Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - O00141 (SGK1_HUMAN)

Protein

Serine/threonine-protein kinase Sgk1

Gene

SGK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na+ retention, renal K+ elimination, salt appetite, gastric acid secretion, intestinal Na+/H+ exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na+ channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K+ channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na+/K+ ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na+ transport than isoform 1.32 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Activity regulationi

Two specific sites, one in the kinase domain (Thr-256) and the other in the C-terminal regulatory region (Ser-422), need to be phosphorylated for its full activation. Phosphorylation at Ser-397 and Ser-401 are also essential for its activity. Activated by WNK1, WNK2, WNK3 and WNK4.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127ATP1
Active sitei222Proton acceptor1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi104 – 112ATP9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium channel regulator activity Source: UniProtKB
  • chloride channel regulator activity Source: UniProtKB
  • potassium channel regulator activity Source: GO_Central
  • protein serine/threonine/tyrosine kinase activity Source: MGI
  • protein serine/threonine kinase activity Source: GO_Central
  • sodium channel regulator activity Source: UniProtKB
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Stress response
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-6804757 Regulation of TP53 Degradation
SignaLinkiO00141
SIGNORiO00141

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Sgk1 (EC:2.7.11.1)
Alternative name(s):
Serum/glucocorticoid-regulated kinase 1
Gene namesi
Name:SGK1
Synonyms:SGK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000118515.11
HGNCiHGNC:10810 SGK1
MIMi602958 gene
neXtProtiNX_O00141

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi127K → M: Abolishes enzymatic activity. 3 Publications1
Mutagenesisi256T → A: Low activity. 1 Publication1
Mutagenesisi256T → D: Low activity. 1 Publication1
Mutagenesisi256T → E: Low activity. 1 Publication1
Mutagenesisi298Y → A: Abolishes interaction with NEDD4 and NEDD4L. 1 Publication1
Mutagenesisi422S → A: Low activity. 4 Publications1
Mutagenesisi422S → D: 10-fold activation. 4 Publications1

Organism-specific databases

DisGeNETi6446
OpenTargetsiENSG00000118515
PharmGKBiPA162403013

Chemistry databases

ChEMBLiCHEMBL2343
DrugBankiDB03247 Riboflavin Monophosphate
GuidetoPHARMACOLOGYi1534

Polymorphism and mutation databases

BioMutaiSGK1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866421 – 431Serine/threonine-protein kinase Sgk1Add BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei74PhosphoserineCombined sources1
Modified residuei78Phosphoserine; by MAPK71 Publication1
Disulfide bondi193Interchain (with C-258)1 Publication
Modified residuei256Phosphothreonine; by PDPK11 Publication1
Disulfide bondi258Interchain (with C-193)1 Publication
Modified residuei369Phosphothreonine; by PKA1 Publication1
Modified residuei397PhosphoserineCombined sources1 Publication1
Modified residuei401PhosphoserineCombined sources1 Publication1
Modified residuei422Phosphoserine3 Publications1

Post-translational modificationi

Regulated by phosphorylation. Activated by phosphorylation on Ser-422 by mTORC2, transforming it into a substrate for PDPK1 which phosphorylates it on Thr-256. Phosphorylation on Ser-397 and Ser-401 are also essential for its activity. Phosphorylation on Ser-78 by MAPK7 is required for growth factor-induced cell cycle progression.6 Publications
Ubiquitinated by NEDD4L; which promotes proteasomal degradation. Ubiquitinated by SYVN1 at the endoplasmic reticulum; which promotes rapid proteasomal degradation and maintains a high turnover rate in resting cells. Isoform 2 shows enhanced stability.1 Publication

Keywords - PTMi

Disulfide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiO00141
MaxQBiO00141
PaxDbiO00141
PeptideAtlasiO00141
PRIDEiO00141
ProteomicsDBi47726
47727 [O00141-2]
47728 [O00141-3]
47729 [O00141-4]
47730 [O00141-5]

PTM databases

iPTMnetiO00141
PhosphoSitePlusiO00141

Expressioni

Tissue specificityi

Expressed in most tissues with highest levels in the pancreas, followed by placenta, kidney and lung. Isoform 2 is strongly expressed in brain and pancreas, weaker in heart, placenta, lung, liver and skeletal muscle.2 Publications

