UniProtKB - O00098 (CISY_EMENI)
Protein
Citrate synthase, mitochondrial
Gene
citA
Organism
Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)
Status
Functioni
Miscellaneous
Citrate synthase is found in nearly all cells capable of oxidative metabolism.
Catalytic activityi
- EC:2.3.3.16PROSITE-ProRule annotation
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.Proteins known to be involved in the 2 steps of the subpathway in this organism are:
- Citrate synthase, mitochondrial (citA)
- Aconitate hydratase, mitochondrial (acoA)
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 310 | PROSITE-ProRule annotation | 1 | |
Active sitei | 356 | PROSITE-ProRule annotation | 1 | |
Active sitei | 411 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- citrate (Si)-synthase activity Source: AspGD
GO - Biological processi
- carbohydrate metabolic process Source: GO_Central
- citrate metabolic process Source: InterPro
- tricarboxylic acid cycle Source: AspGD
Keywordsi
Molecular function | Transferase |
Biological process | Tricarboxylic acid cycle |
Enzyme and pathway databases
BRENDAi | 2.3.3.16, 517 |
UniPathwayi | UPA00223;UER00717 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:citA ORF Names:AN8275 |
Organismi | Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) |
Taxonomic identifieri | 227321 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Nidulantes › |
Proteomesi |
|
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: GO_Central
- mitochondrion Source: AspGD
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 35 | MitochondrionSequence analysisAdd BLAST | 35 | |
ChainiPRO_0000005477 | 36 – 474 | Citrate synthase, mitochondrialAdd BLAST | 439 |
Proteomic databases
PRIDEi | O00098 |
Family & Domainsi
Sequence similaritiesi
Belongs to the citrate synthase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2617, Eukaryota |
HOGENOMi | CLU_022049_2_1_1 |
InParanoidi | O00098 |
OMAi | TVGWCAQ |
OrthoDBi | 1131452at2759 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR010109, Citrate_synthase_euk IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
TIGRFAMsi | TIGR01793, cit_synth_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
O00098-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASTLRLSTS ALRSSTLAGK PVVQSVAFNG LRCYSTGKTK SLKETFADKL
60 70 80 90 100
PGELEKVKKL RKEHGNKVIG ELTLDQAYGG ARGVKCLVWE GSVLDSEEGI
110 120 130 140 150
RFRGLTIPEC QKLLPKAPGG EEPLPEGLFW LLLTGEVPSE QQVRDLSAEW
160 170 180 190 200
AARSDLPKFI EELIDRCPST LHPMAQFSLA VTALEHESAF AKAYAKGINK
210 220 230 240 250
KEYWHYTFED SMDLIAKLPT IAAKIYRNVF KDGKVAPIQK DKDYSYNLAN
260 270 280 290 300
QLGFADNKDF VELMRLYLTI HSDHEGGNVS AHTTHLVGSA LSSPMLSLAA
310 320 330 340 350
GLNGLAGPLH GLANQEVLNW LTEMKKVVGN DLSDQSIKDY LWSTLNAGRV
360 370 380 390 400
VPGYGHAVLR KTDPRYTSQR EFALRKLPDD PMFKLVSQVY KIAPGVLTEH
410 420 430 440 450
GKTKNPYPNV DAHSGVLLQY YGLTEANYYT VLFGVSRALG VLPQLIIDRA
460 470
FGAPIERPKS FSTEAYAKLV GAKL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 167 | C → V in AAC49728 (PubMed:9163747).Curated | 1 | |
Sequence conflicti | 167 | C → V in AAM22645 (PubMed:16372000).Curated | 1 | |
Sequence conflicti | 194 | Y → T in AAC49728 (PubMed:9163747).Curated | 1 | |
Sequence conflicti | 194 | Y → T in AAM22645 (PubMed:16372000).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89675 Genomic DNA Translation: AAC49728.3 AF468824 mRNA Translation: AAM22645.1 AACD01000145 Genomic DNA Translation: EAA59013.1 BN001302 Genomic DNA Translation: CBF74260.1 |
RefSeqi | XP_681544.1, XM_676452.1 |
Genome annotation databases
EnsemblFungii | CBF74260; CBF74260; ANIA_08275 EAA59013; EAA59013; AN8275.2 |
GeneIDi | 2868998 |
KEGGi | ani:AN8275.2 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U89675 Genomic DNA Translation: AAC49728.3 AF468824 mRNA Translation: AAM22645.1 AACD01000145 Genomic DNA Translation: EAA59013.1 BN001302 Genomic DNA Translation: CBF74260.1 |
RefSeqi | XP_681544.1, XM_676452.1 |
3D structure databases
SMRi | O00098 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 162425.CADANIAP00004335 |
Proteomic databases
PRIDEi | O00098 |
Genome annotation databases
EnsemblFungii | CBF74260; CBF74260; ANIA_08275 EAA59013; EAA59013; AN8275.2 |
GeneIDi | 2868998 |
KEGGi | ani:AN8275.2 |
Phylogenomic databases
eggNOGi | KOG2617, Eukaryota |
HOGENOMi | CLU_022049_2_1_1 |
InParanoidi | O00098 |
OMAi | TVGWCAQ |
OrthoDBi | 1131452at2759 |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00717 |
BRENDAi | 2.3.3.16, 517 |
Family and domain databases
Gene3Di | 1.10.230.10, 1 hit 1.10.580.10, 1 hit |
InterProi | View protein in InterPro IPR016142, Citrate_synth-like_lrg_a-sub IPR016143, Citrate_synth-like_sm_a-sub IPR002020, Citrate_synthase IPR019810, Citrate_synthase_AS IPR010109, Citrate_synthase_euk IPR036969, Citrate_synthase_sf |
PANTHERi | PTHR11739, PTHR11739, 1 hit |
Pfami | View protein in Pfam PF00285, Citrate_synt, 1 hit |
PRINTSi | PR00143, CITRTSNTHASE |
SUPFAMi | SSF48256, SSF48256, 1 hit |
TIGRFAMsi | TIGR01793, cit_synth_euk, 1 hit |
PROSITEi | View protein in PROSITE PS00480, CITRATE_SYNTHASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CISY_EMENI | |
Accessioni | O00098Primary (citable) accession number: O00098 Secondary accession number(s): C8V3P7, Q5ATV5, Q8NKF2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 1, 2007 | |
Last modified: | December 2, 2020 | |
This is version 123 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families