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Entry version 40 (07 Oct 2020)
Sequence version 1 (26 Jun 2013)
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Protein
Submitted name:

Cdc39p

Gene

CENPK1137D_4440

Organism
Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressorARBA annotation
Biological processTranscription, Transcription regulationARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Cdc39pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:CENPK1137D_4440Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri889517 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000013192 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome III

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmARBA annotation, NucleusARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini169 – 392CNOT1_HEAT_NInterPro annotationAdd BLAST224
Domaini406 – 546CNOT1_HEATInterPro annotationAdd BLAST141
Domaini592 – 744CNOT1_TTP_bindInterPro annotationAdd BLAST153
Domaini778 – 994CNOT1_CAF1_bindInterPro annotationAdd BLAST217
Domaini1087 – 1229DUF3819InterPro annotationAdd BLAST143
Domaini1715 – 2079Not1InterPro annotationAdd BLAST365

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1324 – 1353DisorderedSequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1021 – 1041Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000286_3_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 1 hit
1.25.40.840, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007196, CCR4-Not_Not1_C
IPR024557, CCR4-Not_Not1su_DUF3819
IPR040398, CNOT1
IPR032191, CNOT1_CAF1_bind
IPR032194, CNOT1_HEAT
IPR032195, CNOT1_HEAT_N
IPR032193, CNOT1_TTP_bind
IPR038535, CNOT1_TTP_bind_sf
IPR016021, MIF4-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR13162, PTHR13162, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16415, CNOT1_CAF1_bind, 1 hit
PF16418, CNOT1_HEAT, 1 hit
PF16419, CNOT1_HEAT_N, 1 hit
PF16417, CNOT1_TTP_bind, 1 hit
PF12842, DUF3819, 1 hit
PF04054, Not1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