Inductioni

Induced by a very large spectrum of stimuli distinct from glucocorticoids and serum. These include aldosterone, cell shrinkage, cell swelling, TGF-beta, ischemic injury of the brain, neuronal excitotoxicity memory consolidation, chronic viral hepatitis, DNA-damaging agents, vitamin D3 psychophysiological stress, iron, glucose, EDN1, CSF2, fibroblast growth factor, platelet-derived growth factor, phorbolesters, follicle-stimulating hormone, sorbitol, heat shock, oxidative stress, UV irradiation, and p53/TP53. Many of these stimuli are highly cell-specific, as is the case, for example for aldosterone, which has been found to stimulate its expression only in cells derived from aldosterone-responsive epithelia. Isoform 2 is not induced by glucocorticoids but by excessive extracellular glucose and by TGFB1, in cultured cells.1 Publication

Gene expression databases

BgeeiENSG00000118515 Expressed in 233 organ(s), highest expression level in female gonad
CleanExiHS_SGK1
ExpressionAtlasiO00141 baseline and differential
GenevisibleiO00141 HS

Organism-specific databases

HPAiCAB022085
CAB025148
HPA051251

Interactioni

Subunit structurei

Homodimer; disulfide-linked. Forms a trimeric complex with FBXW7 and NOTCH1. Interacts with MAPK3/ERK1, MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1. Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1.8 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi112344, 63 interactors
CORUMiO00141
DIPiDIP-42464N
ELMiO00141
IntActiO00141, 16 interactors
MINTiO00141
STRINGi9606.ENSP00000356832

Chemistry databases

BindingDBiO00141

Structurei

Secondary structure

1431
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliO00141
SMRiO00141
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiO00141

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini98 – 355Protein kinasePROSITE-ProRule annotationAdd BLAST258
Domaini356 – 431AGC-kinase C-terminalAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 60Necessary for localization to the mitochondriaAdd BLAST60

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi131 – 141Nuclear localization signal1 PublicationAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi131 – 141Glu/Lys-richAdd BLAST11

Domaini

Isoform 2 subcellular localization at the cell membrane and resistance to proteasomal degradation is mediated by the sequences within the first 120 amino acids.

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Curated

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00930000150811
HOVERGENiHBG108317
InParanoidiO00141
KOiK13302
OMAiEVKEPCN
OrthoDBiEOG091G06FF
PhylomeDBiO00141
TreeFamiTF320906

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: O00141-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK 
        60         70         80         90        100
HPEVQSILKI SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF 
       110        120        130        140        150
LKVIGKGSFG KVLLARHKAE EVFYAVKVLQ KKAILKKKEE KHIMSERNVL 
       160        170        180        190        200
LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN GGELFYHLQR ERCFLEPRAR 
       210        220        230        240        250
FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD FGLCKENIEH 
       260        270        280        290        300
NSTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR 
       310        320        330        340        350
NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK 
       360        370        380        390        400
SHVFFSLINW DDLINKKITP PFNPNVSGPN DLRHFDPEFT EEPVPNSIGK 
       410        420        430 
SPDSVLVTAS VKEAAEAFLG FSYAPPTDSF L
Length:431
Mass (Da):48,942
Last modified:March 7, 2006 - v2
Checksum:iF3697C63AB1F499D
GO
Isoform 2 (identifier: O00141-2) [UniParc]FASTAAdd to basket
Also known as: Sgk1.1, Sgk1_v2

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MTVKTEAAKGTLTYSRMRGMVAILI → MVNKDMNGFP...PRTFWTNDDP

Note: Produced by alternative promoter usage.
Show »
Length:526
Mass (Da):59,904
Checksum:i8CE1E9DFB949D5A5
GO
Isoform 3 (identifier: O00141-3) [UniParc]FASTAAdd to basket
Also known as: Sgk1.2

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MTVKTEAAKGTLTYSRMRGMVAILI → MGEMQGALARARLESLLRPRHKKRAEAQKRSESFLLSGL

Note: Produced by alternative promoter usage.
Show »
Length:445
Mass (Da):50,623
Checksum:iDC7076E1F43BCBAB
GO
Isoform 4 (identifier: O00141-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MTVKTEAAKGTLTYSRMRGMVAILI → MKPSKRFFISPPSST

Note: Produced by alternative splicing of isoform 1.
Show »
Length:421
Mass (Da):47,910
Checksum:i6BDCD1FA7D9AFD0E
GO
Isoform 5 (identifier: O00141-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MTVKTEAAKGTLTYSRMRGMVAILI → MSSQSSSLSE...KEEAIKPPLK

