UniProtKB - O00141 (SGK1_HUMAN)
Serine/threonine-protein kinase Sgk1
SGK1
Functioni
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cellular enzymes, transcription factors, neuronal excitability, cell growth, proliferation, survival, migration and apoptosis. Plays an important role in cellular stress response. Contributes to regulation of renal Na+ retention, renal K+ elimination, salt appetite, gastric acid secretion, intestinal Na+/H+ exchange and nutrient transport, insulin-dependent salt sensitivity of blood pressure, salt sensitivity of peripheral glucose uptake, cardiac repolarization and memory consolidation. Up-regulates Na+ channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2, K+ channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial Ca2+ channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2 and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2, SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine transporter: SLC6A8, Na+/dicarboxylate cotransporter: SLC13A2/NADC1, Na+-dependent phosphate cotransporter: SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT, SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes: GSK3A/B, PMM2 and Na+/K+ ATPase, and transcription factors: CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport into epithelial cells by enhancing the stability and expression of SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L ubiquitin E3 ligase, promoting its interaction with 14-3-3 proteins, thereby preventing it from binding to SCNN1A/ENAC and targeting it for degradation. Regulates store-operated Ca(+2) entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1 directly via its phosphorylation or indirectly via increased interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and activates MDM2-dependent ubiquitination of p53/TP53. Phosphorylates MAPT/TAU and mediates microtubule depolymerization and neurite formation in hippocampal neurons. Phosphorylates SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates APBB1/FE65 and promotes its localization to the nucleus. Phosphorylates MAPK1/ERK2 and activates it by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7 and plays an inhibitory role in the NOTCH1 signaling. Phosphorylates FOXO1 resulting in its relocalization from the nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit from the nucleus and interference with FOXO3-dependent transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits their activity. Phosphorylates SLC9A3/NHE3 in response to dexamethasone, resulting in its activation and increased localization at the cell membrane. Phosphorylates CREB1. Necessary for vascular remodeling during angiogenesis. Sustained high levels and activity may contribute to conditions such as hypertension and diabetic nephropathy. Isoform 2 exhibited a greater effect on cell plasma membrane expression of SCNN1A/ENAC and Na+ transport than isoform 1.
32 PublicationsCatalytic activityi
Activity regulationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 127 | ATP | 1 | |
Active sitei | 222 | Proton acceptor | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 104 – 112 | ATP | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- calcium channel regulator activity Source: UniProtKB
- chloride channel regulator activity Source: UniProtKB
- potassium channel regulator activity Source: GO_Central
- protein serine/threonine/tyrosine kinase activity Source: MGI
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- sodium channel regulator activity Source: UniProtKB
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- cellular response to aldosterone Source: Ensembl
- cellular response to DNA damage stimulus Source: Ensembl
- intracellular signal transduction Source: GO_Central
- long-term memory Source: UniProtKB
- neuron projection morphogenesis Source: GO_Central
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of transporter activity Source: UniProtKB
- protein phosphorylation Source: ProtInc
- regulation of apoptotic process Source: UniProtKB
- regulation of blood pressure Source: UniProtKB
- regulation of catalytic activity Source: UniProtKB
- regulation of cell growth Source: UniProtKB
- regulation of cell migration Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
- regulation of DNA-binding transcription factor activity Source: UniProtKB
- regulation of gastric acid secretion Source: UniProtKB
- regulation of signal transduction by p53 class mediator Source: Reactome
- renal sodium ion absorption Source: UniProtKB
- sodium ion transport Source: ProtInc
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Stress response |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | O00141 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels R-HSA-6804757, Regulation of TP53 Degradation R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | O00141 |
SIGNORi | O00141 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase Sgk1 (EC:2.7.11.1)Alternative name(s): Serum/glucocorticoid-regulated kinase 1 |
Gene namesi | Name:SGK1 Synonyms:SGK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10810, SGK1 |
MIMi | 602958, gene |
neXtProti | NX_O00141 |
VEuPathDBi | HostDB:ENSG00000118515 |
Subcellular locationi
Plasma membrane
Cytoplasm and Cytosol
Nucleus
Mitochondrion
Endoplasmic reticulum
Note: The subcellular localization is controlled by the cell cycle, as well as by exposure to specific hormones and environmental stress stimuli. In proliferating cells, it shuttles between the nucleus and cytoplasm in synchrony with the cell cycle, and in serum/growth factor-stimulated cells it resides in the nucleus. In contrast, after exposure to environmental stress or treatment with glucocorticoids, it is detected in the cytoplasm and with certain stress conditions is associated with the mitochondria. In osmoregulation through the epithelial sodium channel, it can be localized to the cytoplasmic surface of the cell membrane. Nuclear, upon phosphorylation.
Plasma membrane
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Mitochondrion
- mitochondrion Source: UniProtKB-SubCell
Nucleus
- nuclear speck Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 127 | K → M: Abolishes enzymatic activity. 3 Publications | 1 | |
Mutagenesisi | 256 | T → A: Low activity. 1 Publication | 1 | |
Mutagenesisi | 256 | T → D: Low activity. 1 Publication | 1 | |
Mutagenesisi | 256 | T → E: Low activity. 1 Publication | 1 | |
Mutagenesisi | 298 | Y → A: Abolishes interaction with NEDD4 and NEDD4L. 1 Publication | 1 | |
Mutagenesisi | 422 | S → A: Low activity. 4 Publications | 1 | |
Mutagenesisi | 422 | S → D: 10-fold activation. 4 Publications | 1 |
Organism-specific databases
DisGeNETi | 6446 |
OpenTargetsi | ENSG00000118515 |
PharmGKBi | PA162403013 |
Miscellaneous databases
Pharosi | O00141, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2343 |
DrugBanki | DB08191, 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid DB07837, [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid DB03247, Flavin mononucleotide |
GuidetoPHARMACOLOGYi | 1534 |
Genetic variation databases
BioMutai | SGK1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086642 | 1 – 431 | Serine/threonine-protein kinase Sgk1Add BLAST | 431 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 74 | PhosphoserineCombined sources | 1 | |
Modified residuei | 78 | Phosphoserine; by MAPK71 Publication | 1 | |
Disulfide bondi | 193 | Interchain (with C-258)1 Publication | ||
Modified residuei | 256 | Phosphothreonine; by PDPK11 Publication | 1 | |
Disulfide bondi | 258 | Interchain (with C-193)1 Publication | ||
Modified residuei | 369 | Phosphothreonine; by PKA1 Publication | 1 | |
Modified residuei | 397 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 401 | PhosphoserineCombined sources1 Publication | 1 | |
Modified residuei | 422 | Phosphoserine3 Publications | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Phosphoprotein, Ubl conjugationProteomic databases
jPOSTi | O00141 |
MassIVEi | O00141 |
MaxQBi | O00141 |
PaxDbi | O00141 |
PeptideAtlasi | O00141 |
PRIDEi | O00141 |
ProteomicsDBi | 47726 [O00141-1] 47727 [O00141-2] 47728 [O00141-3] 47729 [O00141-4] 47730 [O00141-5] |
PTM databases
iPTMneti | O00141 |
PhosphoSitePlusi | O00141 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000118515, Expressed in female gonad and 248 other tissues |
ExpressionAtlasi | O00141, baseline and differential |
Genevisiblei | O00141, HS |
Organism-specific databases
HPAi | ENSG00000118515, Tissue enhanced (parathyroid) |
Interactioni
Subunit structurei
Homodimer; disulfide-linked.
Forms a trimeric complex with FBXW7 and NOTCH1.
Interacts with MAPK3/ERK1, MAPK1/ERK2, MAP2K1/MEK1, MAP2K2/MEK2, NEDD4, NEDD4L, MAPT/TAU, MAPK7, CREB1, SLC9A3R2/NHERF2 and KCNJ1/ROMK1. Associates with the mammalian target of rapamycin complex 2 (mTORC2) via an interaction with MAPKAP1/SIN1.
