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UniProtKB - O00115 (DNS2A_HUMAN)

Protein

Deoxyribonuclease-2-alpha

Gene

DNASE2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

Miscellaneous

Not required for the generation of the characteristic DNA fragmentation observed in apoptotic cells, but for the degradation of DNA from dying cells.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products. EC:3.1.22.1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei295Curated1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • deoxyribonuclease II activity Source: GO_Central
  • DNA binding Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Endonuclease, Hydrolase, Nuclease
Biological processApoptosis

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.22.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-432720 Lysosome Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Deoxyribonuclease-2-alpha (EC:3.1.22.1)
Alternative name(s):
Acid DNase
Deoxyribonuclease II alpha
Short name:
DNase II alpha
Lysosomal DNase II
R31240_2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DNASE2
Synonyms:DNASE2A, DNL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000105612.8

Human Gene Nomenclature Database

More...HGNCi		HGNC:2960 DNASE2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		126350 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_O00115

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi19C → A: Loss of activity. 1 Publication1
Mutagenesisi86N → Q: Reduced N-glycosylation, complete loss of N-glycosylation; when associated with Q-212; Q-266 and Q-290. 1 Publication1
Mutagenesisi151C → A: Loss of activity. 1 Publication1
Mutagenesisi159C → A: Loss of activity. 1 Publication1
Mutagenesisi212N → Q: Reduced N-glycosylation, complete loss of N-glycosylation; when associated with Q-86; Q-266 and Q-290. 1 Publication1
Mutagenesisi266N → Q: Reduced N-glycosylation, complete loss of N-glycosylation; when associated with Q-86; Q-212 and Q-290. 1 Publication1
Mutagenesisi267C → A: Loss of activity. 1 Publication1
Mutagenesisi290N → Q: Reduced N-glycosylation, complete loss of N-glycosylation; when associated with Q-86; Q-212 and Q-266. 1 Publication1
Mutagenesisi295H → A, K, N, R or S: Loss of activity, but not of DNA-binding. 1 Publication1
Mutagenesisi299C → A: No effect. 1 Publication1
Mutagenesisi308C → A: Loss of activity. 1 Publication1
Mutagenesisi327C → A: Loss of activity. 1 Publication1
Mutagenesisi347C → A: Loss of activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1777

Open Targets

More...OpenTargetsi		ENSG00000105612

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27431

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1250342

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DNASE2

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000729119 – 360Deoxyribonuclease-2-alphaAdd BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi19 ↔ 159Sequence analysis
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi86N-linked (GlcNAc...) asparagine1
Glycosylationi212N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi266N-linked (GlcNAc...) asparagine1
Disulfide bondi267 ↔ 347Sequence analysis
Glycosylationi290N-linked (GlcNAc...) asparagine1
Disulfide bondi308 ↔ 327Sequence analysis

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated. Mutations that eliminate N-glycosylation sites reduce activity, but enzymatic deglycosylation has no effect.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		O00115

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		O00115

MaxQB - The MaxQuant DataBase

More...MaxQBi		O00115

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		O00115

PeptideAtlas

More...PeptideAtlasi		O00115

PRoteomics IDEntifications database

More...PRIDEi		O00115

ProteomicsDB human proteome resource

More...ProteomicsDBi		47717

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1170

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		O00115

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		O00115

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000105612 Expressed in 213 organ(s), highest expression level in pituitary gland

CleanEx database of gene expression profiles

More...CleanExi		HS_DNASE2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		O00115 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		O00115 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA066185

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		108116, 10 interactors

Protein interaction database and analysis system

More...IntActi		O00115, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000222219

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		O00115

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		O00115

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		O00115

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DNase II family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3825 Eukaryota
ENOG4111G8U LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000002634

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000261682

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG051387

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		O00115

KEGG Orthology (KO)

More...KOi		K01158

Identification of Orthologs from Complete Genome Data

More...OMAi		EHRGGGT

Database of Orthologous Groups

More...OrthoDBi		605654at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		O00115

TreeFam database of animal gene trees

More...TreeFami		TF314536

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004947 DNase_II

The PANTHER Classification System

More...PANTHERi		PTHR10858 PTHR10858, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03265 DNase_II, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: O00115-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIPLLLAALL CVPAGALTCY GDSGQPVDWF VVYKLPALRG SGEAAQRGLQ 
        60         70         80         90        100
YKYLDESSGG WRDGRALINS PEGAVGRSLQ PLYRSNTSQL AFLLYNDQPP 
       110        120        130        140        150
QPSKAQDSSM RGHTKGVLLL DHDGGFWLVH SVPNFPPPAS SAAYSWPHSA 
       160        170        180        190        200
CTYGQTLLCV SFPFAQFSKM GKQLTYTYPW VYNYQLEGIF AQEFPDLENV 
       210        220        230        240        250
VKGHHVSQEP WNSSITLTSQ AGAVFQSFAK FSKFGDDLYS GWLAAALGTN 
       260        270        280        290        300
LQVQFWHKTV GILPSNCSDI WQVLNVNQIA FPGPAGPSFN STEDHSKWCV 
       310        320        330        340        350
SPKGPWTCVG DMNRNQGEEQ RGGGTLCAQL PALWKAFQPL VKNYQPCNGM 
       360
ARKPSRAYKI
Length:360
Mass (Da):39,581
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDF1BBFBA8A9676EA
GO
Isoform 2 (identifier: O00115-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     116-170: Missing.