Note: Produced by alternative promoter usage.
Show »
Length:459
Mass (Da):52,119
Checksum:i1B108E7CF17935E5
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PR89E9PR89_HUMAN
Non-specific serine/threonine prote...
SGK1
387Annotation score:
E9PJN2E9PJN2_HUMAN
Serine/threonine-protein kinase Sgk...
SGK1
144Annotation score:
Q7Z3I4Q7Z3I4_HUMAN
Serine/threonine-protein kinase Sgk...
SGK1 DKFZp686H1615
153Annotation score:
E9PP33E9PP33_HUMAN
Serine/threonine-protein kinase Sgk...
SGK1
60Annotation score:
H0YCJ3H0YCJ3_HUMAN
Serine/threonine-protein kinase Sgk...
SGK1
55Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti62Q → E in CAR58097 (Ref. 4) Curated1
Sequence conflicti152K → R in CAR58096 (Ref. 4) Curated1
Sequence conflicti196E → G in CAR58095 (Ref. 4) Curated1
Sequence conflicti228I → V in BAH12848 (PubMed:14702039).Curated1
Sequence conflicti371P → R in CAR58097 (Ref. 4) Curated1
Sequence conflicti381D → E in CAA71138 (PubMed:9114008).Curated1
Sequence conflicti381D → E in CAA04146 (PubMed:9722955).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041071219V → I1 PublicationCorresponds to variant dbSNP:rs34133418Ensembl.1
Natural variantiVAR_041072342A → V1 PublicationCorresponds to variant dbSNP:rs55932330Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0377841 – 25MTVKT…VAILI → MVNKDMNGFPVKKCSAFQFF KKRVRRWIKSPMVSVDKHQS PSLKYTGSSMVHIPPGEPDF ESSLCQTCLGEHAFQRGVLP QENESCSWETQSGCEVREPC NHANILTKPDPRTFWTNDDP in isoform 2. 3 PublicationsAdd BLAST25
Alternative sequenceiVSP_0377851 – 25MTVKT…VAILI → MGEMQGALARARLESLLRPR HKKRAEAQKRSESFLLSGL in isoform 3. 2 PublicationsAdd BLAST25
Alternative sequenceiVSP_0377861 – 25MTVKT…VAILI → MKPSKRFFISPPSST in isoform 4. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_0377871 – 25MTVKT…VAILI → MSSQSSSLSEACSREAYSSH NWALPPASRSNPQPAYPWAT RRMKEEAIKPPLK in isoform 5. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10032 mRNA Translation: CAA71138.1
AJ000512 Genomic DNA Translation: CAA04146.1
EU518415 mRNA Translation: ACD35864.1
FM205707 mRNA Translation: CAR58095.1
FM205708 mRNA Translation: CAR58096.1
FM205709 mRNA Translation: CAR58097.1
FM205710 mRNA Translation: CAR58098.1
AF153609 mRNA Translation: AAD41091.1
AK055077 mRNA Translation: BAG51463.1
AK298688 mRNA Translation: BAH12848.1
AL355881 Genomic DNA No translation available.
AL135839 Genomic DNA No translation available.
Z84486 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47991.1
CH471051 Genomic DNA Translation: EAW47992.1
CH471051 Genomic DNA Translation: EAW47993.1
BC001263 mRNA Translation: AAH01263.1
CCDSiCCDS47476.1 [O00141-2]
CCDS47477.1 [O00141-5]
CCDS47478.1 [O00141-3]
CCDS5170.1 [O00141-1]
RefSeqiNP_001137148.1, NM_001143676.1 [O00141-2]
NP_001137149.1, NM_001143677.1 [O00141-5]
NP_001137150.1, NM_001143678.1 [O00141-3]
NP_001278924.1, NM_001291995.1
NP_005618.2, NM_005627.3 [O00141-1]
XP_011534373.1, XM_011536071.1 [O00141-2]
UniGeneiHs.510078

