_058694 | 1 | M → MRPGLFKGQAPGSRRRPTAG LAVVRADSHKKEPRASGSAR PAM in isoform 6. 1 Publication | 1 | |
Alternative sequenceiVSP_043503 | 53 – 77 | Missing in isoform 3. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_044459 | 78 – 95 | Missing in isoform 4. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77088 mRNA Translation: AAC51167.1 Y10498 mRNA Translation: CAA71523.3 AK294627 mRNA Translation: BAG57808.1 AK302976 mRNA Translation: BAG64119.1 AK316226 mRNA Translation: BAH14597.1 AC010542 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83013.1 CH471092 Genomic DNA Translation: EAW83015.1 CH471092 Genomic DNA Translation: EAW83017.1 HQ205385 Genomic DNA Translation: ADP90853.1 HQ205382 Genomic DNA Translation: ADP90850.1 HQ205383 Genomic DNA Translation: ADP90851.1 HQ205384 Genomic DNA Translation: ADP90852.1 HQ205381 Genomic DNA Translation: ADP90849.1 HQ205380 Genomic DNA Translation: ADP90848.1 HQ205379 Genomic DNA Translation: ADP90847.1 HQ205378 Genomic DNA Translation: ADP90846.1 HQ205377 Genomic DNA Translation: ADP90845.1 HQ205376 Genomic DNA Translation: ADP90844.1 HQ205375 Genomic DNA Translation: ADP90843.1 HQ205374 Genomic DNA Translation: ADP90842.1 HQ205373 Genomic DNA Translation: ADP90841.1 HQ205372 Genomic DNA Translation: ADP90840.1 HQ205371 Genomic DNA Translation: ADP90839.1 HQ205370 Genomic DNA Translation: ADP90838.1 HQ205362 Genomic DNA Translation: ADP90830.1 HQ205363 Genomic DNA Translation: ADP90831.1 HQ205364 Genomic DNA Translation: ADP90832.1 HQ205365 Genomic DNA Translation: ADP90833.1 HQ205366 Genomic DNA Translation: ADP90834.1 HQ205367 Genomic DNA Translation: ADP90835.1 HQ205368 Genomic DNA Translation: ADP90836.1 HQ205369 Genomic DNA Translation: ADP90837.1 HQ205346 Genomic DNA Translation: ADP90814.1 HQ205347 Genomic DNA Translation: ADP90815.1 HQ205348 Genomic DNA Translation: ADP90816.1 HQ205349 Genomic DNA Translation: ADP90817.1 HQ205350 Genomic DNA Translation: ADP90818.1 HQ205351 Genomic DNA Translation: ADP90819.1 HQ205352 Genomic DNA Translation: ADP90820.1 HQ205353 Genomic DNA Translation: ADP90821.1 HQ205354 Genomic DNA Translation: ADP90822.1 HQ205355 Genomic DNA Translation: ADP90823.1 HQ205356 Genomic DNA Translation: ADP90824.1 HQ205357 Genomic DNA Translation: ADP90825.1 HQ205358 Genomic DNA Translation: ADP90826.1 HQ205359 Genomic DNA Translation: ADP90827.1 HQ205360 Genomic DNA Translation: ADP90828.1 HQ205361 Genomic DNA Translation: ADP90829.1 |
CCDSi | CCDS10805.2 [O00142-1] CCDS54016.1 [O00142-3] CCDS54017.1 [O00142-4] CCDS54018.1 [O00142-2] CCDS61955.1 [O00142-5] |
RefSeqi | NP_001166114.1, NM_001172643.1 [O00142-2] NP_001166115.1, NM_001172644.1 [O00142-3] NP_001258864.1, NM_001271935.1 NP_001258979.1, NM_001272050.1 [O00142-5] NP_004605.4, NM_004614.4 [O00142-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U77088 mRNA Translation: AAC51167.1 Y10498 mRNA Translation: CAA71523.3 AK294627 mRNA Translation: BAG57808.1 AK302976 mRNA Translation: BAG64119.1 AK316226 mRNA Translation: BAH14597.1 AC010542 Genomic DNA No translation available. CH471092 Genomic DNA Translation: EAW83013.1 CH471092 Genomic DNA Translation: EAW83015.1 CH471092 Genomic DNA Translation: EAW83017.1 HQ205385 Genomic DNA Translation: ADP90853.1 HQ205382 Genomic DNA Translation: ADP90850.1 HQ205383 Genomic DNA Translation: ADP90851.1 HQ205384 Genomic DNA Translation: ADP90852.1 HQ205381 Genomic DNA Translation: ADP90849.1 HQ205380 Genomic DNA Translation: ADP90848.1 HQ205379 Genomic DNA Translation: ADP90847.1 HQ205378 Genomic DNA Translation: ADP90846.1 HQ205377 Genomic DNA Translation: ADP90845.1 HQ205376 Genomic DNA Translation: ADP90844.1 HQ205375 Genomic DNA Translation: ADP90843.1 HQ205374 Genomic DNA Translation: ADP90842.1 HQ205373 Genomic DNA Translation: ADP90841.1 HQ205372 Genomic DNA Translation: ADP90840.1 HQ205371 Genomic DNA Translation: ADP90839.1 HQ205370 Genomic DNA Translation: ADP90838.1 HQ205362 Genomic DNA Translation: ADP90830.1 HQ205363 Genomic DNA Translation: