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UniProtKB - O00058 (MTDH_UROFA)
Protein
Probable NADP-dependent mannitol dehydrogenase
Gene
PIG8
Organism
Uromyces fabae (Rust fungus)
Status
Functioni
May be involved in hexitol or pentitol metabolism.
Catalytic activityi
- EC:1.1.1.138
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 94 | NADP; via carbonyl oxygenBy similarity | 1 | |
Active sitei | 148 | Proton donorBy similarity | 1 | |
Active sitei | 163 | Proton donorPROSITE-ProRule annotation | 1 | |
Binding sitei | 163 | NADPBy similarity | 1 | |
Active sitei | 167 | Lowers pKa of active site TyrBy similarity | 1 | |
Binding sitei | 167 | NADPBy similarity | 1 | |
Binding sitei | 196 | NADP; via amide nitrogenBy similarity | 1 | |
Binding sitei | 200 | NADPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 21 | NADPBy similarity | 4 | |
Nucleotide bindingi | 67 – 68 | NADPBy similarity | 2 |
GO - Molecular functioni
- mannitol 2-dehydrogenase (NADP+) activity Source: UniProtKB-EC
- NADP binding Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NADP |
Names & Taxonomyi
Protein namesi | Recommended name: Probable NADP-dependent mannitol dehydrogenase (EC:1.1.1.138)Short name: MtDH Alternative name(s): Mannitol 2-dehydrogenase [NADP(+)] Planta-induced rust protein 8 |
Gene namesi | Name:PIG8 |
Organismi | Uromyces fabae (Rust fungus) |
Taxonomic identifieri | 55588 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Basidiomycota › Pucciniomycotina › Pucciniomycetes › Pucciniales › Pucciniaceae › Uromyces |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054729 | 1 – 256 | Probable NADP-dependent mannitol dehydrogenaseAdd BLAST | 256 |
Proteomic databases
PRIDEi | O00058 |
Expressioni
Developmental stagei
Haustoria and rust-infected leaves.
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
i Sequence
Sequence statusi: Complete.
O00058-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFTIDLKDQ CIIVTGGNRG IGLAMSQACA DAGAAVGIIY NSAKDAEDRA
60 70 80 90 100
SEISKKYGVK CKAYQCDVGQ QHKVKEVFKK INEELGPVTG LIANAGVSVV
110 120 130 140 150
KEALQYNKDD FNKIFDVNVF GVFNCAQAMA QIWTDTGFQR GSVVIISSMS
160 170 180 190 200
SQICNRPLTQ CFYNSSKAAV SNLGKCLAAE WAEKSIRVNM LSPGYVKTDQ
210 220 230 240 250
TSHMDQKLRD FQADGVPLKR FAEPEEMAGQ AILLLSPKAS YMTGGEYFVD
GGNLVW
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U81790 mRNA Translation: AAB39878.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U81790 mRNA Translation: AAB39878.1 |
3D structure databases
SMRi | O00058 |
ModBasei | Search... |
Proteomic databases
PRIDEi | O00058 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MTDH_UROFA | |
Accessioni | O00058Primary (citable) accession number: O00058 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | July 1, 1997 | |
Last modified: | December 11, 2019 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |