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Protein

Protein farnesyltransferase subunit beta

Gene

CENPK1137D_3735

Organism
Saccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.UniRule annotation

Catalytic activityi

Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionPrenyltransferaseUniRule annotation, Transferase
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein farnesyltransferase subunit betaUniRule annotation (EC:2.5.1.58UniRule annotation)
Short name:
FTase-betaUniRule annotation
Gene namesi
ORF Names:CENPK1137D_3735Imported
OrganismiSaccharomyces cerevisiae (strain CEN.PK113-7D) (Baker's yeast)Imported
Taxonomic identifieri889517 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000013192 Componenti: Chromosome IV

Subcellular locationi

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliN1P7N9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein prenyltransferase subunit beta family.UniRule annotation

Phylogenomic databases

OrthoDBiEOG092C26Q9

Family and domain databases

CDDicd02893 FTase, 1 hit
InterProiView protein in InterPro
IPR026872 FTB
IPR001330 PFTB_repeat
IPR008930 Terpenoid_cyclase/PrenylTrfase
PANTHERiPTHR11774:SF6 PTHR11774:SF6, 1 hit
PfamiView protein in Pfam
PF00432 Prenyltrans, 5 hits
SUPFAMiSSF48239 SSF48239, 1 hit

Sequencei

Sequence statusi: Complete.

N1P7N9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRQRVGRSIA RAKFINTALL GRKRPVMERV VDIAHVDSSK AIQPLMKELE
60 70 80 90 100
TDTTEARYKV LQSVLEIYDD EKNIEPALTK EFHKMYLDVA FEISLPPQMT
110 120 130 140 150
ALDASQPWML YWIANSLKVM DRDWLSDDTK RKIVDKLFTI SPSGGPFGGG
160 170 180 190 200
PGQLSHLAST YAAINALSLC DNIDGCWDRI DRKGIYQWLI SLKEPNGGFK
210 220 230 240 250
TCLEVGEVDT RGIYCALSIA TLLNILTEEL TEGVLNYLKN CQNYEGGFGS
260 270 280 290 300
CPHVDEAHGG YTFCATASLA ILRSMDQINV EKLLEWSSAR QLQEERGFCG
310 320 330 340 350
RSNKLVDGCY SFWVGGSAAI LEAFGYGQCF SKHALRDYIL YCCQEKEQPG
360 370 380 390 400
LRDKPGAHSD FYHTNYCLLG LAVAESSYSC TPNDSPHNIK CTPDRLIGSS
410 420 430
KLTDVNPVYG LPIENVRKII HYFKSNLSSP S
Length:431
Mass (Da):48,163
Last modified:June 26, 2013 - v1
Checksum:i2699F54A1DD111D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001525 Genomic DNA Translation: EIW11117.1

Genome annotation databases

EnsemblFungiiEIW11117; EIW11117; CENPK1137D_3735

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CM001525 Genomic DNA Translation: EIW11117.1

3D structure databases

ProteinModelPortaliN1P7N9
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEIW11117; EIW11117; CENPK1137D_3735

Phylogenomic databases

OrthoDBiEOG092C26Q9

Family and domain databases

CDDicd02893 FTase, 1 hit
InterProiView protein in InterPro
IPR026872 FTB
IPR001330 PFTB_repeat
IPR008930 Terpenoid_cyclase/PrenylTrfase
PANTHERiPTHR11774:SF6 PTHR11774:SF6, 1 hit
PfamiView protein in Pfam
PF00432 Prenyltrans, 5 hits
SUPFAMiSSF48239 SSF48239, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiN1P7N9_YEASC
AccessioniPrimary (citable) accession number: N1P7N9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 26, 2013
Last sequence update: June 26, 2013
Last modified: November 7, 2018
This is version 24 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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