ADP90831.1 HQ205364 Genomic DNA Translation: ADP90832.1 HQ205365 Genomic DNA Translation: ADP90833.1 HQ205366 Genomic DNA Translation: ADP90834.1 HQ205367 Genomic DNA Translation: ADP90835.1 HQ205368 Genomic DNA Translation: ADP90836.1 HQ205369 Genomic DNA Translation: ADP90837.1 HQ205346 Genomic DNA Translation: ADP90814.1 HQ205347 Genomic DNA Translation: ADP90815.1 HQ205348 Genomic DNA Translation: ADP90816.1 HQ205349 Genomic DNA Translation: ADP90817.1 HQ205350 Genomic DNA Translation: ADP90818.1 HQ205351 Genomic DNA Translation: ADP90819.1 HQ205352 Genomic DNA Translation: ADP90820.1 HQ205353 Genomic DNA Translation: ADP90821.1 HQ205354 Genomic DNA Translation: ADP90822.1 HQ205355 Genomic DNA Translation: ADP90823.1 HQ205356 Genomic DNA Translation: ADP90824.1 HQ205357 Genomic DNA Translation: ADP90825.1 HQ205358 Genomic DNA Translation: ADP90826.1 HQ205359 Genomic DNA Translation: ADP90827.1 HQ205360 Genomic DNA Translation: ADP90828.1 HQ205361 Genomic DNA Translation: ADP90829.1 |
CCDSi | CCDS10805.2 [O00142-1] CCDS54016.1 [O00142-3] CCDS54017.1 [O00142-4] CCDS54018.1 [O00142-2] CCDS61955.1 [O00142-5] |
RefSeqi | NP_001166114.1, NM_001172643.1 [O00142-2] NP_001166115.1, NM_001172644.1 [O00142-3] NP_001258864.1, NM_001271935.1 NP_001258979.1, NM_001272050.1 [O00142-5] NP_004605.4, NM_004614.4 [O00142-1] |
3D structure databases
SMRi | O00142 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 112939, 9 interactors |
IntActi | O00142, 4 interactors |
STRINGi | 9606.ENSP00000299697 |
Chemistry databases
BindingDBi | O00142 |
ChEMBLi | CHEMBL4580 |
DrugBanki | DB02594, 2'-Deoxycytidine DB03312, Brivudine DB04485, Thymidine DB02452, Thymidine 5'-triphosphate |
DrugCentrali | O00142 |
PTM databases
iPTMneti | O00142 |
PhosphoSitePlusi | O00142 |
Genetic variation databases
BioMutai | TK2 |
Proteomic databases
jPOSTi | O00142 |
MassIVEi | O00142 |
MaxQBi | O00142 |
PaxDbi | O00142 |
PeptideAtlasi | O00142 |
PRIDEi | O00142 |
ProteomicsDBi | 20434 47731 [O00142-1] 47732 [O00142-2] 47733 [O00142-3] 5605 |
Protocols and materials databases
Antibodypediai | 29252, 67 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 7084 |
DisGeNETi | 7084 |
GeneCardsi | TK2 |
GeneReviewsi | TK2 |
HGNCi | HGNC:11831, TK2 |
HPAi | ENSG00000166548, Low tissue specificity |
MalaCardsi | TK2 |
MIMi | 188250, gene 609560, phenotype 617069, phenotype |
neXtProti | NX_O00142 |
OpenTargetsi | ENSG00000166548 |
Orphaneti | 254886, Autosomal recessive progressive external ophthalmoplegia 254875, Mitochondrial DNA depletion syndrome, myopathic form |
PharmGKBi | PA36535 |
VEuPathDBi | HostDB:ENSG00000166548.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4235, Eukaryota |
GeneTreei | ENSGT00940000158005 |
HOGENOMi | CLU_030466_1_0_1 |
InParanoidi | O00142 |
OMAi | IFAKYLH |
PhylomeDBi | O00142 |
TreeFami | TF324413 |
Enzyme and pathway databases
BioCyci | MetaCyc:HS09420-MONOMER |
BRENDAi | 2.7.1.21, 2681 |
PathwayCommonsi | O00142 |
Reactomei | R-HSA-73614, Pyrimidine salvage |
SABIO-RKi | O00142 |
Miscellaneous databases
BioGRID-ORCSi | 7084, 5 hits in 997 CRISPR screens |
ChiTaRSi | TK2, human |
GenomeRNAii | 7084 |
Pharosi | O00142, Tchem |
PROi | PR:O00142 |
RNActi | O00142, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000166548, Expressed in testis and 223 other tissues |
ExpressionAtlasi | O00142, baseline and differential |
Genevisiblei | O00142, HS |
Family and domain databases
CDDi | cd01673, dNK, 1 hit |
InterProi | View protein in InterPro IPR002624, DCK/DGK IPR031314, DNK_dom IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF01712, dNK, 1 hit |
PIRSFi | PIRSF000705, DNK, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KITM_HUMAN | |
Accessioni | O00142Primary (citable) accession number: O00142 Secondary accession number(s): B4DGJ7 O15238 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | July 28, 2009 | |
Last modified: | April 7, 2021 | |
This is version 185 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families