Note: No experimental confirmation available.
Show »
Length:305
Mass (Da):33,615
Checksum:i85A0DD26EC28FE2C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENE5K7ENE5_HUMAN
Deoxyribonuclease-2-alpha
DNASE2
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160 – 171Missing in AAB51172 (PubMed:15057824).CuratedAdd BLAST12

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04887039R → I. Corresponds to variant dbSNP:rs36075196Ensembl.1
Natural variantiVAR_048871204H → R. Corresponds to variant dbSNP:rs16978744Ensembl.1
Natural variantiVAR_012044314R → L. Corresponds to variant dbSNP:rs1061192Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056921116 – 170Missing in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB008564 Genomic DNA Translation: BAB55598.1
AF060222 mRNA Translation: AAC39852.1
AF045937 mRNA Translation: AAC35751.1
AF047016 mRNA Translation: AAC77366.1
AB004574 mRNA Translation: BAA28623.1
BT007047 mRNA Translation: AAP35696.1
AK297493 mRNA Translation: BAH12592.1
AK315358 mRNA Translation: BAG37753.1
AC020934 Genomic DNA No translation available.
AD000092 Genomic DNA Translation: AAB51172.1
CH471106 Genomic DNA Translation: EAW84320.1
BC010419 mRNA Translation: AAH10419.3
BC065209 mRNA Translation: AAH65209.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12284.1 [O00115-1]

Protein sequence database of the Protein Information Resource

More...PIRi		JE0206
T45071

NCBI Reference Sequences

More...RefSeqi		NP_001366.1, NM_001375.2 [O00115-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.118243

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000222219; ENSP00000222219; ENSG00000105612 [O00115-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1777

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1777

UCSC genome browser

More...UCSCi		uc002mvn.2 human [O00115-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB008564 Genomic DNA Translation: BAB55598.1
AF060222 mRNA Translation: AAC39852.1
AF045937 mRNA Translation: AAC35751.1
AF047016 mRNA Translation: AAC77366.1
AB004574 mRNA Translation: BAA28623.1
BT007047 mRNA Translation: AAP35696.1
AK297493 mRNA Translation: BAH12592.1
AK315358 mRNA Translation: BAG37753.1
AC020934 Genomic DNA No translation available.
AD000092 Genomic DNA Translation: AAB51172.1
CH471106 Genomic DNA Translation: EAW84320.1
BC010419 mRNA Translation: AAH10419.3
BC065209 mRNA Translation: AAH65209.1
CCDSiCCDS12284.1 [O00115-1]
PIRiJE0206
T45071
RefSeqiNP_001366.1, NM_001375.2 [O00115-1]
UniGeneiHs.118243

3D structure databases

ProteinModelPortaliO00115
SMRiO00115
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108116, 10 interactors
IntActiO00115, 1 interactor
STRINGi9606.ENSP00000222219

Chemistry databases

BindingDBiO00115
ChEMBLiCHEMBL1250342

PTM databases

GlyConnecti1170
iPTMnetiO00115
PhosphoSitePlusiO00115

Polymorphism and mutation databases

BioMutaiDNASE2

Proteomic databases

EPDiO00115
jPOSTiO00115
MaxQBiO00115
PaxDbiO00115
PeptideAtlasiO00115
PRIDEiO00115
ProteomicsDBi47717

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1777
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222219; ENSP00000222219; ENSG00000105612 [O00115-1]
GeneIDi1777
KEGGihsa:1777
UCSCiuc002mvn.2 human [O00115-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1777
DisGeNETi1777
EuPathDBiHostDB:ENSG00000105612.8

GeneCards: human genes, protein and diseases

More...GeneCardsi		DNASE2
HGNCiHGNC:2960 DNASE2
HPAiHPA066185
MIMi126350 gene
neXtProtiNX_O00115
OpenTargetsiENSG00000105612
PharmGKBiPA27431

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3825 Eukaryota
ENOG4111G8U LUCA
GeneTreeiENSGT00390000002634
HOGENOMiHOG000261682
HOVERGENiHBG051387
InParanoidiO00115
KOiK01158
OMAiEHRGGGT
OrthoDBi605654at2759
PhylomeDBiO00115
TreeFamiTF314536

Enzyme and pathway databases

BRENDAi3.1.22.1 2681
ReactomeiR-HSA-432720 Lysosome Vesicle Biogenesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DNASE2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1777

Protein Ontology

More...PROi		PR:O00115

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000105612 Expressed in 213 organ(s), highest expression level in pituitary gland
CleanExiHS_DNASE2
ExpressionAtlasiO00115 baseline and differential
GenevisibleiO00115 HS

Family and domain databases

InterProiView protein in InterPro
IPR004947 DNase_II
PANTHERiPTHR10858 PTHR10858, 1 hit
PfamiView protein in Pfam
PF03265 DNase_II, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNS2A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: O00115
Secondary accession number(s): B2RD06, B7Z4K6, O43910
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: January 16, 2019
This is version 167 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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