N1P976-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLSATYRDLN TASNLETSKE KQAAQIVIAQ ISLLFTTLNN DNFESVEREI
60 70 80 90 100
RHILDRSSVD IYIKVWERLL TLSSRDILQA GKFLLQENLL HRLLLEFAKD
110 120 130 140 150
LPKKSTDLIE LLKERTFNNQ EFQKQTGITL SLFIDLFDKS ANKDIIESLD
160 170 180 190 200
RSSQINDFKT IKMNHTNYLR NFFLQTTPET LESNLRDLLH SLEGESLNDL
210 220 230 240 250
LALLLSEILS PGSQNLQNDP TRSWLTPPMV LDATNRGNVI ARSISSLQAN
260 270 280 290 300
QINWNRVFNL MSTKYFLSAP LMPTTASLSC LFAALHDGPV IDEFFSCDWK
310 320 330 340 350
VIFKLDLAIQ LHKWSVQNGC FDLLNAEGTR KVSETIPNTK QSLLYLLSIA
360 370 380 390 400
SLNLELFLQR EELSDGPMLA YFQECFFEDF NYAPEYLILA LVKEMKRFVL
410 420 430 440 450
LIENRTVIDE ILITLLIQVH NKSPSSFKDV ISTITDDSKI VDAAKIIINS
460 470 480 490 500
DDAPIANFLK SLLDTGRLDT VINKLPFNEA FKILPCARQI GWEGFDTFLK
510 520 530 540 550
TKVSPSNVDV VLESLEVQTK MTDTNTPFRS LKTFDLFAFH SLIEVLNKCP
560 570 580 590 600
LDVLQLQRFE SLEFSLLIAF PRLINFGFGH DEAILANGDI AGINNDIEKE
610 620 630 640 650
MQNYLQKMYS GELAIKDVIE LLRRLRDSDL PRDQEVFTCI THAVIAESTF
660 670 680 690 700
FQDYPLDALA TTSVLFGSMI LFQLLRGFVL DVAFRIIMRF AKEPPESKMF
710 720 730 740 750
KFAVQAIYAF RIRLAEYPQY CKDLLRDVPA LKSQAQVYQS IVEAATLANA
760 770 780 790 800
PKERSRPVQE MIPLKFFAVD EVSCQINQEG APKDVVEKVL FVLNNVTLAN
810 820 830 840 850
LNNKVDELKK SLTPNYFSWF STYLVTQRAK TEPNYHDLYS KVIVAMGSGL
860 870 880 890 900
LHQFMVNVTL RQLFVLLSTK DEQAIDKKHL KNLASWLGCI TLALNKPIKH
910 920 930 940 950
KNIAFREMLI EAYKENRLEI VVPFVTKILQ RASESKIFKP PNPWTVGILK
960 970 980 990 1000
LLIELNEKAN WKLSLTFEVE VLLKSFNLTT KSLKPSNFIN TPEVIETLSG
1010 1020 1030 1040 1050
ALGSITLEQQ QTEQQRQIIL MQQHQQQMLI YQQQQRQQQQ QRQQQQQHHI
1060 1070 1080 1090 1100
SANTIADQQA AFGGEGSISH DNPFNNLLGS TIFVTHPDLK RVFQMALAKS
1110 1120 1130 1140 1150
VREILLEVVE KSSGIAVVTT TKIILKDFAT EVDESKLKTA AIIMVRHLAQ
1160 1170 1180 1190 1200
SLARATSIEP LKEGIRSTMQ SLAPNLMSLS SSPAEELDTA INENIGIALV
1210 1220 1230 1240 1250
LIEKASMDKS TQDLADQLMQ AIAIRRYHKE RRADQPFITQ NTNPYSLSLP
1260 1270 1280 1290 1300
EPLGLKNTGV TPQQFRVYEE FGKNIPNLDV IPFAGLPAHA PPMTQNVGLT
1310 1320 1330 1340 1350
QPQQQQAQMP TQILTSEQIR AQQQQQQLQK SRLNQPSQSA QPPGVNVPNP
1360 1370 1380 1390 1400
QGGIAAVQSD LEQNQRVLVH LMDILVSQIK ENATKNNLAE LGDQNQIKTI
1410 1420 1430 1440 1450
IFQILTFIAK SAQKDQLALK VSQAVVNSLF ATSESPLCRE VLSLLLEKLC
1460 1470 1480 1490 1500
SLSLVARKDV VWWLVYALDS RKFNVPVIRS LLEVNLIDAT ELDNVLVTAM
1510 1520 1530 1540 1550
KNKMENSTEF AMKLIQNTVL SDDPILMRMD FIKTLEHLAS SEDENVKKFI
1560 1570 1580 1590 1600
KEFEDTKIMP VRKGTKTTRT EKFYLVFTEW VKLLQRVENN DVITTVFIKQ
1610 1620 1630 1640 1650
LVEKGVISDT DNLLTFVKSS LELSVSSFKE SDPTDEVFIA IDALGSLIIK
1660 1670 1680 1690 1700
LLILQDFKDD TRRDYINAIF SVIVLVFAKD HSQEGTTFNE RPYFRLFSNI
1710 1720 1730 1740 1750
LYEWATIRTH NFVRISDSST RQELIEFDSV FYNTFSGYLH ALQPFAFPGF
1760 1770 1780 1790 1800
SFAWVTLLSH RMLLPIMLRL PNKIGWEKLM LLIIDLFKFL DQYTSKHAVS
1810 1820 1830 1840 1850
DAVSVVYKGT LRIILGISND MPSFLIENHY ELMNNLPPTY FQLKNVILSA
1860 1870 1880 1890 1900
IPKNMTVPNP YDVDLNMEDI PACKELPEVF FDPVIDLHSL KKPVDNYLRI
1910 1920 1930 1940 1950
PSNSLLRTIL SAIYKDTYDI KKGVGYDFLS VDSKLIRAIV LHVGIEAGIE
1960 1970 1980 1990 2000
YKRTSSNAVF NTKSSYYTLL FNLIQNGSIE MKYQIILSIV EQLRYPNIHT
2010 2020 2030 2040 2050
YWFSFVLMNM FKSDEWNDQK LEVQEIILRN FLKRIIVNKP HTWGVSVFFT
2060 2070 2080 2090 2100
QLINNNDINL LDLPFVQSVP EIKLILQQLV KYSKKYTTSE QDDQSATINR

RQTPLQSNA
Length:2,109
Mass (Da):240,514
Last modified:June 26, 2013 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9521AF54D40F208A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CM001524 Genomic DNA Translation: EIW11822.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EIW11822; EIW11822; CENPK1137D_4440

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001524 Genomic DNA Translation: EIW11822.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblFungiiEIW11822; EIW11822; CENPK1137D_4440

Phylogenomic databases

HOGENOMiCLU_000286_3_1_1

Family and domain databases

Gene3Di1.25.40.180, 1 hit
1.25.40.840, 1 hit
InterProiView protein in InterPro
IPR007196, CCR4-Not_Not1_C
IPR024557, CCR4-Not_Not1su_DUF3819
IPR040398, CNOT1
IPR032191, CNOT1_CAF1_bind
IPR032194, CNOT1_HEAT
IPR032195, CNOT1_HEAT_N
IPR032193, CNOT1_TTP_bind
IPR038535, CNOT1_TTP_bind_sf
IPR016021, MIF4-like_sf
PANTHERiPTHR13162, PTHR13162, 1 hit
PfamiView protein in Pfam
PF16415, CNOT1_CAF1_bind, 1 hit
PF16418, CNOT1_HEAT, 1 hit
PF16419, CNOT1_HEAT_N, 1 hit
PF16417, CNOT1_TTP_bind, 1 hit
PF12842, DUF3819, 1 hit
PF04054, Not1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiN1P976_YEASC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: N1P976
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 40 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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