8 PublicationsBinary interactionsi
O00141
Protein-protein interaction databases
BioGRIDi | 112344, 67 interactors |
CORUMi | O00141 |
DIPi | DIP-42464N |
ELMi | O00141 |
IntActi | O00141, 20 interactors |
MINTi | O00141 |
STRINGi | 9606.ENSP00000356832 |
Chemistry databases
BindingDBi | O00141 |
Miscellaneous databases
RNActi | O00141, protein |
Structurei
Secondary structure
3D structure databases
SMRi | O00141 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | O00141 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 98 – 355 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 258 | |
Domaini | 356 – 431 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 76 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 60 | Necessary for localization to the mitochondriaAdd BLAST | 60 | |
Regioni | 66 – 92 | DisorderedSequence analysisAdd BLAST | 27 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 131 – 141 | Nuclear localization signal1 PublicationAdd BLAST | 11 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000155726 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | O00141 |
OMAi | LCKEDMQ |
OrthoDBi | 614710at2759 |
PhylomeDBi | O00141 |
TreeFami | TF320906 |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTVKTEAAKG TLTYSRMRGM VAILIAFMKQ RRMGLNDFIQ KIANNSYACK
60 70 80 90 100
HPEVQSILKI SQPQEPELMN ANPSPPPSPS QQINLGPSSN PHAKPSDFHF
110 120 130 140 150
LKVIGKGSFG KVLLARHKAE EVFYAVKVLQ KKAILKKKEE KHIMSERNVL
160 170 180 190 200
LKNVKHPFLV GLHFSFQTAD KLYFVLDYIN GGELFYHLQR ERCFLEPRAR
210 220 230 240 250
FYAAEIASAL GYLHSLNIVY RDLKPENILL DSQGHIVLTD FGLCKENIEH
260 270 280 290 300
NSTTSTFCGT PEYLAPEVLH KQPYDRTVDW WCLGAVLYEM LYGLPPFYSR
310 320 330 340 350
NTAEMYDNIL NKPLQLKPNI TNSARHLLEG LLQKDRTKRL GAKDDFMEIK
360 370 380 390 400
SHVFFSLINW DDLINKKITP PFNPNVSGPN DLRHFDPEFT EEPVPNSIGK
410 420 430
SPDSVLVTAS VKEAAEAFLG FSYAPPTDSF L
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PR89 | E9PR89_HUMAN | Serine/threonine-protein kinase Sgk... | SGK1 | 387 | Annotation score: | ||
E9PJN2 | E9PJN2_HUMAN | Serine/threonine-protein kinase Sgk... | SGK1 | 144 | Annotation score: | ||
Q7Z3I4 | Q7Z3I4_HUMAN | Serine/threonine-protein kinase Sgk... | SGK1 DKFZp686H1615 | 153 | Annotation score: | ||
E9PP33 | E9PP33_HUMAN | Serine/threonine-protein kinase Sgk... | SGK1 | 60 | Annotation score: | ||
H0YCJ3 | H0YCJ3_HUMAN | Serine/threonine-protein kinase Sgk... | SGK1 | 55 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 62 | Q → E in CAR58097 (Ref. 4) Curated | 1 | |
Sequence conflicti | 152 | K → R in CAR58096 (Ref. 4) Curated | 1 | |
Sequence conflicti | 196 | E → G in CAR58095 (Ref. 4) Curated | 1 | |
Sequence conflicti | 228 | I → V in BAH12848 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 371 | P → R in CAR58097 (Ref. 4) Curated | 1 | |
Sequence conflicti | 381 | D → E in CAA71138 (PubMed:9114008).Curated | 1 | |
Sequence conflicti | 381 | D → E in CAA04146 (PubMed:9722955).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041071 | 219 | V → I1 PublicationCorresponds to variant dbSNP:rs34133418Ensembl. | 1 | |
Natural variantiVAR_041072 | 342 | A → V1 PublicationCorresponds to variant dbSNP:rs55932330Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_037784 | 1 – 25 | MTVKT…VAILI → MVNKDMNGFPVKKCSAFQFF KKRVRRWIKSPMVSVDKHQS PSLKYTGSSMVHIPPGEPDF ESSLCQTCLGEHAFQRGVLP QENESCSWETQSGCEVREPC NHANILTKPDPRTFWTNDDP in isoform 2. 3 PublicationsAdd BLAST | 25 | |
Alternative sequenceiVSP_037785 | 1 – 25 | MTVKT…VAILI → MGEMQGALARARLESLLRPR HKKRAEAQKRSESFLLSGL in isoform 3. 2 PublicationsAdd BLAST | 25 | |
Alternative sequenceiVSP_037786 | 1 – 25 | MTVKT…VAILI → MKPSKRFFISPPSST in isoform 4. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_037787 | 1 – 25 | MTVKT…VAILI → MSSQSSSLSEACSREAYSSH NWALPPASRSNPQPAYPWAT RRMKEEAIKPPLK in isoform 5. 1 PublicationAdd BLAST | 25 |
Sequence databases
