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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Acinetobacter ursingii ANC 3649
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotationSAAS annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18MagnesiumUniRule annotation1
Metal bindingi77MagnesiumUniRule annotation1
Metal bindingi149MagnesiumUniRule annotation1
Metal bindingi152MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, NucleaseUniRule annotationSAAS annotation
Biological processDNA damage, DNA recombinationUniRule annotationSAAS annotation, DNA repairUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotationSAAS annotation (EC:3.1.22.4UniRule annotationSAAS annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
ORF Names:F942_02174Imported
OrganismiAcinetobacter ursingii ANC 3649Imported
Taxonomic identifieri1257043 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacter
Proteomesi
  • UP000013276 Componenti: Unassembled WGS sequence

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotationSAAS annotation

Phylogenomic databases

OrthoDBiPOG091H0202

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

N9DFU3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNLLFLKSV MPLIIGIDPG SRLTGYGIIE KDGAQLRFID AGTIRTESQG
60 70 80 90 100
MPERLKRIFA GVERIVKFHG PTEAAVEQVF MAQNPDSALK LGQARGAAIA
110 120 130 140 150
ALVNLDLQVA EYTARQIKQS VVGYGAADKE QVQMMVMRIL SLTIKPQADA
160 170 180 190
ADALAAAICH AHVSGSMSKM AVLNALGGMA RGRSRYNSRR R
Length:191
Mass (Da):20,553
Last modified:June 26, 2013 - v1
Checksum:i06CB3D2C4219EFBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
APQC01000015 Genomic DNA Translation: ENV79388.1

Genome annotation databases

EnsemblBacteriaiENV79388; ENV79388; F942_02174
PATRICifig|1257043.3.peg.2118

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
APQC01000015 Genomic DNA Translation: ENV79388.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiENV79388; ENV79388; F942_02174
PATRICifig|1257043.3.peg.2118

Phylogenomic databases

OrthoDBiPOG091H0202

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiN9DFU3_9GAMM
AccessioniPrimary (citable) accession number: N9DFU3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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