Genome annotation databases

EnsembliENST00000237305; ENSP00000237305; ENSG00000118515 [O00141-1]
ENST00000367857; ENSP00000356831; ENSG00000118515 [O00141-4]
ENST00000367858; ENSP00000356832; ENSG00000118515 [O00141-2]
ENST00000413996; ENSP00000396242; ENSG00000118515 [O00141-3]
ENST00000528577; ENSP00000434450; ENSG00000118515 [O00141-5]
GeneIDi6446
KEGGihsa:6446
UCSCiuc003qen.5 human [O00141-1]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10032 mRNA Translation: CAA71138.1
AJ000512 Genomic DNA Translation: CAA04146.1
EU518415 mRNA Translation: ACD35864.1
FM205707 mRNA Translation: CAR58095.1
FM205708 mRNA Translation: CAR58096.1
FM205709 mRNA Translation: CAR58097.1
FM205710 mRNA Translation: CAR58098.1
AF153609 mRNA Translation: AAD41091.1
AK055077 mRNA Translation: BAG51463.1
AK298688 mRNA Translation: BAH12848.1
AL355881 Genomic DNA No translation available.
AL135839 Genomic DNA No translation available.
Z84486 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47991.1
CH471051 Genomic DNA Translation: EAW47992.1
CH471051 Genomic DNA Translation: EAW47993.1
BC001263 mRNA Translation: AAH01263.1
CCDSiCCDS47476.1 [O00141-2]
CCDS47477.1 [O00141-5]
CCDS47478.1 [O00141-3]
CCDS5170.1 [O00141-1]
RefSeqiNP_001137148.1, NM_001143676.1 [O00141-2]
NP_001137149.1, NM_001143677.1 [O00141-5]
NP_001137150.1, NM_001143678.1 [O00141-3]
NP_001278924.1, NM_001291995.1
NP_005618.2, NM_005627.3 [O00141-1]
XP_011534373.1, XM_011536071.1 [O00141-2]
UniGeneiHs.510078

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R5TX-ray1.90A60-431[»]
3HDMX-ray2.60A60-431[»]
3HDNX-ray3.10A60-431[»]
ProteinModelPortaliO00141
SMRiO00141
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112344, 63 interactors
CORUMiO00141
DIPiDIP-42464N
ELMiO00141
IntActiO00141, 16 interactors
MINTiO00141
STRINGi9606.ENSP00000356832

Chemistry databases

BindingDBiO00141
ChEMBLiCHEMBL2343
DrugBankiDB03247 Riboflavin Monophosphate
GuidetoPHARMACOLOGYi1534

PTM databases

iPTMnetiO00141
PhosphoSitePlusiO00141

Polymorphism and mutation databases

BioMutaiSGK1

Proteomic databases

EPDiO00141
MaxQBiO00141
PaxDbiO00141
PeptideAtlasiO00141
PRIDEiO00141
ProteomicsDBi47726
47727 [O00141-2]
47728 [O00141-3]
47729 [O00141-4]
47730 [O00141-5]

Protocols and materials databases

DNASUi6446
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000237305; ENSP00000237305; ENSG00000118515 [O00141-1]
ENST00000367857; ENSP00000356831; ENSG00000118515 [O00141-4]
ENST00000367858; ENSP00000356832; ENSG00000118515 [O00141-2]
ENST00000413996; ENSP00000396242; ENSG00000118515 [O00141-3]
ENST00000528577; ENSP00000434450; ENSG00000118515 [O00141-5]
GeneIDi6446
KEGGihsa:6446
UCSCiuc003qen.5 human [O00141-1]

Organism-specific databases

CTDi6446
DisGeNETi6446
EuPathDBiHostDB:ENSG00000118515.11
GeneCardsiSGK1
HGNCiHGNC:10810 SGK1
HPAiCAB022085
CAB025148
HPA051251
MIMi602958 gene
neXtProtiNX_O00141
OpenTargetsiENSG00000118515
PharmGKBiPA162403013
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0598 Eukaryota
ENOG410XNPH LUCA
GeneTreeiENSGT00930000150811
HOVERGENiHBG108317
InParanoidiO00141
KOiK13302
OMAiEVKEPCN
OrthoDBiEOG091G06FF
PhylomeDBiO00141
TreeFamiTF320906

Enzyme and pathway databases

BRENDAi2.7.11.1 2681
ReactomeiR-HSA-2672351 Stimuli-sensing channels
R-HSA-6804757 Regulation of TP53 Degradation
SignaLinkiO00141
SIGNORiO00141

Miscellaneous databases

ChiTaRSiSGK1 human
EvolutionaryTraceiO00141
GeneWikiiSGK
GenomeRNAii6446
PROiPR:O00141
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000118515 Expressed in 233 organ(s), highest expression level in female gonad
CleanExiHS_SGK1
ExpressionAtlasiO00141 baseline and differential
GenevisibleiO00141 HS

Family and domain databases

InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR011009 Kinase-like_dom_sf
IPR017892 Pkinase_C
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PF00433 Pkinase_C, 1 hit
SMARTiView protein in SMART
SM00133 S_TK_X, 1 hit
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSGK1_HUMAN
AccessioniPrimary (citable) accession number: O00141
Secondary accession number(s): B7UUP7
, B7UUP8, B7UUP9, B7Z5B2, E1P583, Q5TCN2, Q5TCN3, Q5TCN4, Q5VY65, Q9UN56
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again