Genome annotation databases
Ensembli | ENST00000237305; ENSP00000237305; ENSG00000118515 ENST00000367857; ENSP00000356831; ENSG00000118515 [O00141-4] ENST00000367858; ENSP00000356832; ENSG00000118515 [O00141-2] ENST00000413996; ENSP00000396242; ENSG00000118515 [O00141-3] ENST00000528577; ENSP00000434450; ENSG00000118515 [O00141-5] |
GeneIDi | 6446 |
KEGGi | hsa:6446 |
MANE-Selecti | ENST00000367858.10; ENSP00000356832.5; NM_001143676.3; NP_001137148.1 [O00141-2] |
UCSCi | uc003qen.5, human [O00141-1] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2R5T | X-ray | 1.90 | A | 60-431 | [»] | |
3HDM | X-ray | 2.60 | A | 60-431 | [»] | |
3HDN | X-ray | 3.10 | A | 60-431 | [»] | |
SMRi | O00141 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112344, 67 interactors |
CORUMi | O00141 |
DIPi | DIP-42464N |
ELMi | O00141 |
IntActi | O00141, 20 interactors |
MINTi | O00141 |
STRINGi | 9606.ENSP00000356832 |
Chemistry databases
BindingDBi | O00141 |
ChEMBLi | CHEMBL2343 |
DrugBanki | DB08191, 4-(5-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acid DB07837, [4-(5-naphthalen-2-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)phenyl]acetic acid DB03247, Flavin mononucleotide |
GuidetoPHARMACOLOGYi | 1534 |
PTM databases
iPTMneti | O00141 |
PhosphoSitePlusi | O00141 |
Genetic variation databases
BioMutai | SGK1 |
Proteomic databases
jPOSTi | O00141 |
MassIVEi | O00141 |
MaxQBi | O00141 |
PaxDbi | O00141 |
PeptideAtlasi | O00141 |
PRIDEi | O00141 |
ProteomicsDBi | 47726 [O00141-1] 47727 [O00141-2] 47728 [O00141-3] 47729 [O00141-4] 47730 [O00141-5] |
Protocols and materials databases
ABCDi | O00141, 1 sequenced antibody |
Antibodypediai | 19734, 916 antibodies from 47 providers |
DNASUi | 6446 |
Genome annotation databases
Ensembli | ENST00000237305; ENSP00000237305; ENSG00000118515 ENST00000367857; ENSP00000356831; ENSG00000118515 [O00141-4] ENST00000367858; ENSP00000356832; ENSG00000118515 [O00141-2] ENST00000413996; ENSP00000396242; ENSG00000118515 [O00141-3] ENST00000528577; ENSP00000434450; ENSG00000118515 [O00141-5] |
GeneIDi | 6446 |
KEGGi | hsa:6446 |
MANE-Selecti | ENST00000367858.10; ENSP00000356832.5; NM_001143676.3; NP_001137148.1 [O00141-2] |
UCSCi | uc003qen.5, human [O00141-1] |
Organism-specific databases
CTDi | 6446 |
DisGeNETi | 6446 |
GeneCardsi | SGK1 |
HGNCi | HGNC:10810, SGK1 |
HPAi | ENSG00000118515, Tissue enhanced (parathyroid) |
MIMi | 602958, gene |
neXtProti | NX_O00141 |
OpenTargetsi | ENSG00000118515 |
PharmGKBi | PA162403013 |
VEuPathDBi | HostDB:ENSG00000118515 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0598, Eukaryota |
GeneTreei | ENSGT00940000155726 |
HOGENOMi | CLU_000288_63_5_1 |
InParanoidi | O00141 |
OMAi | LCKEDMQ |
OrthoDBi | 614710at2759 |
PhylomeDBi | O00141 |
TreeFami | TF320906 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | O00141 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels R-HSA-6804757, Regulation of TP53 Degradation R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | O00141 |
SIGNORi | O00141 |
Miscellaneous databases
BioGRID-ORCSi | 6446, 12 hits in 1085 CRISPR screens |
ChiTaRSi | SGK1, human |
EvolutionaryTracei | O00141 |
GeneWikii | SGK |
GenomeRNAii | 6446 |
Pharosi | O00141, Tchem |
PROi | PR:O00141 |
RNActi | O00141, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000118515, Expressed in female gonad and 248 other tissues |
ExpressionAtlasi | O00141, baseline and differential |
Genevisiblei | O00141, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit PF00433, Pkinase_C, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SGK1_HUMAN | |
Accessioni | O00141Primary (citable) accession number: O00141 Secondary accession number(s): B7UUP7 Q9UN56 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | March 7, 2006 | |
Last modified: | February 23, 2022 | |
This is version 209 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families