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Protein

Dehydrogenase RED3

Gene

RED3

Organism
Cochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern corn leaf blight fungus) (Bipolaris maydis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Dehydrogenase; part of the Tox1B locus, one of the 2 loci that mediate the biosynthesis of T-toxin, a family of linear polyketides 37 to 45 carbons in length, of which the major component is 41 carbons, and which leads to high virulence to maize (PubMed:8953776, PubMed:20192833). One of the PKSs (PKS1 or PKS2) could synthesize a precursor, used subsequently by the other PKS as starter unit, to add additional carbons (PubMed:16529376). Variability in the length of the final carbon backbone C35-47 could be achieved by varying the number of condensation cycles, or use of different starter or extender units or might be due to decarboxylation of the penultimate product, catalyzed by DEC1 (PubMed:12236595). Additional proteins are required for the biosynthesis of T-toxin, including oxidoreductases RED1, RED2, RED3, LAM1 and OXI1, as well as esterase TOX9 (PubMed:20192833).4 Publications

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Pathwayi: Mycotoxin biosynthesis

This protein is involved in Mycotoxin biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Mycotoxin biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei166Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase RED31 Publication (EC:1.1.1.1PROSITE-ProRule annotation)
Alternative name(s):
T-toxin biosynthesis protein RED3Curated
Gene namesi
Name:RED31 Publication
ORF Names:COCC4DRAFT_155403
OrganismiCochliobolus heterostrophus (strain C4 / ATCC 48331 / race T) (Southern corn leaf blight fungus) (Bipolaris maydis)
Taxonomic identifieri665024 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeBipolaris
Proteomesi
  • UP000012338 Componenti: Unassembled WGS sequence

Pathology & Biotechi

Disruption phenotypei

Significantly reduces the production of T-toxin and decreases the virulence to maize (PubMed:20192833).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004376441 – 196Dehydrogenase RED3Add BLAST196

Structurei

3D structure databases

ProteinModelPortaliN4WW42
SMRiN4WW42
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

OrthoDBiEOG092C3QFN

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

N4WW42-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLVKGNCGC YWGIKGHWSR NCSPVCEIAN KNYYSRRGIA PRRTFWSVSN
60 70 80 90 100
KSLVHLDANS LMIDYENVFY YTTDITSNKA IIESSERIRQ DHGNPSVLIN
110 120 130 140 150
NAGVANGKTI LEESEDERRR VFNVDILAHF SLVREFLPDM IKHNHGHIVT
160 170 180 190
VASTASFLAR PQLVSYSCCK TALIAFHEGL SQELRMRHNA RKVRTT
Length:196
Mass (Da):22,273
Last modified:June 26, 2013 - v1
Checksum:iC6480DE6FF2297A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525909 Genomic DNA Translation: ACP34153.1
KB733525 Genomic DNA Translation: ENH98580.1
RefSeqiXP_014072490.1, XM_014217015.1

Genome annotation databases

EnsemblFungiiENH98580; ENH98580; COCC4DRAFT_155403
GeneIDi25839374

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525909 Genomic DNA Translation: ACP34153.1
KB733525 Genomic DNA Translation: ENH98580.1
RefSeqiXP_014072490.1, XM_014217015.1

3D structure databases

ProteinModelPortaliN4WW42
SMRiN4WW42
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiENH98580; ENH98580; COCC4DRAFT_155403
GeneIDi25839374

Phylogenomic databases

OrthoDBiEOG092C3QFN

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRED3_COCH4
AccessioniPrimary (citable) accession number: N4WW42
Secondary accession number(s): C3JXE9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2016
Last sequence update: June 26, 2013
Last modified: December 20, 2017
This is version 22 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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