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Protein

Putative transcription factor ovo-like protein 3

Gene

OVOL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

May act as a transcription regulator.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri94 – 116C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 173C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri189 – 211C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative transcription factor ovo-like protein 3
Gene namesi
Name:OVOL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105261.7
HGNCiHGNC:14186 OVOL3
MIMi616442 gene
neXtProtiNX_O00110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003206221 – 214Putative transcription factor ovo-like protein 3Add BLAST214

Proteomic databases

PRIDEiO00110
ProteomicsDBi47716

PTM databases

iPTMnetiO00110
PhosphoSitePlusiO00110

Expressioni

Gene expression databases

BgeeiENSG00000105261 Expressed in 60 organ(s), highest expression level in right testis
ExpressionAtlasiO00110 baseline and differential
GenevisibleiO00110 HS

Structurei

3D structure databases

ProteinModelPortaliO00110
SMRiO00110
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri94 – 116C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri122 – 144C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri150 – 173C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri189 – 211C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00920000149010
HOGENOMiHOG000231694
HOVERGENiHBG053384
InParanoidiO00110
OMAiRRHVCRC
OrthoDBiEOG091G0KJS

Family and domain databases

InterProiView protein in InterPro
IPR027756 Ovo-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR10032 PTHR10032, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

O00110-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPRAFLVRSR RPQPPNWGHL PDQLRGDAYI PGGPLTVPGG KGQERRSVTI
60 70 80 90 100
WLFSSDCSSL GGPPAQQSSS VRDPWTAQPT QGNLTSAPRG PGTLGCPLCP
110 120 130 140 150
KAFPLQRMLT RHLKCHSPVR RHLCRCCGKG FHDAFDLKRH MRTHTGIRPF
160 170 180 190 200
RCSACGKAFT QRCSLEAHLA KVHGQPASYA YRERREKLHV CEDCGFTSSR
210
PDTYAQHRAL HRAA
Length:214
Mass (Da):23,826
Last modified:January 25, 2012 - v3
Checksum:iA23D553861191AF4
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YVN9A0A0J9YVN9_HUMAN
Putative transcription factor ovo-l...
OVOL3
190Annotation score:

Sequence cautioni

The sequence AAB51180 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001527 Genomic DNA Translation: AAB51180.1 Sequence problems.
UniGeneiHs.143920

Genome annotation databases

EnsembliENST00000585332; ENSP00000465620; ENSG00000105261
UCSCiuc031rkj.2 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AD001527 Genomic DNA Translation: AAB51180.1 Sequence problems.
UniGeneiHs.143920

3D structure databases

ProteinModelPortaliO00110
SMRiO00110
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiO00110
PhosphoSitePlusiO00110

Proteomic databases

PRIDEiO00110
ProteomicsDBi47716

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000585332; ENSP00000465620; ENSG00000105261
UCSCiuc031rkj.2 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000105261.7
GeneCardsiOVOL3
HGNCiHGNC:14186 OVOL3
MIMi616442 gene
neXtProtiNX_O00110
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00920000149010
HOGENOMiHOG000231694
HOVERGENiHBG053384
InParanoidiO00110
OMAiRRHVCRC
OrthoDBiEOG091G0KJS

Miscellaneous databases

PROiPR:O00110
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105261 Expressed in 60 organ(s), highest expression level in right testis
ExpressionAtlasiO00110 baseline and differential
GenevisibleiO00110 HS

Family and domain databases

InterProiView protein in InterPro
IPR027756 Ovo-like
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PANTHERiPTHR10032 PTHR10032, 1 hit
PfamiView protein in Pfam
PF00096 zf-C2H2, 2 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF57667 SSF57667, 1 hit
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOVOL3_HUMAN
AccessioniPrimary (citable) accession number: O00110
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: January 25, 2012
Last modified: November 7, 2018
This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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